Ascoril - instructions for use, analogs, reviews and release forms (tablets, syrup ekspektorant) drug for cough as a symptom of bronchitis, pneumonia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ascoril. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ascoril in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ascoril in the presence of existing structural analogs. Use to treat cough as a symptom of bronchitis, pneumonia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Ascoril - Combined drug, has a bronchodilator, expectorant and mucolytic effect.

Salbutamol - a bronchodilator, stimulates beta2-adrenoreceptors of bronchi, blood vessels and myometrium. Warns or eliminates spasm of the bronchi, reduces resistance in the airways, increases the vital capacity of the lungs. Causes the expansion of the coronary arteries, does not reduce blood pressure.

Bromhexine - a mucolytic agent, has an expectorant and antitussive effect. Increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces the viscosity of the sputum, increases its volume and improves withdrawal.

Guaifenesin - a mucolytic agent, reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerises acidic mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary arm of the bronchi, facilitates the removal of sputum and facilitates the transition of non-productive cough to productive.

Structure of the preparation

Salbutamol (in the form of sulfate) + Bromhexine hydrochloride + Guaifenesin + excipients.

Pharmacokinetics

Salbutamol

At intake absorption - high. Eating reduces the absorption rate, but does not affect bioavailability. Penetrates through the placenta. It is excreted by the kidneys (69-90%), mainly in the form of an inactive phenol sulfate metabolite (60%) for 72 hours and with bile (4%).

Bromhexine

When ingested almost completely (99%) is absorbed from the digestive tract within 30 minutes. Bioavailability is low (the effect of primary "passage" through the liver). It penetrates the placental barrier and the blood-brain barrier. It is excreted by the kidneys. With chronic renal failure, excretion of metabolites is impaired. With multiple applications can cumulate.

Guaifenesin

Absorption from the gastrointestinal tract - fast (after 25-30 minutes after ingestion). T1 / 2 - 1 hour. Penetrates into tissues containing acidic mucopolysaccharides. Approximately 60% of the injected drug is metabolized in the liver. It is excreted by lungs (with phlegm) and kidneys both in unchanged form and in the form of inactive metabolites.

Indications

In the combination therapy of acute and chronic bronchopulmonary diseases,accompanied by the formation of a difficultly separated viscous secretion:

• bronchial asthma;
• tracheobronchitis;
• obstructive bronchitis;
• pneumonia;
• emphysema of the lungs;
• whooping cough;
• pneumoconiosis;
• pulmonary tuberculosis.

Forms of release

Pills.

Syrup Ascoril ekspektorant (children's form of the drug).

Instructions for use and dosing regimen

Pills

Inside. Adults and children over 12 years of age are prescribed 1 tablet 3 times a day.

Children aged 6 to 12 years - 0.5 or 1 tablet 3 times a day.

Children under the age of 6 are recommended to use the Ascoril Expectorant syrup.

Syrup

Adults and children over 12 years of age are prescribed 10 ml (2 teaspoons) 3 times a day.

Children under the age of 6 years - 5 ml (1 teaspoon) 3 times a day, from 6 to 12 years - 5-10 ml (1-2 teaspoons) 3 times a day.

Side effect

• headache;
• dizziness;
• increased nervous excitability;
• sleep disturbance;
• drowsiness;
• tremor;
• convulsions;
• nausea, vomiting;
• diarrhea;
• exacerbation of peptic ulcer of the stomach and duodenum;
• cardiopalmus;
• it is possible to stain the urine pink;
• allergic reactions (rash, urticaria);
• collapse;
• bronchospasm.

Contraindications

• hypersensitivity to the components of the drug;
• pregnancy;
• lactation period;
• tachyarrhythmia;
• myocarditis;
• heart defects;
• Decompensated diabetes mellitus;
• thyrotoxicosis;
• glaucoma;
• hepatic or renal insufficiency;
• peptic ulcer of the stomach and duodenum in the stage of exacerbation;
• gastric bleeding;
• arterial hypertension;
• children's age till 6 years.

Application in pregnancy and lactation

During pregnancy, use of the drug is not recommended.

If it is necessary to treat the drug during lactation, breastfeeding should be discontinued.

special instructions

With care appoint Ascoril ekspektorant to patients with hyperthyroidism, diabetes, severe cardiovascular diseases, hypertension, peptic ulcer of the stomach and duodenum.

Do not use Ascoril ekspektorant in combination with beta-blockers.

Drug Interactions

Other beta2-adrenomimetic drugs and theophylline increase the effect of Salbutamol and increase the likelihood of side effects.

Ascoril is not prescribed concomitantly with preparations containing codeine, and other antitussive agents, as this makes it difficult to move away diluted sputum.

Included in the composition of the drug Ascoril bromhexine promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

It is not recommended to use the drug Ascoril at the same time as nonselective beta-adrenoreceptor blockers, such as propranolol.

Included in the drug Ascoril salbutamol is not recommended for patients who receive MAO inhibitors.

Diuretics and glucocorticosteroids increase the hypokalemic effect of salbutamol.

It is not recommended to take alkaline drink simultaneously with Ascoril.

Analogs of the drug Ascoril

Ascoril does not have structural analogs for the active substance.

Analogues on the therapeutic effect (secretolitics):

• Ambroxol;
• Amtersol;
• Bromhexine;
• Bronchicum;
• Bronchipret;
• Breast gathering number 1;
• Breast gathering number 2;
• Breast gathering number 3;
• Thoracic elixir;
• Doctor IOM vegetative pastilles from cough;
• Insty;
• Cough;
• Kodelak Broncho with thyme;
• Broncho's Witchcraft;
• Lazolvan;
• Linkas Balm;
• Cough for adults is dry;
• Cough medicine for children is dry;
• Moist-anise drops;
• Expectorant collection;
• Pectusin;
• Pertussin;
• Rinicold Bronho;
• Stoptussin;
• Sudafed;
• Tussin plus;
• Eucatol.

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