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Mexidol - instructions for use, analogs, reviews and release forms (125 mg tablets, injections (in ampoules) 5%) of the drug for the treatment of encephalopathies, head injury and other brain disorders in adults, children and pregnancy

Mexidol - instructions for use, analogs, reviews and release forms (125 mg tablets, injections (in ampoules) 5%) of the drug for the treatment of encephalopathies, head injury and other brain disorders in adults, children and pregnancy

In this article, you can read the instructions for using the drug Mexidol. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mexidol in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mexidol in the presence of existing structural analogues. The use for the treatment of encephalopathies of various genesis, craniocerebral trauma,asthenic conditions and many other brain disorders in adults, children, as well as during pregnancy and lactation.

 

Mexidol antioxidant drug.

 

Mexidol is an inhibitor of free radical processes, a membrane protector. It has antihypoxic, antistress, nootropic, anticonvulsant and anxiolytic effects. The drug increases the resistance of the body to the effects of various damaging factors (shock, hypoxia and ischemia, cerebral circulation disorders, alcohol intoxication and antipsychotic agents / neuroleptics).

 

The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane-protective action. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the "lipid-protein" ratio, reduces the viscosity of the membrane, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine),which enhances their ability to bind to ligands, contributes to the preservation of the structural and functional organization of biomembranes, the transport of neurotransmitters and the improvement of synaptic transmission. Meksidol increases the content in the brain of dopamine. It causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under conditions of hypoxia with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

 

The drug improves the metabolism and blood supply of the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has hypolipidemic action, reduces the content of total cholesterol and LDL.

 

Anti-stress action is manifested in the normalization of post-stress behavior, somato-vegetative disorders, restoration of sleep-wake cycles, disrupted learning and memory processes, reduction of dystrophic and morphological changes indifferent structures of the brain.

 

Mexidol has a pronounced antitoxic effect on withdrawal symptoms. Eliminates neurologic and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also capable of removing cognitive impairments caused by prolonged intake of ethanol and its cancellation. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which helps to reduce their doses and reduce side effects.

 

Pharmacokinetics

 

After taking the drug inside at doses of 400-500 mg quickly absorbed. Quickly distributed in organs and tissues. It is quickly excreted in the urine mainly in the form of metabolites and in a small amount - unchanged. The most intense withdrawal within the first 4 hours after taking the drug.

 

Indications

  • consequences of acute disorders of cerebral circulation, incl. after transient ischemic attacks, in the phase of subcompensation as preventive courses;
  • light craniocerebral injury, the consequences of craniocereberal trauma;
  • encephalopathy of various genesis (dyscirculatory, dismetabolic, posttraumatic, mixed);
  • syndrome of vegetative dystonia;
  • light cognitive disorders of atherosclerotic origin;
  • anxiety disorders in neurotic and neurosis-like states;
  • relief of withdrawal syndrome with alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-abstinence disorders;
  • state after acute intoxication by antipsychotic drugs;
  • asthenic conditions, and also for the prevention of the development of somatic diseases under the influence of extreme factors and loads;
  • influence of extreme (stressor) factors.

 

Forms of release

 

Solution for intravenous and intramuscular injection (in injections (ampoules)) 50 mg / ml (5%).

 

Tablets coated with 125 mg.

 

Instructions for use and dosing regimen

 

The drug is administered orally 125-250 mg 3 times a day. The initial dose is 125-250 mg (1-2 tablets) 1-2 times a day with a gradual increase to obtain a therapeutic effect. The maximum daily dose is 800 mg (6 tablets).

 

Duration of treatment - 2-6 weeks, for relief of alcohol withdrawal - 5-7 days.

 

Treatment is stopped gradually, reducing the dose within 2-3 days.

 

Side effect

  • dyspepsia;
  • allergic reactions.

 

Contraindications

  • acute liver failure;
  • acute renal insufficiency;
  • hypersensitivity to the drug.

