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Sirdalud - instructions for use, reviews, analogs and formulations (2 mg and 4 mg tablets, 6 mg capsules) medications for the treatment of muscle spasms in various diseases in adults, children and pregnancy

Sirdalud - instructions for use, reviews, analogs and formulations (2 mg and 4 mg tablets, 6 mg capsules) medications for the treatment of muscle spasms in various diseases in adults, children and pregnancy

In this article, you can read the instructions for using the drug Sirdalud. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Sirdalud in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sirdalud in the presence of existing structural analogues. Use to treat muscle spasm in various diseases in adults, children, as well as during pregnancy and lactation.Joint reception of alcohol and medicine.

 

Sirdalud - Muscle relaxant of central action. Reduces the increased tone of skeletal muscles, relieves their spasm; reduces the resistance of muscles with passive movements, increases the force of arbitrary contractions. The muscle-relaxing effect of tizanidine (the active substance of the preparation of Sirdalud) is probably due to the suppression of spinal polysynaptic reflexes, which is associated with a decrease in the release of excitatory amino acids from presynaptic terminals of spinal interneurons, as well as stimulation of alpha2-adrenergic receptors. Tizanidine does not affect the transmission of excitation in the neuromuscular synapses.

 

Pharmacokinetics

 

When taken orally, Syrdalud is absorbed almost completely. Long-term release of tizanidine from the dosage form of the modified-release MP capsule results in a "relaxed" pharmacokinetic profile, which maintains a stable therapeutic concentration of tizanidine in the blood plasma for 24 hours. Tizanidine is rapidly and largely metabolized in the liver. Tizanidine is excretedmainly kidneys (approximately 70% of the dose) in the form of metabolites; the share of unchanged substance accounts for only about 2.7%.

 

Sex does not affect the pharmacokinetic parameters of tizanidine.

 

Indications

  • the spastic condition of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord);
  • consequences of cerebral circulation and cerebral palsy (patients over 18 years of age);
  • painful spasm of skeletal muscles, caused by spinal cord injury (cervical and lumbar syndrome) or arising after surgery (for herniation of the intervertebral disc or arthrosis of the hip).

 

Forms of release

 

Tablets 2 mg and 4 mg.

 

Capsules with modified release MP 6 mg.

 

Instructions for use and dosing regimen

 

Pills

 

To stop the painful spasm of skeletal muscles, apply 2-4 mg 3 times a day; in severe cases it is recommended to take 2-4 mg for the night. With spasmodic conditions of muscles caused by neurological diseases, the initial dose is 6 mg per day in 3 divided doses. The dose is gradually increased by 2-4 mg per day every 3-7 days.The optimal therapeutic effect is usually achieved at a dose of 12-24 mg per day, divided into 3-4 doses. Do not exceed the dose of 36 mg per day.

 

Capsules

 

The drug is prescribed inside. The dosage regimen should be set individually.

 

The initial daily dose is 6 mg (1 capsule). If necessary, the daily dose can be gradually ("steps") increased - by 6 mg (1 capsule) at intervals of 3-7 days. Clinical experience shows that for most patients the optimal dose is 12 mg per day (2 capsules); In rare cases, an increase in the daily dose to 24 mg may be required.

 

Treatment of patients with renal insufficiency (CK <25 ml / min) is recommended to start with taking Sirdalud in a dose of 2 mg 1 time per day. Increase the dose in small "steps", taking into account the portability and effectiveness. If it is necessary to obtain a more pronounced effect, it is recommended first to increase the dose prescribed once a day, after which increase the multiplicity of the appointment.

 

Side effect

  • drowsiness;
  • weakness;
  • dizziness;
  • hallucinations;
  • insomnia;
  • sleep disorders;
  • bradycardia;
  • a decrease in blood pressure;
  • a marked decrease in blood pressure until collapse and loss of consciousness;
  • dry mouth;
  • nausea;
  • gastrointestinal disorders;
  • muscle weakness;
  • increased fatigue.

 

Contraindications

  • severe liver dysfunction;
  • simultaneous application with strong inhibitors of CYP1A2 isoenzymes (including fluvoxamine or ciprofloxacin);
  • hypersensitivity to tizanidine or to any other component of the drug.

