Loperamide - instructions for use, reviews, analogs and forms of release (tablets and capsules 2 mg) of the drug for the treatment of diarrhea in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Loperamide. Comments of visitors of the site - consumers of this medicine, as well as opinions of doctors of specialists on the use of Loperamide in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Loperamide analogs in the presence of existing structural analogs. Use to treat diarrhea in adults, children, as well as during pregnancy and lactation.

Loperamide - antidiarrhoeic remedy.Reduces the tone and motility of the smooth muscles of the intestine, apparently due to binding to opioid receptors in the intestinal wall. Inhibits the release of acetylcholine and prostaglandins, reducing peristalsis and increasing the time of passage of the contents through the intestine.

Increases the tone of the anal sphincter. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics

Absorption - 40%. Does not penetrate the blood-brain barrier. It is almost completely metabolized in the liver by conjugation. Excreted mainly by the intestine; a small part is excreted by the kidneys (in the form of conjugated metabolites).

Composition

Loperamide hydrochloride + excipients.

Indications

• symptomatic treatment of acute and chronic diarrhea of ​​various genesis (allergic, emotional, drug, radiation: with a change in diet and quality of food, in violation of metabolism and absorption: as an auxiliary for diarrhea of ​​infectious genesis);
• regulation of stool in patients with ileostomy.

Forms of release

Capsules 2 mg.

Tablets 2 mg.

Instructions for use and dosage

Inside, not liquid, squeezed water.

Adults with acute and chronic diarrhea are initially assigned 2 capsules (0.004 g), then 1 capsule (0.002 g) after each act of defecation in the case of a loose stool. In acute diarrhea, children over 6 years of age are prescribed 1 capsule (0.002 g) after each act of defecation in the case of a loose stool.

The maximum daily dose. In acute and chronic diarrhea in adults - 8 capsules (0.016 g); in children - 3 capsules (0.006 g).

After normalization of the stool or in the absence of stool for more than 12 hours, treatment with Loperamide should be discontinued.

Side effect

• allergic reactions (skin rash);
• drowsiness or insomnia;
• dizziness;
• dryness of the oral mucosa;
• intestinal colic;
• pain or discomfort in the abdomen;
• nausea, vomiting;
• flatulence;
• retention of urine;
• intestinal obstruction.

Contraindications

• hypersensitivity to the drug;
• lactose intolerance;
• deficiency of lactase or glucose-galactose malabsorption;
• diverticulosis;
• intestinal obstruction;
• ulcerative colitis in the acute stage;
• Diarrhea on the background of acute pseudomembranous enterocolitis;
• in the form of monotherapy - dysentery and other infections of the gastrointestinal tract;
• pregnancy (1 trimester);
• lactation period;
• Loperamide in capsules is not prescribed for children under 6 years.

Application in pregnancy and lactation

Contraindicated in the 1st trimester of pregnancy.

In 2 and 3 trimesters of pregnancy Loperamide can be prescribed in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus.

Since a small amount of Loperamide is found in breast milk, taking it during breastfeeding is not recommended.

special instructions

If there is no effect after 2 days of Loperamide use, consult a doctor.

If the treatment develop constipation or bloating, loperamide should be discarded. In patients with impaired liver function, careful monitoring of signs of toxic CNS damage is necessary.

During the treatment of diarrhea, it is necessary to replenish the loss of fluid and electrolytes.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

It is believed that with the simultaneous application of colestyramine may reduce the efficacy of loperamide.

When used simultaneously with co-trimoxazole, ritonavir, the bioavailability of loperamide is increased, which is due to inhibition of its metabolism during the "first passage" through the liver.

In case of an overdose of loperamide, naloxone is used as an antidote.

Analogues of Loperamide

Structural analogs for the active substance:

• Vero-Loperamide;
• Diar;
• Diarol;
• Imodium;
• Laremide;
• Lediumum;
• Loperacap;
• Loperamide Grindex;
• Loperamide-Acry;
• Loperamide hydrochloride;
• Superylope;
• Enterobene.

Similar medicines:

Other medicines: