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LORISTA - instructions for use, reviews, analogs and formulations (tablets 12.5 mg, 25 mg, 50 mg and 100 mg, H and ND - plus with a diuretic hydrochlorothiazide) drugs for the treatment of hypertension in adults, children and pregnancy

LORISTA - instructions for use, reviews, analogs and formulations (tablets 12.5 mg, 25 mg, 50 mg and 100 mg, H and ND - plus with a diuretic hydrochlorothiazide) drugs for the treatment of hypertension in adults, children and pregnancy

In this article, you can read the instructions for using the drug Lorista. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on using Lorist in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Loriste in the presence of existing structural analogues. Use to treat high blood pressure in adults, children, as well as during pregnancy and lactation.

 

Lorista - Selective antagonist of angiotensin 2 receptors of type AT1 of non-protein nature.

 

Lozartan (active substance of Lorist's preparation) and its biologically active carboxylic metabolite (EXP-3174) block all physiologically significant effects of angiotensin 2 on AT1-receptors regardless of the way of its synthesis: leads to an increase in renin plasma activity, reduces the concentration of aldosterone in the blood plasma.

 

Losartan indirectly causes the activation of AT2 receptors by increasing the level of angiotensin 2. Losartan does not inhibit the activity of kinase 2, an enzyme that participates in the metabolism of bradykinin.

 

Reduces OPSS, pressure in a small circle of blood circulation; reduces afterload, has a diuretic effect.

 

It prevents the development of myocardial hypertrophy, increases tolerance to physical activity in patients with chronic heart failure.

 

Reception LORISTA once a day leads to a statistically significant reduction in systolic and diastolic blood pressure. During the day, losartan evenly Controls BP, while the antihypertensive effect corresponds to a natural circadian rhythm.Decrease in blood pressure at the end of the dose of the drug was approximately 70-80% of the effect at the peak of the drug, 5-6 hours after admission. The withdrawal syndrome is not observed; also losartan does not have a clinically significant effect on heart rate.

 

Losartan is effective in men and women, as well as in the elderly (≥65 years) and younger patients (≤ 65 years).

 

Hydrochlorothiazide is a thiazide diuretic whose diuretic effect is associated with a disruption of the reabsorption of sodium, chlorine, potassium, magnesium, water in the distal nephron; delays the excretion of calcium ions, uric acid. Has antihypertensive properties; the hypotensive effect develops due to the expansion of arterioles. Virtually no effect on normal blood pressure. Diuretic effect occurs in 1-2 hours, reaches a maximum after 4 hours and lasts 6-12 hours.

 

Antihypertensive effect occurs in 3-4 days, but it may take 3-4 weeks to achieve the optimal therapeutic effect.

 

Composition

 

Losartan potassium + auxiliary substances.

 

Losartan potassium + Hydrochlorothiazide + auxiliary substances (Lorista N and ND).

 

Pharmacokinetics

 

The pharmacokinetics of losartan and hydrochlorothiazide with simultaneous application does not differ from that in their separate application.

 

Losartan

 

Well absorbed from the digestive tract. The intake of the drug with food does not have a clinically significant effect on its serum concentrations. Virtually does not penetrate the blood-brain barrier (GEB). About 58% of the drug is excreted with bile, 35% - with urine.

 

Hydrochlorothiazide

 

After oral intake of hydrochlorothiazide is 60-80%. Hydrochlorothiazide is not metabolized and is rapidly excreted by the kidneys.

 

Indications

  • arterial hypertension;
  • reduction in the risk of stroke in patients with hypertension and left ventricular hypertrophy;
  • chronic heart failure (as part of combination therapy, with intolerance or ineffective therapy with ACE inhibitors);
  • protection of kidney function in patients with type 2 diabetes mellitus with proteinuria in order to reduce proteinuria, reduce the progression of kidney damage, reduce the risk of developing the terminal stage (preventing the need for dialysis, the probability of increasing serum creatinine levels) or the onset of death.

 

Forms of release

 

Tablets 12.5 mg, 25 mg, 50 mg and 100 mg.

 

Lorist H (additionally contains 12.5 mg of hydrochlorothiazide).

 

Lorista ND (additionally contains 25 mg of hydrochlorothiazide).

