Norkolut - instructions for use, analogs, reviews and release forms (5 mg tablets) of the drug for the treatment of premenstrual syndrome and call of menstruation in adults, children and pregnancy

In this article, you can read the instructions for using the drug Norkolut. The reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on using Norcolut in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Norkolut in the presence of existing structural analogs. Use to treat premenstrual syndrome and call menstruation in women, including during pregnancy and lactation.

Norkolut is a progestogen.It causes the transformation of the uterus envelope from the proliferation phase into the secretory one, blocks the secretion of gonadotropin in the pituitary gland, preventing the maturation of the follicles and the onset of ovulation.

Composition

Norethisterone + excipients.

Pharmacokinetics

Well absorbed from the digestive tract. As a result of intensive primary metabolism in the liver and in the intestinal wall, bioavailability is 50-77%. Metabolites of norethisterone are excreted by the kidneys in the form of conjugates with glucuronic acid. Excretion of conjugated metabolites through the intestine (40%) and kidneys (60%).

Indications

• premenstrual syndrome;
• anovulatory metrorrhagia;
• Dysmenorrhea (accompanied by a shortening of the secretory phase);
• endometriosis;
• uterine myoma;
• mammalgia;
• endometrial hyperplasia;
• diagnostic progesterone test;
• cessation and prevention of lactation.

Forms of release

Tablets 5 mg.

Instructions for use and dosing regimen

Inside.

Premenstrual syndrome, mastodynia, dysmenorrhea: during the 16th to 25th day of the menstrual cycle, 5-10 mg per day (1-2 tablets), can be taken with estrogen.

Myoma of the uterus: 5-10 mg per day from the 5th to the 25th day of the menstrual cycle no more than 6 months.

Diagnostic Progesterone test: the best option is to prescribe 10 mg Norkolut for 10 days. The reaction is regarded as regular if moderate bleeding appeared 3-7 days after the end of Norkolut's administration and persisted for 3-4 days.

Anovulatory metrorrhagia, endometrial hyperplasia (dysfunctional bleeding should be confirmed by histological analysis no more than 6 months before treatment): 5-10 mg per day (1-2 tablets) for 6-12 days. After achieving the desired effect between the 16th and 25th days of the cycle, 5-10 mg per day, usually along with estrogen, to prevent recurrence.

Endometriosis: during the period from the 5th to the 25th day of the cycle, 5 mg per day for 6 months. Further treatment at the discretion of the doctor.

Prevention of lactation: in case of termination of pregnancy between the 16th and 28th weeks on the first day, take 15 mg (3 tablets), on the 2nd and 3rd days take 10 mg per day (2 tablets), with The 4th to the 7th days take 5 mg per day (1 tablet). In case of termination of pregnancy between the 28th and 36th weeks on day 1, take 15 mg (3 tablets), on days 2 and 7 take 10 mg per day (2 tablets).

lactation Termination: from 1st to 3rd days administered 20 mg per day, from 4th to 7th - 15 mg a day, from the 8th to 10th days - 10 mg per day.

Side effect

• headache;
• Breast pressure;
• dyspeptic phenomena (nausea, vomiting);
• acyclic spotting from the vagina;
• paresthesia;
• increase in body weight;
• increased fatigue (does not require additional treatment);
• peripheral edema;
• allergic reactions (skin rash, itching);
• thrombosis;
• thromboembolism.

Contraindications

• the period of puberty;
• breast cancer (including suspected);
• malignant tumors of female genital organs;
• pregnancy (including the suspect, except for cases of application for miscarriage);
• jaundice (including in the anamnesis);
• acute liver diseases (including benign and malignant neoplasms);
• impaired liver and kidney function;
• hyperbilirubinemia;
• propensity to thrombosis;
• acute thrombophlebitis or thromboembolism;
• bleeding from the urinary tract of unknown origin;
• bleeding from the genital tract of unknown origin;
• Cholestatic jaundice of pregnant women or skin pruritus in the anamnesis;
• obesity;
• herpes;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is not used in pregnancy.

At random reception of a preparation in the early period of pregnancy the preparation did not render teratogenic effect, incl. disorders of the development of the heart and limbs.

Admission of the drug in the postpartum period reduces the secretion of milk and changes its quality indicators.

Use in children

Contraindicated during puberty.

special instructions

Before the start of treatment, it is necessary to exclude the presence of malignant neoplasms, to conduct preliminary thorough gynecological, oncological examination and examination of the mammary glands.

If the patient has forgotten to take the next pill, then the missed tablet should be taken as soon as possible, in which case additional methods of contraception should be applied.

Norkolut has no influence on the ability to drive vehicles and mechanisms, the work on which is associated with an increased risk of injury.

Drug Interactions

Inductors of hepatic enzymes accelerate the metabolism of Norkolut.

With caution appoint simultaneously with hypoglycemic drugs, oral anticoagulants, glucocorticosteroids.

It is not recommended to combine with barbiturates, phenytoin, rifampicin, cimetidine and other drugs that affect microsomal oxidation in the liver.

Analogues of the drug Norcolut

Structural analogs for the active substance:

• Primoluth-Nor.

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