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Sibutramine - instructions for use, analogs, reviews and release forms (powder hydrochloride monohydrate for the manufacture of drugs based on it) drugs for the treatment of obesity and weight loss in adults, children and pregnancy. Prohibited or authorized

Sibutramine - instructions for use, analogs, reviews and release forms (powder hydrochloride monohydrate for the manufacture of drugs based on it) drugs for the treatment of obesity and weight loss in adults, children and pregnancy. Prohibited or authorized

In this article, you can read the instructions for using the drug Sibutramine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Sibutramine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sibutramine in the presence of existing structural analogs.Use for the treatment of alimentary obesity and weight loss in adults, children, as well as during pregnancy and lactation. The drug is prohibited or permitted on the territory of Russia and in Europe.

 

Sibutramine - a tool for the treatment of obesity central action. The mechanism of action is due to selective inhibition of reuptake of serotonin and norepinephrine, to a lesser extent - dopamine. Accelerates the attack and prolongs the sense of saturation, which leads to a reduction in food intake. Increases energy consumption by stimulating thermogenesis through the mediated activation of beta3-adrenergic receptors. It acts on both sides of the energy balance and helps to reduce body weight.

 

Sibutramine and its metabolites do not release monoamines and are not MAO inhibitors, do not have an affinity for serotonergic, adrenergic, dopaminergic, muscarinic, histamine, benzodiazepine, and NMDA receptors.

 

Composition

 

Sibutramine hydrochloride monohydrate.

 

Pharmacokinetics

 

After ingestion sibutramine is rapidly absorbed from the digestive tract. Almost completely metabolized in the liver with the participation of isoenzymes of the cytochrome CYP3A4 system with the formation of mono- (dismethylsibutramine) and di-dimethyl (di-dimethylsibutramine) forms of active metabolites (M1 and M2),and also by hydroxylation and conjugation to form inactive metabolites. Quickly and well distributed in tissues. It is excreted mostly by kidneys in the form of inactive metabolites.

 

Indications

  • in the supportive complex therapy of patients with excessive body weight with alimentary obesity with a body mass index of 30 kg / m 2 and more, with alimentary obesity with a body mass index of 27 kg / m 2 and more in the presence of other risk factors due to excessive body weight, in t.ch. Type 2 diabetes mellitus (non-insulin-dependent) or hyperlipidemia.

 

Forms of release

 

Substance powder (used to make preparations based on Sibutramine).

 

Instructions for use and reception scheme

 

The initial dose is 10 mg per day. With insufficient effectiveness when used in this dose (a decrease in body weight of less than 2 kg in 4 weeks) and with good tolerability, the dose can be increased to 15 mg per day.

 

In the absence of effect when administered at a dose of 15 mg per day (weight loss of less than 2 kg for 4 weeks) sibutramine should be discontinued.

 

In patients who do not adequately respond to ongoing therapy, i.e.who for 3 months can not reach 5% of the level of weight loss from the baseline, the duration of use should be no more than 3 months.

 

The course of treatment is no more than 1 year. There is no data on the efficacy and safety of longer-term use.

 

Do not continue to use, if after the achieved weight loss in the course of further therapy, the patient again adds a mass of 3 kg or more.

 

Side effect

  • loss of appetite;
  • constipation;
  • dry mouth;
  • nausea;
  • insomnia;
  • headache;
  • dizziness;
  • anxiety;
  • paresthesia;
  • increased sweating;
  • change in taste;
  • convulsive seizures;
  • acute psychosis;
  • tachycardia;
  • a feeling of palpitations;
  • increased blood pressure;
  • vasodilation (redness of the skin with a sense of heat);
  • exacerbation of hemorrhoids;
  • acute interstitial nephritis;
  • mesangiocapillary glomerulonephritis;
  • thrombocytopenia;
  • purple Shenlaine-Genocha.

 

Contraindications

  • organic cause of obesity;
  • known and established severe eating disorders (anorexia nervosa or bulimia nervosa);
  • mental illness;
  • Tourette's syndrome;
  • IHD;
  • chronic heart failure in the stage of decompensation;
  • congenital heart defects;
  • occlusive diseases of peripheral arteries;
  • tachycardia;
  • arrhythmias;
  • disorders of cerebral circulation (including transient);
  • uncontrolled arterial hypertension (blood pressure more than 145/90 mm Hg);
  • hyperthyroidism;
  • severe renal dysfunction;
  • severe violations of liver function;
  • benign prostatic hyperplasia with the formation of residual urine;
  • pheochromocytoma;
  • glaucoma;
  • established pharmacological narcotic and alcohol dependence;
  • pregnancy;
  • lactation (breastfeeding);
  • simultaneous administration or a period of up to 2 weeks after the abolition of MAO inhibitors or other drugs that have an inhibitory effect on the CNS (antidepressants, antipsychotics, tryptophan) or other medications to reduce body weight;
  • hypersensitivity to sibutramine.

 

Application in pregnancy and lactation

 

Sibutramine is contraindicated in pregnancy and lactation (breast-feeding).