 

Instructions for use and dosage

 

The drug is taken orally, regardless of food intake, the frequency of intake is 1 time per day.

 

With arterial hypertension, the average daily dose is 50 mg. The maximum antihypertensive effect is achieved within 3-6 weeks of therapy. It is possible to achieve a more pronounced effect by increasing the dose of the drug to 100 mg per day in two divided doses or in one dose.

 

Against the background of taking diuretics in high doses, it is recommended to start Loristoy's therapy with 25 mg per day in one session.

 

Elderly patients, patients with impaired renal function (including patients on hemodialysis) do not need correction of the initial dose of the drug.

 

Patients with impaired liver function should be given a lower dose.

 

In chronic heart failure, the initial dose of the drug is 12.5 mg per day in one session. In order to achieve a normal maintenance dose of 50 mg per day, the dose should be increased gradually, at intervals of 1 week (eg, 12.5 mg, 25 mg, 50 mg per day). Lorist is usually prescribed in combination with diuretics and cardiac glycosides.

 

To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, the standard initial dose is 50 mg inday. In the future, hydrochlorothiazide can be added at low doses and / or Lorista dose increased to 100 mg per day.

 

To protect the kidneys in patients with type 2 diabetes mellitus with proteinuria, the standard initial dose of Lorista is 50 mg per day. The dose of the drug can be increased to 100 mg per day, taking into account the decrease in blood pressure.

 

By-products

  • dizziness;
  • asthenia;
  • headache;
  • fatigue;
  • insomnia;
  • anxiety;
  • sleep disturbance;
  • drowsiness;
  • memory disorders;
  • peripheral neuropathy;
  • paresthesia;
  • hyposthenia;
  • migraine;
  • tremor;
  • depression;
  • orthostatic hypotension (dose-dependent);
  • palpitation;
  • tachycardia;
  • bradycardia;
  • arrhythmias;
  • angina pectoris;
  • nasal congestion;
  • cough;
  • bronchitis;
  • edema of the nasal mucosa;
  • nausea, vomiting;
  • diarrhea;
  • abdominal pain;
  • anorexia;
  • dry mouth;
  • toothache;
  • flatulence;
  • constipation;
  • imperative urge to urinate;
  • impaired renal function;
  • decreased libido;
  • impotence;
  • convulsions;
  • pain in the back, chest, legs;
  • tinnitus;
  • a taste disorder;
  • visual impairment;
  • conjunctivitis;
  • anemia;
  • purple Shenlaine-Henoch;
  • dry skin;
  • increased sweating;
  • alopecia;
  • gout;
  • hives;
  • skin rash;
  • itching;
  • angioedema (including swelling of the larynx and tongue, causing airway obstruction and / or swelling of the face, lips, pharynx).

 

Contraindications

  • arterial hypotension;
  • hyperkalemia;
  • dehydration;
  • lactose intolerance;
  • galactosemia or syndrome of impaired glucose / galactose absorption;
  • pregnancy;
  • lactation period;
  • age under 18 years (efficacy and safety in children not established);
  • increased sensitivity to losartan and / or other components of the drug.

 

Application in pregnancy and lactation

 

There are no data on the use of Lorist in pregnancy. Renal perfusion of the fetus, which depends on the development of the renin-angiotensin system, begins to function in the third trimester of pregnancy. The risk to the fetus increases with the use of losartan in the 2nd and 3rd trimesters. When establishing pregnancy, losartan should be discontinued immediately.

 

There is no data on the isolation of losartan with breast milk. Therefore, the question of stopping breastfeeding or abolishing losartan therapy should be addressed, taking into account its importance for the mother.

 

special instructions

 

Patients with a reduced volume of circulating blood (for example, with therapy with large doses of diuretics) may develop symptomatic arterial hypotension. Before starting losartan, it is necessary to eliminate the existing disorders, or start therapy with small doses.

 

In patients with mild and moderate cirrhosis of the liver, the concentration of losartan and its active metabolite in the blood plasma after ingestion is higher than in healthy ones. Therefore, patients with a history of liver disease are recommended therapy in lower doses.

 

In patients with impaired renal function, with or without diabetes mellitus, hyperkalemia often develops, which should be borne in mind, but only in rare cases does it stop treatment. During the treatment period, the concentration of potassium in the blood should be monitored regularly, especially in elderly patients, with renal dysfunction.

