Unidox Solutab - instructions for use, analogs, testimonials and release forms (100 mg tablets) for the treatment of bronchitis, otitis, ureaplasma and other infections, as well as acne in adults, children and pregnancy
In this article you can get acquainted with the instructions for the use of antibacterial medicinal product Yunidox Solutab. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Unidox Solutab in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Unidox Solutab with existing structural analogues. Use for the treatment of bronchitis, otitis, ureaplasma and other infections, as well as acne in adults, children, as well as during pregnancy and lactation.
Yunidox Solutab - long-acting Tetracycline (active ingredient - antibiotic doxycycline) of a wide spectrum of action. It acts bacteriostatically, suppresses protein synthesis in a microbial cell.
It is active against gram-positive and gram-negative aerobic and anaerobic bacteria.
The possibility of acquired resistance to Doxycycline in a number of pathogens, which is often cross-over within the group (ie, strains resistant to doxycycline, will simultaneously be resistant to the entire group of tetracyclines) should be taken into account.
Pharmacokinetics
Absorption is fast and high (100%). The intake of food has a slight effect on the absorption of the drug, which has no clinical significance. Doxycycline reversibly binds to plasma proteins (80-90%), penetrates well into tissues, badly into spinal fluid (10-20% of plasma concentration), but the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal cord. Doxycycline penetrates the placental barrier, in small quantities is secreted into breast milk. Metabolized only a small part of the doxycycline.Approximately 40% of the dose taken is excreted in the biologically active form by tubular secretion in the kidney, 20-40% is excreted through the intestines in the form of inactive forms (chelates).
Indications
Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:
- respiratory tract infection (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, pneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, empyema);
- infection of the ENT organs (including otitis media, sinusitis, tonsillitis);
- infections of the urogenital system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orhiepididimit; endometritis, endocervicitis and oophoritis / in a combination therapy /);
- infections, sexually transmitted infections (urogenital Chlamydia, syphilis patients intolerant penicillins, uncomplicated gonorrhea / as an alternative therapy /, granuloma inguinale, lymphogranuloma venereum);
- gastrointestinal infection and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, diarrhea, travelers);
- skin and soft tissue infections (including wound infections after an animal bite), severe acne (as part of combination therapy);
- Other diseases (yaws, legionellosis, chlamydia of various localizations / including prostatitis and proctitis /, rickettsiosis, fever Ku, spotted fever of the Rocky Mountains, typhus (including swelling, tick-borne recurrent), Lyme disease / 1st stage - erythema migrans /, tularemia, plague, actinomycosis, malaria, leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocyte erlichiosis, whooping cough, brucellosis);
- infectious diseases of the eyes, as part of combination therapy - trachoma;
- osteomyelitis;
- sepsis;
- subacute septic endocarditis;
- peritonitis.
Prevention of postoperative purulent complications and malaria caused by Plasmodium falciparum, with short trips (less than 4 months) in the territory where strains resistant to chloroquine and / or pyrimethamine sulfadoxine are common.
Forms of release
Tablets are dispersible 100 mg.
Instructions for use and dosing regimen
The drug is preferably taken with food. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension.Tablets can also be swallowed whole, divided into parts or chewed, washed down with water. Usually the duration of treatment is 5-10 days.
Adults and children older than 8 years with a body weight of more than 50 kg on the first day of treatment appoint 200 mg per day in 1 or 2 admission, in the following days of treatment - 100 mg per day in 1 reception. In the case of severe infections, 200 mg per day are administered throughout the treatment period.
For children aged 8-12 years with a body weight of less than 50 kg, the average daily dose is 4 mg / kg on the first day, then at 2 mg / kg per day (in 1-2 divided doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg / kg daily throughout the treatment.
With infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.
For uncomplicated gonorrhea (with the exception of anorectal infections in men), adults are prescribed 100 mg twice a day until they are fully cured (on average for 7 days) or within one day 600 mg are given - 300 mg in 2 divided doses (second dose 1 hour after the first).
When primary syphilis is prescribed for 100 mg twice a day for 14 days, with secondary syphilis - 100 mg 2 times a day for 28 days.
