En DE FR ES PL
Kolme - instructions for use, analogs, reviews and release forms (drops for oral administration in ampoules) of a drug for the treatment of chronic alcoholism in adults, children and in pregnancy

Kolme - instructions for use, analogs, reviews and release forms (drops for oral administration in ampoules) of a drug for the treatment of chronic alcoholism in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Colme. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Colm in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Coleme in the presence of existing structural analogues. Use for the treatment of chronic alcoholism in adults, children, as well as during pregnancy and lactation.

 

Colme - a drug for the treatment of alcohol dependence.The mechanism of action is due to the blockade of aldehyde dehydrogenase involved in the metabolism of ethanol. The blockade of this enzyme leads to an increase in the concentration of the metabolite of ethanol - acetaldehyde, which causes negative sensations (including flushing to the face, nausea, tachycardia, dyspnea), which make it extremely unpleasant to drink alcohol after taking the drug and lead to a conditioned reflex aversion to taste and smell of alcoholic beverages.

 

The sensitization effect of Colem on alcohol manifests itself earlier (about 45-60 minutes) and lasts shorter (about 12 hours) than the action of disulfiram. In contrast to Disulfiram cyanamide (the active substance of the drug Colme) does not have an antihypertensive effect and has a lower intrinsic toxicity. In addition, cyanamide has a greater specificity of action: unlike disulfiram, it blocks only aldehyde dehydrogenase and does not affect other enzymes, particularly dopamine-beta hydroxylase.

 

Composition

 

Cyanamide + auxiliary substances.

 

Indications

  • treatment of patients with chronic alcoholism;
  • prevention of recurrences of chronic alcoholism after treatment.

 

Forms of release

 

Drops for oral administration in ampoules.

 

Forms in the form of tablets or capsules do not exist at the time of the drug description in the directory.

 

Instructions for use and reception scheme

 

The drug is prescribed after a thorough examination of the patient. The patient should be warned about possible complications and consequences of the therapy.

 

The drug is taken internally at 36-75 mg (12-25 drops 2 times a day with an interval between doses of 12 hours) according to the individual scheme.

 

For dosing, open the ampoule with the solution of the drug and pour the contents of the ampoule into the vial enclosed in the package. The bottle should be put on a dropper. During storage, the bottle must be closed tightly.

 

Side effect

  • feeling tired;
  • drowsiness;
  • skin rash;
  • noise in ears.

 

The drug is usually well tolerated if the patient does not consume alcohol.

 

Reaction to alcohol: with simultaneous reception of alcohol possible pronounced hyperemia of the skin, a sensation of pulsation in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, increased sweating, and chest pain. In the most severe cases: vomiting, lowering blood pressure, respiratory depression, a collapoid state. The manifestations and the degree of their severity depend on the dose of the drug and the amount of alcohol taken.In severe cases, symptomatic therapy is performed, aimed at maintaining the functions of the respiratory and cardiovascular systems, intravenous administration of antihistamines.

 

Contraindications

  • severe diseases of the cardiovascular system;
  • diseases of the respiratory system;
  • kidney diseases accompanied by impaired function;
  • severe liver disease;
  • pregnancy;
  • lactation (breastfeeding);
  • hypersensitivity to the drug.

 

Application in pregnancy and lactation

 

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

 

special instructions

 

The drug should be used only under the supervision of a doctor and with the patient's consent to the therapy. It should be borne in mind the possibility of a reaction to ethanol contained in certain medicines and food products.

 

Treatment with Colme should be started only after 12 hours after the last use of alcohol.

 

With caution apply Colme in those cases when the patient's reaction to simultaneous use of alcohol can lead to a risk to the patient's health: in hyperthyroidism, diabetes, epilepsy, diseases of the cardiovascular system, kidney diseases.

 

With long-term administration of the drug, it is recommended to monitor the function of the thyroid gland at least once every 6 months.

 

Drug Interactions

 

Simultaneous use of Colem with metronidazole, isoniazid, phenytoin and other aldehyde dehydrogenase inhibitors may increase the response to alcohol consumption (such combinations should be avoided).

 

Between the use of disulfiram and the appointment of Colem should be a break of at least 10 days.

 

Colm is not compatible with aldehyde group preparations (paraldehyde and chloral products).

 

Analogues of the drug Colme

 

Structural analogs for the active substance:

  • Mizo.

 

Analogues on the pharmacological group (funds used for alcoholism and drug addiction):

  • Akofil;
  • Antabus;
  • Anti-E;
  • Anti-wolf;
  • Biotredin;
  • Butyroxane;
  • Vivitrol;
  • Disulfiram;
  • Lidevin;
  • Limonar;
  • Mexidol;
  • Mexipridol;
  • Mexiprim;
  • Mexicin;
  • Metadoxyl;
  • Metostabil;
  • Naltrexone FV;
  • Nicomel;
  • Orvagil;
  • Peptide delta sleep;
  • Proproten-100;
  • Teturam;
  • Cytisine;
  • Champix;
  • Esperal;
  • Ethyl methylhydroxypyridine succinate.

