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Coldrex - instructions for use, reviews, analogues and form of release (powder for the preparation HotRem, syrup Knight and Broncho, MaxGrip, Junior Hotdrink, tablets) medications for colds in adults, children and pregnancy. Composition

Coldrex - instructions for use, reviews, analogues and form of release (powder for the preparation HotRem, syrup Knight and Broncho, MaxGrip, Junior Hotdrink, tablets) medications for colds in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Coldrex. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Coldrex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Coldrex in the presence of existing structural analogues.Use to treat the symptoms of colds and flu in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Coldrex - a combined preparation for the symptomatic treatment of acute respiratory diseases.

 

Paracetamol has antipyretic and analgesic effect. Eliminates fever, reduces headache, pain in muscles and joints, which often accompany the flu.

 

Phenylephrine hydrochloride is a sympathomimetic, narrows the vessels of the nasal mucosa and paranasal sinuses, thereby reducing edema and facilitating nasal breathing.

 

Ascorbic acid replenishes the increased need for vitamin C for colds and flu, especially in the initial stages of the disease.

 

The active components of the drug do not cause drowsiness and do not disturb the concentration of attention.

 

Promethazine is a blocker of histamine H1 receptors. Eliminates edema of the nasal mucosa and upper respiratory tract, restoring nasal breathing and reducing the amount of discharge from the nose.

 

Dextromethorphan is an antitussive drug that depresses the excitability of the cough center and suppresses cough of any origin.

 

Coldroom Broncho - reduces the surface tension and adhesive properties of sputum, which reduces its viscosity and facilitates removal from the respiratory tract. The use of the drug promotes the transition of non-productive cough to productive.

 

Composition

 

Paracetamol + Caffeine + Phenylephrine hydrochloride + Terpin hydrate + Ascorbic acid (vitamin C) + auxiliary substances (Coldrex).

 

Paracetamol + Phenylephrine hydrochloride + Ascorbic acid + excipients (HotRem, MaxGripp and Junior Hotdrink).

 

Paracetamol + Promethazine hydrochloride + Dextromethorphan hydrobromide + excipients (Knight).

 

Guaifenesin + auxiliary substances (Broncho syrup).

 

Pharmacokinetics

 

Paracetamol is quickly and almost completely absorbed from the digestive tract, distribution in body fluids is relatively even. Metabolized mainly in the liver with the formation of several metabolites. The majority of the drug is excreted after conjugation in the liver. In unchanged form, not more than 3% of the received dose of Paracetamol is released.

 

Ascorbic acid is well absorbed from the digestive tract. Distribution in the tissues of the body is wide.Metabolized in the liver, excreted in the urine in the form of oxalate and unchanged. Ascorbic acid, taken in excessive amounts, is quickly excreted unchanged in urine.

 

Phenylephrine is poorly absorbed from the digestive tract and metabolized at the first passage in the intestine and liver under the influence of MAO. When taking phenylephrine inside the bioavailability of the drug is limited. It is excreted in urine almost completely in the form of a sulfuric acid conjugate.

 

Indications

 

Elimination of cold and flu symptoms:

  • increased body temperature;
  • headache;
  • chills;
  • pain in the joints and muscles,
  • nasal congestion;
  • dry cough;
  • acute tracheitis;
  • bronchitis of various etiologies;
  • sore throat;
  • pain in the sinuses of the nose.

 

Forms of release

 

Tablets (Coldrex).

 

Powder for solution for oral administration (for children) (Junior Hotdrink).

 

Powder for solution for oral administration (HotRem and MaxGrip).

 

Syrup (Broncho and Knight).

 

Instructions for use and reception scheme

 

Pills

 

Adults and children over 12 years of age are prescribed 2 tablets up to 4 times a day. Children aged 6-12 years - 1 tablet up to 4 times a day.

 

Do not exceed the recommended dose.The drug is not recommended for more than 5 days without consulting a doctor. If symptoms persist, consult a physician.

