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Irunin - instructions for use, analogs, reviews and release forms (tablets or candles vaginal 200 mg, capsules 100 mg) of the drug for treatment of thrush and nail fungus in adults, children and pregnancy

Irunin - instructions for use, analogs, reviews and release forms (tablets or candles vaginal 200 mg, capsules 100 mg) of the drug for treatment of thrush and nail fungus in adults, children and pregnancy

In this article, you can read the instructions for using the drug Irunin. The reviews of the visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Irunin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Irunin in the presence of existing structural analogs. Use to treat thrush and nail fungus in adults, children, as well as during pregnancy and lactation.

 

Irunin - broad-spectrum antifungal agent, triazole derivative. Inhibits the synthesis of ergosterol cell membrane of fungi. It is active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), yeast fungi Candida spp. (including Candida albicans, Candida glabrata, Candida krusei), mold fungi (Cryptococcus neoformans, Aspergillus spp., Histoplasma spp., Paracoccidioides brasiliensis, Sporothrix schenckii, Fonsecaea spp., Cladosporium spp., Blastomyces dermatidis).

 

Composition

 

Itraconazole + excipients.

 

Pharmacokinetics

 

After oral administration, maximum bioavailability is noted when taking capsules immediately after a dense meal. The concentration of the drug in tissues containing keratin, especially in the skin, is about 4 times higher than the concentration in the blood plasma, and its removal depends on the regeneration of the epidermis.

 

Unlike plasma concentrations that are not detectable after 7 days after discontinuation, the therapeutic concentration in the skin persists for 2-4 weeks after the end of the 4-week course of treatment. Itraconazole is found in the nail keratin just 1 week after the start of treatment and is maintained for at least 6 months after the completion of the 3-month course of treatment. Itraconazole is also defined in the secretion of the sebaceous and sweat glands.

 

Itraconazole is well distributed in tissues that are prone to fungal diseases. Concentrations in the lungs, kidneys, liver, bones, stomach, spleen, muscles were 2-3 times higher than the corresponding concentrations in blood plasma.

 

Itraconazole is metabolized in the liver with the formation of a large number of metabolites. One such metabolite is hydroxyitraconazole, which has an antifungal action comparable to itraconazole.

 

Excretion with feces is 3-18%, excretion by the kidneys is less than 0.03%. Approximately 35% is excreted in the form of metabolites in urine for 1 week.

 

Indications

  • dermatomycosis;
  • onychomycosis caused by dermatophytes and / or yeast and mold fungi;
  • Candidomycosis with skin and mucous membranes;
  • vulvovaginal candidiasis (including recurrent);
  • pityriasis lichen;
  • systemic mycoses, including systemic aspergillosis and candidiasis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis;
  • visceral candidiasis;
  • fungal keratitis.

 

Forms of release

 

Vaginal tablets are 200 mg (sometimes mistakenly called candles).

 

Capsules 100 mg.

 

There are no other forms, be it external creams or ointments.

 

Instructions for use and how to use them

 

Vaginal tablets

 

Applied intravaginally. Vaginal tablets are injected into the vagina once in the evening before going to bed, in a supine position on the back with slightly bent legs.

 

The course of treatment is 7-14 days. If necessary, on the recommendation of a doctor, a repeat course of treatment is possible.

 

Capsules

 

For optimal absorption of the drug, it is necessary to take Irunin in capsules immediately after meals.

 

Capsules should be swallowed whole.

 

  • Vulvovaginal candidiasis - 200 mg twice a day - duration of treatment - 1 day;
  • Pityriasis lichen - 200 mg once a day - duration of treatment - 7 days;
  • Dermatomycosis smooth skin - 200 mg once a day - treatment duration - 7 days;
  • Fungal keratitis - 200 mg once a day - duration of treatment - 21 days;
  • Oral candidiasis - 100 mg once a day - the duration of treatment - 15 days.

 

Lesions of highly keratinized areas, such as hands and feet, require additional treatment for 15 days at a dose of 100 mg per day.

