Ergoferon - instructions for use, reviews, analogs and forms of release (tablets for resorption) of a drug for the treatment and prevention of infectious diseases in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Ergoferon. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ergoferon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ergoferon in the presence of existing structural analogues. Use for the treatment and prevention of infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Ergoferon - used in the complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiology, including atypical pathogens (Mycoplasma pneumoniae, Chlamydophila (Chlamydia) pneumoniae, Legionella spp.), is used to prevent bacterial complications of viral infections, prevents the development of superinfections. in the pre- and post-vaccination period increases the effectiveness of vaccination, provides nonspecific prophylaxis of acute respiratory viral infection and influenza at the time of postvaccinal immunity formation. preventive efficacy against ARVI non-influenza etiology, prevents the development of intercurrent diseases in the post-vaccination period.
The components of the preparation have a single mechanism of action in the form of an increase in the functional activity of the CD4 receptor, receptors for Interferon (IFN) -gamm and histamine, which is accompanied by a pronounced immunotropic effect.
It has been experimentally proved that:
1. Antibodies to interferon-gamma increase the expression of IFN-gamma, IFN alpha / beta, as well as interleukins associated with them (IL-2, IL-4, IL-10, etc.) improve the ligand-receptor interaction of IFN,restore cytokine status; normalize the concentration and functional activity of natural antibodies to IFN-gamma, which are an important factor in the natural antiviral tolerance of the organism; stimulate interferon-dependent biological processes: induction of expression of antigens of the main histocompatibility complex of type 1, 2 types and Fc receptors, activation of monocytes, stimulation of the functional activity of NK cells, regulation of immunoglobulin synthesis, activating the mixed Th1 and Th2 immune response.
2. Antibodies to CD4, probably allosteric modulators of this receptor, regulate the functional activity of the CD4 receptor, which leads to an increase in the functional activity of CD4 lymphocytes, the normalization of the CD4 / CD8 immunoregulatory index, and the subpopulation of immunocompetent cells (CD3, CD4, CD8, CD16, CD20).
3. Antibodies to histamine modify the histamine-dependent activation of peripheral and central H1 receptors and thus reduce the tone of the smooth muscles of the bronchi, reduce the permeability of capillaries, which leads to a reduction in the duration and severity of rhinorrhea,edema of the nasal mucosa, coughing and sneezing, as well as a decrease in the severity of allergic reactions associated with the infectious process by suppressing the release of histamine from mast cells and basophils, the production of leukotrienes, the synthesis of adhesion molecules, the reduction of eosinophil chemotaxis and platelet aggregation in reactions to contact with the allergen.
The combined use of components of a complex preparation is accompanied by an increase in the antiviral activity of its components.
Composition
Antibodies to human gamma interferon affinity purified + Antibodies to histamine affinity purified + Antibodies to CD4 affinity purified + excipients.
Antibodies are applied to lactose in the form of a mixture of three active water-alcohol dilutions of the substance diluted 100 to 12, 100 to 30 degrees, 100 to 200 times, therefore it is permissible to call Ergoferon a homeopathic remedy.
Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to estimate the content of ultra-small doses of antibodies in biological fluids, organs and tissues,which makes it technically impossible to study the pharmacokinetics of the drug Ergoferon.
Indications
- prevention and treatment of influenza A and B (including avian influenza A / H5N1 and swine influenza A / H1N1);
- prevention and treatment of acute respiratory viral infections caused by parainfluenza virus, adenovirus, respiratory syncytial virus, coronavirus;
- prevention and treatment of herpes-viral infections (labial herpes, ophthalmoherpes, genital herpes, chicken pox, herpes zoster, infectious mononucleosis);
- prevention and treatment of acute intestinal infections of viral etiology (caused by calicivirus, adenovirus, coronavirus, rotavirus, enteroviruses);
- prevention and treatment of enterovirus and meningococcal meningitis, hemorrhagic fever with kidney syndrome, tick-borne encephalitis;
- complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including caused by atypical pathogens (Mycoplasma pneumoniae, Chlamydophila (Chlamydia) pneumoniae, Legionella spp.);
- prevention of bacterial complications of viral infections, prevention of superinfections.
Forms of release
Tablets for resorption № 20.
Instructions for use and reception scheme
Inside.The tablet should be kept in the mouth, not swallowing, until it dissolves completely. At one time - 1 tablet (not during a meal).
Children from 6 months. When prescribing drugs for young children (from 6 months to 3 years), it is recommended to dissolve the tablet in a small amount (1 tbsp.) Of boiled water at room temperature.
Treatment should be started as soon as possible, with the first signs of acute infection, according to the following scheme: in the first 2 hours the drug is taken every 30 minutes, then during the first day, 3 more doses are administered at regular intervals. From 2 days and further take 1 tablet 3 times a day until complete recovery.
For the prevention of viral infectious diseases - 1-2 tablets a day. The recommended duration of a preventive course is determined individually and can be 1-6 months.
If necessary, the drug can be combined with other antiviral and symptomatic agents.
Side effect
- reactions of increased individual sensitivity to the components of the drug.
Contraindications
- increased individual sensitivity to the components of the drug;
- galactosemia;
- malabsorption syndrome.
Application in pregnancy and lactation
The safety of the use of Ergoferon during pregnancy and lactation has not been studied. If necessary, the drug should take into account the risk / benefit ratio.
Use in children
Allowed to use the drug for children from 6 months of age.
special instructions
The composition of the drug includes lactose, and therefore it is not recommended for patients with congenital galactosemia, glucose malabsorption syndrome or galactose, or with congenital lactase insufficiency.
Influence on ability of management of vehicles and work with mechanisms
Has no influence.
Drug Interactions
There have been no incidents of incompatibility with other drugs to date.
Analogues of the drug Ergoferon
There are no structural analogs to the active substance of the drug Ergoferon.
Analogues on the pharmacological group of immunomodulators:
- Acidonacetic acid;
- Actipol;
- Alkimer;
- Anaferon;
- Anaferon child;
- Arbidol;
- Arpetol;
- Arpetolide;
- Arpefly;
- Affinoleukin;
- Bactisporin;
- Beast;
- Broncho-Vax;
- Broncho-munal;
- Vilozen;
- Wobenzym;
- Galavit;
- Gepon;
- Glutoxim;
- Groprinosin;
- Deoxynate;
- Derinat;
- Zadaxin;
- Imiquimod;
- Immunal;
- Immunal plus C;
- Immunomax;
- Immunorm;
- Imudon;
- Imunoriks;
- Imunofan;
- Interferon;
- IRS 19;
- Yodantipyrine;
- Beresz Plus drops;
- Copakson Teva;
- Cats Clough;
- Lycopid;
- Marina;
- Myelopid;
- Milife;
- Moliksan;
- Sodium deoxyribonucleate;
- Sodium nucleate;
- Neuroferon;
- Neovastet;
- Optinat;
- ORITOL;
- Panagen;
- Pyrogenal;
- Polyoxidonium;
- Polyferon CD4;
- Posterizan;
- Posterizan forte;
- Profetal;
- Resnian;
- Ribomunyl;
- Rhinital;
- Ruzam;
- Splenin;
- Sporobacterin;
- Stemokin;
- Stimforte;
- Superlimph;
- Tactivin;
- Tamerite;
- Timalin;
- Timogen;
- Timusamine;
- Trekrezan;
- Tubosan;
- Uro Vaxom;
- Ferrovir;
- Phlogenzyme;
- Helixor;
- Exalb;
- Epiphamine;
- Erbisol;
- Estifan;
- Echinacea tincture;
- Echinacea;
- Echinocor.
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