Infanriks - instructions for use, analogs, reviews and release forms (injections in ampoules for Penta and Hex injections) of DTP vaccine for the prevention of diphtheria, tetanus and pertussis in adults, children and pregnancy. Composition, contraindications

In this article, you can read the instructions for the use of the DTP vaccine Infanriks. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Infanricks in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Infanricks in the presence of existing structural analogs. Use for prevention of diphtheria, tetanus and pertussis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Infanriks vaccine against diphtheria, tetanus and pertussis.

Immune response to primary immunization

One month after the three-year course of primary vaccination, conducted in the first 6 months of life, more than 99% of children immunized with Infanrix vaccine titers antibodies to diphtheria and tetanus toxoid are more than 0.1 IU / ml. Antibodies to pertussis antigens (pertussis anatoxin, filamentous hemagglutinin and pertactin) are produced in more than 95% of the vaccinated.

Immune Response to Revaccination

After revaccination with Infanricks vaccine at 2 years of age (13-24 months) in all children who were initially immunized with the Infanricks vaccine, antibodies to diphtheria and tetanus toxoid titres are more than 0.1 IU / ml. A secondary immune response to pertussis antigens is observed in more than 96% of children.

The protective efficacy of the vaccine reaches an average of 88%.

Composition

Diphtheria toxoid + Tetanus toxoid + Pertussis anatoxin + Hemagglutinin filamentosa + Perthactin + auxiliary substances.

Indications

• primary vaccination against diphtheria, tetanus and pertussis in children from 3 months;
• revaccination of children,which were previously immunized with 3 doses of acellular pertussis-diphtheria-tetanus or whole-cell pertussis-diphtheria-tetanus vaccine.

Forms of release

Suspension for intramuscular injection (injections in ampoules for injection).

Instructions for use and usage diagram

A single dose of the vaccine is 0.5 ml.

The course of primary vaccination consists of 3 doses of the vaccine administered according to the National Schedule of Prophylactic Inoculations of Russia at 3, 4.5 and 6 months of life; revaccination is carried out at 18 months.

Before administration, the vaccine is shaken well until a homogeneous turbid suspension is formed and carefully examined. In case of detection of foreign particles, undiluted flakes or change in appearance, the vaccine is not used.

The Infanricks vaccine is administered intramuscularly and alternates with the injection site during the course of vaccination.

The vaccine Infanriks under no circumstances is injected intravenously!

Side effect

• lymphadenopathy;
• irritability;
• drowsiness;
• anxiety;
• unusual crying;
• headache;
• cough;
• bronchitis;
• rhinitis;
• pharyngitis;
• loss of appetite;
• diarrhea;
• vomiting;
• itching;
• rash;
• hives;
• dermatitis;
• redness;
• edema at the injection site;
• fever;
• soreness;
• feeling tired;
• thrombocytopenia;
• hypersensitivity reactions;
• angioedema;
• anaphylactic and anaphylactoid reactions;
• collapse or shock-like state (hypotensive-hypo-sporadic episode);
• convulsions (with or without fever) within 2-3 days after the administration of the vaccine;
• apnea;
• otitis media.

Contraindications

• known hypersensitivity to any component of the present vaccine, and also if the patient has had symptoms of hypersensitivity after the previous administration of the Infarriks vaccine;
• a severe reaction (temperature over 40 degrees, hyperemia or swelling more than 8 cm in diameter), or a complication (collapse or shock-like condition that developed within 48 hours after the administration of the vaccine, continuous crying lasting 3 hours or more, occurred within 48 hours after administration vaccines, convulsions accompanied or not accompanied by a febrile condition that occurred within 3 days after vaccination) for the previous administration of the Infarriks vaccine;
• encephalopathy, developed within 7 days after the previous administration of a vaccine containing a pertussis component.In this case, the vaccination course should continue with a diphtheria-tetanus vaccine.

special instructions

Before vaccination, the history of the child should be studied, paying attention to the previous administration of vaccines and the associated occurrence of adverse reactions, as well as to conduct an examination.

The introduction of the vaccine should be postponed if the child has an acute illness accompanied by fever. With an infectious disease in mild form, vaccination can be carried out after the temperature is normalized.

As with any other vaccine, you should have everything you need ready to stop a possible anaphylactic reaction to Infanrix. Therefore, the vaccinated should be under medical supervision for 30 minutes after immunization.

Infarriks should be used with caution in patients with thrombocytopenia or with clotting disorders, since intramuscular injection may cause bleeding in such patients. To prevent bleeding, press the injection site without rubbing it for at least 2 minutes.

HIV infection is not a contraindication to vaccination.

When the vaccine is administered to patients undergoing immunosuppressive therapy or to patients with immunodeficient conditions, an adequate immune response may not be achieved.

The following conditions are contraindications to the introduction of whole-cell DTP vaccines and can be attributed to general precautions when introducing the Infanriks vaccine:

• temperature 40.5 degrees and above for 48 hours after vaccination, not related to other causes, except for the introduction of the vaccine;
• a collapse or shock-like state (hypotonic-hypo-spontaneous episode) that developed within 48 hours after the administration of the vaccine;
• continuous crying, lasting 3 hours or more, occurred within 48 hours after the introduction of the vaccine;
• convulsions accompanied or unaccompanied by febrile conditions that occurred within 3 days after vaccination.

In children with progressive neurological disorders, including infantile spasms, uncontrolled epilepsy or progressive encephalopathy, the introduction of a vaccine with a pertussis component (whole-cell or acellular) should be postponed until the condition stabilizes. The decision to prescribe a vaccine with a pertussis component should be taken on an individual basis after a thorough assessment of the benefits and risks.

The presence of febrile seizures in the anamnesis, as well as convulsions in the family history is not a contraindication, but requires special attention.

It is necessary to take into account the potential risk of apnea and the need to monitor respiratory function for 48-72 hours during the course of primary vaccination of children born prematurely (less than 28 weeks of gestation) and especially children with respiratory distress syndrome. In view of the need to vaccinate children of this group, vaccination can not be postponed or denied.

Drug Interactions

In accordance with the rules adopted in Russia, Infanriks can be administered simultaneously (on the same day) with other vaccines of the National calendar of preventive vaccinations and inactivated vaccines of the vaccination schedule for epidemiological indications. In this case, other vaccines should be injected into other parts of the body.

It is allowed to mix the Infanricks vaccine with the Hibericks vaccine (Haemophilus influenzae type b vaccine). In this case, the solvent applied to the Hibericks vaccine should be replaced with the Infanriks vaccine.

Analogues of the drug Infanriks

Structural analogs for the active substance:

• Vaccine pertussis-diphtheria-tetanus adsorbed liquid (DTP vaccine);
• Infax Hex;
• Infanricks Penta.

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