En DE FR ES PL
Neuromidine - instructions for use, analogs, reviews and release forms (20 mg tablets, injections in injections) drugs for paresis, paralysis and polyneuropathy in adults, children and pregnancy. Interaction with alcohol

Neuromidine - instructions for use, analogs, reviews and release forms (20 mg tablets, injections in injections) drugs for paresis, paralysis and polyneuropathy in adults, children and pregnancy. Interaction with alcohol

In this article, you can read the instructions for using the drug Neuromidine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Neuromidine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neurromidine in the presence of existing structural analogues.Use for the treatment of paresis, paralysis and polyneuropathies in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

 

Neuromidine cholinesterase inhibitor. It has a direct stimulating effect on impulse conduction on nerve fibers, interneuronal and neuromuscular synapses of the peripheral and central nervous system. Pharmacological action of the drug Neuromidine is based on a combination of two mechanisms of action: blockade of the potassium channels of the membrane of neurons and muscle cells; reversible inhibition of cholinesterase in synapses.

 

Neurromidine enhances the effect on the smooth muscles of not only acetylcholine, but also adrenaline, serotonin, histamine and oxytocin.

 

Neuromidine has the following pharmacological effects: it improves and stimulates the impulse in the nervous system and neuromuscular transmission; strengthens the contractility of smooth muscle organs under the influence of agonists acetylcholine, adrenaline, serotonin, histamine and oxytocin receptors, with the exception of potassium chloride; improves memory, inhibits the progressive course of dementia.

 

Composition

 

Ipidacrine hydrochloride (in the form of monohydrate) + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, the drug is rapidly absorbed from the digestive tract. After parenteral administration, the drug is also rapidly absorbed. Ipidacrin quickly enters the tissues, the half-distribution period is 40 minutes. Metabolised in the liver. It is excreted by the kidneys, and also extrarenally (through the digestive tract).

 

Indications

  • diseases of the peripheral nervous system: mono- and polyneuropathy, polyradiculopathy, myasthenia gravis, myasthenic syndrome of various etiologies;
  • diseases of the central nervous system: bulbar paralysis and paresis; the recovery period of organic lesions of the CNS, accompanied by motor and / or cognitive impairment;
  • treatment and prevention of intestinal atony.

 

Forms of release

 

Tablets of 20 mg.

 

Solution for intramuscular and subcutaneous injection (injections in ampoules for injection).

 

Instructions for use and dosing regimen

 

Doses and duration of treatment Neuromidin is determined individually, depending on the severity of the disease.

 

Diseases of the peripheral nervous system: mono- and polyneuropathy, polyradiculopathy, myasthenia gravis, myasthenic syndrome of different etiology - prescribe inside by 10-20 mg (0.5-1 tablets) 1-3 times a day.Parenteral drug is used intramuscularly or subcutaneously at 5-15 mg 1-2 times a day. The course of treatment is from 1 to 2 months. If necessary, the course of treatment can be repeated several times with a break between courses in 1-2 months.

 

To prevent myasthenic crises in severe disorders of neuromuscular conduction, 1-2 ml (15-30 mg) of 1.5% Neuromidine solution for injections are injected for a short time, then the treatment is continued, prescribing the drug inside in the form of tablets - the dose can be increased to 20-40 mg (1-2 tablets) 5 times a day.

 

Central nervous system diseases: bulbar paralysis and paresis, recovery period of organic CNS lesions (traumatic, vascular and other genesis), accompanied by motor and / or cognitive impairment - inside by 10-20 mg (0.5-1 tablets) 2-3 times a day. The course of treatment is from 2 to 6 months. If necessary, repeat the treatment.

 

Treatment and prevention of intestinal atony: inside the drug is prescribed to 20 mg (1 tablet) 2-3 times a day for 1-2 weeks. If the next dose has not been taken on time, in addition it should not be taken.

 

With parenteral administration, the initial dose of the drug is 10-15 mg per day for 1-2 weeks.The dose of the drug can be increased to 30 mg per day.

 

The maximum daily dose is 200 mg.

 

Side effect

  • salivation;
  • increased sweating;
  • palpitation;
  • nausea, vomiting;
  • diarrhea;
  • bradycardia;
  • pain in epigastrium;
  • increased secretion of bronchial secretions;
  • convulsions;
  • dizziness;
  • headache;
  • general weakness;
  • drowsiness;
  • skin allergic reactions (itching, rash);
  • increase in the tone of the uterus.

 

Contraindications

  • epilepsy;
  • vestibular disorders;
  • extrapyramidal diseases with hyperkinesis;
  • angina pectoris;
  • severe bradycardia;
  • bronchial asthma;
  • peptic ulcer of the stomach or duodenum in the phase of exacerbation;
  • mechanical obstruction of the intestine or urinary tract;
  • pregnancy (the drug raises the tone of the uterus);
  • lactation period (breastfeeding);
  • children and adolescents under 18 years of age (no systematic data on the application);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

Contraindicated use of the drug during pregnancy and lactation (breastfeeding).

