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Levofloxacin - instructions for use, reviews, analogs and formulations (tablets 250 mg, 500 mg and 750 mg Hailefleks, solution for infusions, eye drops 0.5% antibiotic) for the treatment of pneumonia in adults, children and pregnancy. Composition

Levofloxacin - instructions for use, reviews, analogs and formulations (tablets 250 mg, 500 mg and 750 mg Hailefleks, solution for infusions, eye drops 0.5% antibiotic) for the treatment of pneumonia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Levofloxacin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of antibiotic Levofloxacin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Levofloxacin in the presence of existing structural analogues.Use for the treatment of pneumonia, prostatitis, chlamydia and other infections in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Levofloxacin - a synthetic antibacterial agent of a broad spectrum of action from the group of fluoroquinolones, containing as an active substance levofloxacin - the left-handed isomer of ofloxacin. Levofloxacin blocks DNA-gyrase, disrupts supercoiling and cross-linking of DNA gaps, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes.

 

Levofloxacin is active against most strains of microorganisms (aerobic Gram-positive and Gram-negative, as well as anaerobic).

 

Antibiotics are sensitive to Levofloxacin and other microorganisms: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp, Mycobacterium spp, Mycobacterium leprae, Micobacterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae, Ricketsia spp, Ureaplasma urealyticum.

 

Composition

 

Levofloxacin hemihydrate + excipients.

 

Pharmacokinetics

 

Levofloxacin is rapidly and almost completely absorbed after oral administration. Food intake has little effect on the speed and completeness of absorption.It penetrates well into organs and tissues: lungs, bronchial mucosa, sputum, organs of the genitourinary system, bone tissue, cerebrospinal fluid, prostate gland, polymorphonuclear leukocytes, alveolar macrophages. In the liver, a small portion is oxidized and / or deacetylated. It is excreted from the body mainly by the kidneys through glomerular filtration and tubular secretion. After oral administration, approximately 87% of the dose is excreted unchanged for 48 hours, less than 4% with feces for 72 hours.

 

Indications

 

Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:

  • infection of the lower respiratory tract (exacerbation of chronic bronchitis, community-acquired pneumonia);
  • infection of the ENT organs (acute sinusitis);
  • urinary tract infection and kidney infection (including acute pyelonephritis);
  • infections of the genitals (including bacterial prostatitis);
  • infections of the skin and soft tissues (festering atheromas, abscess, boils);
  • intra-abdominal infections;
  • tuberculosis (complex therapy of drug-resistant forms).

 

Forms of release

 

Tablets coated with 250 mg, 500 mg and 750 mg (Haileflox).

 

Solution for infusions 5 mg / ml.

 

Eye drops 0.5%.

 

Instructions for use and dosage

 

Inside, during a meal or during a break between meals, without chewing, squeezed with enough liquid.

 

Doses are determined by the nature and severity of the infection, as well as the suspected pathogen susceptibility,

 

The recommended dose of the drug for adults with normal renal function (CK> 50 ml / min):

 

In acute sinusitis - 500 mg once a day for 10-14 days;

 

With exacerbation of chronic bronchitis - from 250 to 500 mg once a day for 7-10 days;

 

With community-acquired pneumonia, 500 mg 1 or 2 times a day for 7-14 days;

 

In uncomplicated infections of the urinary tract and kidneys - 250 mg 1 time per day for 3 days;

 

With complicated infections of the urinary tract and kidneys - 250 mg once a day for 7-10 days;

 

With bacterial prostatitis - 500 mg once a day for 28 days;

 

For infections of the skin and soft tissues - 250 mg - 500 mg 1 or 2 times a day for 7-14 days;

 

Intra-abdominal infections - 250 mg twice a day or 500 mg once a day - 7-14 days (in combination with antibacterial drugs acting on anaerobic flora).

 

Tuberculosis - inside by 500 mg 1-2 times a day to 3 months.

 

If the liver function is not required, a special dose selection is required, since levofloxacin is only slightly metabolized in the liver and excreted mainly by the kidneys.

