Trigan - instructions for use, analogs, reviews and release forms (tablets D, injections in ampoules for injections) of a drug for the treatment of spasm and colic in adults, children and pregnancy
In this article, you can read the instructions for using the drug Trigan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Trigan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Trigan in the presence of existing structural analogues. Use to treat spasm and colic in adults, children, as well as during pregnancy and lactation.
Trigan - has an antispasmodic effect, causes relaxation of smooth muscles.
Dicycovverin hydrochloride (active ingredient Trigan) tertiary amine, which has a relatively weak indiscriminate m-holinoblokiruyuschim and direct myotropic antispasmodic effect on the smooth muscles of internal organs. In therapeutic doses, it causes effective relaxation of smooth muscles, which is not accompanied by side effects characteristic of atropine.
Included in the drug Trigan D Paracetamol has analgesic, antipyretic and insignificant anti-inflammatory effect. The mechanism of action is associated with moderate inhibition of cyclooxygenase-1 and, to a lesser extent, cyclooxygenase-2 in peripheral tissues and the central nervous system, resulting in inhibition of prostaglandin biosynthesis of pain sensitization modulators, thermoregulation and inflammation.
The combined action of the two components of Trigan D provides relaxation of the spasms of the smooth muscles of the internal organs and the relaxation of pain.
Composition
Dicycloverine hydrochloride + excipients (Trigan).
Paracetamol + Dicycloverine hydrochloride + excipients (Trigan D).
Pharmacokinetics
The drug is well absorbed into the digestive tract. About 80% of the drug is excreted in the urine and in small amounts with feces.
Indications
- spasm of smooth muscles of internal organs;
- intestinal, hepatic and renal colic;
- algodismenorea;
- headache, dental, migraine pain;
- neuralgia;
- myalgia;
- Infectious-inflammatory diseases accompanied by fever.
Forms of release
Solution for intramuscular injection (injections in ampoules for injection).
Tablets (Trigan D).
Instructions for use and dosing regimen
Pills
It is administered to adults and children over 15 years of age for 1 tablet 2-3 times a day. The maximum single dose for adults is 2 tablets, daily 4 tablets. Duration of admission without consulting a doctor is no more than 5 days when prescribed as an anesthetic and 3 days - as an antipyretic. When the drug is used for a long time, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver.
Do not exceed the daily dose; Its increase or longer treatment is possible only under the supervision of a physician, since An overdose of the drug may cause hepatic insufficiency.
Ampoules
Enter intramuscularly (NOT for intravenous administration), a single dose of 20 mg. If repeated administration is necessary, the interval between injections should be 4-6 hours.
Side effect
- dry mouth;
- loss of taste;
- decreased appetite;
- pain in epigastrium;
- constipation;
- skin rash;
- itching;
- hives;
- angioedema;
- multiforme exudative erythema (including Stevens-Johnson syndrome);
- toxic epidermal necrolysis (Lyell's syndrome);
- drowsiness;
- dizziness;
- psychomotor agitation;
- violation of orientation;
- hypoglycemia, up to hypoglycemic coma;
- anemia;
- retention of urine;
- interstitial nephritis;
- papillary necrosis;
- blurred vision;
- increased intraocular pressure;
- decreased potency.
Contraindications
- increased sensitivity to paracetamol and dicycovinone;
- obstructive bowel disease;
- peptic ulcer of stomach and duodenum (exacerbation phase);
- reflux esophagitis;
- hypovolemic shock;
- myasthenia gravis;
- pregnancy;
- lactation period;
- children's age (up to 15 years).
Application in pregnancy and lactation
The drug is contraindicated in pregnancy and lactation.
special instructions
With caution and under the supervision of a doctor, the drug should be administered to patients with impaired liver or kidney function, along with other anti-inflammatory and analgesic agents, as well as with anticoagulants and drugs affecting the central nervous system. When taking metoclopramide, domperidone, or colestyramine, it is also necessary to consult a doctor.
Paracetamol distorts the results of laboratory studies in quantifying the uric acid and glucose levels in the plasma.
To avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, and should also be taken to persons prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.
During long-term treatment, monitoring of the peripheral blood pattern and the functional state of the liver is necessary.
Impact on the ability to drive vehicles and manage mechanisms
When using the drug should refrain from potentially dangerous activities that require increased concentration and speed of psychomotor reactions (vehicle management, etc.)
Drug Interactions
The action of dicyclosterin enhances amantadine, antiarrhythmic drugs of the 1st class, antipsychotic drugs, benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetic drugs, tricyclic antidepressants.
Dicycloverin increases the concentration of dioxin in the blood (due to a slowdown in gastric emptying).
Stimulators of microsomal oxidation in the liver (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which allows the development of severe intoxications with small overdoses of paracetamol. Adrenostimulators, as well as other drugs with anticholinergic action, increase the risk of side effects. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.
Reduces the effectiveness of uricosiric drugs.
Paracetamol improves the effectiveness of indirect anticoagulants.
Analogues of the drug Trigan
Trigan does not have structural analogs for the active substance.
Analogues on the therapeutic effect (antispasmodics):
- Avisan;
- Altalex;
- Bendazole;
- Benzyclan fumarate;
- Vero-Drotaverine;
- Galidor;
- Dibazol;
- Dicetel;
- Driptan;
- Droverin;
- Drotaverine;
- Drotaverin forte;
- Duspatalin;
- Kellin;
- Librax;
- Mebeverine hydrochloride;
- Niaspam;
- Nikoshpan;
- But-shpa;
- But-shpa fort;
- Novitropane;
- Oxybutine;
- Papaverine;
- Plantex;
- Platyphylline;
- Spazmoveralgin Neo;
- Spazmol;
- Spasmodic;
- Spasmonet;
- Spasmonet forte;
- Spasmocystenal;
- Cosporeine;
- Spacock;
- Sparex;
- Cystenal;
- Cystrin;
- Enablex.
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