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Hydrocortisone - instructions for use, analogs, reviews and release forms (eye ointment 0.5%, injections in ampoules suspension for injection) drugs for the treatment of allergic and inflammatory diseases in adults, children and in pregnancy

Hydrocortisone - instructions for use, analogs, reviews and release forms (eye ointment 0.5%, injections in ampoules suspension for injection) drugs for the treatment of allergic and inflammatory diseases in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Hydrocortisone. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Hydrocortisone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Hydrocortisone in the presence of existing structural analogues.Use for the treatment of allergic and inflammatory diseases in adults, children, as well as during pregnancy and lactation.

 

Hydrocortisone - Glucocorticosteroid, has anti-inflammatory, anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes, incl. lymphocytes into the area of ​​inflammation. Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces the binding of immunoglobulins to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferons) from lymphocytes and macrophages.

 

Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane).

 

Reduces the exudative reaction, helps reduce the permeability of capillaries. Reduces the severity of an early immunological response.

 

It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

 

Intended for intramuscular, intra-and periarticular administration, with the aim of providing systemic or local anti-inflammatory, as well as anti-allergic action.With intraarticular administration, the therapeutic effect occurs within 6-24 hours and lasts for several days or weeks.

 

Pharmacokinetics

 

With intraarticular and periarticular administration, hydrocortisone enters the systemic circulation. Metabolised in the liver in tetrahydrocortisone and tetrahydrocortisol, which are excreted by the kidneys in conjugated form. Penetrates through the placental barrier.

 

Indications

  • Rheumatic diseases accompanied by arthritis, incl. osteoarthrosis in the presence of synovitis (with the exception of tuberculosis, gonorrhea, purulent and other infectious arthritis);
  • rheumatoid arthritis;
  • humeroscapular periarthritis;
  • bursitis;
  • epicondylitis;
  • tenosynovitis;
  • allergic eye diseases (dermatitis of the eyelids, blepharitis, conjunctivitis and keratoconjunctivitis);
  • inflammatory diseases of the anterior part of the eye in the absence of violation of the integrity of the epithelium of the cornea (blepharitis, conjunctivitis and keratoconjunctivitis);
  • thermal and chemical eye burn (after complete epithelialization of corneal defects);
  • acute adrenal insufficiency;
  • allergic reactions of immediate type;
  • asthmatic status;
  • prevention and treatment of shock;
  • Myocardial infarction complicated by cardiogenic shock;
  • thyrotoxic crisis;
  • thyroiditis;
  • congenital adrenal hyperplasia;
  • hypercalcemia due to neoplastic disease, short or complementary therapy in the acute period of rheumatic diseases;
  • collagen diseases;
  • pemphigus;
  • bullous herpetiform dermatitis (Dühring's disease);
  • polymorphous bullous erythema;
  • exfoliative dermatitis;
  • mushroom mycosis;
  • severe forms of psoriasis and seborrheic dermatitis;
  • severe acute and chronic allergic and inflammatory processes with eye damage;
  • symptomatic sarcoidosis;
  • Leffler's syndrome, not amenable to other types of therapy;
  • berylliosis;
  • focal or disseminated form of tuberculosis with concurrent anti-tuberculosis chemotherapy;
  • aspiration pneumonitis;
  • secondary thrombocytopenia of adults;
  • acquired (autoimmune) hemolytic anemia;
  • erythroblastopenia;
  • congenital (erythroid) hypoplastic anemia;
  • palliative therapy in leukemia and adult lymphomas;
  • with acute leukemia in children;
  • to enhance diuresis or to reduce proteinuria in nephrotic syndrome without uremia, idiopathic nephrotic syndrome or lupus erythematosus;
  • in the critical stage of ulcerative colitis;
  • tuberculous meningitis with the development of the subarachnoid block or its threat (in combination with anti-tuberculosis chemotherapy);
  • trichinosis with damage to the nervous system or myocardium;
  • bronchial asthma;
  • inflammation of the anterior part of the eyeball with undisturbed corneal epithelium and after trauma and surgical interventions on the eyeball;
  • neurodermatitis;
  • psoriasis;
  • prurigo; pruritis;
  • red flat warty lichen.

 

Forms of release

 

Ointment eye 0.5%.

 

Suspension for intramuscular and intraarticular administration (injections in ampoules for injections).

 

Ointment for external use 1% (ear, skin, nose).

 

There are no other forms of pills or drops of Hydrocortisone, perhaps these drugs are fakes.

 

Instructions for use and dosage

 

Eye Ointment

 

Locally.

 

In the conjunctival sack, 1 smglaznoy ointment is administered 2-3 times a day.

 

The course of treatment is 1-2 weeks. On the recommendation of a doctor, a course of treatment can be extended.

 

Suspension for injection

 

Intra- and periarticular (in the joint).

 

In one day, you can enter no more than 3 joints. Repeated administration of the injection is possible with a 3-week interval.Introduction directly into the joint can have an adverse effect on hyaline cartilage, so the same joint can be treated no more than 3 times a year.