 

If you missed taking the drug should, as soon as possible, take a pill, until the time of the next admission is near. Then continue taking levofloxacin according to the scheme.

 

The duration of therapy depends on the type of disease. In all cases, treatment should continue from 48 to 72 hours after the disappearance of the symptoms of the disease.

 

Side effect

  • itching and redness of the skin;
  • general hypersensitivity reactions (anaphylactic and anaphylactoid reactions) with symptoms such as urticaria, constriction of the bronchi and possibly severe choking;
  • swelling of the skin and mucous membranes (for example, in the face and throat area);
  • sudden drop in blood pressure and shock;
  • increased sensitivity to solar and ultraviolet radiation;
  • allergic pneumonitis;
  • vasculitis;
  • toxic epidermal necrolysis (Lyell's syndrome);
  • exudative erythema multiforme;
  • nausea, vomiting;
  • diarrhea;
  • loss of appetite;
  • stomach ache;
  • pseudomembranous colitis;
  • a decrease in the concentration of glucose in the blood, which is of particular importance for patients suffering from diabetes mellitus (possible signs of hypoglycemia: increased appetite, nervousness, sweating, trembling);
  • exacerbation of porphyria in patients already suffering from this disease;
  • headache;
  • dizziness and / or stupor;
  • drowsiness;
  • sleep disorders;
  • anxiety;
  • shiver;
  • psychotic reactions such as hallucinations and depressions;
  • convulsions;
  • confusion of consciousness;
  • impaired vision and hearing;
  • disorders of taste sensitivity and smell;
  • decreased tactile sensitivity;
  • increased heart rate;
  • joint and muscle pain;
  • rupture of tendons (eg Achilles tendon);
  • impairment of kidney function up to acute renal failure;
  • interstitial nephritis;
  • increase in the number of eosinophils;
  • decrease in the number of leukocytes;
  • neutropenia, thrombocytopenia, which may be accompanied by increased bleeding;
  • agranulocytosis;
  • pancytopenia;
  • fever.

 

Contraindications

  • hypersensitivity to levofloxacin or other quinolones;
  • renal failure (with creatinine clearance less than 20 ml / min - due to the inability to dispense this dosage form);
  • epilepsy;
  • lesions of tendons during the previous treatment with quinolones;
  • children and adolescence (up to 18 years);
  • pregnancy and lactation.

 

Application in pregnancy and lactation

 

Contraindicated in pregnancy and lactation.

 

Use in children

 

Levofloxacin can not be used to treat children and adolescents (under 18 years of age) because of the possibility of joint cartilage damage.

 

special instructions

 

In severe pneumonia caused by pneumococci, levofloxacin may not provide the optimal therapeutic effect. Hospital infections caused by certain pathogens (P. aeruginosa) may require combined treatment.

 

During treatment with Levofloxacin, an episode of seizures may develop in patients with previous brain damage due, for example, to a stroke or severe trauma.

 

Despite the fact that photosensitivity is noted with the use of levofloxacin very rarely, in order to avoid it, it is not recommended to be subjected to severe sunlight or artificial ultraviolet irradiation without special need.

 

If pseudomembranous colitis is suspected, levofloxacin should be immediately discontinued and appropriate treatment initiated. In such cases, drugs that depress intestinal motility should not be used.

 

The use of alcohol and alcoholic beverages in the treatment of Levofloxacin is prohibited.

 

Rarely observed with the use of the drug Levofloxacin tendonitis (primarily inflammation of the Achilles tendon) can lead to rupture of tendons. The elderly are more prone to tendinitis. Treatment with glucocorticosteroids in all likelihood increases the risk of rupture of tendons. If suspicion of tendonitis should immediately stop treatment with Levofloxacin and begin appropriate treatment of the affected tendon.

 

Patients with insufficiency of glucose-6-phosphate dehydrogenase (hereditary metabolic disorders) can react to fluoroquinolones by destruction of erythrocytes (hemolysis). In this regard, the treatment of such patients with levofloxacin should be carried out with great care.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Such side effects of Levofloxacin, such as dizziness or stupor, drowsiness and visual impairment, may impair reactivity and concentration. This can represent a certain risk in situations where these abilities are of particular importance (for example, when driving, servicing machines and mechanisms, performing work in an unstable position).