 

Application in pregnancy and lactation

 

Since controlled trials of tizanidine in pregnant women have not been performed, it should not be used in pregnancy, unless the potential benefit exceeds the potential risk.

 

Sirdalud excreted in breast milk in small amounts. Nevertheless, women who breastfeed children should not use the drug.

 

Use in children

 

The use of Sirdalud in children is not recommended. the experience of using the drug in children is limited.

 

special instructions

 

Reported cases of violations of liver function associated with tizanidine, but with a daily dose of up to 12 mg, these cases were rare. In this regard, it is recommended to monitor functional liver function tests once a month in the first 4 months of treatment in those patients,which is prescribed tizanidine at a daily dose of 12 mg and above, and also in those cases when there are clinical signs suggesting a violation of liver function, such as unexplained nausea, anorexia, a feeling of fatigue. In the case when the levels of ALT and AST in the serum persistently exceed the VGN by 3 times or more, the use of Sirdalud should be discontinued.

 

Do not abruptly cancel Sirdalud, the dose of the drug is reduced gradually.

 

With the sharp cancellation of Sirdalud after prolonged treatment and / or taking high doses of the drug (and also after simultaneous use with antihypertensive medications), development of tachycardia and an increase in blood pressure were noted, which in some cases can lead to acute impairment of cerebral circulation.

 

Care should be taken when using Sirdalud in patients with renal insufficiency. When using Sirdalud in patients with renal insufficiency (KC less than 25 ml / min), correction of the dosing regimen is necessary.

 

Care should be taken when using Sirdalud in elderly patients. The experience of using Sirdalud in elderly patients is limited.Based on pharmacokinetic data, it can be assumed that in some cases, renal clearance in these patients can be significantly reduced.

 

Impact on the ability to drive vehicles and manage mechanisms

 

With the development of drowsiness, dizziness or lowering blood pressure on the background of Sirdalud therapy, one should refrain from types of work requiring high concentration of attention and quick reaction, for example, driving or working with machinery.

 

Drug Interactions

 

When using Sirdalud together with inhibitors of the isoenzyme CYP1A2, an increase in the concentration of tizanidine in the blood plasma is possible.

 

The simultaneous use of tizanidine with fluvoxamine or ciprofloxacin, inhibitors of the 1A2 cytochrome P450 isoenzyme results in a 33-fold or 10-fold increase in the aUC of tizanidine. The result of a combined application may be a clinically significant and prolonged decrease in blood pressure, leading to drowsiness, weakness, inhibited psychomotor reactions (in some cases, up to collapse and loss of consciousness). The simultaneous use of tizanidine with fluvoxamine or Ciprofloxacin is contraindicated.

 

It is not recommended simultaneous administration of Sirdalud with other inhibitors of the isoenzyme CYP1A2 - antiarrhythmic drugs (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (enoxacin, pefloxacin, ciprofloxacin, norfloxacin), rofecoxib, oral contraceptives, ticlopidine.

 

Simultaneous appointment of Sirdalud with antihypertensive drugs, including diuretics, can sometimes cause a decrease in blood pressure (in some cases, up to collapse and loss of consciousness) and bradycardia.

 

Ethanol (alcohol) or sedatives can enhance the sedative effect of Sirdaluda, therefore, concomitant use with other sedatives and / or alcohol is not recommended.

 

Analogues of the drug Sirdalud

 

Structural analogs for the active substance:

  • Sirdalud MR;
  • Tisaloud;
  • Tizanidine hydrochloride;
  • Tizanil.

Similar medicines:

Other medicines:

Reviews (16):
Administrators
admin
According to recent studies of the effect of the active substance Sirdalud, Tizanidine in doses exceeding permissible 2-fold caused in experimental rats negative effects on the reproductive system of these animals. In particular, there was an increase in the period of pregnancy, an increase in the death of cubs, a delay in development.
Guests
Galina
Sirdalud helps me very well from insomnia. I drink 1 table. at night, wake up in the morning vigorous and sleepy.
Guests
Tatyana
Sirdalud was putting pressure on me. It was very high!
Guests
Alicia
We prescribed sirdalud for the treatment of osteochondrosis of the spine. There was a strong spasm of muscles, at first the doctor pricked diprospan, and then he prescribed these pills. As soon as the effect of the injection of improvements was passed, I did not feel any further, although I took these pills as prescribed for a minimum of two weeks. Well, at least there were no side effects, but they are horrible here.
Guests
Galina
Hello. At me an osteochondrosis of a cervical department. Have written out these capsules of 6 mg. 1 capsule in the evening 10 days. I began to drink them, on the first day I had a fever of 38.2, I felt sleepy, there was fever, lost speech, pain in the lower back (there are chronic diseases: renal failure and vegetovascular dystonia, tachycardia).
Visitors
ale5721
Hello. At me an osteochondrosis of a cervical and lumbar departments of a backbone. The neurologist persistently prescribes sirdalud to me for 1t. x 2p.v day. I explain that in addition to insomnia, I have a severe headache, and the doctor does not believe. He says it does not happen. Explain, please, the reason for the pain, is there such a thing, are there analogs without this factor? Thank you.
Administrators
admin
ale5721Does your doctor's sleeplessness do not bother you? Why do you need to prove something to a specialist who rested on one medicine (good, but that does not suit you, because it causes side effects) and only he appoints everyone in a row. Find a doctor who reads the instructions and knows more drugs.

Analogues on the active substance in Sirdaluda a little, most likely these side effects will be inherited by generics, so you need to understand the diagnosis and prescribe drugs from related groups.
Guests
Victoria
A terrible drug! Insomnia, increased pressure, headache increased, pain in the cervical spine increased.
Guests
Lyudmila
Well, there can not be pressure from Sirdalud, well, it can not. With increased pressure, spasm begins, and in Sirdalud another purpose is to relieve the spasm. Yes, I believe in insomnia, although I have drowsiness. Sometimes I did not sleep, nothing helped, not even Relanium. Well, how do you fall asleep, if it hurts, and spasms in the neck? Though on the wall. I have known Sirdalud for a long time, 15 years old. Then, of course, I was younger. I'm a hairdresser, so I'm suffering with the neck. Sometimes it was impossible to turn around. At night 2 mg and in the morning person. Although I have a rare pulse in life, but there was no pimples. Now I'm 70 and gently and more side-by-side, but only Sirdalud can help. Do not get carried away and do not finish sharply, and start with a small dose. It's a wand-rescue.Long do not drink 2-3 days with a decrease in dose. But we are all different. And bouquets of diseases, and nerves, and everyone's life is different. Be attentive to yourself! And all health.
Guests
Natal'ch
A terrible drug. At me cervical osteochondrosis, have written out this preparation. After the first reception there was a terrible drowsiness, strong dizziness, constantly it would be desirable to drink. The feeling, as if suppressed, the shoulders were so heavy.
Guests
vassyl
An excellent product. It helps from everything.
Guests
Yana
Hello. I was prescribed this drug for the first time. It tortures cervical osteochondrosis. But he greatly reduced AD. I'm afraid to take it further ...
Guests
Afro D
The drug Sirdalud except drowsiness in the early days, I did not find any effects.
Guests
Love
At me an osteochondrosis of a backbone, not often, but I accept on purpose of the doctor Sirdalud. He helps me, but I try not to take it for more than a week. It is very important that doctors correctly select the drugs and listen to your body. I wish everyone good health.
Guests
JuliaMamma Pingvina
In 25 years, after a stroke, I was prescribed this drug. Within 20 minutes, consciousness was changed and speech was confused and lethargic, even a spoon could not take everything by (doubled) and did not immediately realize that something was wrong. And was on consultation of the neurologist in other city, one. The doctor said that as soon as I left the room, I immediately went to the pharmacy, bought this medicine, drank it and, supposedly, immediately feel like another person (apparently meant that it would be easy and good))) ... Yes! Feeled, but not healthy and cheerful person, as promised, but a specific dodick))) another neurologist advised me to drink this medicine for the night, but I have not decided yet. It's frightening, damn it, not to wake up, or to wake up as a dodder forever =))) does not suit everyone in general, that's what I wanted to say. Take care of yourself and your loved ones. Be careful.
Guests
GALINA
Decrease in pressure, then a sharp increase. I was always thirsty. There was no strength. Severe dizziness. The doctor lowered the dose of Sirdalud, but I'm afraid.

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