Rigevidone - instructions for use, analogs, reviews and release forms (tablets 21 + 7 with placebo) of the contraceptive for contraception in women, including during pregnancy and lactation. Composition and interaction with alcohol

In this article, you can read the instructions for using the contraceptive drug Rigvedon. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of Rigevidone in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Rigevidone in the presence of existing structural analogues.Use to treat menstrual disorders and contraception in women, including during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Rigvedon - combined monophasic oral hormonal contraceptive. When ingested, depresses the pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As progestin, the progestin derivative contains a derivative of 19-nortestosterone, levonorgestrel, which is progesterone, which is superior in activity to the hormone of the yellow body, and acts on the level of receptors without preliminary metabolic transformations. The estrogen component is ethinyl estradiol.

Under the influence of levonorgestrel comes the blockade of the release of LH and FSH from the hypothalamus, oppression of the pituitary gland by gonadotropic hormones, which leads to inhibition of maturation and release of the ovum ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Preserves high viscosity of the cervical mucus (making it difficult for sperm to enter the uterine cavity).Along with the contraceptive effect with regular intake normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, including. tumor nature.

Composition

Ethinyl estradiol + levonorgestrel + auxiliary substances.

Ethinyl estradiol + Levonorgestrel + Iron fumarate + excipients (Rigevidone 21 + 7).

Pharmacokinetics

Levonorgestrel

After ingestion, levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel is not exposed to the effect of "first passage" through the liver. Most of the levonorgestrel binds in the blood with albumin and SHBG (globulin, binding sex hormones).

Ethinylestradiol

Ethinyl estradiol is rapidly and almost completely absorbed from the intestine. Ethinyl estradiol is exposed to the effect of "first passage" through the liver. When ingestion, ethinyl estradiol is excreted from the blood plasma for 12 hours. Ethinylestradiol is metabolized in the liver and intestines. Metabolites ethinyl estradiol - water-soluble products of sulfate or glucuronide conjugation, enter the intestines with bile, where they are disintegrated with intestinal bacteria.

Indications

• oral contraception;
• functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia);
• premenstrual tension syndrome.

Forms of release

The tablets covered with a cover.

The tablets covered with a cover of two kinds: active and placebo (Rigevidonum 21 + 7).

Instructions for use and reception scheme

The drug is taken orally at the same time of the day, without chewing and washing down with a small amount of liquid.

If hormonal contraception was not performed during the previous menstrual cycle, then Rigevidone for the purpose of contraception is prescribed from the first day of menstruation daily for 1 tablet for 21 days. Then follows a 7-day break, during which menstrual bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets should start the day after the 7-day break, i.e. on the 8th day, even if the bleeding did not stop. Thus, the start of taking the drug from each new package falls on the same day of the week.

When you switch to taking Rhevidone from another oral contraceptive, a similar scheme is used.The drug is taken as long as there is a need for contraception.

After abortion, it is recommended to start taking the drug on the day of abortion or the day after the operation.

After giving birth, the drug can be prescribed only to women who do not breast-feed; to receive a contraceptive should be started no earlier than the 1st day of menstruation. During lactation, the use of the drug is contraindicated.

The missed tablet should be taken within the next 12 hours. If 36 hours have elapsed since the last pill was taken, contraception is unreliable. To avoid intermenstrual bleeding, taking the drug should be continued from the already started package, with the exception of the missed tablets (-ok). In cases of missing tablets, it is recommended to additionally use another, non-hormonal method of contraception (for example, barrier).

For therapeutic purposes, the dose of Rigevidone and the schedule of application the doctor establishes individually in each case.

Rigevidone 21 + 7

If a woman in the previous cycle took a contraceptive, the drug is started on the 1st day of the menstrual cycle and continues for 28 days.You should take 1 tablet a day daily, preferably at the same time of day. First take white tablets (21 days), then during the reception of tablets of a reddish-brown color (7 days), menstrual-like bleeding usually occurs. If it is necessary to continue contraception, the next 28 tablets (21 tablets of white color, then 7 tablets of reddish-brown color) should be taken immediately without interruption in the same scheme. Thus, each reception cycle starts on the same day of the week. In the event that a woman took a contraceptive in the previous cycle, and in the previous package had 21 tablets, the drug should be taken after a 7-day break, on the eighth day.

The composition of tablets of different colors is not the same. Therefore, the beginning and the correct sequence of administration - first 21 white tablets, then 7 reddish-brown tablets - are indicated on the package with numbers and arrows.

When switching to Rhevidone 21 + 7 from another contraceptive, the above scheme should be used.

Taking the drug after childbirth or after an abortion can begin no earlier than the first day of menstruation of the first two-phase cycle. The first two-phase cycle is usually shortened because of premature ovulation.If the drug is taken with the first spontaneous bleeding, the drug can not successfully prevent premature ovulation, so in the first two weeks of the cycle, contraception may not be reliable.

If the tablet was missed within the prescribed period, the missed tablet should be taken within the next 12 hours. In this case, there is no need for additional methods of contraception. The remaining tablets are recommended at the usual time. If more than 12 hours have passed, the last missed tablet should be taken (bypassing the remaining unacceptable tablets) and continue taking the drug in normal mode. In this case, additional methods of contraception (barrier methods, spermicides) should be used in the next 7 days.

