Lotseril - instructions for use, analogs, reviews and release forms (5% solution or varnish for external use) of the drug for the treatment and prevention of nail fungus in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Loceril. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Lotseril in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Loceril in the presence of existing structural analogs. Use for the treatment and prevention of nail fungus in adults, children, as well as during pregnancy and lactation.

Loceril - an antifungal agent for external use. It has a fungistatic and fungicidal effect, based on a change in the cell membrane of the fungus by disrupting the biosynthesis of sterols. Amorolfin (active substance of the drug Loceril) inhibits two different enzymes involved in the biosynthesis of ergosterol - delta14-reductase and delta7-delta8-isomerase.

Amorolfin has a broad spectrum of action, is active against fungi of the genus Candida, Pityrosporum, Cryptococcus, Trichophyton, Microsporum, Epidermophyton, Alternaria, Hendersonula, Scopulariopsis, Cladosporium, Fonseceae, Wangiella, Coccidioides, Histoplasma, Sporothrix.

Bacteria, except Actinomyces, are not sensitive to amorolfine. Propionibacterium acnes shows only weak sensitivity.

Pharmacokinetics

When the solution is applied to the nails, Loceril penetrates into the nail plate and further into the nail bed. Amorolfin almost completely penetrates the nail plate within the first 24 hours. Effective concentration of amorolfin is retained in the affected nail plate within 7-10 days after the first application. Systemic absorption is negligible: the concentration of amorolfin in the plasma is below the sensitivity limit of the detection methods (less than 0.5 ng / ml).

Indications

• treatment of nail lesions caused by various types of fungi (in the form of monotherapy in the event that no more than 2/3 of the nail plate is affected);
• prevention of fungal nail lesions.

Forms of release

Solution for external use 5% (sometimes called nail polish).

Other forms of the drug, be it cream or tablets at the time of adding the drug to the directory were absent.

Instructions for use and how to use them

With onychomycosis, the solution is applied to the affected nails of the fingers or toes 1-2 times a week.

Therapy should be continued until the nail is regenerated and the wound is completely healed. The course of treatment is an average of 6 months for the nails on the hands and 9-12 months for the nails on the legs.

The solution is applied as follows: before the use of the drug, remove the affected areas of the nail (especially on its surface) with the attached nail file. Then the surface of the nail is cleaned and degreased with the attached tampon moistened with alcohol. Nail treatment with a saw blade and a swab with alcohol should be performed before each use of the drug. The solution is applied to the entire surface of the affected nail with a spatula, allow it to dry.The above procedure is repeated for each affected nail.

The spatula should be dipped in a solution, after that take out the spatula from the bottle, without touching its neck. The neck of the vial is wiped with the same swab that processed the nail, and tightly closes the bottle immediately after use. Allow the solution to dry for about 3 minutes. After treatment of all nails, the spatula is wiped with the used tampon. Avoid contact of processed nails and a tampon; the used tampon is discarded.

Side effect

• it may be a burning sensation.

Contraindications

• children's age (due to lack of clinical trials);
• hypersensitivity to the drug.

Application in pregnancy and lactation

Do not recommend the use of Loceril during pregnancy and lactation (breastfeeding).

Use in children

Clinical data on the efficacy and safety of the use of Loceril in children are absent, therefore, do not prescribe Loceril to children.

special instructions

The saws used to treat the affected nails should not be used for the treatment of healthy nails.

Persons working with organic solvents should wear impermeable gloves to protect nails covered with a solution of Loceril.

During treatment with Loceril, avoid using false artificial nails.

Drug Interactions

There is no clinically significant interaction between the drug Lotceril and other drugs.

Analogues of the drug Loceril

Lotseril does not have structural analogs for the active ingredient.

Analogues on the antifungal effect for the treatment of mycosis nails:

• Amphotericin B;
• Anmarine;
• Atitis;
• Batrafen;
• Binafin;
• Bifonazole;
• Griseofulvin;
• Dactanol;
• Diflason;
• Diflucan;
• Itrazole;
• Itramikol;
• Iphenec;
• Lamisyl;
• Lamican;
• Mikozolone;
• Mycomomax;
• Mycospores Set;
• Mycoflucan;
• Miramistin-Darnitsa;
• Nizoral;
• Nofung;
• Orungal;
• Rumikoz;
• Terbisyl;
• Thermic;
• Trozid;
• Fluconazole;
• Flucostat;
• Fungolon;
• Fungoterbine;
• Exifin;
• Exodermil.

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