Ibuklin - instructions for use, reviews, analogs and formulations (tablets, including Junior) of a medicinal product for the treatment of pain and fever in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ibuklin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Ibklin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Ibuklina in the presence of existing structural analogues. Use for the treatment of pain and fever in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Ibuklin - Combined drug, the effect of which is due to its constituent components.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID), has an analgesic, anti-inflammatory, antipyretic effect. Inhibiting cycloxygenase (COX) 1 and 2, disrupts the metabolism of arachidonic acid, reduces the number of prostaglandins (mediators of pain, inflammation and hyperthermia), both in the inflammatory focus and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.

Paracetamol - indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and gastrointestinal mucosa. Has analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of Paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.

The effectiveness of the combination is higher than that of the individual components. Relieves arthralgia at rest and during movement, reduces morning stiffness and swelling of joints, promotes an increase in the volume of movements.

Composition

Ibuprofen + Paracetamol + excipients.

Pharmacokinetics

Ibuprofen

Absorption is high, quickly and almost completely absorbed from the digestive tract. Slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. Exposed to metabolism. More than 90% is excreted by the kidneys (unchanged not more than 1%) and, to a lesser extent, with bile in the form of metabolites and their conjugates.

Paracetamol

Absorption is high, the association with plasma proteins is less than 10% and slightly increases with an overdose. It is evenly distributed in the liquid medium of the body. Penetrates through the blood-brain barrier. About 90-95% of paracetamol is metabolized in the liver with the formation of inactive conjugates with glucuronic acid (60%), Taurine (35%) and cysteine ​​(3%), as well as a small amount of hydroxylated and deacetylated metabolites. It is excreted by the kidneys, mainly in the form of glucuronide and sulfate conjugates (less than 5% in unchanged form). Breast milk penetrates less than 1% of the accepted dose of paracetamol.

Indications

• elevated body temperature (febrile syndrome) for colds and other infectious and inflammatory diseases.

Pain syndrome of mild or moderate intensity of different etiology:

• in inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile and chronic arthritis, ankylosing spondylitis, gouty arthritis);
• with degenerative diseases of the musculoskeletal system (deforming osteoarthritis, osteochondrosis);
• with diseases of periarticular tissues (tendovaginitis, bursitis);
• lumbago, sciatica, neuralgia, myalgia;
• post-traumatic pain syndromes (bruises, sprains, dislocations, fractures, bruises of soft tissues);
• toothache;
• headache.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected.

Forms of release

Tablets coated with a film coat 400 mg + 325 mg.

Tablets for children, dispersible Junior 100 mg + 125 mg.

There are no other dosage forms, whether candles or capsules.

Instructions for use and dosage

Take inside (before or 2-3 hours after eating), without chewing, squeezed with enough water. Adults and children over 12 years - 1 tablet 2-3 times a day. The minimum interval between taking the drug is 4 hours.The maximum dose for adults: single - 2 tablets, daily - 6 tablets.

The drug should not be taken for more than 5 days as an anesthetic and for more than 3 days as an antipyretic without the supervision of a doctor.

Tablets for children

The drug is taken internally. Before use, the Ibuquin tablet should be dissolved in 5 ml (1 teaspoon) of water. The daily dose of the drug is taken in 2-3 divided doses. The minimum time interval between taking the drug is 4 hours.

Single dose for children older than 3 years - 1 tablet. The daily dose depends on the age and weight of the child: 3-6 years (13-20 kg) - 3 tablets per day; 6-12 years (20-40 kg) - up to 6 tablets per day. In case of violations of the kidney or liver function, the interval between doses should be at least 8 hours.

The drug should not be taken for more than 5 days as an anesthetic and for more than 3 days as an antipyretic agent without the supervision of a doctor.

Side effect

• dyspeptic phenomena;
• Thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis;
• skin rash;
• itching;
• hives.

Contraindications

• increased individual sensitivity to the components of the drug (including other NSAIDs);
• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• gastrointestinal bleeding;
• severe renal failure (CC less than 30 ml / min);
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including in history);
• defeat of the optic nerve;
• genetic absence of glucose-6-phosphate dehydrogenase;
• diseases of the blood system;
• period after aortocoronary shunting;
• progressive kidney disease,
• severe hepatic impairment or active liver disease;
• confirmed hyperkalemia;
• active gastrointestinal bleeding;
• inflammatory bowel disease;
• children's age to 3 years (subject to the use of a special children's form Ikbulin).

Application in pregnancy and lactation

If you need to use the drug Ibuklin during pregnancy and lactation (breastfeeding), you should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus or child.

If you need to use in the trimester of pregnancy should be deleted long-term use of the drug Ibuklin.

If you need a short-term use of the drug Ibuklin during lactation, breastfeeding is usually not required.In experimental studies, embryotoxic, teratogenic and mutagenic effects of the components of the drug Ibuklin have not been established.

special instructions

The expediency of using the drug as an antipyretic agent is decided in each case, depending on the severity, nature and tolerability of the febrile syndrome.

To reduce the risk of developing adverse events on the part of the gastrointestinal tract, a minimum effective dose should be used with the minimum possible short course.

At simultaneous application of anticoagulants of indirect action it is necessary to supervise parameters of a coagulating system of blood.

It is necessary to avoid joint ingestion of Ibuklin with other NSAIDs.

During the period of taking the drug should not drink alcohol to prevent possible damaging effects on the liver.

With prolonged (more than 5 days) drug intake, control of peripheral blood and the functional state of the liver is necessary.

The drug may distort the results of laboratory tests in quantitative determination of glucose, uric acid in the blood serum, 17-ketosteroids (it is necessary to cancel the drug 48 hours prior to the study).

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, the patient should refrain from engaging in potentially dangerous activities requiring increased attention and speed of psychomotor reactions

Drug Interactions

With the simultaneous use of the drug Ibuklin with drugs, it is possible to develop various interaction effects.

Long-term combined use with paracetamol increases the risk of developing nephrotoxic effects.

The combination with ethanol (alcohol), glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.

Ibuprofen enhances the action of direct (heparin) and indirect (coumarin and indanedione derivatives) anticoagulants, thrombolytic agents (alteplase, anestreplase, streptokinase, urokinase), antiaggregants, colchicine - increases the risk of hemorrhagic complications.

Strengthens the hypoglycemic effect of insulin and oral hypoglycemic drugs.

Weaken the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).

Increases the concentration in the blood of digoxin, lithium and methotrexate.Caffeine increases the analgesic effect of ibuprofen. Cyclosporine and gold preparations increase nephrotoxicity.

Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the frequency of hypoprothrombinemia.

Antacids and colestyramine reduce the absorption of the drug.

Myelotoxic drugs promote the manifestation of hematotoxicity of the drug.

Analogues of the drug Ibuklin

Structural analogs for the active substance:

• Brustan;
• Next;
• Hyrumat.

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