 

The drug does not have teratogenic, embryotoxic effects.

 

special instructions

 

During the period of treatment, the patient should exclude the use of alcohol. Alcohol increases the side effects of the drug.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During treatment, the patient should refrain from driving motor vehicles, as well as practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

Neuromidine enhances sedation in combination with CNS depressants.

 

The effect of the drug and side effects are enhanced when combined with other cholinesterase inhibitors and m-cholinomimetic agents.

 

In patients with myasthenia gravis, the risk of developing a cholinergic crisis increases with the simultaneous use of Neuromidine with other cholinergic agents.

 

The risk of bradycardia increases if beta-blockers were used before the start of treatment with Neuromidine.

 

The drug can be used in combination with nootropic drugs.

 

Ethanol (alcohol) increases the side effects of the drug.

 

Neuromidine weakens the depressing effect on neuromuscular transmission and conduction of excitation along the peripheral nerves of local anesthetics, aminoglycosides, potassium chloride.

 

Analogues of the drug Neuromidine

 

Structural analogs for the active substance:

  • Aksamon;
  • Amiridin 20 mg.

Similar medicines:

Other medicines:
Reviews (27):
Guests
Sasha
Dear drug, I can not afford it. Although they say memory improves well.
Guests
Tatyana
Nothing it does not help this drug.
Guests
eugene
I've been putting up 5 years and I really like it.
Guests
Alexey
Yes, the effect of it is weak.
Guests
Olga
We are helped (mother-in-law after a stroke).
Guests
Taisia
Her husband had an ischemic stroke last summer, but the recovery period was long enough. And therefore neuromidine was prescribed as one of the first drugs, because today it is considered one of the best for the prevention and treatment of strokes. My husband took it in tablets. The course of treatment was prescribed for a month, but from the digestive tract there were some side effects. In order not to abandon the drug, the doctor began to prescribe this medicine to her husband in pricks, usually 10 injections, this somewhat alleviates the situation.
Guests
Antonina Popushoi
Neuromidin by 1t 3p per day 1month. If you replace with injections, what should be the dosage and what course of treatment?
Administrators
admin
Antonina Popushoi, The doctor decides, based on the patient's state of health and the diagnosis made. Judging by the fact that you have indicated the average dose of Neuromidin, it is likely that injections should be assumed in the same averaged dosages, for example, 15 mg (1 ampoule solution for injection of 15 mg in each ampoule) per day, course for 1-2 months.The maximum daily dose should not be more than 200 mg.
Guests
Love
My husband had a second stroke on 10.12.15. Neuromidine was very helpful. First, injections 20pcs, and now in tablets for two months. I let go of my left arm and leg.
Guests
muyassar
Neuromidine take almost a month improvement until I see, can gradually help. I used to drink Kalimin, and now Neuromidine. I after operation as already 10 months later 9 months at me the eyelid has lowered and our professor from Tajikistan has written out nejromidin. Will the drug help?
Administrators
admin
muyassar, This I can not know. But your professor prescribes medicines from one group (cholinesterase inhibitors), so the first thing I would question is the adequacy of the diagnosis, but this requires a survey and the opinion of another doctor.
Guests
svetlana sv
Hello! To my mother for the period of recovery (for 1 month) after a stroke in the left hemisphere of the cerebellum and left thalamus (24.10.2016) neuromidine was prescribed for 1m 2p \ day.She has a concomitant disease - a mixed, mostly sensory polyneuropathy of the lower extremities. Somewhere on the 2-3 day after the beginning of the reception salivation appeared. After consulting a neurologist, the neuromedin was withdrawn, but today my mother began to complain of a feeling of numbness, a dulling of the sensation in her legs. Do not take the drug for 6 days. Saliva does not stand out now as it was. Tell me, please, can there be sensations in the legs caused by cancellation of the drug and can I continue taking the medication again after such a break, and can I reduce the dose to avoid side effects? Thank you!
Administrators
admin
svetlana svAccording to the description, I would return Neuromidine to the therapy regimen. Neurological symptoms have a higher priority in treatment than a side effect in the form of drooling. The latter can be endured. But in any case, before returning the drug to consult with the attending physician is. Perhaps he will advise something from another pharmacological group that will help in the treatment and will not cause unnecessary side effects.
Guests
Tatyana
To the child of 10 years. He has an enuresis. We were prescribed neuromidine for injections.
Guests
Nellie
To me have written out nejromidin in occasion of ljumboischialgia and hr.pondiloartroza. But I read in the annotation a contraindication - angina, which I have. How to be? I can see a doctor no sooner than 2-3 weeks.
Administrators
admin
