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Orsoten - instructions for use, analogs, reviews and release forms (capsules or tablets 120 mg and 60 mg Slim) drugs for weight loss and reduce excess weight in adults, children and pregnancy. Composition and side effect

Orsoten - instructions for use, analogs, reviews and release forms (capsules or tablets 120 mg and 60 mg Slim) drugs for weight loss and reduce excess weight in adults, children and pregnancy. Composition and side effect

In this article, you can read the instructions for using the drug Orsotene. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Orsotene in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Orsotene in the presence of existing structural analogues. Use to lose weight and reduce excess weight in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

 

Orsotene - a specific inhibitor of gastrointestinal lipases, which has a prolonged action. Has a therapeutic effect in the lumen of the stomach and small intestine, forming a covalent bond with the active serine portion of the gastric and intestinal lipases. Inactivated in this way, the enzyme loses the ability to break down food fats that come in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the intake of calories into the body decreases, which leads to a decrease in body weight.

 

The therapeutic effect of the drug is carried out without absorption into the systemic bloodstream. The action of Orlistat (the active ingredient of the drug Orsoten) leads to an increase in the fat content in the feces after 24-48 hours after taking the drug. After the drug is withdrawn, the fat content in the stools usually returns to the initial level after 48-72 hours.

 

Composition

 

Orlistat + auxiliary substances.

 

Pharmacokinetics

 

Absorption of orlistat is low. Signs of cumulation are absent, which confirms the minimal absorption of the drug.Orlistat is metabolized mainly in the intestinal wall with the formation of pharmacologically inactive metabolites: M1 (hydrolyzed four-membered lactone ring) and M3 (M1 with the cleaved N-formylleucine residue). The main way of elimination is through the intestine - about 97% of the dose of the drug, of which 83% - unchanged. The cumulative excretion through the kidneys of all substances structurally associated with orlistat is less than 2% of the accepted dose of the drug. The time for complete elimination is 3-5 days. Orlistat and metabolites can be excreted with bile.

 

Indications

  • prolonged treatment of obese patients with a body mass index (BMI) ≥ 30 kg / m2, or patients with an overweight (BMI ≥ 28 kg / m2), incl. who are associated with obesity risk factors, in combination with a moderately low-calorie diet (a means to lose weight).

 

Forms of release

 

Capsules 60 mg (Orsotene Slim).

 

Capsules 120 mg.

 

Other dosage forms, such as tablets, do not exist.

 

Instructions for use and reception scheme

 

The recommended single dose is 120 mg.

 

The capsule is taken with water, taking in immediately before each main meal, during meals or not later than 1 hour after a meal.If food is missed or if the food does not contain fat, you can skip the intake of orlistat.

 

Doses of orlistat more than 120 mg 3 times a day do not enhance its therapeutic effect. Duration of therapy - no more than 2 years.

 

Correction of the dose is not required for elderly patients or patients with impaired liver or kidney function.

 

Side effect

  • flatulence, accompanied by secretions from the rectum;
  • desires for defecation;
  • oily / oily stool;
  • oily discharge from the rectum;
  • loose stools;
  • a soft chair;
  • inclusion of fat in stool (steatorrhea);
  • pain / discomfort in the abdomen;
  • more bowel movements;
  • pain / discomfort in the rectum;
  • imperative urges for defecation;
  • fecal incontinence;
  • defeat of teeth and gums;
  • hypoglycemia in patients with type 2 diabetes mellitus;
  • diverticulitis;
  • cholelithiasis;
  • headache;
  • sense of anxiety;
  • itching;
  • rash;
  • hives;
  • angioedema;
  • bronchospasm;
  • anaphylaxis;
  • bullous rash;
  • influenza-like syndrome;
  • feeling tired;
  • upper respiratory infections;
  • urinary tract infections;
  • dysmenorrhea.

 

Contraindications

  • syndrome of chronic malabsorption;
  • cholestasis;
  • pregnancy;
  • lactation period (breastfeeding);
  • children under 18 years of age (efficacy and safety not studied);
  • hypersensitivity to orlistat or any other components of the drug.

 

Application in pregnancy and lactation

 

According to the results of preclinical studies, teratogenicity and embryotoxicity with Orsotene were not observed. Clinical data on the use of orlistat in pregnancy are absent, so you should not prescribe the drug in this period.

 

Data on application during lactation are absent, therefore orlistat should not be prescribed during lactation.

 

special instructions

 

Orsotene is effective for prolonged monitoring of body weight (weight loss, maintaining it at an appropriate level and preventing repeated body weight gain). Treatment with orlistat leads to an improvement in the profile of risk factors and diseases associated with obesity (including hypercholesterolemia, impaired glucose tolerance, hyperinsulinemia, arterial hypertension, type 2 diabetes mellitus), and a reduction in visceral fat.

 

Decreased body weight during treatment with orlistat may be accompanied by an improvement in the compensation of carbohydrate metabolism in patients with type 2 diabetes mellitus, which can reduce the dose of hypoglycemic drugs.

 

To ensure adequate nutrition of patients it is recommended to take multivitamin preparations.

 

Patients should adhere to dietary guidelines. They should receive a balanced, moderately low-calorie diet, containing no more than 30% of calories in the form of fats. Daily intake of fat should be divided into three main meals.