 

Powder Junior HotDrink

 

Children aged 6 to 12 years are prescribed 1 packet every 4 hours. Do not use more than 4 sachets within 24 hours. Do not exceed the indicated dose. The maximum duration of application is no more than 5 days. If symptoms persist, consult a doctor. The doctor determines the necessity of continuing the treatment individually.

 

The contents of 1 sachet pour into a mug, pour about 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.

 

Powder HotRem and MaxGrip

 

Adults are recommended to take 1 packet every 4-6 h, but not more than 4 sachets within 24 hours. The interval between doses should be at least 4 hours.

 

Children over 12 years of age are prescribed 1 packet every 6 hours, but not more than 3 sachets within 24 hours.

 

The contents of 1 sachet should be poured into a glass with hot water (200 ml), stir until completely dissolved, if necessary, you can add cold water or sugar.

 

The maximum duration of the drug is 5 days.

 

Syrup Bronho

 

Adults (including elderly patients) and children over the age of 12 years, the drug is prescribed in a single dose of 200 mg (10 ml). It is necessary to fill the syrup with the attached measuring cup to the level of 10 ml and drink the drug. If necessary, a single dose can be taken repeatedly every 2-3 hours.

 

Children aged 3 to 12 years, the drug is prescribed in a single dose of 100 mg (5 ml). Should be filled with syrup attached measuring cup to the mark of 5 ml and drink the drug. If necessary, a single dose can be taken repeatedly every 2-3 hours.

 

Syrup Knight

 

The drug is taken only once a day, at night, just before bedtime.

 

Adults (including elderly patients) and children over the age of 12 years, the drug is prescribed in a single dose of 20 ml (4 tablespoons of 5 ml).

 

Children aged 6 to 12 years, the drug is prescribed in a single dose of 10 ml (2 tablespoons of 5 ml).

 

Side effect

  • allergic reactions (skin rash, hives, angioedema);
  • thrombocytopenia, leukopenia, agranulocytosis;
  • irritation of the mucosa of the gastrointestinal tract;
  • dry mouth;
  • nausea, vomiting;
  • diarrhea;
  • headache;
  • dizziness;
  • bronchial obstruction;
  • insomnia;
  • a slight increase in blood pressure;
  • palpitation.

 

Contraindications

  • genetic absence of glucose-6-phosphate dehydrogenase;
  • diseases of the blood system;
  • liver disease;
  • kidney disease;
  • thyrotoxicosis;
  • diabetes;
  • arterial hypertension;
  • heart disease (pronounced stenosis of the aortic aorta, acute myocardial infarction, tachyarrhythmias);
  • benign prostatic hyperplasia;
  • angle-closure glaucoma;
  • simultaneous reception with other paracetamol-containing drugs;
  • simultaneous use of antidepressants, including MAO inhibitors and up to 14 days after their withdrawal;
  • epilepsy;
  • pregnancy;
  • lactation (breastfeeding);
  • children under 18 (MaxGripp), under 12 (HotRem), up to 6 years old (Knight and Junior HotDrink), up to 3 years (Bronho);
  • Hypersensitivity to the ingredients that make up the drug.

 

Application in pregnancy and lactation

 

The drug Coldreks is contraindicated in pregnancy.

 

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

 

special instructions

 

The patient should be informed that if the symptoms persist after 5 days of use,should stop receiving it and consult with a doctor.

 

The drug should be taken only at recommended doses.

 

The drug should not be taken concurrently with other drugs containing paracetamol, as well as other non-narcotic analgesics (metamizole sodium), nonsteroidal anti-inflammatory drugs (NSAIDs), barbiturates, anticonvulsants, rifampicin and chloramphenicol.

 

Caudrax should be taken with metoclopramide, domperidone, colestyramine, indirect anticoagulants (warfarin).

 

Patients taking the drug Coldrex should refrain from drinking alcohol. It is not recommended to prescribe the drug for chronic alcoholism.

 

Patients who follow a diet with a reduced sodium content should take into account that 1 packet of the preparation Caldex contains 0.12 g of sodium.