This does not apply to tablets of a reddish-brown color, t. they do not contain hormones.

For medicinal purposes, the dose of the drug and the scheme of application are selected by the doctor for each patient individually.

Side effect

• nausea, vomiting;
• headache;
• engorgement of mammary glands;
• change in body weight and libido;
• mood change;
• acyclic spotting;
• swelling of the eyelids;
• conjunctivitis;
• impaired vision;
• discomfort when wearing contact lenses (these phenomena are temporary and disappear after withdrawal without prescribing any therapy);
• Chloasma;
• hearing loss;
• generalized itching;
• cramps of the calf muscles;
• increased frequency of epileptic seizures;
• increased blood pressure;
• thrombosis and venous thromboembolism;
• skin rashes;
• change in the nature of vaginal secretion;
• candidiasis;
• fatigue;
• diarrhea.

Contraindications

• severe liver disease;
• congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome, Rotor syndrome);
• cholecystitis;
• presence or indication in the history of severe cardiovascular and cerebrovascular diseases;
• thromboembolism and predisposition to them;
• Malignant tumors (primarily breast cancer or endometrium);
• liver tumors;
• family forms of hyperlipidemia;
• severe forms of hypertension;
• endocrine diseases (including severe forms of diabetes mellitus);
• sickle-cell anemia;
• chronic hemolytic anemia;
• vaginal bleeding of unknown etiology;
• bladder skidding;
• migraine;
• otosclerosis;
• idiopathic jaundice of pregnant women in anamnesis;
• severe itching of pregnant women;
• herpes pregnant;
• age over 40 years;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated in pregnancy and lactation (breastfeeding).

special instructions

Before starting the use of hormonal contraception and subsequently every 6 months, a general medical and gynecological examination including cytological analysis of the smear from the cervix, assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, control of blood pressure, urinalysis is recommended.

The appointment of Rhevidone to women with thromboembolic disease at a young age and an increase in blood coagulability in a family history is not recommended.

The use of oral contraception is allowed no earlier than 6 months after the transferred viral hepatitis, provided normalization of hepatic functions.

When there are sharp pains in the upper abdominal areas, hepatomegaly and signs of intra-abdominal bleeding, there may be a suspicion of a liver tumor.If necessary, the drug should be discontinued.

If there is a violation of the liver during the reception of Rigevidone, a consultation of the therapist is necessary.

When acyclic (intermenstrual) bleeding occurs, Rigevidone should be taken, in most cases these bleedings spontaneously cease. If acyclic (intermenstrual) bleeding does not disappear or recur, a medical examination should be performed to exclude the organic pathology of the reproductive system.

In the case of vomiting or diarrhea, the drug should be continued using another, non-hormonal method of contraception.

Smoking women taking hormonal contraceptives have an increased risk of developing cardiovascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and depending on the number of cigarettes smoked (especially in women older than 35 years).

The drug should be discontinued in the following cases:

• when a new or increased migraine headache occurs;
• when there is an unusually strong headache;
• when there are early signs of phlebitis or phlebothrombosis (unusual pain or bloating of the veins on the legs);
• if there is jaundice or hepatitis without jaundice;
• with cerebrovascular disorders;
• with the appearance of stitching pains of unclear etiology during breathing or coughing, pain and tightness in the chest;
• with acute deterioration of visual acuity;
• at suspicion of a thrombosis or a heart attack;
• with a sharp increase in blood pressure;
• when generalized itching occurs;
• with increased epileptic seizures;
• 3 months before the planned pregnancy;
• approximately 6 weeks before the planned surgical intervention;
• with prolonged immobilization;
• at the come pregnancy.

Impact on the ability to drive vehicles and manage mechanisms

Admission of the drug does not affect the ability to drive vehicles and to manage other mechanisms, work with which is associated with an increased risk of injury.

Drug Interactions

Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives are able to enhance the metabolism of the steroid hormones that make up the drug.

Reduction of contraceptive effectiveness of Rhegewidon can be observed with simultaneous administration with some antimicrobial agents (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with changes in the intestinal microflora.

When used simultaneously with anticoagulants, coumarin or indanedione derivatives, an additional prothrombin index and dose change of the anticoagulant may be required.

With the use of tricyclic antidepressants, maprotiline, beta-blockers may increase their bioavailability and toxicity.

The intake of alcohol does not lead to a decrease in the effect of oral contraceptive Rigevidone.

When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.

When combined with bromocriptine, its effectiveness decreases.

When combined with drugs with a potential hepatotoxic effect, for example, with dantrolene, there is an increase in hepatotoxicity, especially in women older than 35 years.

Analogues of the medicinal product Rigevidone

Structural analogs for the active substance:

• Antotevin;
• Microinon;
• Miniziston;
• Miniziston 20 fems;
• Ovidon;
• Oralcon;
• Rhevidone 21 + 7;
• Three-regol;
• Three-regol 21 + 7;
• Trigestrel;
• Trikwilar.

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