Glevo - instructions for the use of antibiotics, analogs, reviews and release forms (tablets of 250 mg and 500 mg) of a drug for the treatment of angina, pneumonia and pyelonephritis in adults, children and pregnancy
In this article, you can read the instructions for using the drug Glevo. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Gleu in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Glevo with available structural analogues. Use for the treatment of angina, pneumonia and pyelonephritis in adults, children, as well as during pregnancy and lactation.
Glevo - antibacterial preparation of a group of fluoroquinolones of a wide spectrum of action. Levofloxacin (active ingredient of the Gleu drug) blocks DNA-gyrase (topoisomerase 2) and topoisomerase 4, disrupts supercoiling and cross-linking of DNA gaps, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes of microorganisms.
The drug is active against aerobic Gram-positive and Gram-negative microorganisms, anaerobic microorganisms, as well as other microorganisms: Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp., Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.
Composition
Levofloxacin (in the form of hemihydrate) + auxiliary substances.
Pharmacokinetics
When ingested quickly and almost completely absorbed. Food intake has little effect on the speed and completeness of absorption. Bioavailability is 99%. Binding to plasma proteins - 30-40%. It penetrates well into organs and tissues (lungs, bronchial mucosa, sputum, organs of the genitourinary system, polymorphonuclear leukocytes, alveolar macrophages). In the liver, a small portion of the drug is oxidized and / or deacetylated. It is excreted from the body mainly by the kidneys through glomerular filtration and tubular secretion.Less than 5% of levofloxacin is excreted as metabolites. After oral administration, about 70% of the dose is excreted in the urine unchanged for 24 hours, about 87% of the dose for 48 hours; less than 4% - with feces for 72 hours.
Indications
Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:
- infection of the ENT organs (including acute sinusitis);
- infections of the lower respiratory tract (including exacerbation of chronic bronchitis, community-acquired pneumonia);
- uncomplicated and complicated infections of the urinary tract and kidneys (including acute pyelonephritis, prostatitis);
- infection of the genitals;
- infections of the skin and soft tissues (festering atheromas, abscess, furunculosis);
- infection of the abdominal cavity (in combination with drugs acting on the anaerobic microflora).
Forms of release
Tablets coated with 250 mg and 500 mg.
Instructions for use and dosing regimen
The drug is taken orally 1-2 times a day. Tablets should be swallowed whole, without chewing and washing down with a sufficient amount of liquid (from 0.5 to 1 cup). The drug can be taken before meals or between meals.
Doses are determined by the nature and severity of the infection, as well as the suspected pathogen susceptibility.
The following dosing regimen is recommended:
With sinusitis, appoint 500 mg once a day for 10-14 days.
With exacerbation of chronic bronchitis - 250 mg or 500 mg 1 time per day for 7-10 days.
With community-acquired pneumonia, 500 mg 1-2 times a day for 7-14 days.
In uncomplicated urinary tract infections - 250 mg once a day for 3 days.
At a prostatitis - on 500 mg once a day within 28 days.
With complicated infections of the urinary tract, including pyelonephritis, 250 mg once a day for 7-10 days.
For skin and soft tissue infections, 250-500 mg 1-2 times a day for 7-14 days.
With infections of the abdominal cavity - 500 mg once a day for 7-14 days (in combination with antibacterial drugs acting on anaerobic flora).
For elderly patients, there is no need to change the dosage regimen.
As with the use of other antibiotics, treatment with Gleu should be continued no less than 48-78 hours after the normalization of body temperature or after a reliable eradication of the pathogen.
If you missed taking the drug, you should take the pill as soon as possible until the time of the next appointment is near. Then continue taking the drug according to the scheme.
Side effect
- nausea, vomiting;
- diarrhea (including with blood);
- decreased appetite;
- abdominal pain;
- pseudomembranous enterocolitis;
- dysbiosis;
- a decrease in blood pressure;
- vascular collapse;
- tachycardia;
- atrial fibrillation;
- hypoglycemia (increased appetite, increased sweating, trembling, nervousness);
- headache;
- dizziness;
- weakness;
- drowsiness;
- insomnia;
- tremor;
- anxiety;
- fear;
- hallucinations;
- confusion of consciousness;
- depression;
- epileptic seizures (in predisposed patients);
- impaired vision, hearing, smell, taste and tactile sensitivity;
- muscle weakness;
- myalgia;
- rupture of tendons;
- rhabdomyolysis;
- interstitial nephritis;
- acute renal insufficiency;
- eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia;
- itching and hyperemia of the skin;
- swelling of the skin and mucous membranes;
- hives;
- malignant exudative erythema (Stevens-Johnson syndrome);
- toxic epidermal necrolysis (Lyell's syndrome);
- bronchospasm;
- suffocation;
- anaphylactic shock;
- allergic pneumonitis;
- vasculitis;
- photosensitization;
- asthenia;
- aggravation of porphyria;
- persistent fever;
- development of superinfection.
Contraindications
- epilepsy;
- the defeat of the tendons during the previous treatment with quinolones;
- pregnancy;
- lactation period (breastfeeding);
- children and adolescence (up to 18 years);
- hypersensitivity to levofloxacin and other fluoroquinolones.
Use in children
Contraindicated in childhood and adolescence (under 18 years).
special instructions
Although levofloxacin is more soluble than other quinolones, patients should conduct adequate hydration of the body.
During treatment, sun and artificial UV irradiation should be avoided to avoid damage to the skin (photosensitivity).
When there are signs of tendonitis, pseudomembranous colitis, Glevo is immediately abolished and appropriate therapy is prescribed.
It should be borne in mind that the development of seizures is possible in patients with a history of brain injury (stroke, severe trauma), with the insufficiency of glucose-6-phosphate dehydrogenase increasing the risk of hemolysis.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Drug Interactions
The action of the drug reduces drugs that depress intestinal motility, sucralfate, aluminum / magnesium-containing antacid drugs and iron salts (a break between intake of at least 2 hours is necessary).
With the simultaneous use of Glevo with non-steroidal anti-inflammatory drugs (NSAIDs), theophylline increases convulsive readiness.
With the simultaneous use of Glevo with glucocorticosteroid (GCS), the risk of rupture of tendons increases.
Cimetidine and drugs that block tubular secretion, slow the withdrawal of levofloxacin.
With the simultaneous use of hypoglycemic drugs with levofloxacin, hypo- and hyperglycemia may develop. Therefore, strict control of blood glucose levels is necessary.
Analogs of the drug Glevo
Structural analogs for the active substance:
- Ivacin;
- Lebel;
- Levot;
- Levotech;
- Levoflox;
- Levofloxabol;
- Levofloxacin;
- Leobeg;
- Leflobact;
- Lefokcin;
- Matlevo;
- OD Levoks;
- Oftakwix;
- Remedy;
- Signictsef;
- Tavanik;
- Tanflomed;
- Flexine;
- Floracid;
- Hayleflex;
- Ecology;
- Eleflox.
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