Klostilbegit - instructions for use, reviews, analogs and forms of release (tablets 50 mg) drugs to stimulate ovulation and infertility in men and women, including during pregnancy and lactation. Side effects after taking

In this article, you can read the instructions for using the drug Clostilbite. The reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Klostilbegit in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Klostilbegit in the presence of existing structural analogs.Use to stimulate ovulation and infertility in men and women, as well as during pregnancy and lactation. Side effects after taking the drug.

Clostilbite - antiestrogenic drug of nonsteroidal structure. The mechanism of action is due to specific binding to the estrogen receptors of the ovaries and the pituitary gland. With a low content in the body, estrogen shows a moderate estrogenic effect, with a high content - antiestrogenic effect. In small doses increases the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation; in high doses inhibits the secretion of gonadotropins. Has no genetic and androgenic activity.

Composition

Clomiphene citrate + auxiliary substances.

Pharmacokinetics

After taking the drug inside, Klostilbegit is well absorbed from the digestive tract. Clomiphene is metabolized in the liver. Undergoes intestinal-hepatic recirculation. It is excreted mainly with bile.

Indications

• anovulatory infertility (induction of ovulation);
• amenorrhea (disgonadotropic form);
• secondary amenorrhea;
• postcontraceptive amenorrhea;
• Stein-Levental syndrome (polycystic ovary syndrome);
• oligomenorrhoea;
• galactorrhea (against a background of a pituitary tumor);
• Chiari-Frommel syndrome (a syndrome of prolonged postpartum amenorrhea-galactorrhea);
• androgen insufficiency;
• in men: oligospermia.

Forms of release

Tablets 50 mg.

Instructions for use and reception scheme

Infertility dose and duration of treatment depend on the sensitivity (response to the drug) of the ovaries.

Patients with a regular menstrual cycle are advised to start treatment on the 5th day of the cycle (or on the 3rd day of the cycle with early ovulation or the duration of the follicular phase is less than 12 days). With amenorrhea, treatment can be started any day.

Scheme 1: 50 mg per day for 5 days with simultaneous control of ovarian response with clinical and laboratory studies. Ovulation usually occurs between 11 and 15 days of the cycle. If such treatment does not lead to ovulation, then scheme 2 should be used.

Scheme 2: from the 5th day of the next cycle, 100 mg per day is administered for 5 days. If at this time ovulation is not observed, then you should repeat the same scheme (100 mg per day). In case of continuing anovulation, the drug should be discontinued for 3 months, and then repeated for 3 months.If the second course is ineffective, subsequent treatment with the drug is also not effective. The maximum total dose of the drug taken during each course is 750 mg.

In the syndrome of polycystic ovary, due to the tendency to hyperstimulation, the initial dose of the drug is 50 mg per day.

With postcontraceptive amenorrhea, the drug should be given at a dose of 50 mg per day daily. As a rule, when applying scheme 1, a five-day course of treatment is successful.

For men, according to the indications, the drug is prescribed 50 mg 1-2 times a day for 6 weeks under a systematic control of the spermogram.

Side effect

• nausea, vomiting;
• gastralgia;
• flatulence;
• diarrhea;
• increased appetite;
• headache;
• dizziness;
• drowsiness;
• slowing of mental and motor reactions;
• increased excitability;
• depression;
• insomnia;
• visual impairment (including a violation of light perception, doubling, blurriness of contours, photophobia);
• increased frequency of urination;
• polyuria;
• pain in the lower abdomen;
• dryness of the vagina;
• mammary gland tightening;
• dysmenorrhea;
• abnormal uterine bleeding;
• increase in the size of the ovary (including cystic);
• tenderness in the mammary glands;
• increases the likelihood of multiple pregnancy, ectopic pregnancy, endometriosis, the growth of existing uterine fibroid;
• alopecia;
• increase or decrease in body weight;
• rash;
• hives;
• allergic dermatitis;
• sensations of a tide of blood to the face with a feeling of heat (they stop after the end of taking the drug).

Contraindications

• hepatic and / or renal insufficiency;
• ovarian cyst (with the exception of polycystic ovary syndrome);
• tumor or hypofunction of the pituitary gland;
• thyroid dysfunction;
• disorders of adrenal function;
• metrorrhagia of unclear etiology;
• long-existing or newly developed visual impairment;
• neoplasm of genital organs;
• endometriosis;
• failure of ovarian function against hyperprolactinemia;
• pregnancy;
• lactation (breastfeeding);
• intolerance to galactose, lactase deficiency or malabsorption of glucose;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Contraindicated use during pregnancy and during breastfeeding.

special instructions

Before starting the drug is recommended to investigate the function of the liver.

Before the start of treatment should be a thorough gynecological examination. Treatment begins when the total content of gonadotropin in the urine is normal or below the lower limit of the norm, the condition of the ovaries with palpation is normal, the functions of the thyroid gland and adrenal glands are normal.

In the absence of ovulation, all other possible forms of infertility should be excluded or cured prior to the use of the drug.

If there is an increase in the ovaries or cystic changes, the treatment should be stopped until the size of the ovaries returns to normal. In the future, the reception can be resumed, but at the same time reduce the dose of the drug or the duration of treatment.

During the treatment, constant monitoring of the gynecologist is necessary, ovarian functions should be monitored, vaginal examinations should be performed, and the phenomenon of "pupil" should be observed. Often during the course of treatment, it is difficult to determine the moment of ovulation, and often the lack of a yellow body. Therefore, after conception, prophylactic treatment with Progesterone is recommended.

Increases the likelihood of multiple pregnancy.

The drug is contraindicated in patients with intolerance to galactose, lactase deficiency or malabsorption of glucose, tk. each tablet contains 100 mg of lactose.

Impact on the ability to drive vehicles and manage mechanisms

Because the drug can cause visual impairment, patients should be cautious when driving vehicles and engaging in other potentially hazardous activities during the treatment period that require increased attention and speed of psychomotor reactions.

Drug Interactions

Compatible with preparations of gonadotropic hormones.

Analogues of the drug Klostilbegit

Structural analogs for the active substance:

• Clomid;
• Clomiphene;
• Serofen;
• Serpafar.

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