Vinpocetine - instructions for use, reviews, analogs and formulations (tablets 5 mg and 10 mg forte, injections in ampoules for injection) of a drug for the treatment of vascular diseases in adults, children and pregnancy
In this article, you can read the instructions for using the drug Vinpocetine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Vinpocetine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Vinpocetin analogs in the presence of existing structural analogues. Use to treat the effects of stroke and other vascular diseases in adults, children,as well as during pregnancy and lactation.
Vinpocetine vasodilator drug. Improves the metabolism of the brain, increasing the intake of glucose and oxygen by brain tissue. Increases the resistance of neurons to hypoxia; facilitates the transport of glucose to the brain, through the BBB; translates the process of the decay of glucose into an energetically more economical, aerobic pathway; selectively blocks Ca2 + -dependent phosphodiesterase; increases the content of adenosine monophosphate (AMP), cyclic guanosine monophosphate (cGMP), ATP, norepinephrine, serotonin and the ratio of ATP / AMP in the brain tissues; has an antioxidant effect.
Reduces platelet aggregation and increased blood viscosity; increases the deforming ability of erythrocytes and blocks the utilization of adenosine by red blood cells; helps to increase the return of oxygen in the erythrocytes.
Increases cerebral blood flow; reduces the resistance of cerebral vessels without a significant change in the indices of the systemic circulation. Does not have the effect of "stealing" and enhances blood supply, especially in ischemic areas of the brain.
Composition
Vinpocetine + auxiliary substances.
Pharmacokinetics
Quickly absorbed.Absorption occurs mainly in the proximal parts of the gastrointestinal tract. When passing through the wall of the intestine is not exposed to metabolism. It is excreted by the kidneys and through the intestine in a ratio of 3: 2. Penetrates through the placental barrier.
Indications
- neurological and mental symptoms in various forms of cerebral circulatory insufficiency (including the recovery stage of ischemic or hemorrhagic stroke, the consequences of a stroke, transient ischemic attack, vascular dementia, vertebrobasilar insufficiency, cerebral atherosclerosis, posttraumatic and hypertensive encephalopathy);
- chronic vascular diseases of the choroid and retina (due to arteriosclerosis, angiospasm, thrombosis); degenerative changes in the macula caused by atherosclerosis or angiospasm; secondary glaucoma (due to vascular obturation);
- age-related vascular or toxic (medicamentous) hearing disorders, Meniere's disease, idiopathic tinnitus, dizziness of labyrinthine origin;
- vasovegetative manifestations of climacteric syndrome.
Forms of release
Tablets 5 mg.
Tablets 10 mg fort.
Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).
Instructions for use and dosing regimen
Pills
Inside for 5 mg (1 tablet) after eating. The drug is applied 3 times a day. The initial daily dose is 15 mg. The maximum daily dose is 30 mg. Duration of treatment to 3 months. Possible repeated courses 2-3 times a year.
In diseases of the kidneys or liver, the drug is prescribed in the usual dose.
Before cancellation, the dosage of the drug should be gradually reduced.
Ampoules
Intravenously drip (infusion rate should not exceed 80 cap / min). The initial daily dose is 20 mg (dissolve in 0.5-1 L 0.9% solution of sodium chloride or solutions containing dextrose). The average daily dose at a body weight of 70 kg is 50 mg. With good tolerability for 2-3 days, the dose is raised to the maximum - 1 mg / kg per day. The course of treatment is 10-14 days. After achieving the improvement, they switch to taking the drug inside.
Side effect
- ECG change (ST depression, QT interval prolongation);
- tachycardia;
- extrasystole;
- lability of blood pressure;
- sensation of tides;
- sleep disorders (insomnia, increased drowsiness);
- dizziness;
- headache;
- general weakness;
- increased sweating;
- dry mouth;
- nausea;
- heartburn;
- skin allergic reactions.
Contraindications
- acute phase of hemorrhagic stroke, CHD, severe arrhythmias;
- pregnancy (possibly placental bleeding and spontaneous abortion, probably as a result of increased placental blood supply);
- lactation period (when using the drug, it is necessary to stop breastfeeding);
- children under 18 years of age (due to insufficient data);
- hypersensitivity to any of the components of the drug;
- intolerance to galactose;
- deficiency of lactase;
- glucose-galactose malabsorption.
special instructions
The presence of the syndrome of the prolonged QT interval and the use of drugs that cause prolongation of the QT interval requires periodic monitoring of the ECG.
Impact on the ability to drive vehicles and manage mechanisms
Data on the effect of vinpocetine on the ability to drive a car and perform work that requires speed of psychomotor reactions is not.
Drug Interactions
Interactions are not observed with simultaneous use with beta-blockers (chloranolol, pindolol), clopamid, glibenclamide, digoxin, acenocoumarol and hydrochlorothiazide, imipramine.
The simultaneous use of vinpocetine and methyldopa sometimes caused some strengthening of the hypotensive effect, so this treatment requires regular monitoring of blood pressure.
Increases the risk of hemorrhagic complications against Heparin therapy.
Despite the lack of data confirming the possibility of interaction, it is recommended to exercise caution when concurrently administering with the drugs central, antiarrhythmic and anticoagulant action.
Analogues of the drug Vinpocetine
Structural analogs for the active substance:
- Bravinton;
- Vero-Vinpocetine;
- Vinpoton;
- Vinpocetine forte;
- Vinpocetine AKOS;
- Vinpocetine Acry;
- Vinpocetine ESKOM;
- Vincetin;
- Cavinton;
- Cavinton forte;
- Teletext.
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