Tamoxifen - instructions for use, reviews, analogs and formulations (tablets 10 mg, 20 mg, 30 mg and 40 mg Ebove) a drug for the treatment of breast, ovarian and kidney cancer in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Tamoxifen. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of physicians specialists on the use of Tamoxifen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tamoxifen in the presence of existing structural analogues. Use for the treatment of breast, ovarian and kidney cancer in adults, children, as well as during pregnancy and breast-feeding.

Tamoxifen - is a non-steroidal antiestrogenic agent that also has weak estrogenic properties. Its action is based on the ability to block estrogen receptors. Tamoxifen, as well as some of its metabolites, compete with estradiol for binding sites to the cytoplasmic estrogen receptors in the tissues of the mammary gland, uterus, vagina, anterior pituitary gland and tumors with a high estrogen receptor content. In contrast to the receptor complex of estrogen, the receptor complex of tamoxifen does not stimulate the synthesis of DNA in the nucleus, but inhibits cell division, which leads to regression of tumor cells and their death.

Composition

Tamoxifen citrate + excipients.

Pharmacokinetics

After ingestion, Tamoxifen is well absorbed. Metabolised in the liver with the formation of metabolites. It is allocated mainly in the form of conjugates, mainly with fecal masses and only small amounts are excreted in the urine.

Indications

• estrogen-dependent breast cancer in women (especially menopause) and mammary glands in men;
• ovarian cancer;
• endometrial cancer;
• kidney cancer;
• melanoma;
• sarcoma of soft tissues in the presence of estrogen receptors in the tumor;
• for the treatment of prostate cancer in resistance to other medicines;
• anovulatory infertility.

Forms of release

Tablets 10 mg, 20 mg, 30 mg and 40 mg.

Instructions for use and dosing regimen

The dosage regimen is usually set individually, depending on the indications. The daily dose is 20-40 mg. As a standard dose, taking 20 mg of tamoxifen inside daily for a long time is recommended. When there are signs of progression of the disease, taking the drug is canceled.

Tablets should be taken without chewing, squeezed a small amount of liquid, in one dose in the morning, or, sharing the necessary dose for two meals in the morning and evening.

Side effect

• paroxysmal sensations of heat (hot flashes);
• vaginal bleeding or discharge;
• itching in the genital area;
• alopecia;
• pain in the area of ​​the lesion;
• ossalgia;
• increase in body weight;
• fluid retention;
• anorexia;
• nausea, vomiting;
• constipation;
• increased fatigue;
• depression;
• confusion of consciousness;
• headache;
• dizziness;
• drowsiness;
• increased body temperature;
• skin rash;
• impaired vision;
• retinopathy;
• retrobulbar neuritis;
• increase in the size of soft tissue formations, sometimes accompanied by severe erythema of affected areas and adjacent areas at the beginning of treatment;
• thrombophlebitis;
• thromboembolism;
• Transient leukopenia and thrombocytopenia;
• development of cystic ovarian tumors;
• changes in the endometrium, including hyperplasia, polyps and in isolated cases - endometrial cancer;
• uterine fibroid.

Contraindications

• pregnancy;
• lactation period;
• increased sensitivity to tamoxifen and / or any other ingredient in the drug.

Application in pregnancy and lactation

Contraindicated.

Tamoxifen can cause ovulation, which increases the risk of pregnancy, and therefore women who have an active sexual life during (and within about 3 months after) treatment with tamoxifen recommended the use of a mechanical or non-hormonal contraceptive.

special instructions

Women receiving Tamoxifen should undergo a regular gynecological examination. When bloody discharge from the vagina or vaginal bleeding occurs, the drug should be discontinued.

In patients with metastases in the bone, periodically during the initial period of treatment should determine the concentration of calcium in the blood serum. In case of severe disorders, tamoxifen should be temporarily discontinued.

When signs of thrombosis of the veins of the lower extremities (pain in the legs or their swelling), embolism of the pulmonary artery (dyspnea), the drug should be stopped.

During the period of therapy, it is necessary to periodically monitor the blood clotting parameters, the calcium content in the blood, the blood picture (leukocytes, platelets), liver function indices, blood pressure, and check with the oculist.

In patients with hyperlipidemia, the concentration of cholesterol and TG in serum should be monitored during treatment.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous administration of Tamoxifen and cytostatics, the risk of thrombosis increases.

Antacids, histamine H2 receptor blockers and other drugs of similar effect, increasing the pH value in the stomach, can cause premature dissolution and loss of protective effect of the enteric-soluble tablet. The interval between taking tamoxifen and these drugs should be 1-2 hours.

There have been reports of an increase in Tamoxifen anticoagulant effect of coumarin drugs (eg, warfarin).

Drugs that reduce the excretion of calcium (eg, thiazide diuretics) may increase the risk of hypercalcemia.

Joint use of tamoxifen and tegafur can promote the development of active chronic hepatitis and cirrhosis of the liver.

Simultaneous use of Tamoxifen with other hormonal drugs (especially estrogen-containing contraceptives) leads to a weakening of the specific effects of both drugs.

Analogues of the drug Tamoxifen

Structural analogs for the active substance:

• Biel;
• Vero Tamoxifen;
• Zitazonium;
• Novofen;
• Nolvadex;
• Tamoxen;
• Tamoxifen Tamoplex;
• Tamoxifen Hexal;
• Tamoxifen of Lahema;
• Tamoxifen Ebwe;
• Tamoxifen citrate.

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