Antigrippin - instructions for use, reviews, analogs and forms of release (powder for the preparation of solution, effervescent tablets, Maxi capsules and Anv) for the treatment of influenza and ARVI in adults, children and pregnancy. Alcohol

In this article, you can read the instructions for using the drug Antigrippin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Antigrippin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogrypin analogs in the presence of existing structural analogues.Use to treat influenza and ARVI in adults, children, as well as during pregnancy and lactation. Joint intake of the drug and alcohol. Composition.

Antigrippin combined preparation.

Paracetamol has an analgetic and antipyretic effect; eliminates headache and other types of pain, reduces fever.

Ascorbic acid (vitamin C) is involved in the regulation of oxidation-reduction processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine is a blocker of H1-histamine receptors, has an antiallergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Rutoside (rutin) is an angioprotector. Reduces the permeability of capillaries, reduces swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of erythrocyte deformation.

Metamizole sodium has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of the synthesis of prostaglandins.

Diphenhydramine has an anti-allergic, anti-edematous effect.Reduces the permeability of blood vessels, eliminates swelling and flushing of the nasal mucosa, reduces perspiration in the throat and manifestations of allergic reactions from the upper respiratory tract.

Calcium gluconate is a regulator of calcium and phosphorus metabolism, reduces vascular permeability. In allergic diseases or conditions, its combined use with antihistamines is recommended.

Rimantadine is an antiviral agent that is active against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release the ribonucleoprotein, thereby inhibiting the most important stage of viral replication. It induces the production of interferons alpha and gamma. With influenza caused by virus B, rimantadine exerts an antitoxic effect.

Composition

Paracetamol + Chlorphenamine maleate + Ascorbic acid + excipients (Antigrippin Natur product).

Ascorbic acid + Acetylsalicylic acid + Rutozide + auxiliary substances (Antigrippin ARVI).

Diphenhydramine + Calcium gluconate + Metamizole sodium + excipients (Antigrippin ARVI).

Paracetamol + Rimantadine hydrochloride + Ascorbic acid + Loratadine + Rutoside (in the form of trihydrate) + Calcium gluconate monohydrate + excipients (Antigrippin Maximum).

Acetylsalicylic acid + Ascorbic acid + Rutozide + auxiliary substances (Antigrippin Anvi).

Metamizol sodium + Diphenhydramine hydrochloride + Calcium gluconate monohydrate + excipients (Antigrippin Anvi).

Pharmacokinetics

Paracetamol

Absorption is high. Penetrates through the blood-brain barrier (BBB). It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

Rimantadine

After oral administration, it is almost completely absorbed from the intestine. Absorption is slow. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - in unchanged form.

Ascorbic acid

Ascorbic acid is absorbed from the digestive tract (mainly in the jejunum). Easily penetrates into leukocytes, platelets, and then into all tissues; the greatest concentration is achieved in glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier.The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in plasma. With deficient states, the concentration in leukocytes decreases later and more slowly and is considered as the best criterion for assessing the deficit than the concentration in the plasma. It is excreted by the kidneys, through the intestine, with sweat in unchanged form and in the form of metabolites.

Smoking and the use of ethanol (alcohol) accelerate the destruction of ascorbic acid (conversion into inactive metabolites), drastically reducing stocks in the body.

Loratadin

After oral administration, it is quickly and completely absorbed from the digestive tract. Does not penetrate the BBB. It is excreted by the kidneys and with bile.

Rutozid

It is excreted mainly with bile and, to a lesser extent, kidneys.

Calcium gluconate

Approximately 1 / 5-1 / 3 part of the orally administered calcium gluconate is absorbed into the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) is through the intestines.

Indications

• Infectious and inflammatory diseases (acute respiratory viral infection, influenza) accompanied by fever, chills, headache, joint and muscle pains, nasal congestion and pains in the throat and sinuses of the nose.

Forms of release

Powder for solution for oral administration (Natur Product).