 

Drugs acting on the renin-angiotensin system can increase urea and creatinine in the serum in patients with bilateral renal artery stenosis or unilateral stenosis of the artery of a single kidney.Changes in kidney function can be reversible after the abolition of therapy. During the treatment period, it is necessary to regularly monitor the serum creatinine concentration at regular intervals.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Data on the influence of Lorist on the ability to manage transport or other technical means are absent.

 

Drug Interactions

 

There was no clinically significant drug interaction with hydrochlorothiazide, digoxin, indirect anticoagulants, cimetidine, phenobarbital, Ketoconazole and erythromycin.

 

During simultaneous administration with rifampicin and fluconazole, a decrease in the level of the active metabolite of losartan potassium was noted. The clinical consequences of this phenomenon are unknown.

 

Simultaneous use with potassium-sparing diuretics (eg spironolactone, triamterene, amiloride) and potassium preparations increases the risk of hyperkalemia.

 

Simultaneous use of non-steroidal anti-inflammatory drugs, including selective inhibitors of COX-2, can reduce the effect of diuretics and other antihypertensive agents.

 

If Lorista is prescribed concomitantly with thiazide diuretics, the decrease in blood pressure is approximately additive. Strengthens (mutually) the effect of other antihypertensive drugs (diuretics, beta-blockers, sympatholytics).

 

Analogs of Lorist's drug

 

Structural analogs for the active substance:

  • Bloktran;
  • Brozaar;
  • Vasotensis;
  • Vero Losartan;
  • Zisakar;
  • Cardomin Sanovel;
  • Karzartan;
  • Cosaar;
  • Lacka;
  • Lozap;
  • Lozarel;
  • Losartan;
  • Losartan potassium;
  • Losakor;
  • Lothor;
  • Prezartan;
  • Renikard.