 

Women of childbearing age in the period of treatment should apply adequate methods of contraception.

 

special instructions

 

Apply only in cases where all measures to reduce body weight are ineffective (i.e.weight loss is less than 5 kg for 3 months).

 

Treatment should be conducted only within the framework of complex therapy for weight loss under the supervision of a doctor who has practical experience in the treatment of obesity. Complex therapy includes both changing diet and lifestyle, and increasing physical activity. Thus, the prerequisites for a permanent change in eating habits and lifestyle are formed, which are necessary to maintain the achieved weight loss after the abolition of drug therapy.

 

With caution apply simultaneously with drugs that increase the QT interval in patients with hypokalemia and hypomagnesemia, epilepsy, with violations of the liver function of mild and moderate severity (because there may be an asymptomatic increase in the concentration of sibutramine in the blood plasma), with impaired renal function mild to moderate severity (because inactive metabolites are partially excreted by the kidneys), in patients with motor tics or vocalisms in a family history, concomitantly with drugs that increase blood pressure and heart rate (including medication by means of cough, allergy and colds).

 

On the territory of the Russian Federation, the drug based on Sibutramine (Reduxin) is included in the list of potent drugs that can be sold only for a special prescription of the doctor.

 

Do not use in people older than 65 years due to the lack of sufficient clinical experience with the use of sibutramine in geriatric patients.

 

During the treatment period it is necessary to control blood pressure and heart rate: in the first 2 months of therapy - every 2 weeks, then monthly. In patients with arterial hypertension (blood pressure more than 145/90 mm Hg), monitoring of these parameters should be carried out particularly carefully and, if necessary, more often. If blood pressure during repeated measurement twice exceeded 145/90 mm Hg, then sibutramine should be discontinued.

 

Regular medical supervision during treatment should pay attention to progressive dyspnea, chest pain and swelling, although the relationship between sibutramine intake and the development of primary pulmonary hypertension is not established.

 

Reactions to the abolition of sibutramine (headache, increased appetite) are rare.

 

During the treatment period, you should not drink alcohol because of the need to follow a diet.

 

Do not use in children and adolescents under the age of 18 due to lack of sufficient clinical experience in this category of patients.

 

Influence on the ability to drive vehicles and control mechanisms

 

At present, the influence of sibutramine on the ability to engage in potentially hazardous activities has not been established. However, it is impossible to exclude the possibility of such an impact. Use with caution in patients whose activities require increased attention and speed of psychomotor reactions.

 

Use of the drug in the US and European countries

 

In the United States, the drug is approved for use under the Meridia brand name, but only as directed by the doctor and with a large number of sales restrictions. The US Food and Drug Administration has conducted a study of 10,000 volunteers with varying degrees of obesity and, as a result of a significant number of deaths reported from Sibutramine, recommended the use of this drug only in absolutely healthy patients, without presence of problems with health, especially from the side of the cardiovascular system.

 

The implementation of sibutramine, used to treat obesity, is stopped in all EU countries.

 

The implementation of preparations based on sibutramine was discontinued in the Old World, as the European Committee on Medical Preparations discovered the negative effect of sibutramine on the cardiovascular system. To obtain such data, special studies were conducted with the participation of patients exposed to cardiovascular diseases.

 

Drug Interactions

 

When applied simultaneously with the means of inhibiting the activity of the isoenzyme CYP3A4 (ketoconazole, erythromycin, troleandomycin, cyclosporin) increased plasma concentration of metabolites of sibutramine, QT interval increases slightly.

 

With simultaneous use with rifampicin, phenytoin, carbamazepine, phenobarbital, dexamethasone, antibiotics of the macrolide group, it is possible to accelerate the metabolism of sibutramine.

 

While the use of selective serotonin reuptake inhibitors (with citalopram, fluoxetine, paroxetine, sertraline), agonists of 5-HT1-receptorsderivatives of alkaloids of ergot, opioid analgesics, antitussive agents of central action, the risk of developing serotonin syndrome increases.

 

Analogues of the drug Sibutramine

 

Structural analogs for the active ingredient and preparations containing Sibutramine:

  • Goldline;
  • Lindax;
  • Meridia;
  • Reduxine;
  • Sibutramine hydrochloride monohydrate;
  • Slimia.

Similar medicines:

Other medicines:

Reviews (17):
Guests
Liana
As tired of being fat ... And I can not eat, my hands are drawn to the refrigerator. It turned into addiction, and I'm only 29. I can not stand a single diet, I'm broken. Since my childhood I have not been friends. The only way out is to drink medreparaty, reducing appetite. Subtracted that the drug Sibutramine is very good, but it has many side effects. And which drug does not have them? .. I decided to try it. Appetite has significantly decreased, an amazing thing - I'm looking at pastries at the store and I do not want to eat it, it never happened to me before.Yes, the creepy body began to often "run through", yes, chapped lips and dry mouth - I want to drink constantly, and yes, I became more nervous. But! I am losing weight! And this is exactly what I need right now. Hence, I will drink Sibutramine further.