 

In connection with insufficient study of the effect of the drug:

  • childhood;
  • pregnancy;
  • lactation period (breastfeeding).

 

Application in pregnancy and lactation

 

Mexidol is contraindicated in pregnancy and lactation (breastfeeding) due to insufficient study of the drug.

 

special instructions

 

Mexidol can be combined with all drugs used to treat somatic diseases.

 

Use in Pediatrics

 

Mexidol is not prescribed to children due to insufficient study of the effect of the drug.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

 

Drug Interactions

 

When combined, Mexidol enhances the action of benzodiazepine derivatives, antidepressants, anxiolytics,antiparkinsonian and anticonvulsants.

 

Mexidol reduces the toxic effect of ethyl alcohol (alcohol).

 

Analogues of the medicinal product Mexidol

 

Structural analogs for the active substance:

  • Medomexi;
  • Mexidant;
  • Mexicor;
  • Mexiprim;
  • Mexicin;
  • Metostabil;
  • Neurox;
  • Cerekard;
  • Ethyl methylhydroxypyridine succinate.

Similar medicines:

Other medicines:

Reviews (59):
Guests
Irishka
Nonsense, not medicine. It seems to help from everything, but in fact the effect of it was not felt anyway, so I do not recommend taking this pacifier, just wasting money, and you will suffer as much as diarrhea.
Guests
mondayborn
mexidol - did injections once a day for 10 days. He just cured me for all the indications prescribed in the instructions !!! I will repeat as soon as possible!
Guests
he helped me
Mexidol is good for vegetative-vascular dystonia. With this diagnosis, I have been suffering for several years and crises, of which at least I hang, met quite often, but everything that was prescribed before Mexidol helped poorly.Therefore, when there was such a medicine as this, which started to really help, I naturally got hooked and conducted a full course of treatment, as our new neurologist from the polyclinic advised.
Guests
Liana
Mexidol is a good drug. He is often prescribed after a stroke. The drug improves the results of rehabilitation of patients, contributing both to an increase in the degree of recovery of neurological functions, and to an increase in the level of household adaptation.
Guests
Natalia
Took after an injury after an accident (sotra.mozga). Has helped. I stopped feeling dizzy, my head hurt. Clearly expressed soothing effect. I recommend.
Guests
Dasha
Mexidol was prescribed to my friend after a stroke. The drug helps to recover. His speech and memory were broken. There is something connected with blood vessels and blood circulation. The bottom line is that the drug helped. After the course of injections, the speech became much clearer.
Guests
I.Irina
I agree with Dasha's statement.Half a year ago, my aunt suffered a stroke, they thought all the trouble would remain confined to bed! But timely treatment, including mexidol, and physical rehabilitation gave good results! Of course this is a long, painstaking work, but with the efforts of our whole family we put aunt on our feet!
Guests
ANNA 095
I can only say good things about mexidol, since my close friend after a stroke literally could not say a word, and after the use of this drug speech began to return. Now he is undergoing a course of rehabilitation - medicines plus a speech therapist.
Guests
Vky
Relative after the stroke was taking mexidol. Even him, a man no longer young helped to solve problems with memory. Gradually. During the course of this drug, I managed to remember all the relatives.
Guests
Elena
And after the course of Methidol's application my memory improved and my handwriting was even. The diagnosis is truncation of the aneurysm of the main basilar artery (in adolescence after head trauma) now I am 54 years old.Mexidol and nootropilum take a course for 10-14 days twice a year. I'll try to take Neurox. All I wish to watch over the health!
Guests
Paul
The consequences of multiple head injury with epipriplets. Passed the course of Mexidol in combination with Depakin (Anticonvulsant drug), it became much easier, only drowsiness was observed from side effects ... but in general, a good drug, I recommend.
Administrators
admin
Site visitor feedback Squirrel, moved to the required section:
Maybe Irishka got a counterfeit Mexidol. I am now myself on the treatment of this drug, on the recommendation of a doctor, and the result is satisfied. But in order to obtain a stable effect from the treatment of Mexidol, you need to continue the treatment with pills after the injections. I highly recommend this drug, it is checked on myself. Good health to everyone.
Visitors
Kustova
My husband had a head injury. Over the years, attacks of headaches intensified, speech and coordination were disturbed (he walked and spoke like a drunk). Mexidol helped him to recover.The result was visible after 2-3 days.
Guests
alla
During the session, I was terribly worried, the dream disappeared. The doctor prescribed mexidol, but it only got worse. To the already existing problems, a retardation was added. I had to take the risk of changing the drug to another.
Guests
Nina
Is it possible to inject 5 ml of mexidol after iv administration of 5 ml of Actovegin?
Administrators
admin
Nina, Neuropathologists practice the joint use of these drugs in patients. If this combination is prescribed to you by the attending physician, then take as prescribed.
Guests
Ivan
Whether it is possible after intravenous introduction tseretona (drip) to enter 5 ml meksidola strujno?
Administrators
admin
IvanThere is no significant adverse interaction of these drugs in the instructions. So, take the medication prescribed by your doctor. Jet Mexidol is also acceptable.
Administrators
admin
A recent study of the effectiveness of Mexidol in the acute period of ischemic stroke showed that the early administration of the drug (up to 24 hours, and ideally in the first 6 hours after the onset of the pathological process) normalizes the functional activity of the brain, increases the activity of the antioxidant system. In general, some advantages for the diseased brain and its vascular bed.