Tablets are effervescent for adults and children (Natur Product).

Capsules (Antigrippin Anvi, Maximum and SARS).

Powder for solution for oral administration (Antigrippinum Maximum).

Instructions for use and reception scheme

Antigrippin Natur product

Inside. Adults and children over 15 years of age per 1 packet 2-3 times a day. The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution immediately drunk. It is better to take the drug between meals. The maximum daily dose is 3 sachets. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses should be at least 8 hours.

Duration of admission without consulting a doctor is no more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

Antigrippin the Maximum

The drug should be taken orally after a meal.

Adults Antigrippin-maximum capsules are prescribed 1 capsule of blue and 1 capsule of red color 2-3 times a day until the symptoms disappear. Capsules are washed down with water.

Adults and children over 12 years Antigrippin-maximum in the form of powder to prepare a solution for oral administration apply 1 packet 2-3 times a day until the symptoms disappear. Preparation of the solution: dissolve the contents of 1 sachet in 1 glass of boiled hot water. Use in hot form, pre-stirring.

The duration of treatment is 3-5 days (not more than 5 days). If within 3 days after starting the use of the drug, there is no improvement in the state of health, the patient should stop taking the drug and consult a doctor.

Antigrippin Anvi

The drug is prescribed to adults and adolescents older than 15 years for 2 capsules per reception: 1 green capsule (from blister A) and 1 white capsule (from blister B).

Duration of admission is 3-5 days before the disappearance of the symptoms of the disease.

Capsules are taken orally 2-3 times a day after meals, washed down with water. The patient should be warned that if there is no improvement in the state of health, the drug should be stopped and consult a doctor.

Side effect

• anorexia;
• nausea, vomiting;
• gastralgia;
• diarrhea;
• erosive and ulcerative lesions of the gastrointestinal tract;
• gastrointestinal bleeding;
• liver failure;
• increased blood pressure;
• tachycardia;
• skin rash;
• angioedema;
• bronchospasm (with propensity to bronchospasm may provoke an attack);
• kidney failure;
• thrombocytopenia, agranulocytosis, leukopenia;
• dizziness;
• headache;
• visual impairment;
• noise in ears;
• deafness;
• hemorrhagic syndrome (including nasal bleeding, gum bleeding, purpura);
• anaphylactic shock;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis (Lyell's syndrome);
• kidney damage with papillary necrosis;
• impaired renal function;
• oliguria;
• anuria;
• proteinuria;
• interstitial nephritis;
• staining the urine in red by excretion of the metabolite;
• in children - Reye's syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction).

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);
• gastrointestinal bleeding;
• increased tendency to bleeding;
• bronchial asthma and diseases accompanied by bronchospasm (including "aspirin" asthma);
• oppression hemopoiesis (agranulocytosis, neutropenia, leukopenia);
• hemorrhagic diathesis (hemophilia, von Willebrand's disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
• deficiency of vitamin K;
• severe violations of liver function;
• portal hypertension;
• severe renal dysfunction;
• hereditary hemolytic anemia (including associated with deficiency of glucose-6-phosphate dehydrogenase);
• exfoliating aortic aneurysm;
• hypercalcemia (concentration of calcium ions should not exceed 12 mg% or 6 meq / l);
• hypercalciuria;
• nephrolithiasis (calcium);
• sarcoidosis;
• glycoside intoxication (risk of arrhythmia);
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation (breastfeeding);
• children and adolescence up to 15 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy. If necessary, appointments during lactation should stop breastfeeding for the period of use of the drug.

Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads todevelopment of cleavage of the upper sky; in the third trimester - to premature closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circle of blood circulation, and to inhibition of labor (due to inhibition of the synthesis of prostaglandins).

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function.

Use in children under 12 years of age

Contraindicated: children and adolescence under 15 years. The drug is not prescribed as an antipyretic agent for children under the age of 15 with acute respiratory viral diseases because of the danger of developing Reye syndrome (Reynaud) (encephalopathy and acute fatty liver dystrophy with acute development of liver failure).

special instructions

When the drug is used for a long time, it is necessary to monitor the pattern of peripheral blood and laboratory indicators of the functional state of the liver.