Nellie, Without a doctor in any way, because you need to change the treatment schedule, and for this the history of the disease, the passed analyzes and studies, accompanying diseases are important. Drugs from other pharmacological groups will be prescribed, because angina pectoris is a contraindication to taking Neuromidine.
Visitors
Natalia 08042015
The neurologist has appointed or nominated this preparation (nejromidin) at an accompanying disease a stenocardia. Angina pectoris of functional class 4, there is aortic stenosis, deterioration of cardiac contractility. Honestly, I'm in shock. It's good that they did not start this stage of treatment (dad). What to do? Any advice is needed.The main diagnosis in a neurologist is: polyneuropathy, unspecified etiology. Diagnosis of the therapist: iron deficiency anemia and vitamin B12 deficiency.
Administrators
admin
Natalia 08042015, Neuromidine is a good medicine for the treatment of diseases of the peripheral nervous system, but your father has angina, and at the same time the diagnosis of using this medication is contraindicated. So repeat the consultation (you can have another doctor) to adjust the treatment.
Guests
Olga
Neuromidine was prescribed as part of a comprehensive treatment. Perhaps it was my luck, but the drug also helped, and there were no side effects. After several operations in a short time and 6 courses of chemotherapy, I began to have problems with memory and general brain work, could not concentrate, almost did not remember anything, impoverished the speech reserve and as a whole I strongly surrendered in terms of the mind. At 100% brain work failed to recover, but things got much better.
Guests
Tamara Yegorova
Absolutely did not feel any improvement.Osteochondrosis of the cervical region, numb the little finger, ring finger and thumb on the left hand, and the big and the second finger on the left leg. Constant "goose bumps" and cold hands.
Visitors
o.silvanovi4
Hello I have a diagnosis: H93.3 Dv.hr.SNT 2 degrees, I was prescribed neuromidine in tablets. After reading the annotation, I began to doubt whether it should be used? And the more inexpensive drug can replace Tanakan with the same diagnosis?
Administrators
admin
o.silvanovi4In case of sensorineural hearing loss, both Tanakan and Neuromidine can be used, it all depends on the possible causes of the development of the disease or the expected causes, because sometimes the true cause can not be established, so it is necessary to sort out a possible range of medicines. Such questions should be asked your doctor.
Visitors
Alex PI
Neyromidin was appointed in a complex of diplopia treatment, which occurred after a severe, short (about a week) hyperglycemia (25-27 mmol) with hypoxia in combination with hypertension (blood pressure more than 200).After a three-week stabilization of sugar and blood pressure according to a classical protocol in this situation, the therapy was directed to treatment of the brain and affected nerves (cerebrolysin IV, B vitamins IM, nicotine IM, pentoxifylline tablets, neuromidine tablets). After two weeks of treatment, there was no improvement in vision, although the brain became much better. I independently decided to replace Neuromidine tablets with injections - and then broke through. Perhaps a cumulative effect of previous therapy, but literally after the first injection, after 3-4 hours, the weakening of double vision and a sensation of spasm of the eyes was noted. Today in the morning the second injection - in the evening went home for 20 minutes and never closed a sore eye - which was not already a month and a half. He did not squint or turn his head to see the road, although looking at his side, even a little bit is still impossible - but there are still 8 ampoules ahead. In general, it works.
Guests
Anatoly Kovalchuk
At the wife a polyneuropathy, completely was deprived mobility. After the course of treatment, regularly (after 3 months) pierce neuromidine 1.5% 10 injections, after the pill one on three times a day (in April 2018 will be three years).The movement function is completely restored: there is no cocking gait, sensitivity of limbs (axons) is restored.
Visitors
Natalia 08042015
Hello. How is it possible to replace neuromidine with a diagnosis of polyneuropathy against a background of vitamin B12 deficiency? Do they have analogs that can be prescribed to a patient with angina and stenosis? The question is not for self-treatment, to prepare for a conversation with a doctor. Very important. Without your help can not cope. Last year there was already a neuromidine appointment, then, in addition to stenocardia and aortic stenosis, there was a pre-infarction condition, the cardiologist said that it was necessary to wait for stabilization.
Thank you in advance for your support.
Sincerely.
Visitors
Natalia 08042015
Does neuromidine block potassium channels? If so, is it possible to take it if already in the constant reception there is a cordon (potassium channel activator) and he (cordon) literally saves life? Associated diagnoses are angina, aortic stenosis.
Administrators
admin
Natalia 08042015Neurromidine is not the best choice in your situation. Where there is a pre-infarction, there is angina, and this is a contraindication to the use of this medication. If the cardiologist is not against it, you can try, but I would be in his place was against it.

Rules for publishing reviews and visitor questions