Groprinsin - instructions for use, reviews, analogs and forms of release (tablets 500 mg) of a medicament for the treatment of herpes, cytomegalovirus and HPV in adults, children and pregnancy. Interaction with alcohol
In this article, you can read the instructions for using the drug Groprinosin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Groprinosin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Groprinosina in the presence of existing structural analogs. Use for the treatment of herpes, cytomegalovirus and HPV in adults, children, as well as during pregnancy and lactation.Interaction of the drug with alcohol.
Groprinosin - immunostimulating drug with antiviral effect. It is a complex containing inosine and N, N-dimethylamino-2-propanol in a molar ratio of 1: 3.
The effectiveness of the complex is determined by the presence of inosine, the second component increases its availability for lymphocytes. Groprinsin stimulates biochemical processes in macrophages, increases the production of interleukins. Enhances the synthesis of antibodies, enhances the proliferation of T-lymphocytes, T-helpers, natural killer cells.
Stimulates the chemotactic and phagocytic activity of monocytes, macrophages and polymorphonuclear cells. Groprinosin suppresses the replication of DNA and RNA viruses by binding to the cell's ribosome and changing its stereochemical structure.
The drug is well tolerated, because has a low toxicity. It can be prescribed to patients in old age with angina pectoris or chronic circulatory failure.
With the timely use of the drug, the incidence of viral infections decreases, the duration and severity of the disease decreases.
The use of the drug is indicated for patients with insufficient immune protection.
When Gropronosin is prescribed as an auxiliary drug for infection of the mucous membranes and skin caused by the Herpes simplex virus, faster healing of the affected surface occurs than with conventional treatment. More rarely new vesicles, swelling, erosion and relapse of the disease.
Composition
Inosine pranobeks + auxiliary substances.
Pharmacokinetics
After ingestion, the drug is well absorbed from the digestive tract and is characterized by good bioavailability. Rapidly metabolized. Inosine is metabolized by a cycle typical of purine nucleotides, with the formation of uric acid, a level of which in the blood serum can sometimes increase. As a result, it is possible to form crystals of uric acid in the urinary tract. No cumulation of the drug in the body. It is excreted by the kidneys.
Indications
- immunodeficiency states caused by viral infections in patients with normal and weakened immune system, incl. diseases caused by Herpes simplex virus types 1 and 2 (including genital herpes and herpes of other localization), chicken pox, human papillomavirus;
- subacute sclerosing panencephalitis.
Forms of release
Tablets 500 mg.
Instructions for use and dosage
The drug is taken orally after meals, at regular intervals (8 or 6 hours) 3-4 times a day.
Adults prescribe a dose of 3-4 g (6 to 8 tablets) per day, divided into 3-4 admission.
Children aged 3 to 12 years are prescribed at a dose of 50 mg / kg per day, divided into 3-4 doses.
In adults and children with severe infectious diseases, the dose can be increased individually under the supervision of a doctor to 100 mg / kg per day in 4-6 receptions.
The drug is usually used for 5 days, sometimes longer, depending on the course of the disease. After an 8-day break, the course of treatment can be repeated.
Tablets are taken with a small amount of water.
Side effect
- decreased appetite;
- nausea, vomiting;
- diarrhea;
- a slight increase in the concentration of uric acid in the blood and urine;
- allergic reactions.
Contraindications
- gout;
- urolithiasis disease;
- arrhythmia;
- children under 3 years;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breastfeeding), t. its safety in this category of patients is not established.
Use in children
Contraindicated in children under 3 years.
special instructions
Do not prescribe the drug to patients with hyperuricemia in connection with the possibility of increasing the content of uric acid in the serum and urine. If you need to use the drug in this category of patients should regularly monitor the content of uric acid in the body. Patients with a significant increase in the content of uric acid are encouraged to simultaneously take drugs that lower its level.
Patients with acute hepatic impairment require a reduction in the dose of the drug. the process of metabolism of inosine pranobeks occurs in the liver.
In elderly patients, dose adjustment is not required.
Increases the toxic effect of alcohol on the liver. Use with alcoholic beverages is prohibited.
Impact on the ability to drive vehicles and manage mechanisms
For patients taking Groprinosin, there are no special contraindications regarding the driving of vehicles and the maintenance of moving mechanisms.
Drug Interactions
Immunosuppressants reduce the effectiveness of the drug.
Analogues of the drug Groprinosin
Structural analogs for the active substance:
- Isoprinosine.
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