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Reviews (80):
Visitors
taisa
Saw 4 years of calchek (amlodipine), constantly had a high pulse, I had to add bisocardium. The second month I drink Lori 25mg + 6mg hypothiazide. The pressure stabilized after a month of reception, the pulse became normal without bisocardia. But there were pains in the calf of the left leg, numbness of the leg below the knee, the doctor said the veins and prescribed detraleks. I'll drink the tip.
Administrators
admin
taisa, Thanks for the tip.It will be very interesting to know the result of your treatment. The case is interesting.
Guests
Larissa
I drank beeprolet, fell off badly, kept 140 to 90 at least. Month I drank to Lori 25mg. 10 days already I do not drink, and pressure super 120 on 80. I will be only with her, with interruptions.
Administrators
admin
Larissa, Treatment of hypertension should be continuous, properly selected drugs, so that there are no harmful candles in the form of single and sudden pressure rises. This has a very negative effect on health.
Guests
elena
Prior to that, I took various drugs against pressure, but it was temporarily reduced, then the doctor prescribed the analogue of the losers cosaar. Very much helped with this drug, but its price is 10 times more expensive than the lorist. I switched to a drug of lorist 25 mg. Excites only one question - it is the possibility of its application continuously for several years or more. Whether this is harmful and may need to take a break in treatment. After all, as I understood from the annotation to the drug, it is a problem with calcium in the body with long-term administration. For the answer I will be grateful.
Administrators
admin
elena, Lorista H and ND contain in their composition a diuretic hydrochlorothiazide, which can wash away calcium from the body after long-term use (and this is the probability, maybe, or may not be). If you accept Lorist without any additional letters, then this problem should not worry you, there will not be any washing out. Still it is necessary to add, that tablets from pressure accept for life, without breaks in treatment. A Cosaar and Lorista are absolute analogues for the active substance, the difference is only in firms producers.
Guests
Nina
Hello! Judging by the previous record, addiction to the drug does not occur? Do I understand correctly?
Administrators
admin
NinaHow can there be an addictive to tablets that take on continuously? And after all Loristu drink for life. There may come an inertness of action when it ceases to help and will have to change the treatment regimen, but this usually does not come soon.
Guests
Lyudmila
Assigned to Lorist at the end of February. The pressure returned to normal.
Guests
Tatyana
Lorist does not reduce the pressure.
Guests
Tatyana
Have registered to Lorist. Very well helps with pressure.
Guests
Olga
Accepted Lorist for many years, the pressure was kept, but the last 2 months I drink Lorist, and the pressure does not decrease. Has bought or purchased a new packing - pressure in norm or rate. The pharmacy said that there are a lot of complaints from buyers about the quality of Loriste.
Guests
Galina
Assigned Lorist 50 mg. After intake, the pressure drops to 90/60, then gradually rises, but I feel not very comfortable.
Guests
Lyudmila
Have appointed Lorista 25 mg, I drink the second month. The pressure is normal. But at night they torture leg cramps.
Guests
Alexander Nikolaevich 57 years old
The pressure was 180/120, appointed Enap 10mg, Concor 2.5mg + Lorist 25mg. After a two-week reception, it was 120/80, pulse 58, but began to feel tingling in the heart, which had never happened before.
Guests
Ilona
For several years I use Lorista 25 mg once a day. Very well helped, the pressure was normal. Recently I bought a new package - and as if I do not drink. Pressure at 180/100. Probably a fake, or something ... I do not know what to think ...
Guests
Pechorin Alexander Yurievich
I drink to the lorist for more than 2 years, the pressure was basically normal. I recently took a pack of SPB, and as if it did not work, a hand-made article or something else.
Guests
Tatiana s.
I changed the drug. Assigned to the lorist. I drink 25 days, and the pressure does not decrease - 180/80.
Guests
Evgen
Insidious drug ... side effects usually in a complex. Despite the diuretic effect, the body quickly accumulates edematous fluid, especially in the legs and on the belly. Refusal of the drug is very tricky - in fact, a very long breakdown begins. And what initially blocks the lorist, by no means is soon restored. The usual accompanying phenomena - fatigue and loss of strength, the legs refuse to go under the load.
Guests
Olga
Pugh Lorist, and the pressure still jumps. Rises in the evenings to 170.
Guests
Eleanor
I, too, do not help the lorist. Side effect has got out - the back and legs are heavy hurts. I will change to another drug.
Guests
Olga
Pugh Lorist year. Occasionally, the pressure jumps anyway and the lower pressure still does not drop below 90.
Guests
Eugene
I take Loriste two weeks of pressure 160 for 100, head pressure, nausea, palpitations, I take a pill and wait for the effect, but alas. I measure pressure 150 on 100, signs same. Does not help or dosage is not the same, or just chalk.
Guests
Fedya
Three days of drinking and libido completely gone. Guys - be careful!
Guests
Natalia Kuligina
Saw 2 weeks later, the pressure of lorist nd decreased. It was 180 \ 105 now 124 \ 82, but there was a tremor, anxiety, and most importantly a very bad dream or do not sleep at all until 6 am or half-asleep, completely worn out.
