Aquadetrim - instructions for use, reviews, analogs and formulations (aqueous solution) of medicines for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns) and during pregnancy. Composition
In this article, you can read the instructions for using the drug Aquadetrim. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Vitamins Aquadetrim in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aquadetrim in the presence of existing structural analogues.Use for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns), as well as during pregnancy and lactation. Composition of the preparation.
Aquadetrim - a drug that regulates the exchange of calcium and phosphorus. Vitamin D3 is an active antirachitic factor. The most important function of vitamin D is the regulation of calcium and phosphate metabolism, which contributes to the mineralization and growth of the skeleton.
Vitamin D3 is a natural form of vitamin D, which is formed by a person in the skin under the influence of sunlight. Compared with vitamin D2 is characterized by 25% higher activity.
Kolekaltsiferol plays an important role in the absorption of calcium and phosphate in the intestine, in the transport of mineral salts and in the process of calcification of bones, it also regulates the excretion of calcium and phosphate by the kidneys.
The presence of calcium ions in the blood in physiological concentrations ensures the maintenance of muscle tone of skeletal muscles, the function of the myocardium, facilitates the conduction of nervous excitement, regulates the process of blood coagulation.
Vitamin D is necessary for the normal functioning of the parathyroid glands, also participates in the functioning of the immune system, affecting the production of lymphokines.
Vitamin D deficiency in food, impaired absorption, calcium deficiency, as well as insufficient sun exposure during the child's rapid growth leads to rickets, in adults - to osteomalacia, pregnant women may experience tetany, a violation of the processes of calcification of newborn bones.
An increased demand for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal disorders.
Composition
Kolekaltsiferol (vitamin D3) + auxiliary substances.
Pharmacokinetics
Aquadetrim aqueous solution is absorbed better than the oil solution (this is important when used in premature infants, because in this category of patients there is a lack of production and the intake of bile in the intestines, which violates the absorption of vitamins in the form of oily solutions). After ingestion, colcalciferol is absorbed from the small intestine. Metabolised in the liver and kidneys. Penetrates through the placental barrier. Excreted in breast milk. Kolekaltsiferol cumulates in the body. It is excreted by the kidneys in a small amount, most of it is excreted with bile.
Indications
Prevention and treatment:
- vitamin D deficiency;
- rickets and rachitis-like diseases;
- hypocalcemic tetany;
- osteomalacia;
- metabolic osteopathy (hypoparathyroidism and pseudohypoparathyroidism);
- osteoporosis, incl. postmenopauznogo (as part of complex therapy).
Forms of release
Drops for oral administration 10 ml (aqueous solution).
Instructions for use and dosage
The dose is set individually, taking into account the amount of vitamin D that the patient receives as part of the diet and in the form of medications.
The drug is taken in 1 spoon of liquid (1 drop contains 500 IU of colcalciferol).
For the purpose of prevention of full-term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient stay in the open air, the drug is prescribed in a dose of 500-1000 IU (1-2 drops) per day.
Preterm infants from 4 weeks of life, twins and children living in unfavorable conditions, appoint 1000-1500 IU (2-3 drops) per day.
In the summer, the dose can be reduced to 500 IU (1 drop) per day.
Pregnant daily appoint 500 IU (1 drop) per day during the entire pregnancy, or 1000 IU per day, starting from the 28th week of pregnancy.
In the postmenopausal period 500-1000 IU (1-2 drops) are prescribed per day.
In order to treat rickets, the drug is prescribed daily at a dose of 2000-5000 IU (4-10 drops) per day for 4-6 weeks, depending on the severity of rickets (1, 2 or 3) and the course of the disease.In this case, the patient's clinical condition and biochemical parameters (calcium, phosphorus, activity of the alkaline phosphatase in the blood and urine) should be monitored. The initial dose is 2000 IU per day for 3-5 days, then with good tolerability the dose is increased to an individual therapeutic dose (usually up to 3000 IU per day). A dose of 5000 IU per day is prescribed only with pronounced bone changes. If necessary, after 1 week break, the course of treatment can be repeated.
Treatment should continue until a clear therapeutic effect, followed by a transition to a prophylactic dose of 500-1500 IU per day.
In the treatment of rachitis-like diseases, 20,000-30,000 IU (40-60 drops) per day are prescribed depending on the age, body weight and severity of the diseases, under the control of biochemical blood indices and urinalysis. The course of treatment is 4-6 weeks.
In the treatment of postmenopausal osteoporosis (as part of complex therapy) 500-1000 IU (1-2 drops) are prescribed per day.
Side effect
- loss of appetite;
- nausea, vomiting;
- head, muscle and joint pain;
- constipation;
- dryness in the oral cavity;
- polyuria;
- weakness;
- violation of the psyche, incl. depression;
- loss of body weight;
- sleep disturbance;
- temperature increase;
- in the urine appears protein, white blood cells, hyaline cylinders;
- increase in the level of calcium in the blood and its excretion in the urine;
- it is possible calcification of kidneys, blood vessels, lungs;
- hypersensitivity reactions.
Contraindications
- hypervitaminosis D;
- hypercalcemia;
- hypercalciuria;
- urolithiasis (formation of calcium oxalate stones in the kidneys);
- sarcoidosis;
- acute and chronic kidney disease;
- kidney failure;
- active form of pulmonary tuberculosis;
- children up to 4 weeks;
- increased sensitivity to vitamin D3 and other components of the drug (especially benzyl alcohol).
Application in pregnancy and lactation
In pregnancy, do not use Akvadetrim in high doses because of the possibility of teratogenic effects in case of an overdose.
With caution should be appointed Aquadetrim during lactation, tk. when using the drug in high doses in a nursing mother, it is possible to develop symptoms of an overdose in a child.
During pregnancy and during breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day.
Use in children
Contraindicated in children under 4 weeks.
special instructions
When prescribing the drug, you must consider all possible sources of vitamin D.
The use of the drug for medical purposes in children should be carried out under careful medical supervision and adjust the dosage regimen during periodic examinations, especially in the first months of life.
Long-term use of Aquadetrim in high doses or use of the drug in shock doses can lead to chronic hypervitaminosis D3.
Do not simultaneously use Aquadetrim and calcium in high doses.
Control of laboratory indicators
When using the drug for therapeutic purposes, it is necessary to monitor the level of calcium in the blood and urine.
Drug Interactions
With the simultaneous use of Aquadetrim with antiepileptic drugs, rifampicin, colestyramine, the absorption of colcalciferol decreases.
With the simultaneous use of Aquadetrim and thiazide diuretics, the risk of hypercalcemia increases.
Simultaneous use of Aquadetrim with cardiac glycosides can enhance their toxic effect (the risk of heart rhythm disturbances increases).
Analogues of the medicinal product Aquadetrim
Structural analogs for the active substance:
- Wigantol;
- Videchol;
- Videole solution in oil;
- Vitamin D3;
- Vitamin D3 100 SD / S dry;
- Vitamin D3 Bon;
- Vitamin D3 aqueous solution;
- Cholecalciferol.
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