Erespal - instructions for use, analogs, testimonials and release forms (syrup, tablets 80 mg) of the drug for cough, hoarseness and perspiration in the throat in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Erespal. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Erespal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Erespal in the presence of existing structural analogues. Use to treat coughing, hoarseness, throat swelling and other infections of the upper and lower respiratory tract in adults, children, as well as during pregnancy and lactation.
Erespal The anti-inflammatory and anti-bronchoconstrictive activity of Erespal is due to the fact that fenspiride reduces the production of a number of biologically active substances (cytokines, especially tumor necrosis factor alpha (TNF-alpha), arachidonic acid derivatives, free radicals) that play an important role in the development of inflammation and bronchospasm.
Inhibition of fenspiride metabolism of arachidonic acid is potentiated by blockade of histamine H1 receptors, histamine stimulates the formation of its products (prostaglandins and leukotrienes). Fenspiride blocks alpha-adrenergic receptors, stimulation of which is accompanied by an increase in the secretion of bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of pro-inflammatory factors, the development of inflammation and bronchial obstruction.
Fenspiride also has an antispasmodic effect.
Structure of the preparation
1 tablet, coated, contains fenspiride hydrochloride 80 mg. Excipients: calcium phosphate disubstituted, hypromellose, povidone, colloidal anhydrous silicon, magnesium stearate, titanium dioxide, glycerol, macrogol 6000; in a blistere of 15 pcs., in a box of 2 blisters.
1 ml of syrup - 2 mg of fenspiride hydrochloride.Auxiliary substances: honey aroma (honey, rum, alcoholates and alcohol extracts of honey, rose and orange flowers), Licorice root extract (concentrated licorice tincture, glucose syrup, anise oil) and vanilla extract (water-alcohol decoction of vanilla pods, glycerol, dye sunset yellow S, methylparahydroxybenzoate, propyl parahydroxybenzoate, saccharin, sucrose, potassium sorbate, distilled water); in the bottle 150 ml, in the box 1 bottle.
Pharmacokinetics
Well absorbed from the digestive tract. It is excreted mainly with urine (90%), through the intestine 10%.
Indications
Diseases of the upper and lower respiratory tract:
- rhinopharyngitis and laryngitis;
- tracheobronchitis;
- bronchitis (in the background of chronic respiratory failure or without it);
- bronchial asthma (as part of complex therapy);
- respiratory effects (cough, hoarseness, throat swelling) with measles, pertussis, influenza;
- infectious diseases of the respiratory tract accompanied by a cough, when standard antibiotic therapy is shown;
- otitis and sinusitis of various etiologies.
Forms of release
Tablets, film-coated 80 mg.
Syrup 2 mg / ml (pediatric form of the drug).
Instructions for use and dosage
Adults prescribe 80 mg (1 tablet) 2-3 times a day or 3-6 table spoons (45-90 ml) of syrup per day. 1 tablespoon contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.
The maximum daily dose is 240 mg. The duration of treatment is determined by the doctor.
Erespal in the form of tablets is not intended for the treatment of children and adolescents under the age of 18 years. To use the drug in this category of patients, Erespal is recommended in the form of a syrup.
For children and adolescents, the drug is prescribed at the rate of 4 mg / kg of body weight per day. Children aged 0 to 2 years (body weight up to 10 kg) - 2-4 teaspoons of syrup (10-20 ml) per day, can be added to a bottle with (1 teaspoon contains 10 mg of fenspiride hydrochloride and 3 of sucrose). Children aged 2 to 16 years (body weight more than 10 kg) - 2-4 tablespoons of syrup (30-60 ml) per day.
The drug should be taken before meals. Syrup before use should be shaken.
Side effect
- moderate tachycardia, the severity of which decreases with a decrease in the dose of the drug
- gastrointestinal disorders
- nausea
- epigastric pain
- drowsiness
- erythema, rash, hives, angioedema.
Contraindications
- children under 18 years (for tablets);
- hypersensitivity to the active substance and / or any of the components of the drug.
Application in pregnancy and lactation
Taking the drug during pregnancy is not recommended.
Therapy with fenspiride is not a reason for interrupting the pregnancy that has occurred.
Do not use Erespal during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
special instructions
For the treatment of children and adolescents under 18 years of age, Erespal Syrup should be used.
The composition of the drug includes the yellow S sanset, so that the use of Erespal can provoke the development of allergic reactions, including asthmatic attacks, especially in people with hypersensitivity to aspirin.
Drug Interactions
Because of the possible sedative effect when taking blockers of histamine H1 receptors, the use of Erespal in combination with drugs with sedative effect or with alcohol is not recommended.
Analogues of Erespal
Structural analogs for the active substance:
- Fenspiride hydrochloride.
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