Mifepristone - instructions for use, analogs, reviews and release forms (200 mg tablets) medications for the stimulation of labor and medical abortion in the early stages of women, including during pregnancy

In this article, you can read the instructions for using the drug Mifepristone. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mifepristone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mifepristone in the presence of existing structural analogues. Use to stimulate labor and medical abortion in the early stages of women, as well as during pregnancy and lactation.

Mifepristone - the drug is a synthetic steroidal anti-gestagen. Blocks the action of Progesterone at the receptor level. Gestagenic activity does not possess, antagonism with glucocorticosteroids (GCS) is noted (due to competition at the level of communication with receptors).

Increases the contractile ability of the myometrium, stimulating the release of interleukin-8 in choroid-epidural cells and increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug desquamation of the decidual membrane occurs and excretion of the fetal egg.

Pharmacokinetics

Absolute bioavailability is 69%. Binding to plasma proteins is 98% (with albumin and acid alpha-1 glycoprotein). Excretion is carried out in two phases: first slow release of the drug for 12-72 h (the concentration of mifepristone in the blood plasma is reduced by 2 times), then the phase of rapid elimination of the drug.

Indications

• interruption of uterine pregnancy in the early stages (up to 42 days of amenorrhea);
• induction of labor in term of full term pregnancy.

Instructions for use and reception scheme

The drug should be used only in specialized institutions with the necessary equipment.

For drug-induced abortion in early terms, the drug is prescribed in a dose of 600 mg (3 tablets) once. In the presence of a doctor, the drug is taken inside 1-1.5 hours after eating (light breakfast), with half a glass of boiled water.

The patient should be observed for at least 2 hours after using the drug. After 36-48 hours after taking Mifepristone, the patient should report to the medical institution for ultrasound control and, if necessary, she should prescribe misoprostol.

After 10-14 days, a clinical examination and ultrasound examination is repeated, if necessary, determine the level of chorionic gonadotropin to confirm spontaneous abortion.

In the absence of the effect of the drug on day 14 (incomplete abortion or continuing pregnancy), a vacuum is performed followed by a histological examination of the aspirate.

For the induction of labor in term of pregnancy, the drug is prescribed in a dose of 200 mg (1 tablet) once a day. The drug is taken in the presence of a doctor. After 24 hours, re-administer the drug at a dose of 200 mg. After 48-72 hours, the condition of the birth canals is evaluated and, if necessary,prostaglandins or oxytocin.

Side effect

• feeling of discomfort in the lower abdomen;
• general weakness;
• headache;
• nausea and vomiting;
• dizziness;
• hyperthermia;
• Lochiometer;
• subinvolution of the uterus;
• bloody discharge from the genital tract;
• exacerbation of inflammatory processes of the uterus and appendages.

Contraindications

General contraindications:

• adrenal insufficiency;
• long-term use of GCS;
• acute or chronic renal failure;
• acute or chronic hepatic impairment;
• porphyria;
• uterine myoma;
• severe anemia;
• violations of hemostasis (including previous therapy with anticoagulants);
• inflammatory diseases of female genital organs;
• the presence of severe extragenital pathology (without consulting a therapist);
• smoking women older than 35 years;
• hypersensitivity to the components of the drug (in anamnesis).

With drug abortion:

• suspicion of ectopic pregnancy;
• pregnancy, not confirmed by clinical studies;
• pregnancy for more than 42 days amenorrhea;
• Pregnancy caused by the use of intrauterine contraception or after the abolition of hormonal contraception.

When preparing and induction of labor:

• severe gestosis;
• preeclampsia;
• eclampsia;
• premature or premature pregnancy;
• discrepancy between the size of the pelvis of the mother and the head of the fetus;
• abnormal position of the fetus;
• bloody discharge during pregnancy from the genital tract, unspecified etiology.

Application in pregnancy and lactation

When prescribing the drug, you should stop breastfeeding for 3 days after taking Mifepristone in case of medical abortion.

The use of mifepristone for the preparation of the cervix for delivery does not affect subsequent lactation.

special instructions

Patients using Mifepristone for early termination of pregnancy should be informed that if there is no effect on the 10-14 day use of the drug (incomplete abortion or continuing pregnancy), pregnancy should necessarily be discontinued in another way because of the risk of congenital malformations in the fetus.

The use of the drug requires the prevention of rhesus-alloimmunization and other common activities associated with abortion.

Mifepristone should be avoided concomitantly with non-steroidal anti-inflammatory drugs.

Drug Interactions

With the simultaneous use of Mifepristone and GCS, it is necessary to increase the dose of the latter.

Analogues of the drug Mifepristone

Structural analogs for the active substance:

• Agesta;
• Ginepristone;
• Gynestrel;
• Wife;
• Miropristone;
• Mifegin;
• Mifeprex;
• Pencrofton.

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