Cerebrolysin - instructions for use, reviews, analogs and formulations (injections in ampoules for intravenous and intramuscular injections of 1 ml, 5 ml, 10 ml and 30 ml) of the drug for the treatment of brain injuries in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Cerebrolysin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Cerebrolysin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cerebrolysin in the presence of existing structural analogues.Use to treat stroke and brain damage in adults, children, as well as during pregnancy and lactation.

Cerebrolysin - Nootropic preparation.

Cerebrolysin contains low molecular weight biologically active neuropeptides that penetrate the blood-brain barrier and directly enter the nerve cells. The drug has an organ-specific multimodal effect on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

Metabolic regulation: Cerebrolysin improves the efficiency of aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain.

Neuroprotective action: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, increases the experience and prevents the death of neurons in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate).

Neurotrophic activity: Cerebrolysin is the only nootropic peptidergic drug with proven neurotrophic activity,similar to the action of natural factors of neuronal growth (NGF), but manifested in conditions of peripheral administration.

Functional neuromodulation: the drug has a positive effect in the violation of cognitive functions, improves concentration of attention, memorization processes.

Pharmacokinetics

The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional action, does not allow for a routine pharmacokinetic analysis of individual components.

Indications

• Alzheimer's disease;
• a syndrome of dementia of various genesis;
• chronic cerebrovascular insufficiency;
• ischemic stroke;
• traumatic brain and spinal cord injuries;
• mental retardation in children;
• hyperactivity and attention deficit in children;
• endogenous depression, resistant to antidepressants (as part of complex therapy).

Forms of release

Solution for injection 1 ml, 5 ml, 10 ml and 30 ml (injections in ampoules).

Instructions for use and dosage

The drug should be used parenterally (intravenously or intramuscularly).The dose and duration of use depend on the nature and severity of the disease, as well as the age of the patient. A single administration of the drug in a dose of up to 50 ml is possible, but a course of treatment is more preferable.

The recommended course of treatment is a daily injection for 10-20 days:

• Acute conditions (ischemic stroke, craniocerebral trauma, complications of neurosurgical operations) - from 10 ml to 50 ml.
• In the residual period of cerebral stroke and traumatic damage of the brain and spinal cord - from 5 ml to 50 ml.
• Psycho-organic syndrome and depression - from 5 ml to 30 ml.
• Alzheimer's disease, dementia of vascular and combined alzheimer's-vascular genesis - from 5 ml to 30 ml.
• In neuropediatric practice (in children) - 0.1-0.2 ml / kg of body weight.

To improve the effectiveness of treatment, repeated courses can be conducted as long as there is an improvement in the patient's condition due to treatment. After the first course, the frequency of injection can be reduced to 2 or 3 times a week.

Cerebrolysin is used parenterally in the form of intramuscular injections (up to 5 ml) and intravenous injections (up to 10 ml).The drug in a dose of 10 ml to 50 ml is recommended to be administered only by means of slow intravenous infusions after dilution with standard solutions for infusions. The duration of the infusion is 15 to 60 minutes.

After opening the ampoule / vial Cerebrolysin solution should be used immediately.

Side effect

• sensation of heat;
• sweating;
• loss of appetite;
• dyspepsia;
• diarrhea;
• constipation;
• nausea and vomiting;
• excitement, manifested by aggressive behavior, confusion, insomnia;
• major epileptic seizures;
• convulsions;
• reactions of hypersensitivity, manifested by headache, pain in the neck, extremities, lower back, dyspnea, chills and collapsoid condition;
• hyperemia of the skin;
• itching and burning at the injection site;
• arterial hypertension;
• arterial hypotension;
• fatigue;
• tremor;
• depression;
• apathy;
• dizziness;
• influenza-like symptoms (cough, runny nose, respiratory tract infections).

Contraindications

• acute renal insufficiency;
• status epilepticus;
• hypersensitivity to the drug.

Application in pregnancy and lactation

Caution should be used Cerebrolysin in the 1st trimester of pregnancy and during lactation.

The use of the drug during pregnancy and during breastfeeding is possible only if the intended benefit to the mother exceeds the potential risk for the fetus / newborn.

The results of experimental studies do not give grounds to believe that Cerebrolysin has any teratogenic effect or has a toxic effect on the fetus. However, similar clinical studies have not been conducted.

special instructions

If the injection is performed too quickly, a sensation of fever, sweating, dizziness is possible. Therefore, the drug should be administered slowly.

The compatibility of the preparation was checked and confirmed (for 24 hours at room temperature and illumination) with the following standard solutions for infusions: 0.9% sodium chloride solution, Ringer's solution, 5% Dextrose (glucose) solution.

Simultaneous application of Cerebrolysin with Vitamins and preparations that improve cardiac circulation is allowed, however, these preparations should not be mixed in the same syringe with Cerebrolysin.

Do not mix Cerebrolysin and balanced amino acid solutions in a single solution for infusions.

Only use a clear solution of Cerebrolysin and only once.

Impact on the ability to drive vehicles and manage mechanisms

Clinical trials have shown that Cerebrolysin does not affect the ability to drive vehicles and use mechanisms.

Drug Interactions

With the simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors, mutual enhancement of their action is possible. In such cases it is recommended to reduce the dose of antidepressant.

Cerebrolysin is incompatible with solutions that contain lipids, and with solutions that modify the pH of the medium (5.0-8.0).

Analogues of the drug Cerebrolysin

Structural analogues of the active substance of the drug Cerebrolysin does not.

Analogues for the pharmacological group (nootropic drugs):

• Actovegin;
• Amylonosar;
• Aminalon;
• Ampasse;
• Bilobil;
• Gamalon;
• Glaser;
• Gliatilin;
• Glycine;
• Glutamic acid;
• Gopantam;
• Hopantenic acid;
• Delecite;
• Demanol;
• Idebenon;
• Intelland;
• Cortexin;
• Lucetsam;
• Mexiprim;
• Mexicin;
• Memotropized;
• Minisem;
• Neuromet;
• Nootropil;
• Noochlin Rompharm;
• Noocetam;
• Pantogam;
• Pikamilon;
• Piraben;
• Piracetam;
• Pyriditol;
• Pramistar;
• Semax;
• Tenoten;
• Fenibut;
• Phenotropil;
• Ceraxon;
• Cerebramine;
• Cerebrial;
• Cerebrosolate;
• Encephabol;
• The escotrope.

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