PAS - instructions for use, analogs, reviews and release form (tablets of 500 mg and 1000 mg), drugs to treat tuberculosis in adults, children and in pregnancy
In this article, you can read the instructions for using the drug PASK. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of PASK in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues PASK in the presence of existing structural analogues. Use to treat various forms of tuberculosis in adults, children, as well as during pregnancy and lactation.
PASK - has a bacteriostatic effect on Mycobacterium tuberculosis.Aminosalicylic acid competes with para-aminobenzoic acid and suppresses the synthesis of folate in mycobacteria tuberculosis. The drug is active against multiplying mycobacteria, practically does not affect bacteria that are at rest or located intracellularly. Reduces the likelihood of development of resistance of mycobacteria to streptomycin and isoniazid.
Composition
Sodium para-aminosalicylate + auxiliary substances.
Pharmacokinetics
Absorption is high. Metabolised in the liver. Easily penetrates through the histogematic barriers and is distributed in tissues. High concentrations of the drug are found in the lungs, kidneys and liver. Moderately penetrates into the cerebrospinal fluid only with inflammation of the membranes, in this case the concentration of aminosalicylic acid in the cerebrospinal fluid is 10-50% of the concentration of the drug in the blood plasma. It is excreted mainly with urine (80% of the drug is excreted within 10 hours), with 50% in the form of an acetylated derivative.
Indications
- tuberculosis (various forms and localizations) in complex therapy.
Forms of release
The tablets covered with a cover, soluble in an intestine of 500 mg.
Instructions for use and dosing regimen
Inside, 0.5-1 hour after meals, washed down with boiled water.
Adults - 9-12 grams per day (3-4 grams 3 times a day), for malnourished patients with a body weight of less than 50 kg - 6 grams per day.
Children are prescribed at the rate of 0.2 g / kg per day in 3-4 divided doses, the maximum dose is 10 g per day.
In an outpatient setting, the entire daily dose can be administered in a single dose.
Side effect
- decreased appetite;
- nausea, vomiting;
- flatulence;
- abdominal pain;
- diarrhea or constipation;
- proteinuria, hematuria, crystalluria;
- thrombocytopenia, leukopenia (up to agranulocytosis);
- drug hepatitis;
- B12-deficient megaloblastic anemia;
- fever;
- dermatitis (urticaria, purpura, enanthema);
- eosinophilia;
- bronchospasm;
- hypothyroidism;
- goiter;
- myxedema.
Contraindications
- hypersensitivity;
- kidney failure;
- liver failure;
- hepatitis;
- cirrhosis of the liver;
- amyloidosis of internal organs;
- peptic ulcer of the stomach and duodenum;
- enterocolitis (exacerbation);
- Myxedema (uncompensated);
- nephritis;
- decompensated chronic heart failure (including on a background of heart disease);
- thrombophlebitis;
- hypocoagulation;
- pregnancy;
- lactation;
- children under 3 years.
Application in pregnancy and lactation
The drug is contraindicated in pregnancy and lactation.
special instructions
Used in combination with antituberculous drugs. In the treatment it is recommended to monitor the activity of hepatic transaminases.
Decreased kidney function against tuberculous intoxication or specific damage is not a contraindication to the appointment. The development of proteinuria and hematuria require a temporary discontinuation of the drug.
Drug Interactions
PASK is compatible with other antituberculous drugs. When combined with Isoniazid increases its concentration in the blood. Violates the absorption of rifampicin, Erythromycin and lincomycin. It interferes with the absorption of vitamin B12 (the risk of anemia increases).
When combined with capreomycin, it is possible to increase electrolyte disturbances, decrease the potassium concentration and pH. Increases the concentration of isoniazid in the blood, reducing its acetylation. Enhances the effect of derivatives of coumarin and indanedione due to a decrease in the synthesis of liver coagulation factors in the blood (correction of the dose of anticoagulants is required). Do not use together with pyrazinamide and ammonium chloride.Probenecid and sulfinpyrazone reduce tubular secretion, increasing the concentration of aminosalicylic acid in the blood and the risk of toxic effects. The risk of developing hypothyroidism increases with simultaneous administration with ethionamide and protionamide.
Cross-sensitivity to compounds containing a para-aminophenyl group (some sulfonamides and dyes) is possible.
Analogs of the drug PASK
Structural analogs for the active substance:
- Aquapasque;
- Aminosalicylic acid;
- IAC-PAS;
- Monopas;
- Sodium para-aminosalicylate;
- Paser;
- Para-aminosalicylate sodium;
- PAS Sodium;
- PAS-Fatol H;
- PASK-Acry;
- Pasconat;
- Simpas.
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