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Singulary - instructions for use, analogs, reviews and release forms (5 mg and 10 mg tablets, 4 mg chewable) medicines for the treatment of bronchial asthma and allergic rhinitis in adults, children and in pregnancy

Singulary - instructions for use, analogs, reviews and release forms (5 mg and 10 mg tablets, 4 mg chewable) medicines for the treatment of bronchial asthma and allergic rhinitis in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Singular. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Singular in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs of the Singular if there are existing structural analogues. Use for the treatment of bronchial asthma and allergic rhinitis in adults, children, as well as during pregnancy and lactation.

 

Singular antagonist of leukotriene receptors. The singular selectively inhibits the CysLT1 receptors of cysteinyl leukotrienes (LTC4, LTD4, LTE4) of the respiratory tract epithelium, and also prevents the bronchospasm caused by the inhalation of cysteinyl leukotriene LTD4 in patients with bronchial asthma. A dose of 5 mg is sufficient to stop the bronchospasm induced by LTD4. Application in doses exceeding 10 mg once a day does not improve the effectiveness of the drug.

 

The Singular causes bronchodilation within 2 hours after ingestion and may supplement the bronchodilation caused by beta2-adrenomimetics.

 

Composition

 

Montelukast + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, the Singular is quickly and almost completely absorbed from the digestive tract. Bioavailability with ingestion is 64%. Montelukast is actively metabolized in the liver. When used in therapeutic doses, the concentration of metabolites of montelukast in plasma in an equilibrium state in adults and children is not determined. After oral administration of montelukast, 86% is excreted with feces for 5 days and less than 0.2% with urine, which confirms that montelukast and its metabolites are excreted almost exclusively with bile.

 

When taking montelukast in the morning and evening hours, there is no difference in pharmacokinetics.

 

The pharmacokinetics of montelukast in women and men has a similar character.

 

Since montelukast and its metabolites are not excreted in the urine, the pharmacokinetics of montelukast in patients with renal insufficiency have not been evaluated. Correction of dose in this category of patients is not required.

 

Indications

 

Prophylaxis and long-term treatment of bronchial asthma in adults and children aged 6 years and older, including:

  • prevention of day and night symptoms of the disease;
  • treatment of bronchial asthma in patients with hypersensitivity to acetylsalicylic acid;
  • prevention of bronchospasm caused by physical exertion;
  • relief of daytime and nighttime symptoms of seasonal allergic rhinitis (in adults and children 6 years of age and older) and persistent allergic rhinitis (in adults and children 6 years and older).

 

Forms of release

 

The tablets covered with a cover of 10 mg.

 

Tablets chewing 5 mg and 4 mg.

 

Instructions for use and reception scheme

 

Film-coated tablets

 

The drug is taken orally 1 time per day, regardless of food intake. To treat bronchial asthma, Singular should be taken in the evening.In the treatment of allergic rhinitis, the drug can be taken at any time of the day. With a combined pathology (bronchial asthma and allergic rhinitis), the drug should be taken in the evening.

 

Adults and adolescents aged 15 years and older are prescribed a dose of 10 mg (1 tablet, coated) per day.

 

Tablets, chewing

 

Inside 1 time per day, regardless of food intake.

 

For treatment of bronchial asthma, the Singular preparation should be taken in the evening.

 

In the treatment of allergic rhinitis drug can be taken at any time of the day at the request of the patient.

 

Patients with bronchial asthma and allergic rhinitis should take 1 tablet of Singular once a day in the evening.

 

Children aged 6 to 14 years are prescribed a dose of 5 mg (1 tablet chewing) per day. The choice of dose for this age group is not required.

 

Children aged 2 to 5 years are prescribed a dose of 4 mg (1 tablet chewing) per day.

 

General recommendations

 

The therapeutic effect of the Singular preparation on the indicators reflecting the course of bronchial asthma develops during the first day. The patient should continue to take the Singular as in the period of achieving control over the symptoms of bronchial asthma, and during periods of exacerbation of bronchial asthma.

 

For elderly patients, patients with renal insufficiency, as well as patients with mild or moderate liver function disorders, and also depending on gender, a special dose selection is not required.

 

Purpose of the preparation Singular at the same time as other types of treatment for bronchial asthma

 

The Singular preparation can be added to the treatment of the patient with bronchodilators and inhaled glucocorticosteroids (GCS).

 

Side effect

  • anaphylaxis;
  • angioedema;
  • rash;
  • itching;
  • hives;
  • unusual bright dreams;
  • hallucinations;
  • drowsiness;
  • irritability;
  • Excitement (including aggressive behavior);
  • fatigue;
  • headache;
  • suicidal thoughts and suicidal behavior (suicidal);
  • insomnia;
  • convulsive seizures;
  • nausea, vomiting;
  • diarrhea;
  • stomach ache;
  • arthralgia;
  • Myalgia, including muscle cramps;
  • nodular erythema;
  • tendency to increase bleeding, subcutaneous hemorrhage;
  • palpitation;
  • edema.

 

Contraindications

  • children under 6 years (for coated tablets), up to 2 years (for chewing tablets);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

Singular should be used during pregnancy and lactation only in cases where the expected benefit for the mother exceeds the potential risk to the fetus or the baby.

 

Use in children

 

Contraindicated in the form of chewable tablets for children under 2 years old, for coated tablets - before the age of 6 years.

 

For children aged 2 to 5 years with bronchial asthma and / or allergic rhinitis, the dose is 4 mg (1 chewable tablet) per day.

 

Children aged 6 to 14 years are prescribed a dose of 5 mg (1 chewable tablet) per day. The choice of dose for this age group is not required.

 

Application in elderly patients

 

For elderly patients, no special dose selection is required.

 

special instructions

 

Singular is not recommended for the treatment of acute attacks of bronchial asthma. In the acute course of bronchial asthma, patients should be prescribed medications for the treatment, stopping and preventing the onset of the disease.

 

The dose of concomitantly with the preparation Singular of inhaled glucocorticosteroids can be gradually reduced under the supervision of a doctor. Do not dramatically replace the drug Singular therapy with inhaled or oral GCS.

 

A decrease in the dose of GCS for systemic administration in patients receiving antiasthmatic drugs, including leukotriene receptor antagonists, was rarely accompanied by the appearance of one or more of the following: eosinophilia, hemorrhagic rash, exacerbation of pulmonary symptoms, cardiac complications and / or neuropathy, sometimes diagnosed as a syndrome of Charge-Straus (systemic eosinophilic vasculitis). Although the causal relationship of these adverse events with therapy with leukotriene receptor antagonists has not been established, care should be taken when observing a reduction in the systemic dose of GCS in patients receiving Singular, and appropriate clinical monitoring is performed.

 

Influence on the ability to manage motor vehicles and work with mechanisms

 

Data suggesting that the administration of the drug Singular affects the ability to drive or move vehicles is not detected.

 

Drug Interactions

 

The singular can be prescribed together with other drugs traditionally used for the prevention and long-term treatment of bronchial asthma.Montelukast at the recommended clinical dose had no clinically significant effect on the pharmacokinetics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (ethinyl estradiol / norethindrone 35/1), terfenadine, Digoxin and warfarin.

 

In patients who simultaneously received phenobarbital, the AUC of montelukast decreased by about 40%. Selection of a dose of Singular for this category of patients is not required.

 

If the bronchodilators are ineffective as a monotherapy for bronchial asthma, a singularity can be added to the treatment. When the therapeutic effect (usually after the first dose) is reached, the dose of bronchodilators can be gradually reduced against the background of therapy with the Singular preparation.

 

Treatment with Singular provides an additional therapeutic effect in patients receiving inhaled glucocorticosteroids. At achievement of stabilization of a status of the patient reduction of a dose of GCS is possible. The dose of GCS should be reduced gradually, under the supervision of a doctor. In some patients, the intake of inhaled glucocorticosteroids can be completely abolished. It is not recommended to sharply replace inhaled glucocorticosteroids with Syngular.

 

Analogues of the medicinal product Singular

 

Structural analogs for the active substance:

  • Moncast;
  • Montelukast sodium amorphous;
  • Singlon;
  • Singularus.

Similar medicines:

