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Ultop - instructions for use, reviews, analogs and forms of release (capsules or tablets 10 mg, 20 mg and 40 mg, injections in injections) of a drug for the treatment of ulcers and gastritis in adults, children and pregnancy. Composition

Ultop - instructions for use, reviews, analogs and forms of release (capsules or tablets 10 mg, 20 mg and 40 mg, injections in injections) of a drug for the treatment of ulcers and gastritis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ultop. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ultopa in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Ultopa in the presence of existing structural analogs. Use to treat ulcers and gastritis in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Ultop - antiulcer drug, inhibitor of H-K-ATPase. It inhibits the activity of H-K-ATPase in parietal cells of the stomach and blocks the final stage of formation of hydrochloric acid, which leads to a decrease in the level of basal and stimulated secretion, regardless of the nature of the stimulus.

 

After taking the drug once inside, the action of Omeprazole (the active substance of the drug Ultop) occurs within the first hour and lasts for 24 hours, the maximum effect is achieved after 2 hours. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains an intragastric pH-3 during 17 hours After discontinuation of the drug secretory activity is completely restored after 3-5 days.

 

Composition

 

Omeprazole + auxiliary substances.

 

Pharmacokinetics

 

After taking the drug inside Ultop is quickly absorbed from the digestive tract. Bioavailability is 30-40%. Binding to plasma proteins is about 90-95%. Omeprazole is almost completely biotransformed in the liver. It is excreted mainly by the kidneys (70-80%) and with bile (20-30%).

 

Indications

 

Capsules enteric in solution 20 mg and 40 mg

  • peptic ulcer of the stomach and duodenum (in the phase of exacerbation and anti-relapse treatment), incl.Associated with Helicobacter pylori (as part of combination therapy);
  • Gastroesophageal reflux disease (GERD), incl. reflux-esophagitis and non-erosive forms of reflux disease (NERD);
  • erosive and ulcerative lesions of the stomach and duodenum associated with the administration of NSAIDs, stress ulcers;
  • Zollinger-Ellison syndrome and other pathological conditions associated with increased gastric secretion.

 

Capsules, enteric, soluble 10 mg

  • short-term therapy of non-ulcer dyspepsia, which manifests itself in pain in the stomach, nausea, heartburn, belching;
  • long-term maintenance therapy for the prevention of recurrences of gastroesophageal reflux
  • disease (GERD) (prevention of recurrence of heartburn);
  • long-term maintenance therapy to prevent recurrences of gastric and duodenal ulcers.

 

Forms of release

 

Capsules 10 mg, 20 mg and 40 mg (sometimes mistakenly called tablets).

 

Lyophilizate for the preparation of a solution for infusions (injections in ampoules for injections).

 

Instructions for use and reception scheme

 

The drug is taken orally, before meals (because eating slows the absorption of the drug), squeezed with a small amount of water (the contents of the capsule can not be chewed).

 

With duodenal ulcer in the phase of exacerbation, Ultop is prescribed 20 mg per day for 2-4 weeks. In resistant cases, it is possible to increase the dose to 40 mg per day.

 

With peptic ulcer in the phase of exacerbation and erosive-ulcerative esophagitis - 20-40 mg per day for 4-8 weeks.

 

For gastroesophageal reflux disease (GERD), patients with moderate inflammation of 1 tablet 20 mg once a day in the morning, before breakfast for 4-8 weeks. To ensure the following dosing regimen, it is possible to take the drug at another registered dosage (Ultop, enteric-soluble capsules 40 mg). The duration of the main course of treatment is usually 4-8 weeks. After healing of erosive esophagitis, supportive treatment for 26-52 weeks is shown, with severe esophagitis - for life. In cases of relapse of severe GERD or resistant GERD, the treatment can be extended up to 4-8 weeks.

 

With Zollinger-Ellison syndrome and other pathological conditions associated with increased gastric secretion, the dose is selected individually depending on the initial level of gastric secretion, usually starting at 60 mg per day.If necessary, increase the dose to 80-120 mg per day, in this case, it is divided into 2-3 doses.

 

To eradicate Helicobacter pylori - 20 mg twice a day for 7 or 14 days (depending on the treatment scheme used) in combination with antibacterial drugs.

 

With non-ulcer dyspepsia, the usual dose is 10 mg to 20 mg once daily for 2-4 weeks. If after 4 weeks of taking the drug the condition does not improve, or the symptoms of dyspepsia appear again soon after stopping the intake, the diagnosis should be revised.

 

For the prevention of recurrences of peptic ulcer of the stomach and duodenum, 10-20 mg per day are prescribed.

 

For the prevention of recurrence of GERD - 20 mg per day for a long time. The safety and efficacy of 12-month maintenance therapy have been proven. Application on demand is possible.

 

For elderly patients, correction of the treatment regimen is not required.