In uncomplicated urogenital infections,caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, are prescribed 100 mg twice a day for 7 days.
When acne is prescribed for 100 mg per day, the course of treatment is 6-12 weeks.
For the prevention of malaria appoint 100 mg once a day for 1-2 days before travel, then - daily during the trip and within 4 weeks after return; children older than 8 years - 2 mg / kg 1 time per day.
To prevent travel diarrhea - 200 mg on the first day of travel in 1 or 2 admission, then - 100 mg once a day during the stay in the region (not more than 3 weeks).
For treatment of leptospirosis - 100 mg orally 2 for 7 days; for the prevention of leptospirosis - 200 mg once a week during a stay in a dysfunctional area and 200 mg - at the end of the trip.
To prevent infections, medical abortion is prescribed 100 mg per hour before and 200 mg after the intervention.
Maximum daily doses for adults - up to 300 mg per day or up to 600 mg per day for 5 days with severe gonococcal infections. For children older than 8 years with a body weight of more than 50 kg - up to 200 mg, for children 8-12 years with a body weight of less than 50 kg - 4 mg / kg daily for the entire treatment.
In renal (KK less than 60 ml / min) and / or liver failure, a daily dose of doxycycline is required.
Side effect
- anorexia;
- nausea, vomiting;
- dysphagia;
- diarrhea;
- enterocolitis;
- pseudomembranous colitis;
- photosensitization;
- hives;
- angioedema;
- anaphylactic reactions;
- hemolytic anemia;
- thrombocytopenia;
- neutropenia;
- eosinophilia;
- Candidiasis (glossitis, stomatitis, proctitis, vaginitis) as manifestations of superinfection.
Contraindications
- severe dysfunction of the liver and / or kidney;
- porphyria;
- pregnancy;
- lactation period (breastfeeding);
- children's age till 8 years;
- hypersensitivity to antibiotics of the tetracycline group.
Application in pregnancy and lactation
Unidox Solutab is contraindicated in pregnancy.
The drug is contraindicated for use during lactation (breastfeeding). Doxycycline is excreted in breast milk.
special instructions
There is the possibility of cross-resistance and hypersensitivity with other drugs of the tetracycline series.
Tetracyclines may increase prothrombin time, the appointment of tetracyclines in patients with coagulopathies should be carefully monitored.
The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea Nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal insufficiency, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.
With prolonged use of the drug requires periodic monitoring of laboratory blood parameters, liver and kidney function.
In connection with the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.
Prolonged use of the drug Unidox Solutab can cause dysbacteriosis and as a result - the development of hypovitaminosis (especially B vitamins).
To prevent dyspeptic phenomena, it is recommended to take the drug while eating.
Impact on the ability to drive vehicles and manage mechanisms
The peculiarities of the influence on the ability to drive a car and to control mechanisms have not been investigated.
Drug Interactions
Antacids containing aluminum, magnesium, calcium, iron preparations, sodium hydrogen carbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by a 3-hour interval.
In connection with the suppression of intoxic microflora by doxycycline, the prothrombin index decreases, which requires correction of the dose of indirect anticoagulants.
When doxycilin is combined with bactericidal antibiotics that disrupt the cell wall synthesis (penicillins, cephalosporins), the efficacy of the latter is reduced, which should be taken into account in the treatment of meningitis and tonsillopharyngitis caused by Streptococcus pyogenes.
Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.
Ethanol (alcohol), barbiturates, rifampicin, carbamazepine, phenytoin, speeding up the metabolism of doxycycline, reduce its concentration in the blood plasma.
Simultaneous use of doxycycline and Retinol helps increase intracranial pressure.
Analogues of the drug Unidox Solutab
Structural analogs for the active substance:
- Bassado;
- Vibramycin;
- Widokcin;
- Dovitsin;
- Doxal;
- Doksybeene;
- Doxilan;
- Doxycycline;
- Doxycycline Nycomed;
- Stox's doxycycline;
- Doxycycline-AKOS;
- Doxycycline hydrochloride;
- Xedocine;
- Monocline.
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