Flebodia 600 - instructions for use, reviews, analogs and formulations (600 mg tablets) of a drug for the treatment of hemorrhoids and varicose veins in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Flebodia 600. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Flebodia 600 in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Flebodia 600 in the presence of existing structural analogs. Use for the treatment of hemorrhoids and varicose veins in adults, children, as well as during pregnancy and lactation.
Flebodia 600 - angioprotective agent.It has a venotonic effect (reduces the dilatability of the veins, increases their tone (dose-dependent effect), reduces venous stasis), improves lymphatic drainage (increases the tone and frequency of lymphatic capillary contraction, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases resistance of capillaries ( dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into parainous tissues, improves oxygen diffusion and perfusion skin tissue, has anti-inflammatory action. Strengthens the vasoconstrictive effect of epinephrine (adrenaline), norepinephrine (noradrenaline), blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Pharmacokinetics
Quickly absorbed from the gastrointestinal tract, found in the plasma 2 hours after ingestion. Cmax in the blood plasma is reached after 5 hours after administration. Evenly distributed in all layers of the wall of the hollow veins and subcutaneous veins of the lower limbs, to a lesser extent - in the veins of the kidneys, liver, lungs and other tissues.The selective accumulation of Diosmin (the active substance of the preparation Flebodia 600) and / or its metabolites in venous vessels reaches a maximum 9 hours after ingestion and persists for 96 hours. It is excreted in the urine - 79%, with feces - 11%, with bile - 2.4% .
Indications
- Varicose veins;
- chronic lymphovenous insufficiency of the lower extremities;
- hemorrhoids;
- disturbance of microcirculation.
Forms of release
Tablets coated with 600 mg.
Instructions for use and dosing regimen
With varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in the legs), 1 tablet is prescribed per day in the morning on an empty stomach for 2 months, with severe forms of chronic lymphovenous insufficiency (edema, pain, cramps) - treatment continues for 3 -4 months, with trophic changes and ulcers - 6 months or more. The course of treatment is repeated after 2-3 months.
With an exacerbation of hemorrhoids, 2-3 tablets are prescribed per day during meals for 7 days, then, if necessary, you can continue taking 1 tablet 1 time per day for 1-2 months.
In the treatment of chronic lymphovenous insufficiency in 2 and 3 trimesters of pregnancy, 1 tablet is prescribed 1 time per day and is canceled 2-3 weeks before the birth.
In case of missing one or more of the doses, the drug should be continued in the usual dose.
Side effect
- dyspepsia;
- headache;
- allergic reactions (requiring interruption in treatment) associated with hypersensitivity to the components of the drug.
Contraindications
- children and adolescents under 18;
- lactation period (breastfeeding);
- 1 trimester of pregnancy;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
So far, in clinical practice, there have been no reports of any side effects when the drug is used in pregnant women. Use during pregnancy in the 2nd and 3rd trimesters is possible only according to the doctor's prescription in those cases when the expected benefit for the mother exceeds the potential risk to the fetus.
In experimental studies, there was no teratogenic effect on the fetus.
During breastfeeding, taking the drug is not recommended, because there is no data on the penetration of the drug into breast milk.
special instructions
Treatment of an acute attack of hemorrhoids is carried out in conjunction with other drugs,in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy.
There are data on the possible effectiveness of the drug in the treatment of fetoplacental insufficiency, for the prevention of bleeding that occurs with the use of the intrauterine device and in the post-phlebectomy period.
The patient should inform the attending physician of the appearance of any side effects when taking the drug.
Impact on the ability to drive vehicles and manage mechanisms
There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.
Drug Interactions
Clinically significant drug interaction between Flebodia 600 and other drugs has not been established.
Analogues of the drug Flebodia 600
Structural analogs for the active substance:
- Vasoket;
- Diovenor 600;
- Diosmin;
- Phlebofa.
Analogues on the effect (angioprotectors and microcirculatory correctors):
- Agapurin;
- Actovegin;
- Alprostan;
- Anvenol;
- Antistaks;
- Ascorutin;
- Aescin;
- Betaver;
- Betagistin;
- Betaserc;
- Betacentrine;
- Bilobil;
- Vazaprostan;
- Vazonite;
- Vasoserk;
- Venarus;
- Venoruton;
- Vestap;
- Hesperidin;
- Ginkor fort;
- Detraleks;
- Dipyridamole;
- Dicycin;
- Xantinol nicotinate;
- Courantil;
- A nicotinic acid;
- Oxygenyl;
- Parsedil;
- Pentoxifylline;
- Rutin;
- Solcoseryl;
- Trental;
- Troxevasin;
- Troxsevenol;
- Troxerutin;
- Flexitale;
- Emoxipine;
- Endothelon;
- Escuzan;
- Etamsylate.
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