 

Side effect

  • diarrhea;
  • constipation;
  • nausea;
  • vomiting;
  • flatulence;
  • abdominal pain;
  • irritable bowel syndrome;
  • heartburn;
  • dry mouth;
  • violation of taste;
  • stomatitis;
  • loss of appetite;
  • change in the color of stool;
  • Candidiasis of the esophagus;
  • atrophy of the tongue mucosa;
  • impaired liver function or hepatic encephalopathy;
  • headache;
  • dizziness;
  • aggressiveness;
  • apathy;
  • nervousness;
  • excitation;
  • drowsiness;
  • insomnia;
  • tremor;
  • paresthesia;
  • depression;
  • hallucinations;
  • confusion of consciousness;
  • angina pectoris;
  • tachycardia;
  • bradycardia;
  • increased blood pressure;
  • peripheral edema;
  • interstitial nephritis;
  • hematuria;
  • gynecomastia;
  • pain in the testicles;
  • muscle weakness;
  • myalgia;
  • arthralgia;
  • ossalgia (pain in the bones);
  • muscle cramps;
  • pancytopenia, agranulocytosis, anemia (including hemolytic anemia), neutropenia, thrombocytopenia, leukocytosis, leukopenia;
  • itching;
  • skin rash;
  • photosensitization;
  • exudative erythema multiforme;
  • hair loss;
  • dry skin;
  • epidermal necrosis;
  • Stevens-Johnson syndrome;
  • a sore throat;
  • cough;
  • copious nosebleeds;
  • tinnitus;
  • hives;
  • angioedema;
  • bronchospasm;
  • anaphylactic shock;
  • increased sweating;
  • general fatigue;
  • general weakness;
  • weight gain;
  • fever.

 

Contraindications

  • childhood;
  • pregnancy;
  • lactation (breastfeeding);
  • hereditary fructose intolerance, glucose-galactose malabsorption syndrome, sugarase / isomaltase deficiency;
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The safety of Ultop during pregnancy and lactation is not known. Therefore, prescribe during pregnancy is not recommended. If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

 

special instructions

 

Before the start of treatment, it is necessary to exclude the presence of malignant process (especially with gastric ulcer), since treatment, masking the symptoms, can delay the setting of the correct diagnosis.

 

The intake of food slows the absorption of omeprazole, so the drug is taken before meals.

 

In special cases, if there are difficulties with swallowing the whole capsule, you can swallow its contents after opening or dissolving the capsule, and you can mix the contents of the capsule with a slightly acidic liquid (juice, yogurt) and use the resulting suspension for 30 minutes.

 

Caution is necessary to take Ultop in patients with cirrhosis; the daily dose should not exceed 20 mg.

 

Also with caution, it is necessary to take the Ultop drug in patients with impaired renal function. In patients on dialysis, the pharmacokinetic parameters of omeprazole do not change.

 

Ultop contains sucrose, so the drug is not recommended for patients with glucose malabsorption syndrome and / or galactose or sucrose / isomaltose deficiency.

 

Impact on the ability to drive vehicles and manage mechanisms

 

When using the drug in recommended doses does not affect the ability to drive vehicles and control mechanisms.

 

Drug Interactions

 

Long-term use of omeprazole 20 mg once daily in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol (alcohol), cyclosporine, lidocaine, quinidine and estradiol did not change their plasma concentration.

 

No interaction of omeprazole with concomitant antacids was noted.

 

Omeprazole can reduce the absorption of ampicillin esters, iron salts, Itraconazole and Ketoconazole (as omeprazole increases the pH of the stomach).

 

Being an inhibitor of cytochrome P450, omeprazole can increase the concentration and reduce the excretion of diazepam, an anticoagulant of indirect action, phenytoin, which in some cases may require a reduction in the doses of these drugs.

 

With simultaneous reception, the absorption of omeprazole and Clarithromycin is increased.

 

Analogues of Ultop drug

 

Structural analogs for the active substance:

  • Vero Omeprazole;
  • Gastrozole;
  • Demeprazole;
  • Zhelezolic;
  • A zerocide;
  • Zolser;
  • Chrismel;
  • Losek;
  • Omez;
  • Omez Insta;
  • Omesol;
  • Omekaps;
  • Omeprazole;
  • Omepros;
  • Omeface;
  • Omizak;
  • OmiPix;
  • Omitox;
  • Ortanol;
  • Ozid;
  • Pepticum;
  • Pleom 20;
  • Pomez;
  • Romesque;
  • Ulzol;
  • Ulcozol;
  • Helicid;
  • Helol;
  • Cisagast.

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Reviews (3):
Guests
Dina
Chronic gastritis has earned itself in the student years.The first time treated this diagnosis lightly: I did not adhere to a diet, I did not go to doctors, and I took no medicine. Stomach periodically made itself felt, but I tried not to pay attention to it, lived on the principle of "boleit - cease." In the end, after all, it took me, so much so that because of the festive table I went straight to the hospital. After this incident, it finally came to me that with a stomach jokes are bad. Now I am on the account of a gastroenterologist, I try to follow a diet, with exacerbations I take Ultopic. A good medicine, except for the fact that it constantly causes constipation. After the course of treatment ends, there are no problems with the stool, but during the treatment you have to suffer. Another drawback - large capsules, and could not get used to them, I swallowed with difficulty. But these are all little things, but in general I am happy with the drug. Take it easy: one capsule on an empty stomach before breakfast - and an hour later forget about the pain and heartburn. I drink a course of 2 weeks, the effect after the course lasts a long time.
Guests
Victor
Ultopa was prescribed to me in the hospital after a perforated ulcer (they had an operation) withThat time my stomach does not bother me, I really drink the ultop now, but it's better than the horror that I was.
Guests
Ivan
Hello. After using this drug, constipation began.

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