MIG 400 - instructions for use, reviews, analogs and formulations (tablets 400 mg) of the drug for the treatment of headache and toothache and lowering the temperature in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug MIG 400. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of MIG 400 in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of MIG 400 with existing structural analogues. Use to treat headaches and toothaches and reduce temperature in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

MIG 400 non-steroidal anti-inflammatory drug (NSAID). Ibuprofen (the active substance of MIG 400) is a derivative of propionic acid and has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of COX-1 and COX-2, as well as the inhibitory effect on the synthesis of prostaglandins.

Analgesic effect is most pronounced for inflammatory pains. The analgesic activity of the drug does not apply to the narcotic type.

Like other NSAIDs, ibuprofen has antiaggregant activity.

Composition

Ibuprofen + excipients.

Pharmacokinetics

After ingestion, the drug is well absorbed from the digestive tract. Binding to plasma proteins is about 99%. It is slowly distributed in the synovial fluid and is withdrawn from it more slowly than from the plasma. Ibuprofen is metabolized in the liver mainly by hydroxylation and carboxylation of the isobutyl group. Metabolites are pharmacologically inactive. Up to 90% of the dose can be detected in the urine in the form of metabolites and their conjugates. Less than 1% is excreted unchanged in the urine and to a lesser extent - with bile.

Indications

• headache;
• migraine;
• toothache;
• neuralgia;
• pain in muscles and joints;
• menstrual cramps, febrile condition for colds and flu.

Forms of release

The tablets covered with a cover of 400 mg.

Instructions for use and dosing regimen

The drug is taken orally. The dosage regimen is set individually, depending on the indications.

Adults and children over 12 years of age, the drug is prescribed, usually in the initial dose - 200 mg 3-4 times a day. To achieve a rapid therapeutic effect, the dose can be increased to 400 mg three times a day. When the therapeutic effect is achieved, the daily dose is reduced to 600-800 mg.

The drug should not be taken more than 7 days or at higher doses. If it is necessary to take longer, or at higher doses, a doctor's consultation is required.

Side effect

• stomach ache;
• nausea, vomiting;
• heartburn;
• deterioration of appetite;
• diarrhea;
• flatulence;
• constipation;
• ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding;
• irritation or dryness of the oral mucosa;
• pain in the mouth;
• ulceration of the gingival mucosa;
• aphthous stomatitis;
• dyspnea;
• bronchospasm;
• hearing loss;
• ringing or noise in the ears;
• toxic damage of the optic nerve;
• blurred vision or double vision;
• edema of the conjunctiva and eyelids (allergic genesis);
• headache;
• dizziness;
• insomnia;
• anxiety;
• nervousness and irritability;
• psychomotor agitation;
• drowsiness;
• depression;
• confusion of consciousness;
• hallucinations;
• aseptic meningitis (more often in patients with autoimmune diseases);
• heart failure;
• tachycardia;
• increased blood pressure;
• acute renal insufficiency;
• nephrotic syndrome (edema);
• skin rash (usually erythematous or urticaria);
• itching;
• angioedema;
• anaphylactoid reactions;
• anaphylactic shock;
• bronchospasm;
• fever;
• multi-form exudative erythema (including Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• eosinophilia;
• allergic rhinitis;
• anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia;
• decrease in serum glucose concentration.

Contraindications

• erosive and ulcerative diseases of organs: gastrointestinal tract (including gastric ulcer and duodenal ulcer in the phase of exacerbation, Crohn's disease, NJC);
• "aspirin triad";
• hemophilia and other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis;
• bleeding of various etiologies;
• deficiency of glucose-6-phosphate dehydrogenase;
• diseases of the optic nerve;
• pregnancy;
• lactation period;
• children's age till 12 years;
• hypersensitivity to the components of the drug;
• Hypersensitivity to acetylsalicylic acid or other NSAIDs in the anamnesis.

Application in pregnancy and lactation

Adequate and strictly controlled studies of the safety of the use of MIG 400 during pregnancy are not available. The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

The use of ibuprofen can adversely affect female fertility and is not recommended for women planning a pregnancy.

special instructions

If there are signs of bleeding from the gastrointestinal tract, MIG 400 should be discarded.

Ibuprofen may mask objective and subjective symptoms, so the drug should be administered with caution to patients with infectious diseases.

The emergence of bronchospasm is possible in patients,suffering from bronchial asthma or allergic reactions in the anamnesis or in the present.

Side effects can be reduced by using the drug in the lowest effective dose. With prolonged use of analgesics, there is a risk of developing analgesic nephropathy.

Patients who report visual impairment with ibuprofen therapy should stop treatment and undergo ophthalmic examination.

Ibuprofen may increase the activity of hepatic enzymes.

During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys.

When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a blood test with determination of hemoglobin, hematocrit, analysis of feces for latent blood is shown.

To prevent the development of NSAID-gastropathy, MIG 400 is recommended to be combined with preparations of prostaglandin E (misoprostol).

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.

During the period of treatment, ethanol (alcohol) is not recommended.

Impact on the ability to drive vehicles and manage mechanisms

Patients should refrain from all activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

It is possible to decrease the effectiveness of Furosemide and thiazide diuretics due to the delay of sodium associated with inhibiting the synthesis of prostaglandins in the kidneys.

Ibuprofen may enhance the effect of oral anticoagulants (simultaneous use is not recommended).

With concomitant administration with acetylsalicylic acid, MIG 400 reduces its antiaggregant effect (possibly an increase in the incidence of acute coronary insufficiency in patients receiving low doses of Acetylsalicylic acid as an antiplatelet agent).

Ibuprofen may reduce the effectiveness of antihypertensive drugs.

In the literature, single cases of an increase in plasma concentrations of digoxin, phenytoin and lithium with simultaneous administration of ibuprofen have been described.

Ibuprofen, like other NSAIDs, should be used with caution in combination with acetylsalicylic acid or other NSAIDs and GCS because this increases the risk of adverse effects of the drug on the gastrointestinal tract.

MIG 400 can increase the concentration of Methotrexate in plasma.

Combined therapy with zidovudine and ibuprofen may increase the risk of hemarthrosis and hematoma in HIV-infected patients with hemophilia.

The combined use of ibuprofen and tacrolimus may increase the risk of developing nephrotoxic effects due to impaired prostaglandin synthesis in the kidneys.

Ibuprofen enhances the hypoglycemic effect of oral hypoglycemic agents and insulin; it may be necessary to adjust the dose.

Analogs of MIG 400

Structural analogs for the active substance:

• Advil Liquvi-Jels;
• Advance;
• ArthroCam;
• Bonifen;
• Brufen;
• Brufen retard;
• Burana;
• Deblock;
• Children's Motrin;
• Dolgit;
• Ibuprom;
• Ibuprom Max;
• Ibuprom Sprint Caps;
• Ibuprofen;
• Ibusan;
• Ibutop gel;
• Ibufen;
• Iprene;
• MIG 200;
• Nurofen;
• Nurofen for children;
• Nurofen fort;
• Pedee;
• Solpaflex;
• Faspik.

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