Guests
Galina
Somewhere about a year saw Lorista, 50 mg in the morning. The legs began to ache when walking in calves and become heavy. Now I drink indap the fourth day. My legs stopped hurting. And in the morning I take Concor 2.5 mg. Concor I take about 3 years.
Guests
Irina
Took Dilaprel 5 ml in the morning, 3 years helped. Then 2 times 5 ml each. But 4 days ago the BP jumped 180/110 and did not help the former drug had to call an ambulance. Have told or said it is necessary to make correction of a preparation. The doctor prescribed Lorist 50 ml. Took 3 days BP 160/100 - 150/100. Has come to the doctor again she has increased up to 100 ml. I do not know yet how to help or not.
Guests
Talina
Took only 5 days I thought I was going to die: weakness, dizziness strong, pinched my nose, my shoulders were shaking, tremors trembled my legs, elbows and knees just seemed to stretch my muscles, my pulse slowed, my ears slowed down. I took 50 mg - it all started in 10 minutes. 25 mg - the same thing only after 40 minutes and slightly weaker.
Visitors
postgal
Hello. I began to increase pressure from 130/70 to 150 / 70-90. The doctor prescribed Loriot for 12.5 mg in the morning.I have bronchial asthma of complex genesis and osteoporosis. I take Bivalos and calcium preparations. Preparations from a pressure did not accept earlier. They said that drinking constantly. I'm confused by the small dose?
Administrators
admin
postgalStart better with a small dose to assess the effect on the body and to weaken possible side effects if they appear. Especially the numbers of excess pressure you have small. So your doctor did everything right, given that before you did not take medications to treat hypertension. After a couple of weeks of treatment and monitoring of the pressure, you can adjust the dosage, if necessary.
Guests
Tatyana
The drug did not take, but you have to go to a cardiologist for a fee, so do not get. Was at two, both have written out a heap of tablets different. My sister already has a terry hypertensive, and I'm a beginner, the pills have been prescribed the same. They do not know a damn thing. We know our organism better.
Guests
Tatyana
Has started to drink lorista, already two weeks for the night the bottom does not fall.Advice to all - check your spine.
Guests
Irina
Hello. Can I take a lorist tablet with a toothache? Thank you.
Administrators
admin
Irina, In no way Lorist does not help to reduce the toothache. This drug is from a different area (to reduce high blood pressure, not pain).
Guests
Tamara 60 years old
My blood pressure rose at night. Saw enalapril 5 mg at night did not help and excruciated dry cough. Side effect, I think, from him. The pharmacy offered Lorist 25 mg. I drink at night. Has ceased tussis, I sleep all the night long, a BP in norm or rate. Only a week passed.
Visitors
rold57
In the course of 5 years, I take 12.5 mg of Loriot overnight, in the morning amlodipine 5 mg, the pressure is normal - 120-140 / 80-90, but I feel a constant stuffiness of the nose. With the abolition of the lorist, the stuffiness disappears, but the pressure rises by 10-20 units. What can be replaced with the lorist so that there is no stagnation?
Administrators
admin
rold57There are a lot of drugs and in your case, an individual approach is needed, which can not be given online consultation. You can try other drugs from the same group of angiotensin 2 receptor antagonists, but do not contain losartan, but other active substances: valsartan (drugs Valz, Diovan and others), telmisartan (preparations Telmisartan, Mikardis and others). If, in this case, a similar side effect persists, then a search for drugs to reduce high blood pressure from other pharmacological groups is shown.
Visitors
Irina Khramtsova
Can I start taking Lorist if the pressure is 200/120? I take Egrantil 30 mg. Another diabetes.
Administrators
admin
Irina Khramtsova, Ebrantil is somewhat out of steppe, his antihypertensive effect is secondary, but Loriste is closer to reducing pressure. So with such figures you need to change something and such a replacement is justified, if recommended by the patient's attending physician. To do something urgently, such a high pressure is a fast way to the terrible complications to which the increased pressure leads.
Guests
Love
My mother drinks Lorist and she started dizzy, every day in the morning.
Guests
Tatyana
I have been drinking for many years, helping, and it is very beneficial to drink once a day in the morning. I take metoprolol together. But lately joints and hands are aching.
Visitors
gfwbtyn
Fedya, soon there will be a year as I accept to the lover, there are no problems with libido and the pressure is more or less normal, but I think something can be found cheaper.
Guests
Marina Pakhorukova
Is it possible to drink Lorist twice a day?
Administrators
admin
Marina Pakhorukova, No, the instruction does not imply this. If there are not enough recommended doses of the drug to normalize the pressure digits, then you need to change the dosage or treatment regimen. Consult a doctor who appointed Lorist to you for correction.
Guests
Marina Piminova
I drink to the lorist 2 days 12.5, the upper pressure dropped from 180 to 160, and the lower one does not hold 100.
Guests
Zinaida
I have been drinking cigarettes for almost a year, but sometimes I take a short break, as the head starts to ache after an hour, and then the itch of the skin, but as for other cough preparations, I have to continue drinking to the lorist.
Guests
Irina
After hypertensive crisis, the doctor added to the concreter 2.5 mg of lorist 2 times a day for 25 mg. Within a week, the pressure returned to normal, then began to decline in the daytime to 100/65. The doctor recommended reducing the dose to 12.5 mg. Today the pressure all day is even lower. I do not know how much to take at night or not at all? There was a paresthesia of brushes and feet and pains in a back that was not earlier.
Administrators
admin
Irina, It is enough for Lorist to take 1 time a day. So I would have left 12.5 mg in the morning, and canceled the evening reception. If the pressure will still fluctuate below the norm, you can recommend leaving the morning reception of Concor or Lorista (to understand which of the drugs gives the desired therapeutic effect, and another to remove). So gradually choosing the dosage and the regimen, you will come to the necessary therapeutic effect.For pressure during the selection should be monitored regularly and measure blood pressure in the morning and evening.
Visitors
KlSergay
After a heart attack, I take Lori 25 and thrombopol 75 for the third year. Recently there was nausea, checked the blood rose bilirubin twice. Against the background of nausea, I do not sleep well and eat, sometimes my back and chest pain are hurting, and about half a year I have a pain in the elbow joint of my left hand.
Guests
ValPet
Accepted then enap + enap-n, then waltz, then lorist + indapamide. For various reasons they had to be abandoned. The doctor advised Lorist-N. This medicine suited me. I've been taking him for over a year now. Everything would be fine, but there was dryness in the mouth (sugar is normal). At first it is not very noticeable, but now in the morning the tongue literally sticks to the palate, and in the nasopharynx there is a mucus that neither swallows nor coughs. I try to drink a lot of fluids, during the day it helps a little, but at night I do not. I do not want to go to the doctor, I will replace the medicine again, but it suits me. How to be?
Administrators
admin
ValPetThen go out two or to the doctor to change Lorist H to another drug, or to look for the cause of dryness, although as you describe it may not be from the medicine. You can try to take Lorist without H (that is, without the diuretic component of hydrochlorothiazide). Or try to consult at an ENT, probably he will find other reason of your changes of a mucous mouth and occurrence of not clear slime.
Guests
ValPet
From Lori N do not want to refuse. The pressure stabilized, the arrhythmia and tachycardia disappeared. I already accepted Loristu without N, pressure jumps strongly. Thank you for suggesting the LOR. I thought about the stomach, but I did not think about the throat. I'll go to the LOR.
Guests
GALINA
My mom had a stroke six months ago. And two years ago there was a heart attack, lying down. Have appointed loristu nd. The pressure reduces well, but very diuretic, not enough for a day 3-4 diapers and she refuses to drink it because of this.
Guests
Elena Nikolaevna
Took the drug for about 2 years. I never would have thought that this could damage a small pill.During these 2 years, I periodically suffered from urticaria (such a diagnosis is made by a doctor), but in fact it is an angioedema (this is only later in a paid clinic I was diagnosed with this diagnosis, and even there they did not tell me that such side effects could be from a simple drug prescribed by a doctor from pressure, although I always said that I accept the lorist). Has handed over many analyzes, has passed or has taken place the recommended treatments. But this is all money. I am a pensioner. I write because there are no medicines that would not harm our health. These are all poisons. I was absolutely healthy person, and after retiring I wanted to do my favorite thing, but became an invalid.
Guests
Olga
I accept Loriste 4 days total. Sharply worsened the general condition, numbness of the limbs, unsteadiness in walking, dizziness, abdominal pain, visual acuity decreased. Pressure 110/70 does not rise.
Guests
Tatyana
I drink to the lorist for 3 months. There was a strong suffocating, dry cough, especially when I go to bed. Before that, I saw a lopaz + nothing like that. I decided to refuse from the lorist.
Visitors
letuthi
I'm 47, the pressure is 173/115. With what dose to take Lorist. Before that, nothing was taking and not controlling the pressure. And now the device has appeared and the high pressure has been holding for two weeks as much as the apparatus.
Administrators
admin
letuthi, You can start with 50 mg 1 time per day in the morning, regardless of the meal (you can before meals, you can after). But you have to watch the concomitant diseases, if you are allowed to take this medication by additional parameters, and this is already a matter for your doctor, it is better if it is a cardiologist. And why exactly Lorista? Doctors usually begin primary therapy with other traditional drug groups (ACE inhibitors, beta-blockers).
Visitors
Vivlad
3 years lorist 12.5 well helped, now stopped. Gradually increased the dose to 75 mg. For the fourth week I'm waiting for the result - the pressure is 150/100. What would advise - to increase the dose to 100 or, perhaps, a fake drug was caught? How do you define a fake?
Administrators
admin
Vivlad, Counterfeit by external signs now, unfortunately, are not distinguishable. You can determine if at the time of purchase and the appearance of doubt, ask the pharmacist for documents on the lot of the medicine. For the forgery of documents is a criminal liability, and for the sale of counterfeit - no, so fake lots usually sell without legal documents (batch numbers in documents must match those sold on packages).

Increase the dose taken by Lorista, based on the description of your problem, it is meaningless. In your case, rather, there is an addiction to the drug, which will require the appointment of a new therapy regimen. For this purpose it is necessary to address to the attending physician, it is better if it will be the cardiologist.
Guests
Yuri Panin
For more than a year I have been accepting Lorist H 12.5 / 50. Everything was like nothing, but lately I had to go to the toilet every 2-3 hours. Uncomfortable. Has passed on simply Lorista. The problem with frequent going to the toilet is gone, but there are swelling under the eyes, which has never happened before. Here such here a dilemma.
Guests
Belozerov Vladimir Ivanovich
Drank to the larist 100 in the morning, in the evening amlodipine 10, cordarone in the morning.5 years, the pressure was kept within the norm. This year, there was edema of the feet, hands. The doctor abolished the lorist, amlodipine, appointed featherbed 8 mg in the evening, in the morning arifon 1.5, 3 times erinitis. 3 days the pressure keeps high until 180/95 saves captopril, isotope spray. The doctor said that I do not take a little fever, I prescribed an additional sildnofarm 2 mg in the morning and in the evening, the heart rate dropped to 49, the pulse is small, the pressure is high up to 180/90, canceled - 59,65. The pressure keeps in high limits up to 180/90, rescues captopril, isotope spray. At high pressure presses in the left side of the chest.
Guests
Vladimir Sergeevich
Is it possible for Lorist 100 to divide the pill into two parts? I accidentally bought the wrong dosage.
Administrators
admin
Vladimir SergeevichIf the memory does not change, lorista 100 mg tablets do not have a separation risk, plus they are covered with a film sheath, so you will not be able to competently divide, uneven halves will come out, and this is a violation of the treatment process and additional risk, and what the effect will be impossible to predict.
Guests
Tatyana
The pressure was 160/100, appointed perinevu and concor. Feeling bad, behind the wheel it was terrible to sit down. The last 9 months I drink Lorist, the pressure stabilized 110/70, 120/80. But the face, arms, legs began to swell.
Guests
galena
I accept Lorist 100 mg for 2 years already. Initially, the pressure decreased from 180/85 to 160/80, but now almost half a year began to notice that there is no effect.
Guests
Ramses
I have sinus bradycardia. And I'm suffering with high blood pressure. Has started to drink lorista 25 mg already half a year. The pressure was normalized rarely when it rises. And for me, 50 mg is too much. I still do not see any side effects, but I'm afraid that the potassium is being washed. And the doctors, they first ask that you drink and say yes, keep drinking, they do not know anything and do not want to know.
Guests
Alla
Several years I drank from pressure Indapamid retard 1.5, the pressure kept within 130 (135) at 85, but sometimes jumped the bottom to 90 - 95 for incomprehensible reasons for me. The doctor advised me to change it on Lorist N. Pugh for a week, the pressure was 150 to 98, the condition worsened, there was dizziness, nausea, weakness and pain in my hands.
Guests
Natalia M
I am 40 years old. I've been drinking lorist for 100 months. The pressure is 120/90, and it was up to 180 jumped. All is pleasant, but it began to reduce legs, run creeps on legs and arms, and muscles are still twitching all over the body.
Guests
Tatyana
Pugh Lorist more than 15 years. First, the doctor prescribed 50 mg, then 100 mg at bedtime. Plus in the morning Ravel. The pressure is usually 150/90. I feel fine, but when it rises to 200, I still drink Amlodipine. All anything, but I still do not have 60, and my teeth are almost gone, the dentist said that this is just a side effect of taking these medicines, and recently they diagnosed arthrosis of the knees of the third degree.
Guests
Sergey Viktorovich
The main cause of hypertension is excess weight. To ensure normal blood flow, the body is forced to increase blood pressure in the blood supply system. Due to the decrease in blood pressure, under the influence of antihypertensive drugs and with a large body mass index, there is insufficient blood flow in the limbs, which leads to convulsions in them. Watch your weight and stay healthy.
Guests
ttiana
Propyl Loresto 2 months - heaviness in the legs and severe pain in the back in the kidney area. Now I drink Lazarel I feel better.
Guests
Valentina Vladimirovna
Took me three Tenoxes a month. There were cramps in the legs at night, and then started to reduce fingers. Terrible condition. It was excruciated, then has decided to cancel these tablets and accepted within a month only in the morning Bisoprololum. The spasms passed. Then the doctor prescribed to Lorist, drank 10 days, again there were cramps. I concluded that all drugs affect these or other organs. It is necessary to try another drug.
Guests
Galina Georgievna
Lorist 100 mg take a long time in the morning, in the morning bisoprolol 5 mg, side obviously did not observe, well helped, my working pressure kept 140-80. But now the pressure began to rise at night, there was a hypertensive crisis, I had to call an ambulance, I could not manage it myself. I bought another pack of Lorist, maybe she was a fake. Has addressed to the doctor - have appointed or nominated Lozap H (it has appeared analogue Lorista) in the morning and moxonidine 0,2 mg in the evening and kardiomagnol 75mg in a dinner. I took the first day, the pressure was 130-70, I will try these drugs.Diabetic type 2, hypertensive a very long time. I wish everyone to pick up the right drugs and not give up. With the Coming, long healthy and happy life of all.
Visitors
9271397524
Lived up to that age when the beginning to excruciate the raised or increased pressure. To get to the doctor is problematic, tell me from which drugs you can start treatment? The pressure by the evening rises to 180/100, and in the daytime 150/95 or 160/95, and the constant 130-140 / 90. We were advised to drink 100 mg of lorist in the morning + veroshpiron 50 mg and in the evening moxonidine 0.4 mg. I drink the second day, this morning I drank a lorist 50 mg, not 100 mg, was dizzy, and now the head is heavy, it means does not fit the lorist or drink further?
Guests
Natalia Vladimirovna
I'm a young hypertensive patient since the summer of 2017. Saw enalapril hexal, coughed up to vomiting. Have appointed or nominated to the lover on 25 mg in the morning and 25 mg in the evening. In the evenings, the pressure rises from 130 to 160, ripple in the left leg; pulsation in the head when I lay down on the pillow; the lower pressure began to rise to 100, the heartbeat to 100. Two times in 3 months, the pressure rose to 180. I think that we should go and change the medicine.
Administrators
admin
9271397524, Start with morning Lorists 50 mg as you started taking plus Veroshpiron. If the pressure figures stabilize, you can leave it without the evening Moxonidine. If blood pressure is higher than your age, then add Loriot and evening Moxonidine to your recommended dosage, although I do not like the dosage for a long period of time.

