Midantan - instructions for use, reviews, analogs and formulations (100 mg tablets) of the drug for the treatment of Parkinson's disease in adults, children and pregnancy

In this article, you can read the instructions for using the drug Midantan. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of Midantana in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Midantan in the presence of existing structural analogs. Use for the treatment of Parkinson's disease in adults, children, as well as in pregnancy and lactation.

Midantan - antiparkinsonian preparation, tricyclic symmetric adamantamine.It blocks glutamate NMDA receptors (including in black substance), thereby reducing the excessive stimulating effect of cortical glutamate neurons on the neostriatum. developing against the background of insufficient isolation of dopamine. Reducing the intake of ionized Ca2 + in neurons, reduces the possibility of their destruction. Mostly affects the stiffness (rigidity and bradykinesia).

Pharmacokinetics

After oral administration, it is well absorbed into the digestive tract. It is excreted by the kidneys unchanged.

Indications

• Parkinson's disease;
• Parkinsonism syndrome.

Forms of release

Tablets coated with 100 mg.

Instructions for use and dosing regimen

Inside, after eating. With Parkinson's disease, the initial dose is 100 mg per day, with an interval of 6 hours (the last dose before dinner) for 3 days; from 4 to 7 days - 200 mg per day; within 2 weeks - 300 mg per day; from the 3rd week, depending on the patient's condition - 300-400 mg per day. The maximum dose is 600 mg per day.

In elderly patients, reduced doses are used.

Side effect

• motor or mental arousal;
• convulsions;
• headache;
• dizziness;
• irritability;
• insomnia;
• tremor;
• mental disorders, accompanied by visual hallucinations;
• heart failure;
• tachycardia;
• orthostatic hypotension;
• dry mouth;
• nausea;
• anorexia;
• dyspepsia;
• acute urinary retention in patients with prostatic hyperplasia;
• polyuria;
• nocturia;
• dermatosis;
• the appearance of a bluish color of the skin of the upper and lower extremities;
• decreased visual acuity.

Contraindications

• liver failure;
• chronic renal failure;
• psychoses (in the anamnesis);
• thyrotoxicosis;
• epilepsy;
• angle-closure glaucoma;
• hyperplasia of the prostate;
• arterial hypotension;
• heart failure 2-3 items;
• excitation;
• pre-divisions;
• delirious psychosis;
• simultaneous administration of triamterene and hydrochlorothiazide;
• pregnancy (1 trimester);
• lactation period;
• hypersensitivity.

Application in pregnancy and lactation

Contraindicated in the 1st trimester of pregnancy and lactation. With care - 2 and 3 trimester.

special instructions

Information on the effectiveness in the treatment of extrapyramidal disorders against the background of treatment with antipsychotic drugs (drug parkinsonism) is contradictory. Therapy can not be stopped suddenly, becausepossibly sharp exacerbation of the disease.

The use of ethanol (alcohol) against the background of taking the drug is contraindicated.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

Drugs that stimulate the CNS and ethanol (alcohol) increase the risk of side effects.

Midantan enhances the action of levodopa, psychostimulants.

Compatible with central anticholinergics and other antiparkinsonian means.

Analogues of the medicament Midantan

Structural analogs for the active substance:

• Neomidantan;
• PC-Merz.

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