 

With systemic fungal infections, the recommended doses vary depending on the type of infection:

  • Aspergillosis - 200 mg once a day - duration of treatment - 2-5 months;
  • Candidiasis - 100-200 mg once a day - treatment duration from 3 weeks to 7 months;
  • Cryptococcosis (except for meningitis) - 200 mg once a day - treatment duration from 2 months to 1 year;
  • Cryptococcal meningitis - 200 mg twice a day - treatment duration from 2 months to 1 year;
  • Histoplasmosis - from 200 mg once a day to 200 mg twice a day - the duration of treatment is 8 months;
  • Sporotrichosis - 100 mg once a day - duration of treatment 3 months;
  • Paracoccidiomycosis - 100 mg once a day - duration of treatment is 6 months;
  • Chromomycosis - 100-200 mg once a day - duration of treatment is 6 months;
  • Blastomycosis - from 100 mg once a day to 200 mg twice a day - the duration of treatment is 6 months.

 

Side effect

  • dyspepsia;
  • nausea;
  • stomach ache;
  • constipation;
  • anorexia;
  • cholestatic jaundice;
  • toxic liver damage, incl. case of acute hepatic insufficiency with a lethal outcome;
  • headache;
  • fatigue;
  • dizziness;
  • peripheral neuropathy;
  • menstrual cycle disorders;
  • hypercreatininaemia;
  • staining the urine in a dark color;
  • edema;
  • hyperkalemia;
  • chronic heart failure;
  • pulmonary edema;
  • itching;
  • rash;
  • hives;
  • angioedema;
  • Stevens-Johnson syndrome;
  • alopecia.

 

Contraindications

  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

In pregnancy, Irunin is prescribed only in cases of extreme necessity, when the expected benefit of therapy for the mother exceeds the existing risk for the fetus.

 

Itraconazole is excreted in small amounts with breast milk. If it is necessary to administer Irunin during lactation, the expected benefit of therapy for the mother and the potential risk for the infant should be carefully evaluated. In case of doubt, the question of stopping breastfeeding should be addressed.

 

Women of childbearing age during the application of Irunin should use reliable contraceptive methods throughout the course of treatment until the onset of the first menstruation after it is completed.

 

Use in children

 

Since clinical data on the use of Irunin in capsules in children is not enough, it is recommended to prescribe the drug to children only if the expected benefit of therapy exceeds the potential risk.

 

special instructions

 

Itraconazole has a negative inotropic effect. Given this, Irunin should not be prescribed to patients with chronic heart failure (incl.in the anamnesis), except for cases when the expected benefit of therapy considerably surpasses the potential risk. In this regard, such factors as the severity of the indications, the dosing regimen and individual risk factors for the development of chronic heart failure (including the presence of IHD, heart valve lesions, COPD, renal failure) should be taken into account.

 

With a reduced acidity of the stomach, the absorption of itraconazole is disrupted. Patients receiving antacid preparations (eg aluminum hydroxide) are recommended to take them no earlier than 2 hours after taking Irunin. Patients with achlorhydria or using histamine H2 receptor blockers or proton pump inhibitors are advised to take Irunin capsules with a cola drink.

 

In very rare cases, with the use of itraconazole, severe toxic liver damage developed, incl. cases of acute hepatic insufficiency with lethal outcome. In most cases, this was observed in patients who already had liver disease, as well as in patients receiving other drugs that have a hepatotoxic effect.In this regard, it is recommended to regularly monitor liver function in patients receiving itraconazole therapy.

 

In case of appearance of symptoms suggesting the development of hepatitis, incl. anorexia, nausea, vomiting, weakness, abdominal pain and darkening of the urine, it is necessary to immediately stop taking the drug and perform an examination of the liver function. Patients with elevated levels of hepatic enzymes or liver disease in the active phase should not be treated with Irunin, unless the expected benefit justifies the risk of liver damage. In these cases, it is necessary to control the level of hepatic enzymes during treatment.

 

In the case of the development of neuropathy, which can be caused by oral ingestion of itraconazole, treatment should be discontinued.

 

There is no evidence of cross-hypersensitivity to itraconazole and other antifungal agents, the azole derivative. Irunine in capsules should be administered with caution to patients with hypersensitivity to other azoles.

 

Impact on the ability to drive vehicles and manage mechanisms

 

The drug does not affect the ability to drive and activities,associated with the need for a high concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

It is not recommended simultaneous use with rifampicin, rifabutin and phenytoin, which are strong inducers of microsomal enzymes of the liver. these drugs can significantly reduce the bioavailability of itraconazole and hydroxyitraconazole, which leads to a significant decrease in the effectiveness of the drug. Studies on the interaction of itraconazole with other inducers of hepatic enzymes, such as carbamazepine, Phenobarbital and isoniazid, have not been carried out, but a similar effect can be expected.

