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Pentaxim - instructions for use, analogs, reviews and release forms (injections in injectable ampoules) of the vaccine for the prevention of pertussis, tetanus and diphtheria in adults, children and pregnancy. Composition and adverse reactions

Pentaxim - instructions for use, analogs, reviews and release forms (injections in injectable ampoules) of the vaccine for the prevention of pertussis, tetanus and diphtheria in adults, children and pregnancy. Composition and adverse reactions

This article describes the instructions for the use of the vaccine Pentaxim. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Pentaxim in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pentaxim in the presence of existing structural analogs. Use for the prevention of pertussis, tetanus and diphtheria in adults, children, as well as during pregnancy and lactation. Composition and adverse reactions of the vaccine.

 

Pentaxim - vaccine for the prevention of diphtheria, tetanus, pertussis, poliomyelitis and diseases caused by Haemophilus influenzae type b.

 

Composition

 

Anatoxin diphtheria + Anatoxin tetanus + Anatoxin pertussis + Hemagglutinin filamentous + Poliomyelitis virus inactivated, 1 type + Polio virus inactivated, 2 types + Poliomyelitis virus inactivated, 3 types + auxiliary substances.

 

Indications

 

Prevention in children starting from 3 months of age:

  • diphtheria;
  • tetanus;
  • whooping cough;
  • poliomyelitis;
  • invasive infection caused by Haemophilus influenzae type b (meningitis, septicemia, etc.).

 

Forms of release

 

Lyophilizate for the preparation of a suspension for intramuscular injection (injections in ampoules for injection).

 

Instructions for use and usage diagram

 

The vaccine is given intramuscularly at a dose of 0.5 ml, the recommended place of administration is the middle third of the anterolateral lateral surface of the thigh. Do not administer intradermally or intravenously. Before administration, it must be ensured that the needle does not penetrate into the blood vessel. For a package with two separate needles, the needle should be tightly fixed before turning the vaccine, rotating it a quarter of a turn relative to the syringe.To prepare the vaccine, after completely removing the plastic colored cap from the vial, completely enter the suspension for intramuscular injection (vaccine for the prevention of diphtheria, tetanus, pertussis and poliomyelitis) through the needle from the syringe into the vial with lyophilizate (vaccine for the prevention of infection caused by Haemophilus influenzae type b) .

 

Shake the vial without removing the syringe from it, and wait until the lyophilisate is completely dissolved (no more than 3 minutes). The resulting suspension should be cloudy and have a whitish hue. The vaccine should not be used in case of discoloration or presence of foreign particles. The vaccine thus prepared should be completely injected into the same syringe. Ready vaccine should be entered immediately.

 

Vaccination course Pentaxime consists of 3 injections of one dose of vaccine (0.5 ml) at intervals of 1 -2 months, starting at 3 months of age. Revaccination is carried out.

 

Vaccination course Pentaxim consists of 3 injections of one dose of vaccine (0.5 ml) at intervals of 1-2 months, starting at 3 months of age. Revaccination is performed by administering 1 dose of Pentaxim at the age of 18 months of life.

 

In accordance with the National Calendar of preventive vaccinations of the Russian Federation, the vaccination course for the prevention of diphtheria, tetanus,pertussis and poliomyelitis consists of 3 injections of the drug at intervals of 1.5 months, at the age of 3, 4.5 and 6 months, respectively; Revaccination is carried out once at the age of 18 months.

 

If the schedule of vaccination is not met, subsequent intervals between the administration of the next dose of the vaccine do not change, including the interval before the 4th (revaccinating) dose - 12 months.

 

If the first dose of Pentaxim was administered at the age of 6-12 months, the second dose is administered 1.5 months after the first, and as a 3rd dose administered 1.5 months after the second, a vaccine should be used to prevent diphtheria, tetanus; pertussis and poliomyelitis, initially presented in a syringe (i.e., without dilution of the lyophilizate in the vial (Hlb)). As a revaccinating (4th dose), the usual dose of Pentaxime (with dilution of lyophilizate (Hlb)) is used.

 

If the first dose of Pentaxim is administered at the age after 1 year of age, then the vaccine for the prevention of diphtheria, tetanus, pertussis and poliomyelitis, initially presented in a syringe, without dilution of the lyophilizate should be used for the 2 nd, 3 rd and 4 th (revaccinating) dose in the vial (Hlb).

 

In all cases of violation of the vaccination schedule, the doctor should be guided by the National Calendar of preventive vaccinations of the Russian Federation.