Similar medicines:

Other medicines:

Reviews (24):
Guests
Glory
The doctor first prescribed the colme, but something did not go very well for me, then the Esperl wanted to sew, I refused. We stopped at the leader. I was amazed that there was no such severity and headache after him. It helped, I have not been drinking for two years, which I wish to all who have such a problem.
Guests
Sveta
And my martyr only with the help of the kolma and stopped his beer binges, all could not believe that the beer is also addicted as to any alcohol there.
Visitors
larkinalm
After the appointment of the doctor, my husband has been drinking Kolma for 3 months. The narcologist is visited once a month to adjust the treatment. While the mood is fine, it does not pull you into drinking.
I expect that there will be somewhere in half a year, we have time between bouts about 6 months.
Guests
Marina Sh.
The drug has helped, but not as long as indicated in the annotation. Those. he treated her husband without his knowledge 3 months, then stopped giving him drops, 3 months later, drinking again. Reaction to alcohol as indicated in the instructions: shortness of breath.tachycardia, redness of the skin ... And his disappointment is that you can not drink! I will continue to give, if possible. It still helps.
Guests
Irina
Kolme is not on sale, what will not happen again?
Administrators
admin
Irina, I have an assumption that the loss of the drug Colme from pharmacies has economic reasons. Since this is a brand-name drug of European manufacture, due to the devaluation of the ruble, it became more expensive at least twice and stopped selling in economic quantities sufficient for economic benefit, so it was simply turned off to Russia. Perhaps there are other reasons, for example, lobbying domestic producers of indirect analogs (that is, analogs for a group of drugs to combat alcohol dependence, but not according to the active substance). Everything is possible with us.
Guests
Olga
Analog, except in drops?
Administrators
admin
Olga, On the territory of Russia, a dosage form in the form of drops of the drug Colme has been registered, others do not.
Administrators
admin
Distributors of the drug Colme, I warn you that the Directory is not a place for illegal sale of drugs. Medicines should be sold in official pharmacies, and not with the hands. At us in the country and so falsification suffices also I it will not aggravate advertising of illegal dealers. More can not try.
Guests
Victor Avdeev
Colme disappeared from pharmacies because his youngsters started to forge and sell with the same name. In no other country can this be, only with us. By the way, they again try to stretch a fake on the Russian market called Mizo.
Guests
Timikuli
The drops of colum helped to get rid of alcohol addiction to my close relative. Before buying and using drops, we consulted their account with the doctor. Since the drops do not have taste and smell, we dripped them right into the food, secretly from a relative, because, as usual, alcoholics do not consider themselves such. I recommend everyone who has a problem with alcohol in the family.
Guests
Alyona DASS
Drops are good, they help to instill aversion to alcohol, with them not that to drink, with them the smell of alcohol will not be tolerated.
Guests
Sonja
Where can I find the kolma?
Administrators
admin
SonjaLegally, in Russia, this drug is not currently sold.
Guests
Xenia 663
My husband was drinking ... for how many years, I did not know what to do, my acquaintances had already turned away from him, and from me. I gave and give this drug - of course with the knowledge of my husband, I went to it after the conversation, I was ready and set myself, because I saw that this is also very oppressive. Alcoholism is necessary and can be treated.
Guests
Cyril2525
A couple of months ago I started using colma, craving for alcohol has decreased significantly and I have not had a drink for a month, but I feel normal psychologically.
Guests
Andrei
Once, after a series of failures in the business sphere, he began to drink, and incredibly hard.Colm's drops advised a friend, they helped get rid of this addiction. Took only three days, and the desire to drink disappeared. Alcohol was not used for treatment, so the treatment was very gentle. I know those who did not help the drops at all. So everything is individual. Plus, it's very important to be able to cope with the dependence and understanding that it is.
Guests
Ivano
Drops of kolma are absolutely safe for human health, do not cause side effects and allergic manifestations, unless of course take them according to the instructions. After a few applications, the result is noticeable.
Guests
Olga
Good afternoon. My husband began to drink from the new year and all January almost drank, agreed to droppers, after he had been swallowed, I deceived him, said that she had coded, and herself became quietly in the food once a day for 12 drops to give Kolme. The vial is enough for a month. Were not even touched a drink, said he did not pull at all. Previously, after a dropper, I could drink the next day.
Guests
Elena .
Information, for those women whose husbands are drinking. The pharmacy advised the Mizo, gave 3,000 rubles, the effect was zero, the drink became even greater, the aggressive became straight. Do not spend money on such drugs.
Guests
Lily.
On the advice of the pharmacy also bought to his son to cure, so as not to drink booze, and now since February, he drinks and drops these, and drunk every evening. I'm all waiting for a miracle, but it probably will not happen. The next placebo.
Guests
Irina Olegovna
My Olezhka started drinking after the army. I do not know what they are doing or what they are teaching, but the guy who left the army from the third year of the institute, the guy who never touched a glass, started drinking as if in a breakout. She persuaded, begged, swore, cried, beat him. I went to the center of anonymous alcoholics there and advised a modern Italian drug - a drop of sobriety mizo. Together with Olezhka we decided to be treated. For a month not to know the guy. He even started to go to the sports ground and said that he would return to the institute. I was afraid, I asked. He told me that he was sick at the word vodka. Please spread my opinion. I want my moms to know that I can help the child.
Guests
Nicholas.
The narcologist, who is on the account, made it clear that the mizo drops with a questionable result and a bunch of side effects.
Guests
Nikolai
Nikolai and the rest, Another third-party adverts in the Colma card and I'll start applying measures to guilty comrades and customized reviews, before that I only deleted your ads.
admin

Rules for publishing reviews and visitor questions