 

When tendinitis injection should be introduced into the vagina of the tendon - you can not inject it directly into the tendon. Not suitable for systemic treatment and for the treatment of Achilles tendon.

 

Adults: depending on the size of the joint and the severity of the disease, 5-50 mg intra- and periarticular. In / m adults, the drug is injected deep into the gluteus muscle at a dose of 125-250 mg per day.

 

Children: 5-30 mg per day, divided into several doses. Single dose for periarticular administration for children aged 3 months to 1 year: 25 mg, 1 to 6 years: 25-50 mg, 6 to 14 years: 50-75 mg.

 

Ampoules

 

For parenteral use. Dosing regimen is individual. Applied intravenously struino, intravenously drip (in droppers), rarely - intramuscularly. For urgent therapy, IV administration is recommended. The initial dose is 100 mg (administered for 30 seconds) - 500 mg (administered 10 minutes), then repeatedly every 2 to 6 hours, depending on the clinical situation. High doses should be used only until the patient's condition is stabilized, but usually no more than 48-72 hours, because possibly the development of hypernatremia. Children - at least 25 mg / kg per day.In the form of a depot form administered intra- or periarticularly in a dose of 5-50 mg once with an interval of 1-3 weeks. Intramuscularly - 125-250 mg per day.

 

Ointment for external use

 

Outer - 1-3 times a day.

 

Side effect

  • Steroid diabetes mellitus or manifestation of latent diabetes mellitus;
  • oppression of adrenal function;
  • the Itenko-Cushing syndrome (including the lunar face, obesity of the pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, striae);
  • delay in sexual development in children;
  • hypocalcemia;
  • weight gain;
  • increased sweating;
  • fluid retention and sodium ions (peripheral edema);
  • disorientation;
  • euphoria;
  • hallucinations;
  • affective insanity;
  • depression;
  • paranoia;
  • increased intracranial pressure;
  • nervousness or anxiety;
  • insomnia;
  • dizziness;
  • headache;
  • convulsions;
  • arrhythmias;
  • bradycardia (up to cardiac arrest);
  • development (in predisposed patients) or increased severity of chronic heart failure;
  • increased blood pressure;
  • with intracranial administration (in the nose) - epistaxis;
  • nausea, vomiting;
  • steroid ulcer of the stomach and duodenum;
  • bleeding and perforation of the gastrointestinal tract;
  • increased or decreased appetite, flatulence;
  • hiccough;
  • sudden loss of vision (with parenteral administration in the area of ​​the head, neck, nasal concha, scalp may deposition of drug crystals in the vessels of the eye);
  • propensity to develop secondary bacterial, fungal or viral infections of the eyes;
  • slowing growth and ossification processes in children (premature closure of epiphyseal growth zones);
  • osteoporosis (very rare - pathological bone fractures, aseptic necrosis of the head of the humerus and femur);
  • rupture of muscle tendons;
  • decrease in muscle mass (atrophy);
  • with intra-articular injection - increased pain in the joint;
  • steroid acne;
  • stria;
  • generalized (including skin rash, skin itching, anaphylactic shock), allergic reactions;
  • local allergic reactions;
  • with parenteral administration - burning, numbness, pain, paresthesia and infection at the injection site, necrosis of surrounding tissues, scar formation at the injection site;
  • when intramuscular introduction (especially in the deltoid muscle) - atrophy of the skin and subcutaneous tissue;
  • withdrawal syndrome;
  • itching;
  • hyperemia;
  • burning;
  • dryness;
  • allergic dermatitis.

 

Contraindications

  • hypersensitivity to hydrocortisone.

 

For intraarticular administration and administration directly to the lesion:

  • previous arthroplasty;
  • pathological hemorrhage (endogenous or caused by the use of anticoagulants);
  • intra-articular bone fracture;
  • infectious (septic) inflammatory process in the joint and periarticular infections (including in the anamnesis), as well as general infectious disease;
  • pronounced near-joint osteoporosis;
  • absence of signs of inflammation in the joint ("dry" joint, for example, with osteoarthritis without synovitis);
  • severe bone destruction and joint deformity (a sharp narrowing of the joint space, ankylosis);
  • joint instability as the outcome of arthritis;
  • aseptic necrosis of the joints forming the epiphyses of bones.

 

For external use:

  • bacterial, viral, fungal skin diseases;
  • lupus;
  • cutaneous manifestations of syphilis;
  • skin tumors;
  • postvaccination period;
  • violation of the integrity of the skin (ulcers, wounds);
  • children's age (up to 2 years, with itching in the anus - up to 12 years);
  • rosacea;
  • Acne vulgaris;
  • perioral dermatitis.

 

For use in ophthalmology:

  • bacterial, viral, fungal diseases of the eyes;
  • tuberculosis of the eyes;
  • trachoma;
  • violation of the integrity of the ocular epithelium.

