Zorex - instructions for use, analogs, reviews and release forms (capsules 150 mg and 250 mg, effervescent tablets Morning) drug for treating poisoning and hangover in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Zorex. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Zorex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Zorex analogs in the presence of existing structural analogs. Use for treatment of poisoning with metals and glycosides, hangovers in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Zorex complexing drug. Donator of sulfhydryl (thiol) groups. Has detoxification (including in relation to the products of half-life of ethanol (alcohol), heavy metals and their compounds, arsenic compounds) action. In clinical studies hepatoprotective and antioxidant action of unithiol (active substance of Zorex preparation) is shown.

Active sulfhydryl groups of unithiol, interacting with thiol poisons and alcohol (ethanol) half-life products, which are in the blood and tissues, form nontoxic compounds (complexes) with them, which are excreted in the urine.

When taking the drug inside unitiol with portal bloodstream penetrates the liver, where it quickly and physiologically irreversibly binds to acetaldehyde, which causes the subsequent removal of ethyl alcohol from other organs and tissues. Zorex also activates alcohol dehydrogenase, enhancing the process of ethanol oxidation and detoxification of its toxic agents by the enzyme system of the liver.

The presence in the formulation of Zorex calcium pantothenate enhances the detoxication effect of unithiol.Calcium pantothenate is well absorbed from the intestine and is cleaved, releasing pantothenic acid, which participates in carbohydrate and fat metabolism, stimulates the formation of corticosteroids, accelerates regeneration processes.

Composition

Sodium dimercaptopropanesulfonate (unitiol) + Calcium pantothenate + auxiliary substances.

Acetylsalicylic acid + succinic acid + auxiliary substances (Zorex Morning).

Pharmacokinetics

Average time of drug in the body is 9-11 hours, incl. in the gastrointestinal tract - 15-20 minutes.

Calcium pantothenate is well absorbed from the intestine and is cleaved, releasing pantothenic acid.

About 60% of the drug is excreted in the urine, in part - with feces.

Indications

• alcoholic abstinence syndrome (for the prevention and treatment of hangovers);
• headache with alcohol withdrawal syndrome;
• chronic alcoholism (as part of complex therapy);
• acute and chronic poisoning by organic and inorganic compounds of arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony, intoxication with cardiac glycosides.

Forms of release

Capsules 150 mg and 250 mg.

Pills effervescent (Zorex Morning).

Instructions for use and reception scheme

Capsules

The drug is prescribed inside. Capsules should be taken 30 minutes before meals, without chewing, washing with water.

For prophylaxis of a hangover - after reception of alcohol 1 capsule (250 mg + 10 mg) in the evening before a dream.

For the treatment of alcohol withdrawal syndrome - 1 capsule (250 mg + 10 mg) 1-2 times per day (the doses are given in terms of unithiol and calcium pantothenate). If necessary, the daily dose can be increased to 750 mg (unithiol), and the frequency of reception should be increased to 3 times a day. The drug should be taken 3-7 days before the symptoms of intoxication stop.

In chronic alcoholism, one capsule (150 mg + 7 mg) is prescribed 1-2 times a day for 10 days (the doses are given in terms of unitiol and calcium pantothenate).

When poisoning with arsenic compounds and heavy metal salts, 300-1000 mg per day (unithiol) are prescribed, divided into 2-3 doses for 7-10 days.

Effervescent tablets

The drug is taken orally. The effervescent tablet should be dissolved in a glass of water before use.

Adults and children over 15 years of age in a single dose of 1-2 tablets with an interval between admission 4-8 hours; the maximum daily dose is 8 tablets

Duration of treatment should not exceed 7 days with the appointment as an anesthetic and 3 days - as an antipyretic.

Side effect

• itching;
• hives;
• rash on the skin and mucous membranes;
• swelling of the mucous membranes;
• genital itching;
• stomatitis;
• the appearance of an allergic reaction such as angioedema or Stephen-Johnson syndrome (sudden rise in body temperature, malaise, spotty vesiculosis or bullous rashes on the skin, mucous membranes of the oral cavity, genital organs, in the anus);
• nausea;
• dizziness;
• tachycardia;
• pallor of the skin.

Contraindications

• severe liver disease in the stage of decompensation;
• severe kidney disease in the stage of decompensation;
• children's age till 18 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Data on the use of Zorex during pregnancy and lactation (breastfeeding) are not available. In connection with the lack of necessary information, use during pregnancy and during breastfeeding is contraindicated.

Use in children

Contraindicated in children under the age of 18 years.

special instructions

With caution, use the drug with low blood pressure.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (driving and other vehicles, working with moving mechanisms, dispatcher and operator work, etc.).

Drug Interactions

It is not compatible with drugs containing salts of heavy metals, as well as with alkalis (rapidly decomposes).

Analogs of the drug Zorex

Structural analogs for the active substance:

• R-IKS 1;
• Uni thiol;
• Unithiol Ferein.

Analogues for the pharmacological group (antidotes and detoxifying agents):

• N Methylglucamine;
• Anexam;
• Antakson;
• Artamine;
• Acisol;
• Balance;
• Bianodine;
• Brydan;
• Gambrosol trio;
• Hemolactol;
• Gepa Merz;
• Gluconeodes;
• Glutamic acid;
• Dalizol;
• Desferal;
• Dianil;
• Digitalitis antidote BM;
• Ionostigmine;
• Calcium-phosphinate Ebevé;
• Calcium folinate;
• Carbactin;
• Carboxym;
• Carbopect;
• Carbosorb;
• Cardiosan;
• Kuprenil;
• Lamisplat;
• Levulose;
• Leucovorin;
• Lignin hydrolyzed oxidized;
• Marina;
• Meglumine sodium succinate;
• Medetopect;
• Mesna;
• Milife;
• Naloxone;
• Naltrexone;
• Ornitsetil;
• Pelixim;
• Pentacin;
• Polyphane;
• Polyphepan;
• Sanfinate;
• Sorbeks;
• Trekrezan;
• Activated carbon;
• Uromitexan;
• Ferrocin;
• STI Filter;
• Calcium folinate;
• Fosrenol;
• Eksidzhad;
• Extranil;
• Entereroz;
• Epilapton;
• Ethyl.

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