The study involved 51 people, plus 27 people received a placebo (dummy drug). Mexidol was administered at a dosage of 300 mg per day for 14 days from the onset of the disease.
Visitors
nata
No, there was irritability, a condition similar to depressive, apathy and mood at zero.
Guests
natalia
I do not understand, my whiskey is hurting, my face is red. Colleagues were frightened. Pikamilon and mexidol together gave this reaction? Afobazol and donormil while drinking. I am afraid to do or make nyxes. Irritation increases ...
Administrators
admin
natalia, Any of the drugs you mentioned can cause both an allergic reaction and an individual intolerance, which can be accompanied by headaches and redness of the skin. Even such safe as Pikamilon and Mexidol. Given that you are already taking two drugs, the likelihood of catching a pimple on one of these drugs is increasing.

I also noticed one medical nastykovochku in your treatment scheme. Afobazol is used to treat anxiety disorders and sleep disorders as a result of unreasonable anxiety, and in the preparation of Pikamilon, side effects show irritability and anxiety. Combination of these drugs, I would at least recognize the irrational and canceled one of these drugs (most likely Pikamilon, since Afobazol I understand your base drug).
Guests
Tatyana is 65 years old
At me after an intramuscular injection 5 ml meksidola the pressure has jumped up to my maximum 170 \ 100 that happens extremely seldom and there was a real pain in a breast. The attack lasted 4 hours. I had to call an ambulance. I do not know how to explain it.Can individual reaction to the medicine. Applied for the first time as prescribed by the doctor.
Administrators
admin
Tatyana is 65 years old, There may be an individual reaction to a specific medicine. From this no one is immune.
Guests
galena
The neurologist has appointed or nominated to mum (85 years, a disk encephalopathy), a course of 2 months. But the ambulance doctor said that you need to take it all the time. We accept akatinol, enap HL, seroquel, atorvastatin.
Administrators
admin
galenaUsually Mexidol takes courses several times a year. It is better to consult a full-time doctor with all the examinations and the history of the disease.
Guests
Alexey
I am 54 years old. 10 months after ischemic stroke. With mexidol I accept ceretone, noopept. No effect, as stated in the instructions.
Guests
Tatyana
A good drug. Helps really.
Guests
Marousia
I take Mexidol a second time - headaches (a number of reasons). I am 55 years old.It is necessary except for medicines also to do gymnastics, massage of a head. It helps. Try it. Do not be ill!
Guests
Vera Ivanovna
Took 10 injections of 100 mg each. Headaches have decreased, continue to take in tablets. Earlier meksidolom it was not treated, I do not know what will be result. Venous outflow is difficult for me, probably, it is necessary to accept something else.
Guests
Margarita.
The drug is beautiful. I have chronic cerebrovascular insufficiency. Dopekali sudden dizziness. After the course of treatment, everything passed.
Guests
Alevtina
Mexidol is a very good drug. After the first application, my memory improved, there was some kind of lightness in my head, speech came back to normal. At me patalogich. tortuosity of the ICA on both sides. Vascular disease. Headaches ceased, I take them 2 times a year.
Guests
Tatyana
The neurologist has appointed or nominated "meksidol 2 ml" intramuscularly №10, on the third nyxis the strong pain has not allowed to make an injection, I hardly have lost consciousness, it is very sick, intolerable.
Guests
Lyudmila
To me the preparation has very much helped or assisted, even itself did not expect. Became worried about dizziness, the neurologist prescribed Mildronate and mexidol spray in / in. On the second injection, dizziness stopped. Very satisfied.
