Permixon - instructions for use, analogs, testimonials and release forms (capsules 160 mg) drugs for the treatment of prostatic adenoma in men. Composition

In this article, you can read the instructions for using the drug Permixon. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Permixon in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Permixon in the presence of existing structural analogues. Use to treat prostate adenoma in men.

Permixon - lipidosterol extract of palm fruits Serenoa repens. Has antiandrogenic, anti-inflammatory, anti-edematous and antiproliferative effects, selectively manifested at the level of the prostate gland.In this case, the drug does not affect the level of sex hormones in the blood plasma, does not affect the potency and libido and does not change the level of prostate-specific antigen in the blood plasma.

The mechanism of local antiandrogenic action is due to the inhibition of the synthesis of dihydrotestosterone (due to inhibition of the enzyme 5-alpha-reductase 1 and 2 types) and its fixation to the cytosolic receptors, which prevents the penetration of the hormone into the nucleus. As a result, protein synthesis is reduced.

The mechanism of local anti-inflammatory action is due to the fact that lipidosterol extract of Serenoa repens inhibits the activity of phospholipase A2 and the release of arachidonic acid, thereby reducing the synthesis of prostaglandins and leukotrienes, which are inflammatory mediators. Permixon during the first weeks of therapy reduces capillary permeability and vascular stasis, reduces swelling and inflammation in the prostate, eliminates the compression of the neck of the bladder and urinary canal, improving the urodynamics.

Local antiproliferative effect of the drug is manifested by a decrease in the activity of growth factors (primarily epidermal and fibroblastic) and the acceleration of processesapoptosis of prostate cells, which is reflected in inhibition of growth and the subsequent decrease in the volume of the prostate gland.

Thus, the drug Permixon contributes, on the one hand, to a decrease in the severity of the pathological symptoms of benign prostatic hyperplasia (dysuria, pollakiuria, nocturia, pain and tension when urinating, incomplete emptying of the bladder), increased volume and strength of urination. On the other hand, against the background of the use of the drug, further growth and increase in the volume of the prostate gland is somewhat slowed down.

Composition

Lipidosterol extract of fruits Serenoa repens + auxiliary substances.

Indications

• benign hyperplasia (adenoma) of the prostate 1 and 2 stages.

Forms of release

Capsules 160 mg.

Forms in the form of tablets in the market are not represented.

Instructions for use and reception scheme

The optimal treatment regimen is set individually, based on the diagnostic examination.

The daily dose is 320 mg. It is recommended to take 160 mg (1 capsule) 2 times a day or 320 mg (2 capsules) in 1 dose.

The duration of treatment is at least 3 months.If necessary, repeated courses of therapy are possible.

Side effect

• nausea;
• heartburn;
• gastralgia (usually occurring when taking the drug during meals).

Contraindications

• hypersensitivity to the drug.

special instructions

Permixone is recommended for taking with meals.

Drug Interactions

There was no evidence of Permixon antagonism and drugs from the groups most commonly used in the treatment of this disease: antibiotics, uroseptics and anti-inflammatory drugs.

Analogues of the medicinal product Permixon

Structural analogs for the active substance:

• Palprostes;
• They will prostate;
• Prostagut mono;
• Prostamol Uno;
• Prostaplant;
• Serenoi creeping fruit extract is dry;
• Serpens.

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