Lidase - instructions for use, analogs, reviews and release forms (injections in ampoules for injections and local electrophoresis 64 UE in solution) drugs for the treatment of scars and contractures in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Lidase. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Lidaz in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lidase in the presence of existing structural analogues. Use for the treatment of scarring and contracture of joints in adults, children, as well as during pregnancy and lactation.

Lidase - an enzyme preparation isolated from testes of cattle. Cleaves the major component of the connective tissue interstitial substance - hyaluronic acid (mucopolysaccharide, which consists of acetylglucosamine and glucuronic acid, a cementing substance of connective tissue), reduces its viscosity, increases vascular permeability and the fabric, facilitates the movement of fluids in the interstices spaces; reduces puffiness of the tissue, softens and flattens scars, increases the amount of movement in the joints, reduces contractures and prevents their formation. Hyaluronidase causes the decomposition of hyaluronic acid to Glucosamine and glucuronic acid, and thereby reduces its viscosity. Duration of action with / to the introduction - up to 48 h.

Composition

Hyaluronidase + auxiliary substances.

Indications

• burn, traumatic, postoperative scars;
• long-term healing ulcers (including radiation);
• Dupuytren's contracture;
• stiffness of the joints;
• contracture of joints (after inflammation, trauma);
• osteoarthritis;
• ankylosing spondylitis;
• severe diseases of lumbar discs;
• chronic tendovaginitis;
• scleroderma (skin manifestations);
• hematoma of soft tissues of surface localization;
• preparation for skin and plastic surgery for scarring;
• myocardial infarction;
• hydrocephalus;
• tuberculosis of the lungs (complicated by nonspecific lesions of the bronchi);
• inflammatory processes in the upper respiratory tract and bronchi with obstruction;
• complex therapy of allergic rhinitis, rheumatoid arthritis, arachnoiditis;
• traumatic lesions of the nerve plexus and peripheral nerves (plexitis, neuritis);
• to improve the absorption of drugs administered subcutaneously and intramuscularly;
• hyphema;
• hemophthalmus;
• retinopathy of various etiologies.

Forms of release

Liofilizate for the preparation of solution for injection and topical application (injections in ampoules for injections) 64 UE.

Other forms, such as suppositories, ointment, tablets or drops do not exist.

Instructions for use and how to use them

For scar lesions subcutaneously (under scar tissue) or intramuscularly (near the lesion), 64 UU (1 ml) are administered daily or every other day (10-20 injections in total).

When traumatic lesions of the nerve plexus and peripheral nerves are injected sc, into the region of the affected nerve (64 UE in the procaine solution) every other day; on the course - 12-15 injections. The course of treatment, if necessary, is repeated.

In ophthalmology: subconjunctival - 0.3 ml, parabulbar - 0.5 ml, and also by electrophoresis.

Patients with pulmonary tuberculosis with a productive nature of inflammation are prescribed in complex therapy to increase the concentration of antibacterial drugs in the lesions in the form of injections and / or inhalations. Inhalations are performed daily 1 time, using 5 ml of solution (320 UE). The course of treatment consists of 20-25 inhalations. If necessary, repeat courses with intervals of 1.5-2 months.

Outer, in the form of dressings, impregnated with a solution of the drug. To prepare the solution, every 64 UE is dissolved in 10 ml of a sterile 0.9% solution of sodium chloride or boiled water at room temperature. This solution is moistened with a sterile dressing, folded in 4-5 layers, applied to the affected area, covered with wax paper and fixed with a soft bandage. The dose depends on the area of ​​the lesion (20-60 IU / cm2), on the average - 300 IU per bandage. The dressing is applied daily for 15-18 hours for 15-60 days. With prolonged use every 2 weeks make a break for 3-4 days.

When applied by electrophoresis or phonophoresis, 300 IU is dissolved in 60 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid are added and injected from the anode onto the affected area for 20-30 minutes. The course of treatment - 15-20 sessions.Application dosage can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

Side effect

• allergic reactions;
• locally irritating effect.

Contraindications

• hypersensitivity;
• acute infectious and inflammatory diseases;
• recent hemorrhages;
• for inhalation: pulmonary tuberculosis with severe respiratory insufficiency; pulmonary hemorrhage, hemoptysis; acute intercurrent diseases; malignant neoplasms;
• fresh vitreous hemorrhage;
• concomitant reception of estrogens.

Application in pregnancy and lactation

Caution is prescribed during pregnancy during lactation.

special instructions

The solution should not be administered through a catheter into which solutions containing cations were previously administered.

Solutions for injection are prepared on a 0.9% solution of sodium chloride or 0.5% solution of procaine, for inhalations - 0.9% solution of sodium chloride, for electrophoresis - on distilled water.

Before starting treatment, it is advisable to perform a test with intradermal administration of 20 μl of hyaluronidase.

Do not enter into areas of infectious inflammation and tumors.

Drug Interactions

Improves the absorption of drugs injected with or into / m, enhances the effect of local anesthetics.

Analogues of Lidase drug

Structural analogs for the active substance:

• Lidase-M;
• RONIDASE.

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