 

Side effect

  • soreness (usually expressed by a short crying at rest or with slight pressure in the area of ​​injection);
  • redness and denseness at the injection site (in 0.1-1% of cases -> 5 cm in diameter);
  • increased body temperature;
  • irritability;
  • drowsiness;
  • sleep disorders;
  • anorexia;
  • diarrhea;
  • vomiting;
  • prolonged crying;
  • rash;
  • hives;
  • febrile and afebrile convulsions;
  • hypotension and hypotonic-hyporeactive syndrome;
  • anaphylactic reactions (face swelling, Quincke's edema, shock);
  • cases of edema of one or both lower extremities (with the predominance of edema on the limb, where the vaccine was introduced);
  • Guillain-Barre syndrome;
  • neuritis of the brachial nerve.

 

Contraindications

  • Progressive encephalopathy, accompanied by cramps or without such;
  • encephalopathy, developed within 7 days after the administration of any vaccine containing the antigens Bordetella pertussis;
  • a strong reaction that developed within 48 hours after a previous vaccination with a vaccine containing a pertussis component: an increase in body temperature to 40 ° C or higher, a syndrome of prolonged unusual crying, febrile or afefril convulsions, hypotonic hyporeactive syndrome;
  • an allergic reaction that developed after the previous administration of the vaccine to prevent diphtheria, tetanus, pertussis, poliomyelitis and a vaccine to prevent infection caused by Haemophilus influenzae type b;
  • diseases accompanied by an increase in body temperature, acute manifestations of an infectious disease or exacerbation of a chronic disease. In these cases, vaccination should be postponed until recovery;
  • confirmed systemic hypersensitivity reaction to any ingredient in the vaccine, as well as glutaraldehyde, neomycin, streptomycin and polymyxin B.

 

special instructions

 

Pentaxime does not form immunity against infection caused by other serotypes of Haemophilus influenzae, as well as against meningitis of a different etiology.

 

The physician should be informed of all cases of adverse reactions, including those not listed in this manual. Before each vaccination, to prevent possible allergic and other reactions, the doctor should clarify the state of health, the history of immunization, the history of the patient and the next of kin (in particular, allergic), the incidence of side effects on previous vaccines.The physician should have the medicines and tools necessary for the development of a hypersensitivity reaction.

 

Immunosuppressive therapy or the state of immunodeficiency can cause a weak immune response to the administration of the vaccine. In these cases it is recommended to postpone the vaccination before the end of such therapy or remission of the disease. However, for people with chronic immunodeficiency (eg, HIV infection), vaccination is recommended even if the immune response can be weakened.

 

When thrombocytopenia and other disorders of blood clotting, the administration of the vaccine should be carried out with caution because of the risk of developing bleeding with a / m injection.

 

When developing a history of Guillain-Barre syndrome or neuritis of the brachial nerve in response to any vaccine containing tetanus toxoid, the decision to vaccinate with Pentaxim should be carefully justified. As a rule, in such cases, the completion of primary immunization is justified (if less than 3 doses are administered).

 

Drug Interactions

 

With the exception of immunosuppressive therapy, there is no reliable evidence of a possible mutual effect when used with other drugs, including other vaccines.

 

The doctor should be informed of the recent or concurrent vaccination with the introduction of any other medication (including over-the-counter drugs) to the child.

 

Analogues of the drug Pentaxim

 

Structural analogs for the active substance (vaccines against tetanus, pertussis and diphtheria in combinations):

  • Bubo-Kok;
  • Bubo-M;
  • Vaccine pertussis-diphtheria-tetanus adsorbed liquid (DTP vaccine);
  • Vaccine against pertussis, diphtheria, tetanus and hepatitis B adsorbed liquid (DTP-Hep B vaccine);
  • D.T. Vax;
  • Imovax DT Adult;
  • Infanriks;
  • Infanrix Hex (Vaccine for the prevention of diphtheria, tetanus, pertussis (acellular), poliomyelitis (inactivated), hepatitis B combined, adsorbed with the vaccine to prevent infection caused by Haemophilus influenzae type b conjugated, adsorbed);
  • Infanrix Penta (Vaccine for the prevention of diphtheria, tetanus, whooping cough (cell-free), poliomyelitis (inactivated), hepatitis B combined, adsorbed);
  • Sinflorix (Vaccine 10-valent pneumococcal polysaccharide, conjugated with D-protein, non-typed Haemophilus influenza, tetanus and diphtheria toxoid, adsorbed);
  • Tetrakok 05;
  • Tetraksim.

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