Clotrimazole - instructions for use, analogs, reviews and release forms (suppositories, vaginal tablets, ointment, cream, gel and 1% solution) for the treatment of thrush (candidiasis) in men and women, including during pregnancy

In this article, you can read the instructions for using the drug Clotrimazole. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Clotrimazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Clotrimazole analogs in the presence of existing structural analogues. Use to treat thrush (candidiasis) and other fungal and genital infections in men and women,including during pregnancy and lactation.

Clotrimazole - is a broad-spectrum antifungal agent for topical application. The antifungal effect of clotrimazole (an imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

Clotrimazole is active against dermatophytes, yeast-like and mold fungi, as well as the causative agent of the multi-colored lichen (Pityriasis versicolor) and the causative agent of erythrasma. Clotrimazole has an antimicrobial effect against gram-positive (staphylococcus, streptococcus) and gram-negative bacteria (Bacteroides spp., Gardnerella vaginalis), and also against Trichomonas vaginalis.

Pharmacokinetics

When clotrimazole is administered vaginally, resorption is 3-10% of the administered dose.

Indications

• genital infections caused by yeast-like fungi of the genus Candida and / or Trichomonas vaginalis (candidiasis vulvovaginitis, trichomoniasis);
• genital superinfections caused by microorganisms sensitive to clotrimazole.

Forms of release

Vaginal tablets are 100 mg and 500 mg.

Candles vaginal 100 mg.

Solution for external use 1%.

Ointment for external use 1%.

Cream for external use 1%.

Gel for external use 1%.

Instructions for use and how to use them

Only for local (vaginal application).

Vaginal tablets of clotrimazole are administered in the evening in the vagina as deep as possible in the supine position with slightly bent legs, daily for 6 days for 1 vaginal tablet. A second course of treatment is possible after consulting a doctor.

In the presence of candidal vulvitis or candidal balanitis it is recommended to simultaneously appoint clotrimazole in the form of a cream, applying it externally 2-3 times a day for 6-12 days to the affected area.

Candles. For women and adolescent girls (after the onset of sexual activity), vaginal suppositories are injected into the vagina in the evening, as deep as possible, in the supine position with slightly bent legs, daily for 6 days for 1 100 mg vaginal suppository. A second course of treatment is possible after consulting a doctor.

Cream, ointment or gel. Apply a thin layer 2-3 times a day on the previously cleaned (using soap with a neutral pH value) and dry the affected skin and gently rub.

The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy. Treatment of dermatomycosis is not less than 4 weeks, pityriasis lichen - 1-3 weeks. In fungal diseases of the foot skin, therapy is recommended to continue for at least 2 more weeks after the symptoms have been removed.

Solution (can be used in adults and children). A few drops of the solution are applied a thin layer on the cleansed and dry affected and surrounding skin areas 2 (morning and evening) and carefully rubbed. After elimination of acute symptoms of the disease should continue treatment on average about 4 weeks.

In the case of dermatomycosis, the stop drug should be used for another 2 weeks after the removal of all symptoms of the disease. It is recommended to use the solution after each washing of the feet.

Side effect

• increased sensitivity to the drug in the form of itching and burning sensations in the vagina.

Contraindications

• period of menstruation;
• 1 trimester of pregnancy;
• increased sensitivity to clotrimazole or excipients.

Application in pregnancy and lactation

In clinical and experimental studies, it has not been established that the use of clotrimazole during pregnancy or during lactation has a negative effect on the health of women or the fetus (child). However, the question of the appropriateness of prescribing the drug should be addressed individually after consulting a doctor.

Use in children

Clotrimazole is used topically in adults and children.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners (can be used as a solution in men) is necessary.

When trichomoniasis for more successful treatment with clotrimazole, other drugs that have a systemic effect (for example, Metronidazole inside) should be used.

Drug Interactions

With vaginal administration, clotrimazole reduces the activity of amphotericin and other polyene antibiotics.

With simultaneous application with nystatin, the activity of clotrimazole may decrease.

Analogues of the drug Klotrimazol

Structural analogs for the active substance:

• Amicon;
• Antifungole;
• Guine-Lotrimin;
• Imidil;
• Yenamazole;
• Kandibene;
• Candide;
• Candisol;
• Kanesten;
• Canison;
• Clotrimazole-Acry;
• Lotrimin;
• Faktodin.

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