 

When performing tests to determine the level of uric acid and blood glucose levels, the doctor should be warned about the use of the Coldrex preparation, since the drug can distort the results of laboratory tests assessing the concentration of glucose and uric acid.

 

Drug Interactions

 

Paracetamol, when taken for a long time, increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

 

Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol (alcohol), flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effects in overdoses and simultaneous administration with paracetamol.

 

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.

 

Paracetamol decreases the effectiveness of diuretic drugs.

 

Metoclopramide and Domperidone are increased, and colestramine reduces the rate of absorption of paracetamol.

 

Paracetamol increases the effects of MAO inhibitors, sedatives, ethanol (alcohol).

 

Codrex when taken with MAO inhibitors may lead to an increase in blood pressure.

 

Phenylephrine reduces the effectiveness of the action of beta-blockers and antihypertensive drugs.

 

Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, simultaneous administration of halothane with phenylephrine increases the risk of ventricular arrhythmia.

 

Phenylephrine reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

 

Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

 

Simultaneous appointment of glucocorticosteroids (GCS) with phenylephrine increases the risk of developing glaucoma.

 

Analogues of the drug Coldrex

 

Structural analogs for the active substance:

  • Flukoldeks forte.

 

Analogues for the pharmacological group (anilides in combinations):

  • Agicold;
  • AnGriCaps maximum;
  • Antigrippin;
  • Antiflu;
  • Antiflu Kids;
  • Апап С Plus;
  • Brustan;
  • Viks Active Symptomax;
  • Guevadal;
  • Grippex;
  • Grippostad;
  • Grippostad Good Night;
  • Grippostad C;
  • Influenza from the cold and flu;
  • Grippoflu extra for cold and flu;
  • The Gripend;
  • Gripand HotActiv;
  • Gripand HotActive Max;
  • Daleron C;
  • Daleron C junior;
  • Children's Tylenol for colds;
  • Dolaren;
  • Ibuklin;
  • Influblock;
  • Influenza;
  • Caffetin;
  • Kaffetin Cold;
  • Kodelmikst;
  • Caged Flux Plus;
  • Coldrex MaxGripp;
  • Coldrex Knight;
  • Coldrex Hotrem;
  • Coldrex Hotrem with lemon flavor;
  • Coldrex Hotrem with lemon and honey taste;
  • Coldrex Junior Hot Drink;
  • Coldfri;
  • Coffedon;
  • Lemp's Lemon;
  • Lemsip Max;
  • Lemsip Black Currant;
  • Maxiokold;
  • Maxikold Reno;
  • Meksavit;
  • Migraine;
  • Migrenol;
  • Mulcinex;
  • Next;
  • Neoflum 750;
  • Novalgin;
  • Padeviks;
  • Panadine;
  • Panadol Extra;
  • Panoxen;
  • Paracodamol;
  • Paralen extra;
  • Paracetamol Extra;
  • Paracetamol Extra Children;
  • Pentalgin;
  • Pentaflucine;
  • Pliwalgin;
  • Prostudox;
  • Prohodol forte;
  • Rince;
  • Rinzasip;
  • Rinicold;
  • Saridon;
  • Solpadein;
  • Solpadein Fast;
  • Stopgrispan;
  • Stopgripan forte;
  • Strymol plus;
  • Tylenol for the common cold;
  • TeraFlu;
  • TeraFlu from influenza and colds;
  • TeraFlu from influenza and colds Extra;
  • TerraFlu Ekstrutab;
  • Toff plus;
  • Trigan D;
  • Fastoric;
  • Fastorik plus;
  • Febricet;
  • Femizol;
  • Fervex;
  • Fervex for children;
  • Fervex from a dry cough;
  • Fervex rhinitis;
  • Flukoldin;
  • Fluxcold;
  • Flukomp;
  • Flukomp Extract;
  • Flute;
  • Hyrumat;
  • Efferalgan with vitamin C;
  • Yunispaz.

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Reviews (1):
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Tatyana
We like koldreks. Helps actually.

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