Guests
Raisa
I was very well helped. For many many years I have been suffering from neuropathy of the eye against the background of diabetes mellitus, a violation of cerebral blood supply. It became good after the 1st injection.
Guests
Daria
The drug is very good, I drank it for 1 month, but when I stopped drinking it, dizziness appeared and my head ached terribly.
Visitors
Assel
Good afternoon! At what age can Mexidol be taken?
Administrators
admin
Assel, Children Mexidol is not currently prescribed, as controlled studies of the use of the drug in this age group of patients have not been conducted and data are not enough.Any use of this medicine in children is carried out at your own risk and under the responsibility of that doctor, that he has appointed and only if there is no alternative to use (when it can not be replaced with anything for the children).
Guests
galena
At me after introduction of a mexidomium intravenously pressure 180. And in two hours 120.
Guests
Galina
A good drug.
Guests
Emma
Kolya the 4th day. I go in a sleepy state. For work it is not convenient. I wait at the end of the course for positive results.
Visitors
Golovin Love
Hello! A month ago, faced with such a problem as neurosis (the neurologist put such a diagnosis). I'll tell you a little about what preceded this disease. Two years ago there was a severe head injury, then moving to another city to live, a job that was full of stress, dismissal ... and a breakdown in early May this year. Panic, anxiety, fear from the fact that you can not see anything brighter ahead, panic began sharply, the heart jumped out of the chest, the face is red, the legs are shaking, the desire to do something quickly - to solve the problem, throwing, etc.She ran to the psychiatrist, he sent me to the neurologist. To me have registered: Mexidol 10 nyxes, magnesium B6 15 days, afobazol month and 6 injections kokarnit in day. I started to take all this on May 5. Three days ago the symptoms returned, of course not as it was, but close. Please, tell me if I can still be beaten Mexidol or Cortexin (pricking him after an injury - it seemed that helped). Can I still examine myself? Who to contact? I'm at a loss.
Administrators
admin
Golovin Love, I advise you to apply to a competent psychologist. Still it is possible to stop similar conditions in special branches of neurosises (they are often opened by psychiatric services on the basis of somatic or usual hospitals). In your case, medical treatment is rather secondary, you need to quietly and gradually unravel or forget about the heap of problems that have fallen on you. Medicines have a secondary effect, and when accentuated on these problems after the end of the course of treatment, these symptoms will return. So calm and competent expert who can speak out and who gently redirect your negative ina positive channel. With neurological drugs, it is better not to risk self-medication, the results can be unpredictable.
Guests
galena
Not everyone helps. I have a cyst in the right hemisphere, post-traumatic hydrocephalus. The drug was prescribed by a doctor, but it did not get better, dizziness. I am 63 years old.
Is it possible to use Mexidol (ampoules) if there is a suspicion of brain oncology? To make MRT while there is no possibility - I wait for turn. Will the drug do any harm in this case? Thank you.
Administrators
admin
Maria IvanovnaIf you are appointed Mexidol physician, then if you suspect a cancer or proven cancer, its use is possible. From the instruction does not follow negative side effects or contraindications when using this drug in brain cancer. Another thing, if you want to use it yourself, then it's unclear why, from oncology it is unlikely to help, and other reasons are not indicated in the question.Probably, it is necessary to wait for the results of MRI and after start to receive the prescribed treatment.
