Cerucal - instructions for use, analogs, reviews and release forms (10 mg tablets, injections in ampoules for intravenous and intramuscular injections) of a drug for the treatment of nausea and vomiting in adults, children and during pregnancy (toxicosis)

In this article, you can read the instructions for using the drug Cerucal. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Cerucal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cerukal in the presence of existing structural analogues. Use to treat nausea and vomiting in adults, children, as well as during pregnancy (toxicosis) and breastfeeding.

Cerucal - a specific blocker of dopamine receptors, weakens the sensitivity of the visceral nerves that transmit pulses from the pyloric and duodenum to the vomiting center. Through the hypothalamus and the parasympathetic nervous system, it has a regulating and coordinating effect on the tone and motor activity of the upper part of the gastrointestinal tract (including the tone of the lower digestive sphincter at rest). Increases the tone of the stomach and intestines, accelerates the emptying of the stomach, reduces the hyperacid stasis, prevents pyloric and esophagal reflux, stimulates intestinal peristalsis.

Pharmacokinetics

Metabolised in the liver. It is excreted by the kidneys during the first 24 hours in unchanged form and in the form of metabolites (about 80% and once taken dose). Easily penetrates the blood-brain barrier and is excreted in breast milk.

Indications

• vomiting and nausea of ​​various origins;
• atony and hypotension of the stomach and intestines (in particular, postoperative);
• dyskinesia of biliary tract, reflux esophagitis, functional stenosis of the pylorus;
• to enhance peristalsis during radiocontrast studies of the gastrointestinal tract;
• paresis of the stomach in diabetes mellitus;
• as a means to facilitate duodenal sounding (to accelerate the emptying of the stomach and promote food through the small intestine).

Forms of release

Tablets 10 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosage

Pills

Inside, 30 minutes before eating, squeezed with water.

Adults: The recommended dose is 1 tablet (10 mg metoclopramide) 3-4 times a day.

Adolescents older than 14 years: the recommended dose is 0.5 - 1 tablet 2-3 times a day.

The maximum single dose: 2 tablets (20 mg); the maximum daily dose: 6 tablets (60 mg).

The duration of treatment is about 4-6 weeks. In some cases, treatment can be continued up to 6 months.

Ampoules

Intramuscularly or slowly intravenously.

Adults and adolescents older than 14 years: 1 ampoule (10 mg metoclopramide) 3-4 times a day.

Children from 3 to 14 years of age: The therapeutic dose is 0.1 mg Metoclopramide / kg body weight, the maximum daily dose is 0.5 mg metoclopramide / kg body weight.

Prevention and treatment of nausea and vomiting caused by the use of cytostatics:

Scheme 1.

Short-term drop infusion (dropper) (for 15 minutes) at a dose of 2 mg / kg half an hour before the start of treatment with cytostatic agent, and then after 1.5 hours, 3.5 hours,5.5 h and 8.5 h after the application of cytostatics.

Scheme 2.

Continuous drip infusion at a dose of 1.0 or 0.5 μ / kg per hour, starting 2 hours before the application of the cytostatic agent, then at a dose of 0.5 or 0.25 mg / kg per hour for the next 24 hours after the application of the cytostatic agent.

Drip infusion is carried out briefly for 15 minutes after preliminary dilution of the dose of cerucal in 50 ml of the infusion solution.

The injectable solution of cerucal can be diluted with an isotonic solution of sodium chloride or 5% glucose solution.

Cerucal is used throughout the treatment period with cytostatic agents.

Side effect

• feeling tired;
• headache;
• dizziness;
• feeling of fear;
• anxiety;
• depression;
• drowsiness;
• noise in ears;
• dyskinetic syndrome (involuntary tick-like twitching of the muscles of the face, neck or shoulders);
• the appearance of extrapyramidal disorders: spasm of facial musculature, trismus, rhythmic protrusion of the tongue, bulbar type of speech, spasm of extraocular muscles (including oculogic crisis), spastic torticollis, opisthotonus, muscular hypertonia;
• Parkinsonism (tremor, twitching of muscles, limited mobility, risk of development in children and adolescents increases with exceeding the dose of 0.5 mg / kg per day);
• late dyskinesia (in elderly patients with chronic renal insufficiency);
• agranulocytosis;
• supraventricular tachycardia;
• hypotension;
• hypertension;
• constipation;
• diarrhea;
• dry mouth;
• gynecomastia (increased mammary glands in men);
• galactorrhea (spontaneous discharge of milk from the mammary glands);
• menstrual cycle disorders.

Contraindications

• increased sensitivity to metoclopramide;
• pheochromocytoma (possible hypertensive crisis, in connection with the ejection of catecholamines);
• intestinal obstruction, intestinal perforation and gastrointestinal bleeding;
• prolactin-dependent tumor;
• 1 trimester of pregnancy;
• lactation;
• epilepsy and extrapyramidal movement disorders, the first trimester of pregnancy and lactation period, the age of up to 2 years.

Application in pregnancy and lactation

Contraindicated in 1 trimester of pregnancy and lactation.

In the 2 and 3 trimesters of pregnancy, the drug is prescribed only for vital indications

special instructions

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities,requiring increased concentration of attention and speed of psychomotor reactions.

In the process of treatment, alcohol consumption is prohibited.

In adolescents and in patients with severe impairment of kidney function, follow the possible development of side effects, if they occur, the drug is canceled.

It is not effective for vomiting of vestibular genesis.

Against the background of the use of metoclopramide, there are possible distortions of these laboratory parameters of liver function and determination of the concentration of aldosterone and prolactin in plasma.

Drug Interactions

Incompatible with infusion solutions that have an alkaline environment.

Reduction of the effect of anticholinesterase agents.

Strengthens the absorption of antibiotics (tetracycline, ampicillin), paracetamol, levodopa, lithium and alcohol.

Reduces absorption of Digoxin and cimetidine.

Strengthens the effect of alcohol and drugs, depressing the central nervous system.

It should not be used simultaneously with metoclopramide to prescribe neuroleptic drugs in order to avoid a possible increase in extrapyramidal disorders.

It can affect the effect of tricyclic antidepressants, monoamine oxidase (MAO) inhibitors and symptomatic agents.

Reduces the effectiveness of therapy with H2-histaminoblockers.

Increased risk of hepatotoxicity when combined with hepatotoxic agents.

Reduces the effectiveness of pergolide, levodopa.

Increases the bioavailability of cyclosporine, which may require monitoring of its concentration.

With the simultaneous appointment of cerulek with thiamine (Vitamin B1), the latter rapidly disintegrates.

Analogues of the drug Cerucal

Structural analogs for the active substance:

• Apo-Metoclop;
• Metamol;
• Metoclopramide;
• Metoclopramide-Acry;
• Metoclopramide-Vial;
• Metoclopramide-Promed;
• Metoclopramide-ESCOM;
• Perinorm;
• Raglan;
• Ceruglan.

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