I can not say that the drug is ideal. After 2 weeks of admission, constipation began. The mental state is also unstable. I'm glad that at least I realize this. But there is a goal - to lose weight by 15 kg, 5 of them are already behind. Heavy morally, especially nervous tension irritates. But while I continue.
Administrators
admin
Liana, neater with serious medications and side effects to them, and then you can "drive" the body, after which you will need real help from doctors and already have nobody to blame except yourself.
Guests
nata
Tell me, sibutramine is released in tablets, I saw it in the pharmacy?
Administrators
admin
nata, Sibutramine is presented in the Russian market in the form of a powder substance, then from it it is possible to prepare at least tablets, at least capsules, so it is quite possible that derivatives appeared in the form of tablets.But the name will be, for example Sibutramine Neo or even some additional words, that is not the pure name of the active substance.
Administrators
admin
Visitor question Alyona, moved to the required section:
Sibutramine and Reduxin are structural analogues or not?

AlyonaIn the production of Reduxin is used as an active substance Sibutramine. In tablets Sibutramine you will not find, only if the medicine or dietary supplements on its basis.
Guests
Ira
I grew thin on the reduction. I liked the very process of losing weight, passed unnoticed and the result. Has thrown off 10 kg for 3 months and on a correct delivery has passed.
Guests
Tamara
This is a very harmful drug. It affects the liver and kidneys. Refers to narcotic banned drugs. People, be vigilant!
Visitors
richch5
Advise, please, a less safe drug for help in losing weight, again took up his weight,after the illness in winter, little moved and scored 20 kg extra, and all excess on the table +35, I also want to push the body with medicines for the fastest return to the form - if it is possible to do harmlessly !?
Administrators
admin
richch5First you need to understand how long you gained weight. If it is fast, then for the beginning it is necessary to be surveyed at the endocrinologist for the disturbances of a hormonal background. If the excess weight set is long, then it is also desirable to be examined by an endocrinologist, to calm down, and then contact a dietician who will prescribe you a diet, a physical regimen and, if necessary, additional medication. It is not worthwhile playing with metabolic and drug disorders, you can destroy the entire exchange system and harm your body.
Guests
markiza30
Has started to drink "slimeks 15". I drink the third day, while I watch drowsiness constant, my appetite decreased only slightly, we'll see next. I still do not observe any side effects.
Guests
Elena
Tell me please. I bought sibutramine hydrochloride. Yellow tablets, manufactured by: Shanghai Modern Pharmaceutical Co (China). Now I'm a little afraid. Does such someone know? And one more question. Can I take sibutramine with detraleksom?
Administrators
admin
Elena, I do not know such tablets and in Russia you can not buy pure Sibutramine in pharmacies, only medicines based on it with other names. So the question of adequacy of this medicine should be addressed to the seller.

Reception Detraleksa with Sibutraminom combine. There are no negative side effects in the joint admission should not be.
Guests
Rita
The drug sibutramine is one of the few drugs that we can use in the fight against obesity, which brings much more harm than the administration of the drug. But it must be applied strictly according to the doctor's prescription and in accordance with the instructions. The drug is intended for young and middle-aged patients without cardiovascular pathology. It is not necessary to give it up, but it also should not use it without a doctor's appointment and supervision, preferably an endocrinologist.
Guests
I will not say my name
This is a psychotropic drug that puts the heart. Very dangerous drug.
Guests
Yelenochka
The drug, as in all other drugs, has both bad and good sides. I have diabetes mellitus type 2 obesity, respectively, Weight was 117 kg. Is it not dangerous for the heart? And how. I wanted to eat till horror. Lived from eating to eat. Yes, this is a metabolic disorder. But on the drug, I lose weight. Sugar accordingly becomes smaller. I feel better. And significantly. First the first week was very thirsty. However, because of the high sugar I wanted to drink earlier. But here a little more. Dryness in the mouth just kept me from living. But from the second week, it all sort of calmed down. I drink much less than before taking the drug. The first week the heart was beating. I already have tachycardia, it's paroxysmal. The first three days provoked an attack. Then at night I began to drink valocordin. Somehow felt better. Has grown thin up to 112 kg. And then thank you! Of course, somehow there was an opportunity to move more. She began to walk a little. I calmly walk 3 km. I understand that the achievements are scanty, but they are huge for me.To sleep badly, a dream is restless. But even without that it was not particularly. The drug is excellent if there is a need for it. From 65 to 60, you should not lose weight on it.
Administrators
admin
Feedback from the site visitor Inna moved to the required section:
Sibutramine in Russia since 2005 refers to narcotic substances by its action as amphetamine, for their sale in pharmacies they were closed and criminal cases were initiated, which changed during this time is not clear, it is again freely sold, and even advertised on sites. The madhouse.
Visitors
Olechka111
I take meridia on the basis of sibutramine. For a month and a half minus 13 kg. I drink with vitamins, which probably does not suffer from any side effects.

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