 

Drug Interactions

 

There are reports of a marked decrease in the threshold of convulsive readiness with the simultaneous use of quinolones and substances that, in turn, can reduce the cerebral threshold of convulsive readiness. Equally, this also applies to the simultaneous use of quinolones and theophylline.

 

Effect of the drug Levofloxacin significantly weakened with simultaneous application with sucralfate. The same happens with the simultaneous use of magnesium- or aluminum-containing antacid agents, as well as iron salts. Levofloxacin should be taken at least 2 hours before or 2 hours after taking these drugs. Calcium carbonate was not detected.

 

With the simultaneous use of vitamin K antagonists, control over the blood coagulation system is necessary.

 

Elimination (renal clearance) of levofloxacin slightly slowed down by the action of cimetidine and probenicide. It should be noted that this interaction has practically no clinical significance. Nevertheless, with the simultaneous use of drugs such as probenicid and cimetidine blocking a certain way of excretion (tubular secretion), treatment with levofloxacin should be done with caution.This applies primarily to patients with limited renal function.

 

Levofloxacin slightly increases the half-life of cyclosporine.

 

The use of glucocorticosteroids increases the risk of rupture of tendons.

 

Analogues of the drug Levofloxacin

 

Structural analogs for the active substance:

  • Glevo;
  • Ivacin;
  • Lebel;
  • Levot P;
  • Levotech;
  • Levoflox;
  • Levofloxabol;
  • Levofloxacin STADA;
  • Levofloxacin Teva;
  • Levofloxacin hemihydrate;
  • Levofloxacin hemihydrate;
  • Leobeg;
  • Leflobact;
  • Lefokcin;
  • Matlevo;
  • OD Levoks;
  • Oftakwix;
  • Remedy;
  • Signictsef;
  • Tavanik;
  • Tanflomed;
  • Flexine;
  • Floracid;
  • Hayleflex;
  • Ecology;
  • Eleflox.

Similar medicines:

Other medicines:

