Pantokaltsin - instructions for use, reviews, analogs and formulations (tablets 250 mg and 500 mg) of a drug for the treatment of epilepsy, enuresis and stuttering in adults, children (including infants and newborns) and in pregnancy
In this article, you can read the instructions for using the drug Pantokalcin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Pantokaltsin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pantokaltsin in the presence of existing structural analogues.Use for the treatment of epilepsy, enuresis and stuttering in adults, children (including infants and newborns), as well as during pregnancy and lactation. Composition of the preparation.
Pantokalcin - Nootropic preparation. The spectrum of action is related to the presence of GABA in the structure. The mechanism of action is due to the direct influence of pantocalcin on the GABAB-receptor-channel complex. It has neurometabolic, neuroprotective and neurotrophic properties.
Increases brain resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons.
Has an anticonvulsant effect, reduces motor excitability with simultaneous ordering of behavior. Increases mental and physical performance. Helps normalize the GABA content in chronic alcohol intoxication and the subsequent abolition of ethanol. Has an analgesic effect.
The drug is able to inhibit the acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, thereby prolonging the action of the latter.
It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.
Composition
Calcium gopantenate (pantogam or calcium salt of gopantenic acid) + auxiliary substances.
Pharmacokinetics
Quickly absorbed from the digestive tract. The greatest concentrations are created in the liver, kidneys, in the wall of the stomach, the skin. Penetrates through the blood-brain barrier (BBB). It is not metabolized. It is unchanged for 48 hours (67.5% with urine, 28.5% with feces).
Indications
- Cognitive impairment with organic brain lesions and neurotic disorders;
- in the complex therapy of cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels; senile dementia (initial form), residual organic brain damage in persons of mature age and elderly;
- cerebral organic insufficiency in patients with schizophrenia (in combination with neuroleptics, antidepressants);
- extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (including Huntington's chorea, hepatocerebral dystrophy, Parkinson's disease);
- consequences of the transferred neuroinfections and craniocerebral traumas (as part of complex therapy);
- for the correction of the side effect of antipsychotics and for the preventive purpose simultaneously as "cover therapy"; extrapyramidal neuroleptic syndrome (hyperkinetic and akinetic);
- epilepsy with a slowing of mental processes (in combination with anticonvulsant drugs);
- psycho-emotional overload, decreased mental and physical performance; to improve concentration and memorization;
- urination disorder: enuresis, daytime incontinence, pollakiuria, urinary urgency;
- children with mental retardation (mental delay, speech, motor development, or combinations thereof), cerebral palsy, stuttering (predominantly clonic form), epilepsy (in combined therapy with anticonvulsants, especially when the polymorphic attacks and small seizures).
Forms of release
Tablets 250 mg and 500 mg.
Instructions for use and dosing regimen
The drug is administered orally, 15-30 minutes after eating.
Single dose for adults is 0.5-1 g, for children - 0.25-0.5 g; daily dose for adults - 1.5-3 g, for children - 0.75-3 g Duration of treatment - from 1 to 4 months, in some cases up to 6 months.After 3-6 months, a repeat course of treatment is possible.
With neuroleptic syndrome (as an adjunct to the side effects of neuroleptic drugs), adults are prescribed 0.5-1 g three times a day; children - 250-500 mg 3-4 times a day. The course of treatment is 1-3 months.
For hyperkinesis (tics), adults are prescribed 1.5-3 g daily for 1-5 months; children are prescribed 250-500 mg 3-6 times a day. daily for 1-4 months.
At the consequences of neuroinfections and craniocerebral injuries, 250 mg 3-4 times a day are prescribed.
To restore working capacity under increased loads and asthenic conditions, 250 mg 3 times a day are prescribed.
With epilepsy, adults are prescribed 0.5-1 g 3-4 times a day; children - 250-500 mg 3-4 times a day. The drug is taken daily for a long time (up to 6 months).
In disorders of urination, adults are prescribed 0.5-1 g 2-3 times a day, a daily dose of 2-3 g; children - 250-500 mg daily dose - 25-50 mg / kg. The course of treatment is from 2 weeks to 3 months (depending on the severity of the disorders and the therapeutic effect).
Children with mental retardation are prescribed 0.5 g 4-6 times daily for 3 months; with a delay in speech development - 500 mg 3-4 times a day for 2-3 months.
Side effect
- rhinitis;
- conjunctivitis;
- skin rashes.
Contraindications
- acute renal insufficiency;
- 1 trimester of pregnancy;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Pantokaltsin is contraindicated in the first trimester of pregnancy.
Data on the safety of the drug in the 2nd and 3rd trimester of pregnancy and during lactation are not provided.
special instructions
This drug form of the drug (tablets 250 mg and 500 mg) is not recommended for children under the age of 3 years (ie, infants and newborns).
Drug Interactions
Pantokaltsin prolongs the action of barbiturates, enhances the effects of drugs that stimulate the central nervous system, anticonvulsants, the action of local anesthetics (procaine).
Prevents the side effects of phenobarbital, carbamazepine, antipsychotic drugs (neuroleptics).
The action of gopanthenic acid is enhanced in combination with glycine, xyediphon.
Analogues of the drug Pantokaltsin
Structural analogs for the active substance:
- Gopantam;
- Hopantenic acid;
- Calcium salt of gopantenic acid;
- Calcium gopentate;
- Pantogam.
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