Other medicines:
Reviews (29):
Guests
Natalia
Hello! The drug singular is very good, my child (2g 3m) takes in a dose of 4 mg, has bronchial asthma, against the background of receiving Singularia, it was possible to cancel Pulmicort. The effect is positive, but there is a question of how to cancel the singular, the child takes for 3 months, k / day. Is it necessary to gradually cancel the drug or can I stop taking it right away? The doctor did not respond to us, the instructions are also not indicated. Thank you!
Administrators
admin
Natalia, about the children I will not say - not my profile. But the Singular in adults when achieving stabilization of the state with bronchial asthma must be taken further, that is, therapy is lifelong. And so any medications with asthma are canceled gradually, that is, they do not immediately stop taking the medication, but only if there are sufficient grounds and mainly as a result of substituting for others - more effective medicines.
Guests
Vera
To the child of 5 years, accepted 3 months, any positive effect, twice there were attacks. Now have appointed for 6 months fluticasone.
Guests
Irina
Hello, tell or say has the right to appoint or nominate the doctor this medicine without the recipe and record in a card having written down it or him on a leaf or sheet and whether it is necessary to apply it in this case since side effects are very frightening.
Administrators
admin
Irina, Many doctors still write appointments on "leaflets", although the instructions to Singular clearly state - It is released by prescription. And even without writing to the card - it's generally beyond the bounds of understanding, some kind of clandestine appointment of a complex drug with side effects and contraindications.
Guests
Galina
Hello, I'm 48 years old. Have diagnosed a bronchial asthma. The doctor prescribed Symbicort 160 mg. 2 times a day and Singular 10 mg. 1 tablet. I read the pimping from Singular, especially from the nervous system and somehow it became scary to take it. Moreover, in the pharmacy, where they give out preferential medicines, they said that such a drug was not prescribed to anyone.Tell me, please, is it really so harmful or are these isolated cases and it is really so rare to appoint? Thanks for the answer.
Administrators
admin
Galina, Normal preparation, especially for complex therapy of bronchial asthma. You need to look at the side to understand what in the body can change when taking this medication, but this is not a 100% guarantee that this pimple will appear exactly at you. In any case - better Singular than hormones in tablets. And why they rarely appoint - so can the antimuscular protocols for the treatment of asthma in our country. So do not worry and be treated, see for your sensations and for the dynamics of the course of the disease.
Guests
Inna
My child has hypertrophy of adenoids, plus permanent rhinitis and rhinopharyngitis (to a child 3 years 6 m.). And even when sleeping (day and night) terrible snoring with a heavy breath. There was a local pediatrician at home, appointed a singular 4 mg for 3 months. On an allergic panel (handed over) it's OK, allergies are not present. Snoring with breathing difficulty from 1 year old. Should we take this medication?
Administrators
admin
Inna, The drug of all available is good, if the doctor has appointed - you can take, the more the problem is. Allergies may not give in the classical sense. For a child, a dosage of 4 mg can be given, starting from 2 years and older.
Guests
Angela
My grandson accepted. We started taking in 2 g 8 months, we drank three months. Prior to taking the Singular, they were ill every two weeks. There was a strong cough. While Singular was not once not been on the sick leave. Today the medicine has been canceled, tk. have already spent three months drinking, we will see what will happen without a singular.
Guests
Julia Semenova
We take a year. How to cancel, we begin to ache until we cancel everything well. This grieves, that is, he does not heal, but simply supports. Child 5.6, diagnosed with asthma a year ago. I do not know if we are now on it for life: (
Visitors
kaktus
Hello. I am 40 years old. Allergic bronchial asthma, lg E (1972) was diagnosed, and a singular 10 mg, nazonex and symbiocortis were prescribed.Yesterday I started taking the singular, spent the whole night asleep, in the afternoon I was lethargic, and by the time I fell asleep again and did not come out of a sleepy state, was it a side effect? And whether it is possible to accept further?
Administrators
admin
kaktus, It looks like a side effect. Moreover, he is stated in the instructions to Singular. I can recommend taking the drug for another 3-4 days, if drowsiness persists and will interfere with work and life, then it is worthwhile to see a doctor who has prescribed this treatment regimen for correction of the treatment regimen and replacement of the drug. It all depends on you, how much this side effect interferes with life. In terms of fear for life and health, from your story, I do not see any danger.
Guests
Olga
Hello. Children 5 and 3 years. Have appointed or nominated a preparation the Singular for three months. Diagnosis of bronchial asthma is not worth it. We suffer from private bronchitis. Analgesies which have revealed an allergy on feather and flour mite handed over. For further treatment, you need to finish testing, but for this you need at least two weeks not to get sick and do not take medication. So far it does not work out.The doctor on the leaflet made the appointment of the preparation Singular. I read the annotation and I have doubts. Whether so this medicine is necessary in the absence of the diagnosis a bronchial asthma.
Administrators
admin