 

Because itraconazole is mainly metabolized with the participation of the CYP3A4 isoenzyme of the cytochrome P450 system, strong inhibitors of this enzyme (including ritonavir, indinavir, Clarithromycin and erythromycin) can increase the bioavailability of itraconazole.

 

Itraconazole can inhibit the metabolism of drugs that are biotransformed with the participation of the CYP3A4 isoenzyme. The result of this may be an intensification or prolongation of their effect, incl. and side effects.After discontinuation of treatment, the concentrations of itraconazole in the plasma decrease gradually, depending on the dose and duration of treatment.

 

Simultaneously with Irunin, terfenadine, astemizole, misolastine, cisapride, triazolam, midazolam (oral), dofetilide, quinidine, pimozide metabolized by the isoenzyme CYP3A4, inhibitors of HMG-CoA reductase (simvastatin and lovastatin) can not be administered simultaneously.

 

Calcium channel blockers have a negative inotropic effect, which can enhance the similar effect of itraconazole; Itraconazole can reduce the metabolism of calcium channel blockers. Caution should be used with itraconazole simultaneously with calcium channel blockers.

 

Drugs that require the control of plasma concentrations: oral anticoagulants; HIV protease inhibitors (ritonavir, indinavir, saquinavir); some anticancer drugs (vinca alkaloids pink, busulfan, docetaxel, trimetrexate); calcium channel blockers metabolized with the participation of the CYP3A4 isoenzyme (dihydropyridine and verapamil); Some immunosuppressants (cyclosporine, tacrolimus, sirolimus); other drugs - digoxin, carbamazepine, buspirone, alfentanil, alprazolam,brotisolam, rifabutin, methylprednisolone, ebastin, reboxetine. With simultaneous application with Irunin, if necessary, the dose of these drugs should be reduced.

 

Interactions between itraconazole and zidovudine and fluvastatin were not detected.

 

Irunin's influence on the metabolism of ethinylestradiol and norethisterone was not noted.

 

Studies have demonstrated a lack of interaction between itraconazole and such drugs as imipramine, propranolol, diazepam, cimetidine, indomethacin, tolbutamide and sulfamethazine, when bound to plasma proteins.

 

Analogues of the medicinal preparation Irunin

 

Structural analogs for the active substance:

  • Itrazole;
  • Itraconazole;
  • Itramikol;
  • Canditral;
  • Miconiol;
  • Orungal;
  • Orungamine;
  • Orunite;
  • Rumikoz;
  • Tecnazol.

Similar medicines:

Other medicines:

Reviews (3):
Guests
Anna V.
Only healed Irunin with the whole family, I hasten to share my impressions. It all began with the fact that our child brought to the house of the unfortunate woman who had been picked up on the street. Naturally, without genus and tribe and with a full bouquet of various ailments. To throw out the misfortune on the street the hand did not rise, the cat was obviously required vet help. Hungry, thin, deprived shaving a fur coat with a bizarre "haircut," on rare wisps of wool, a desperate war was waged for a place in the sun between ticks and fleas. Glistov just did not, to the surprise. The kitten, frankly, could hardly stand on its own feet.

Without thinking for long, she took him to a vet clinic, where he was prescribed a bunch of drugs. The main one was Irunin - about 50% of the body area was affected. Plus all sorts of ointments, pills and lotion from ticks and fleas. A separate song, as I divided the contents of the tablet into 6 receptions, but the main thing was the result. The cocktail was obviously lightening by leaps and bounds, the bald patches quickly began to overgrow. Appetite was excellent, apparently, pobochki not manifested. After 2 weeks, the cat became handsome. BUT! While they were treating him, they got infected themselves. A nightmare, as I remember! The same Irunin is now drinking ourselves.Over a week prevailed.

What was pleasantly surprised, my chronic thrush also gave up under the charms of the drug. And I already lost hope, tried so many things, but there were always relapses. And now, like, this trend has stopped. Already a month full order.

In general, this drug is happy. Although the side effects are declared serious, but we, fortunately, did not show up.
Guests
Olga
Irunin is a good supplement to the usual treatment of nail fungus, you can even take strong medications with it. The only drawback - to drink it should be a long time, the liver can suffer.
Guests
True
True and the rest, Another advertisement of your Orungamin means in reviews to other drugs and will seriously punish. Do not abuse my peace of mind.
admin

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