 

The likelihood of adverse reactions from the GI tract may increase if orlistat is taken amid a diet rich in fats (for example, 2000 kcal per day,> 30% of the daily caloric intake comes in the form of fats, which is approximately 67 g of fat). Patients should be aware that the more precisely they observe a diet (especially regarding the allowed amount of fat), the less likely the development of adverse reactions. A low-fat diet reduces the likelihood of adverse reactions from the gastrointestinal tract and helps patients control and regulate fat intake.

 

If after 12 weeks of therapy there was no decrease in body weight, at least 5%, Orsoten should be stopped.

 

Drug Interactions

 

Patients receiving Warfarin or other anticoagulants and orlistat may experience a decrease in the level of prothrombin, an increase in INR, leading to changes in haemostatic parameters.

 

Interactions with amitriptyline, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, oral contraceptives, phentermine, Nifedipine (including delayed release), sibutramine, furosemide, captopril, atenolol, glibenclamide or ethanol have not been observed.

 

Increases the bioavailability and hypolipidemic effect of pravastatin, increasing its concentration in plasma by 30%.

 

A decrease in body weight can improve metabolism in diabetic patients, and as a result, it is necessary to reduce the dose of oral hypoglycemic agents.

 

Treatment with Orsotenum can potentially interfere with the absorption of fat-soluble Vitamins (A, D, E, K). If multivitamins are recommended, they should be taken no earlier than 2 hours after taking orlistat or before bedtime.

 

With the simultaneous administration of orlistat and cyclosporine, a decrease in the level of cyclosporine concentration in the blood plasma was noted, therefore it is recommended to conduct a more frequent determination of the level of cyclosporin concentration in the blood plasma.

 

Patients receiving Amiodarone should be more carefully monitored and monitored by the ECG; cases of a decrease in the level of amiodarone concentration in the blood plasma are described.

 

Analogues of the drug Orsoten

 

Structural analogs for the active substance:

  • Allie;
  • Xenalten;
  • Xenical;
  • Orlimax;
  • Orlistat;
  • Orsoten Slim.

Similar medicines:

Other medicines:

Reviews (12):
Guests
Angela
Took Orsotenum slim 2,5 months. More simply it was not required in view of weight, it was spent by means of tablets and a path with an angle of inclination of almost 11 kg. In the first month 5, then more. I drank vitamins, I did not feel any bad sensations, even my head was not sick.
Guests
Elizabeth
From personal experience. I bought an orotenum slim in August, I drink about four months.It took 8 kg, for an ideal it is necessary that it would take another 5. But the course he has half a year, so that can also go. I believe in the best.
Guests
Valentina
It turns out the first month of weight loss with Orsotene Slim is the "slowest", because it took only 2 kg. And then with a stretch. All the following months I dropped 3 kg each) I finished the course even earlier than I expected))
Guests
Regina
Of course, in the first month, a lot of kilos will not go away. The body should tune in to weight loss. When I lost weight with Orsotene Slim, I did not even hold out for the first month before 2x. And then 3-4 went away) When I) I was just studying sports for a while.
Guests
Varvara
Some positive reviews, does everyone help, and everyone is losing weight. I did not feel this on myself, took orsoten slim for three months, did not eat fat, I waited for when the weight loss would begin. But there were no changes, I had to give up, now I'm looking for an alternative.
Visitors
EUL
Barbara, there are not all the positive reviews! At me - negative.The drug has a lot of side effects, though, the instructions are all spelled out, but how do you know if they have it or not. Give an encouraging advice that if, they say, a low-fat diet will be respected, then all the pimples will go away ... They did not leave me. Two weeks of taking Orsotene, and trying to be close to the toilet, it was simply impossible to control diarrhea, plus all the pain in the abdomen. I will not take it any more.
Guests
Gadzolya
Before taking medications for weight loss, you should consult a doctor, take tests and put out the presence of diseases, especially chronic ones.
Guests
Ninel
From Orsoten simply dark side effects, not even pass. And especially separately it is necessary to put fat allocation, thus it is not possible to control them. I went for months with gaskets, then decided to stop taking them, because the weight did not go away at all.
Guests
gal
At me zhkt and hr.gastrit. Pain in the abdomen constantly, as I did not observe a diet. On orsotene sat 6 months, from personal experience, I myself do not believe in anything, and I'm afraid to drink tablets.Before drinking read reviews, I decided, as they are recommended for obesity by dieticians themselves. The first 2 months. it seemed a waste of money threw, but a month later started again, drank every day for 6 months. Ela did not limit herself, somehow she began eating less, dropped 19 kg. Physical work was only at work, I have a profession confectioner. The pains are gone, now I have given birth, I have again collected, I have to drop it, but it is so expensive now. I would like to find an analog for him, so that it will be cheaper.
Administrators
admin
Site visitor feedback Alla moved to the required section:
On what I just grew thin - then some super-teas from unknown herbs, then tablets according to the recipes of Tibetan monks. They divorced like a sucker, shorter. Immediately would Orsotene bought - would save a lot of money. From him though the effect is, and not bad!
Visitors
nikul
I would like to know if it is possible to apply the drug for hr.pancreatitis, hr.gastrita, hr.hepatitis, hr.cholecystitis, obesity 3 st or more - all in one person?
Administrators
admin
nikul, On the liver, the drug Orsoten can act negatively, so before the start of treatment should check the liver and bile duct (biochemical analysis with markers of hepatitis, plus ultrasound of the liver and gallbladder). If all indicators are normal and stable - taking this medication is possible with regular monitoring of hepatic parameters in blood tests and under medical supervision.

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