Guests
Lika
Mexidol is a good preparation, but only Russian.
Guests
Valentina Radkevich
A wonderful drug. After a micro stroke, the head was very dizzy, but it's necessary to work. The doctor prescribed 10 injections. After the second injection I felt much better.
Guests
Irina
My mother is 77 years old. A friend advised her and bought it, recommended taking. Oh, the horror - allergic reaction, barely pumped out, all in swelling and red streaks all over the face, now departs and the fluid flows from the skin where there were swelling. Forbid this medicine!
Guests
Radkevich Valentina
A wonderful drug. Two days after the injections, I felt a significant improvement.
Guests
LOVE
It seems that there is an improvement, but it is not yet fully understood.
Guests
Ev11
He left the drinking-bout (very long), from medicines for the head he used mexidol. Has left with the minimum losses, literally for 2 days.
Guests
Irene
Made a couple of injections. Very satisfied, a burst of strength, mood.
Visitors
Tatiana P
3 years ago, after the acute respiratory viral infection, dizziness started and the pressure dropped steadily. In general I suffer VSD. Have appointed meksidol in tablets and riboksin. It helped a lot. Mexidol drank tablets of 125 mg twice a day (as the doctor appointed). Now the same condition after ARI and even exacerbation of cervical chondrosis. I started to drink Mexidol myself in the same dosage, but I do not feel the effect. Can drink 250 mg and / or 3 times a day as in the instructions. I am 47 years old, weight 58 kg.
Administrators
admin
Tatiana PThere are two ways to solve the problem. Or add to the treatment regimen Riboxin, which most likely helped the last time in conjunction with Mexidol. Or, what is more preferable, contact your doctor, because the universal pill does not exist. Perhaps, vascular disturbances from the effect of osteochondrosis were compensated for the first time and there was enough treatment that was prescribed, and now it is required to strengthen therapy with other medications.
Good afternoon. Since 2010 I struggle for survival: Diabetes mellitus, Hypertension, osteochondrosis, osteoarthrosis, EKS, prostatitis, gout, glaucoma, encephalopathy, hydrocephalus, chronic tracheobronchitis, tonsillitis. In February, Mexidol was drunk in the hospital. On the 4th day, sugar fell, on the 6th pressure - I had to abandon the tablets. He left the hospital as a healthy person, but a week later it was as if a fan had been switched on - a noise in the ears and all the sores had recovered. Doctors say that Mexidol can be dripped after 6 months. Tell me what to do?
Administrators
admin
gtynjrcbabkkbyThe course can be repeated depending on the situation and after 3 months, and 6 months is the optimal break. More often than 3 months interval I would not use it. And yes, it is necessary to cancel this medicine gradually reducing the dose within 3 days. Although during the week the withdrawal syndrome should have already manifested itself, so you had activation because of something else.
The neurologist has appointed or nominated tablets: Mydocalm 150mg, Mysidol 125mg, Cavinton 10mg + injections Dexalgin 2.0 №5, Kombilipen 2,0 №10. Complaints about memory loss, pain in the area of ​​the collar zone and pain in the area of ​​the sciatic nerve. Maybe something superfluous, it hurts a lot of pills.
Administrators
admin
Svetlana SvetlanaThe combination is good. All drugs combine with each other and potentiate (enhance) the mutual positive effect. The question of using specific medications on the conscience of the attending physician, but such a combination is acceptable.

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