Since acetylsalicylic acid has an antiaggregant effect, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid, which can in some cases provoke a gout attack.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

In patients with bronchial asthma and pollinosis when taking the drug may develop reactions of increased sensitivity.

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the kidneys and blood pressure.

It is not recommended to prescribe a drug with anticoagulants, glucocorticosteroids, ticlopidine, uricosuric and antihypertensive agents.

Ascorbic acid can distort the results of various laboratory tests (determination of glucose, bilirubin and activity of hepatic transaminases, LDH in blood plasma).

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during the use of metamizole sodium.

Against the background of the drug, patients should avoid drinking alcohol because of the increased risk of developing gastrointestinal bleeding.

Impact on the ability to drive vehicles and manage mechanisms

During the period of drug use, one should refrain from engaging in potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of Antigrippin enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents.

With the simultaneous use of Antigrippin reduces the effectiveness of spironolactone, furosemide, antihypertensive and uricosuric agents.

Antigrippin enhances the side effects of glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

With the simultaneous use of the drug Antigrippin with barbiturates, antiepileptic drugs, zidovudine, rifampicin and ethanol-containing drugs, the risk of hepatotoxic effect increases. These combinations should be avoided.

Metamizol sodium

Tricyclic antidepressants, oral contraceptives and Allopurinol disrupt metamizole metabolism in the liver and increase its toxicity.

Simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in blood plasma.

Sedatives and tranquilizers increase the analgesic effect of metamizole sodium.

With simultaneous use with metamizole sodium thiamazole and melphalan increase the risk of developing leukopenia.

Metamizole sodium enhances the effects of alcohol-containing beverages.

Ascorbic acid

• increases the concentration in the blood of benzylpenicillin and tetracyclines;
• improves absorption in the intestine of iron preparations (converts trivalent iron into bivalent); can increase excretion of iron with simultaneous application with deferoxamine;
• increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood;
• increases the total clearance of ethanol (alcohol);
• with simultaneous use reduces the chronotropic effect of isoprenaline.

Can both increase and decrease the effect of anticoagulant drugs.Reduces the therapeutic effect of antipsychotics (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Simultaneous reception of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate

Chlorphenamine maleate enhances the effect of hypnotic drugs.

Antidepressants, antiparkinsonian agents, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids - increase the risk of developing glaucoma. Ethanol (alcohol) enhances the sedative effect of chlorphenamine maleate.

Paracetamol

In the reaction of Paracetamol and inducers of hepatic microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increased production of active hydroxylated metabolites, which makes the possibility of severe intoxication with small overdoses.

Against the background of taking paracetamol, ethanol (alcohol) contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects.

Simultaneous reception of diflunisal and paracetamol increases the concentration in the blood plasma of the latter by 50%, increasing hepatotoxicity. Simultaneous reception of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs.

Analogues of the drug Antigrippin

Structural analogs for the active substance:

• Antiflu Kids.

Analogues for the pharmacological group and the therapeutic effect:

• Akamol-Teva;
• Aldolor;
• Antigrippin Maximum;
• Antigrippin Anvi;
• Apap;
• Acetaminophen;
• GrippoFlu;
• Daleron;
• Children's Panadol;
• Children's Tylenol;
• Influenza;
• Ithymol;
• Kalpol;
• Coldrex;
• Xoomapar;
• Lupocet;
• Mexalen;
• Pamol;
• Panadol;
• Paracetamol;
• Pentalgin;
• Perfalgan;
• Prostudox;
• Pro-Efferalgan;
• Prohodol;
• Rince;
• Sanidol;
• Strymol;
• Tylenol;
• Tylenol for infants;
• Teraflu;
• Febricet;
• Fervex;
• Cefekon D;
• Efferalgan.

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