Teraflex - instructions for use, reviews, analogs and forms of release (capsules, cream or ointment, m and the advance form) for the treatment of arthrosis and osteochondrosis in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Teraflex. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Teraflex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Teraflex in the presence of existing structural analogs. Use for the treatment of arthrosis and osteochondrosis in adults, children, as well as during pregnancy and lactation.
Teraflex - a stimulant for the regeneration of cartilaginous tissue.
Glucosamine hydrochloride and Chondroitin sodium sulfate take part in the biosynthesis of connective tissue, helping to prevent cartilage destruction processes and stimulating tissue regeneration. The introduction of exogenous Glucosamine enhances the production of the cartilaginous matrix and provides non-specific protection against chemical damage to the cartilage. Another possible action of glucosamine is the protection of damaged cartilage from metabolic destruction caused by non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), as well as its own moderate anti-inflammatory effect.
Chondroitin sodium sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronone, the synthesis of proteoglycans and collagen type 2, and also protects hyaluronone from enzymatic cleavage (by suppressing the activity of hyaluronidase); maintains the viscosity of the synovial fluid, stimulates mechanisms of cartilage repair and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down the cartilage.In the treatment of osteoarthritis, it alleviates the symptoms of the disease and reduces the need for NSAIDs.
Composition
Glucosamine hydrochloride + chondroitin sodium sulfate + excipients.
Teraflex Advance additionally contains Ibuprofen.
Pharmacokinetics
Glucosamine sulfate
Bioavailability of glucosamine when ingested is 25% (due to the effect of "first passage" through the liver). After absorption, radiolabeled glucosamine is first detected in the plasma and later penetrates into the tissue. The highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in bone and muscle tissue. It is excreted mainly with urine in unchanged form, partly with feces.
Chondroitin sulfate
Bioavailability is about 12%. It is metabolized by desulfurization. It is excreted by the kidneys.
Indications
- arthrosis of large joints;
- osteochondrosis of the spine, accompanied by a moderate pain syndrome.
Forms of release
Capsules.
Cream for external use Teraflex M (sometimes mistakenly called ointment).
Capsules Teraflex Advance.
Instructions for use and dosing regimen
Capsules
Adults and children over 15 years of age during the first three weeks of the drug prescribed 1 capsule 3 times a day; in the following days - 1 capsule 2 times a day. Duration of treatment - 3-6 months. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.
The drug is taken orally, regardless of food intake, with a small amount of water.
Cream
A strip of cream 2-3 cm long is applied to the skin over the lesion site 2-3 times a day and rubbed to a full suction.
Advance Capsules
Adults are prescribed 2 capsules 3 times a day after meals. Capsules are taken orally, with a small amount of water. Duration of admission without consulting a doctor should not exceed 3 weeks. Further use of the drug should be agreed with the doctor.
Side effect
- pain in epigastrium;
- flatulence;
- diarrhea;
- constipation;
- dizziness;
- headache;
- drowsiness;
- insomnia;
- tachycardia;
- peripheral edema;
- pain in the legs;
- allergic reactions.
Contraindications
- severe renal failure;
- pregnancy;
- lactation period (breastfeeding);
- age up to 15 years;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Clinical data on the effectiveness and safety of the use of Teraflex during pregnancy and during breastfeeding are absent.
special instructions
If there are side effects from the digestive system, the dose should be reduced 2 times, and in the absence of improvement - cancel the drug.
Teraflex can be used as part of a combination therapy with GCS and NSAIDs.
Drug Interactions
Increases the absorption of tetracyclines.
Reduces the effect of semisynthetic penicillins and chloramphenicol.
Chondroitin sulfate enhances the effect of anticoagulants.
Analogues of the drug Teraflex
Structural analogs for the active substance:
- Arthra;
- Artra MSM forte;
- KONDRONOV;
- Hondroflex.
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