Reviews (29):
Visitors
Svetlana
Haileflox (Levofloxacin) in a 750 mg dose of 10 days showed a marked clinical (87.5%) and bacteriological (90%) efficacy in chronic bacterial prostatitis.Undesirable effects that did not require discontinuation of therapy were detected in 7.5% of cases. These results are comparable with the literature data on the effectiveness of a prolonged course of Levofloxacin in a dosage of 500 mg - once a day - 28 days. In this short course of antibiotic therapy can reduce the adverse effects on the patient's body, associated with a prolonged intake of antibiotics.
Further analysis is needed to determine the duration of the disease-free period.
Guests
khoruzhikh53
Gentlemen, drink this medication with caution! After a long illness: bronchitis, sinusitis, the doctor prescribed me levofloxacin. For 5 days, almost no signs of sinusitis is left. But ... Only today, turning over an outpatient card, I found the reason for the complete absence of smell. For six months now I live without smells. It's creepy ...
Guests
Ass
Creepy drug. The pills emerged after 2 tablets of 500 mg each. Insomnia, not funny, tomorrow to work. Bright nightmares and a strong sense of anxiety. Further I will not accept and pile up people. I drink to my tea, vit. In, glycine.I hope, let him go. Especially funny pobochka - suicide. Someone in general controls the release of such rubbish?
Guests
Tatyana
The same reaction as in the previous commentary, also the body is not mine. And this is after two pills! Polysorbent and water. I do not sleep the third night - tin.
Visitors
sergei
Do not drink levofloxacin, very harmful. I drank it for 28 days, I feel very bad after it. It turns out that you can not drink it for more than 3-5 days! If the doctor prescribes 28 days to drink it, then this "doctor" chhat on you and your health in general. Levofloxacin did not help me!
Guests
Mariya Aksenova
I got sick with flu, temperature 39, strong dry cough. They prescribed levofloxacin the next day, the temperature subsided, but my condition was not bearable: a pun in my head, my memory was gone, I can not concentrate, irritation at everything, I did not sleep for 3 nights and fear, anxiety, nausea, vomiting, then I felt sick like with toxicosis. So I was sick and did not understand what. I carried the flu as usual, 3-5 days without all these symptoms. And now for 5 days I have been treating the flu, and the condition seems to be dying, worse and worse, very afraid for my brains.Also has understood, what is it from this preparation. Tomorrow I will stop taking it because I have already accepted it today. The doctor was aware of my condition, but the drug was not canceled. So I was sick more from this drug. Do not drink it.
Guests
Tatyana
The doctor levofloxacin has written out, there was a complication ORVI - a bronchitis with a yellow sputum (individual dry wheezes in the bottom departments of lungs); a dose of 1 tab. (500 mg) 2 times a day, 7 days together with antihistamine (because I have allergic reactions). I bought the original drug with this active substance - Tavanik. After drinking one pill in the evening, I felt a fever in the whole body, the temperature rose to 37, a feeling of heaviness in my head (as if my head was stuffed with something), weakness in the muscles of the legs and hands. In the morning the temperature subsided, I strongly sweated, drank another pill, weakness in the arms and legs persisted, heaviness in my head - too. By the evening, the sputum was getting worse, the farther away, the stronger, looked in the instructions - this is a pimple from the respiratory system - bronchospasm. I stopped drinking this medicine. I do not advise even to try, because there is even such a side effect as the destruction of cartilage. Do not experiment!
Guests
Natalia Sa
I decided to attach my comment. Treated enterocolic intestinal. Have appointed or nominated Levofloksatsin 500 on 1 tab - 10 days. Four hours after taking the 1st pill, it started: diarrhea, nausea, bloating, tremor, dizziness, stomach twisted like a sea knot, the pressure jumped - a complete nightmare! I was very frightened. The next day - half a day lay, a pain in the stomach, urine was almost brown and severe pain in the kidneys. Day after 2 pain in the pancreas. That's how we are poisoned for our money. Avoid this drug - it is very toxic.
Guests
Marina -
He treated pneumonia with this drug. Vlepila, but also pobochki were: insomnia, anxiety, irritability, brains do not work (hard to concentrate).
Guests
Tatyana
20 minutes after the administration of a terrible allergic reaction: swollen very strongly eyelids, it was very scary, until now the swelling has not come down.
Guests
Madeleine
A terrible medicine. Poured out allergies, vomiting, dizziness, kidney problems. Do not take this medication.
Guests
Olga
The doctor prescribed 20 capsules of levofloxocin 500 mg for 1 capsule 1 time per day. The son drank 15 capsules. Result: bronchitis has not passed! But the stomach is upset, a strong allergy on the eyelids and scalp, weakness, trembling of hands, insomnia, dizziness ... Horror! I am against such treatment and such antibiotics. They do not cure, they maim.
Guests
and once again no if you want to live
No way, it's poison. All the muscles after a single tablet so twisted that you then treat the entire body for a month.
Guests
a guest
I drank with horror the third pill, now I'm lying and I'm thinking of calling an ambulance or going through. The nose feels like it is full of herpes, the mouth is full of bitterness, eyes are foggy, ears are burning. People do not drink it!
Guests
olga
Very heavy drug. The head itself is not its own. Bitterness in the mouth is terrible. He turns his legs. Pulse 120. The pressure is high. Saw 4 days, I can not any more.
Guests
Marina Kokoreva
Has treated an otitis Hajlefloks. It helped a lot, pobachek not found. It is necessary to take after eating.Due to the increased resistance to levofloxacin in a standard dosage of 500 mg, pulmonologists have to increase the duration of treatment, and 750 mg for 5 days can cure pneumonia. Well, the quality of the drug is simply amazing - no adverse reactions, no dysbiosis, no dyspepsia.
Guests
PSPFUN
I drank it for 5 days. On the 4th day, the joints began to twist. In the head porridge, thoughts can not be collected. The medicine helped, the pains passed (exacerbation of pyelonephritis). Today is the third day after the reception, the state is wadded, the body is not your own. I did not fit, I hope I will never have to use it again.
Guests
Starry Lord
I drink the 6th pill. No pobochek there. Only after the first pill, the brains were hard, but now everything is normal. That only helps or not is not yet clear)
Guests
Alexandra
Poison is not the word. Saw 7 days. Treated golden Staphylococcus aureus (tonsillitis). I gave the analysis for sensitivity to antibiotics. The doctor appointed. Everything was done by science :) This medicine did not help at all.While drinking - there were no side effects. After 2 days after - the jaw joints began to hurt madly. It is a pity that the reviews read very late. But it could be worse, judging by what others write ...
Guests
Elena Alexandrovna
Saw 3 days. From a cystitis the doctor for some reason has appointed or nominated in the morning and in the evening on 500 mg. There is not even such a thing in the manual! Now he turned his muscles on his legs, knuckles in his knees - a wild pain, a fog in his mind that almost started panic attacks - the fear of death and all that. Now I read that the cartilage in the joints can no longer be restored. What's this? Will my legs be taken off? For 3-4 days? Treat it like - is unknown. Do not drink this stuff. Here correctly written: who is responsible for those who this drug ruined?
Guests
Elena Alexandrovna
Everything passed the next day after the drug was discontinued - and knees, and pain in the muscles, and nervous overloads. No "pain in the knees for 90 days after stopping taking Levofloxacin," as they say in other forums, for example, where they discuss the treatment of prostatitis, I do not feel yet. I feel light in the body, all microbes seem to have disappeared.Perhaps, only such a drug can stop such neglected bacterial infections. We, of course, do not live in an epidemic of plague, but other drugs do not cope at all.
Guests
Antonina Ivanovna
To the husband have registered from a prostatitis, course of treatment unrealistically long.
Guests
Andrei.
I take levofloxacin for 194 days and drink two tablets (500 mg). Of the side effects, only joints in the shoulders ache. And until the end of treatment, I will have to drink it as much, along with three more equally toxic and heavy preparations (18 tablets). And I work, every day at the wheel and physically. And the side effects do not pay attention. And you drank three, five tablets and lie almost dead.
Guests
Vasilisa Lorochkina
Bronchitis, in sputum 50-60 thousand leukocytes, sputum does not depart, propyla vilprafen, he did not help. The doctor prescribed levofloxacin 500 mg 3 times a day! For 7 days! After the first pill, the temperature immediately subsided, and the cough became better, but the aches in the entire body, spontaneous muscle contraction and fog in the head. I also read reviews.
Guests
Nina Alekseevna
8 days the temperature is 38.8, the medications do not help, I did not eat anything, only I drank water. Analyzes are all good, only in blood high soy 58. Nothing hurts. After taking 2 Levofloxacin tablets, my temperature began to drop, and after 2 days I stabilized. In total I drank 7 tablets. I feel good. Thank you for the medicine.
Guests
Konstantin Lebedev
I am writing a review and I can not collect my thoughts. Hard drug, very, it was prescribed with an exacerbation of prostatitis, everything in the pills is said, but effective, the pain in the lower abdomen went through the day after the first intake. My head is spinning, I had to call an ambulance, I had vomiting with bile in the morning, my knees ache, it feels as though in intoxication, the reaction decreased, I did not get under the car in the morning, if I take it, then just lying in the hospital, under the supervision of a doctor, but I will not drink it any more.
Guests
Lyudmila
Great for helping with the so-called Morgellon's disease in conjunction with some additional drugs. Unfortunately, how much time to take the drugs is unknown.
Guests
L
No pobochki I do not feel, have appointed or nominated after operation on an ear.
Guests
Julia Anatolievna
Have appointed or nominated at treatment of a pneumonia, before it it is put down a course of ceftriaxone (the temperature and a strong tearful cough was saved). On the second day of taking levofloxacin, it felt much better - the temperature was normal, the cough improved (sputum departs). On the third day - a little sick, but the effect of improving the condition with pneumonia on the face. My opinion is that the drug is heavy, but effective.

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