In the first days of taking antihypertensive drugs, headache, dizziness, and the like can occur. If these symptoms are tolerable, the medication can be continued and within 2 weeks of regular admission they should disappear, if this does not happen - it is worth to apply again to the attending physician for adjustments in the therapy.
Guests
Olga
I drank one Lorista H pill (12.5) in the evening, and in the morning, I had a throat and a nose. Then the strongest convulsions from the tips of the toes to the abdomen started, plucked the sting, massaged both legs about half an hour and all day lay in bed because of weakness in the legs.
Visitors
Anna Prim
Years 8 saw Arifon retard, then Indapamide, the pressure was perfectly regulated, but there were pains in the joints of the hands and toes. The rheumatologist suspected gout, but diagnosed reactive arthritis. As the effects of taking Indapamide. The therapist replaced the drug on Lorist 25 mg in the morning and 50 mg in the evening. The pressure is between 140-150 at 70-80. She drank 2 weeks. I came to the therapist, Lorish added in the morning. Question: Does Lorista N also have a diuretic effect? My joints will also react?
Administrators
admin
Anna Prim, I can assume that gout or arthritis (by the way, now the level of medicine, analysis and diagnosis allows you to accurately diagnose, and not to assume, this stone in the garden of your rheumatologist) you have on their own, and taking medications by itself is not in the direct cause-and-effect relationship. In the instructions of the drugs you mentioned, there is no indication of joint side effects or the provocation of these problems. Although if, against the background of the abolition of Indapamide with joints, it is better, then it is quite acceptable and such an option as an individual reaction.Lorist H contains a diuretic component of hydrochlorothiazide and it is from another group of diuretics than Indapamide and its trading analogues.

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