Olga, Here already only the full-time physician can help, to which it is necessary to come with all analyzes and researches, it is better if he will be a narrow specialist - pulmonologist or allergist. The singular is shown not only in bronchial asthma. Your doubts are understandable, but on the description of the situation, to say that the drug is not shown to your children, I can not.
Visitors
nina52
Hello. IgE 1430, presumably food allergy. Allergen is not installed. The bronchospasm begins and begins to choke. But it does not start after eating, but after 3-4 hours. Provokes bronchospasm every time in different ways. I have a cold allergy in winter, photodermatitis in the summer. Since the summer of 2015 pollinosis - rhinitis, polyps in the nose. The pulmonologist is budesonide, fenoterol. The attack was not removed. Lor - tafen, nasal, avamis. And the last appointment - nazoneks and singular 10 mg.After taking the singular, after 2 hours BP 190. In the morning a black chair, severe heartburn (on a diet - porridge on the water), seizures on the lips. I drank 3 days and stopped. The doctor ENT expressed bewilderment, said that it is usually well tolerated in other patients. Still at me podtashnivaet after reception tsitramona (atsetilsalitsilovaja to-that?). But I take it very rarely. On the day of admission, the singular did not take Citramonum.
Guests
Lyudmila
Have diagnosed BA in doubt. Cough was killed, there was not enough air, but played the accordion in the bronchi. Assigned a Singular 10 ml. with Symbicort (inhale) and lordestin (from allergies) and a miracle! All as a hand took off. Oh yes, I forgot Nazonex (drops in the nose). I breathe clean, forgot about the cough, I feel just fine! No pobochki there. The only sleep soundly, a little more than before.
Guests
Alexandra
Hello. To the child of 7 years. Suspicion of bronchial asthma, t. often has obstructive bronchitis. The doctor appointed the Singular to take 3 months. Will this drug cause addiction and the child will depend on it?
Administrators
admin
Alexandra, Singular is not addictive. Also, there were no symptoms of withdrawal, that is, you can stop taking the medicine at any time. Although the course of 3 months for a child with suspected bronchial asthma seems to me a long one, but there is little input data on the question, so decide with the attending physician of the baby.
Guests
Tatyana
Hello. Singular is a hormonal drug? Can I take it with hormonal failures like a woman? The child is 18 years old.
Administrators
admin
Tatyana, Singular does not contain hormones and hormone-like substances in its composition. Indications are exhaustively listed in the instructions and others are not available at the moment.
Administrators
admin
Site visitor question masha.shepeleva moved to the required section:
Hello. My child is 9 years old, 8 of them we have almost every month bronchitis with spasms. We do inhalations with ventilin. The doctor advises a singular. It's scary to start. I can not find it is addictive and should it be taken with frequent bronchitis?
masha.shepeleva, Solves the doctor anyway.But 8 years each month to give bronchitis, requiring the use of bronchodilators, it's too ... So, to bronchial asthma, you can spare your child. I advise you to make the function of external respiration, pass tests on allergens and panel, and then seek advice from an allergist, pulmonologist, perhaps an immunologist with a ready immunogram it would be nice to pass.
Visitors
olga.koval
Good afternoon. All life long frequent chases with the subsequent long curing of cough (to me 54 years) pursue. The last time in the summer managed to quickly cope with a cold, but the cough remained - a periodic dry cough. The chest radiograph is clean, the breathing is hard at the top. The doctor suggested the initial stage of bronchial asthma (in the presence of many years of pollinosis, allergy to wormwood, etc.), the singular was prescribed. In the insert-instructions to the medicine, she discovered "infectious-viral diseases" in side effects in the respiratory system. What does it mean? The drug weakens the resistance? And as to me to act in a concrete case - now just I am on a stage olechivanija next cold, cough importunate, attacks,phlegm is almost never gone. Is it possible to start treatment with a singular now?
Administrators
admin
olga.koval, You can start treatment as recommended by your doctor. A side effect is a probability that was once recorded, but occurs in a small number of patients taking Singular. Especially such a side effect as the risk of developing infectious diseases, against the background of taking this medication.
Guests
Gohar
To the child of 10 years, the doctor has appointed or nominated a singularity of 10 mg. I gave 10 days, but the child has a dyskinesia - diarrhea. And he became aggressive and irritated.
Guests
Mary Novgorod
Good afternoon. At the child (6) allergic rhinitis and predisposition to a bronchial asthma (since there is a cough a dry rare). According to the analysis, a minimal allergy to pollen and dust mites. The allergist has appointed or nominated Singuljar 5 mg - have spent on drink it or him 4 months, tussis only now has passed or has taken place also snot too.
Guests
Love
Everyone writes about the appointment of Singular in AD, I was prescribed by an ENT doctor with a vasomotor rhinitis. I have been suffering since 1997.(me 64g.), has worsened to such an extent that it stops breathing, if you lie down even in the daytime. Together with Singuljarom are appointed and sprays-complex for 3 months.
Guests
Tatyana
The instructions say that the drug can be used in children from the age of 6, and they are prescribed from 2 years.
Administrators
admin
TatyanaAll correctly appointed. These are Singular chewable tablets in a dosage of 4 mg, they can be prescribed to children from 2 years of age. I painted it in more detail in the instructions, but earlier, apparently, it was not clear.

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