 

Application in pregnancy and lactation

 

Use in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus; it is recommended to use minimal doses and short-term therapy. Children whose mothers received hydrocortisone during pregnancy are to be closely monitored for signs of adrenocortical insufficiency.

 

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

 

In experimental studies, it has been shown that glucocorticosteroids (GCS) can cause fetal developmental disorders. At present, there is no clear confirmation of this data in humans.

 

special instructions

 

Use with caution in case of parasitic and infectious diseases of a viral, fungal or bacterial nature (currently or recently transferred, including recent contact with a patient) - herpes simplex, herpes zoster (viremic phase), chicken pox, measles, amebiasis, strongyloidiasis (established or suspect),systemic mycosis; active and latent tuberculosis. The use in severe infectious diseases is permissible only against the background of specific therapy.

 

Use with caution for 8 weeks before and 2 weeks after vaccination, with lymphadenitis after BCG vaccination, in immunodeficient conditions (including AIDS or HIV infection).

 

Be wary of in diseases of the gastrointestinal tract: gastric ulcer and duodenal ulcers, esophagitis, gastritis, acute or latent peptic ulcer, recently established intestinal anastomosis, ulcerative colitis, with the threat of perforation or abscess, diverticulitis.

 

With caution apply for diseases of the cardiovascular system, incl. after a recent myocardial infarction (in patients with acute and subacute myocardial infarction it is possible to spread the necrosis foci, slow the formation of scar tissue and, as a result, rupture of the heart muscle), with decompensated chronic heart failure, hypertension, hyperlipidemia), endocrine diseases - diabetes mellitus including violation of tolerance to carbohydrates), thyrotoxicosis, hypothyroidism, Itenko-Cushing's disease,with severe chronic renal and / or hepatic insufficiency, nephrourolythiasis, with hypoalbuminemia and conditions predisposing to its occurrence, with systemic osteoporosis, myasthenia gravis, acute psychosis, obesity (grade 3-4), in poliomyelitis (except for the form of bulbar encephalitis), openly - and zakratougolnoy glaucoma, pregnancy, lactation.

 

If necessary, intraarticular administration should be used with caution in patients with a general severe condition, ineffectiveness (or short-term) of the effect of the previous 2 injections (taking into account the individual properties of the SCS used).

 

With insufficient hydrocortisone for 48-72 h and the need for longer therapy, it is advisable to replace hydrocortisone with another glucocorticoid drug that does not cause sodium retention in the body. During treatment with hydrocortisone, it is recommended to prescribe a diet with sodium restriction and high potassium content.

 

The relative adrenal insufficiency caused by hydrocortisone can persist for several months after its withdrawal. Taking this into account, under stressful situations that arise during this period, hormone therapy is resumed with the simultaneous administration of salts and / or mineralocorticoids.

 

In patients with active tuberculosis, hydrocortisone should be used in conjunction with appropriate anti-tuberculosis therapy. When the latent form of tuberculosis or during the bending of tuberculin samples, the patient's condition should be carefully monitored, and if necessary, chemoprophylaxis should be carried out.

 

Drug Interactions

 

With simultaneous application of hydrocortisone increases the toxicity of cardiac glycosides (because of the resulting hypokalemia, the risk of arrhythmias increases); with Acetylsalicylic acid - accelerates its elimination and reduces its concentration in the blood plasma (with the abolition of hydrocortisone, the concentration of salicylates in the blood increases and the risk of side effects increases); with Paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and the formation of a toxic metabolite of paracetamol); with cyclosporin - increased side effects of hydrocortisone due to the inhibition of its metabolism; with Ketoconazole - increased side effects of hydrocortisone due to a decrease in its clearance.

 

Hydrocortisone reduces the effectiveness of hypoglycemic agents; enhances the effect of indirect anticoagulants of coumarin derivatives.

 

Hydrocortisone reduces the effect of vitamin D on the absorption of calcium ions in the lumen of the intestine. Ergocalciferol and parathyroid hormone interfere with the development of osteopathy caused by GCS.

 

Hydrocortisone increases the metabolism of isoniazid, mexiletine (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid; reduces the concentration of praziquantel in the blood.

 

Hydrocortisone in high doses reduces the effect of somatropin.

 

Hypokalemia caused by SCS can increase the severity and duration of muscle blockade against the background of muscle relaxants.

 

With simultaneous use with GCS, thiazide diuretics, inhibitors of carbonic anhydrase, other glucocorticosteroids, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - edema and increased blood pressure.

 

NSAIDs and ethanol (alcohol) increase the risk of ulceration of the gastrointestinal mucosa and bleeding, in combination with NSAIDs for the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect.Indomethacin, displacing GCS from bond with albumin, increases the risk of its side effects.

 

The therapeutic effect of GCS decreases under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampicin) due to an increase in the metabolic rate of these substances.

 

Inhibitors of the function of the adrenal cortex (including mitotane) may necessitate an increase in the dose of GCS.

 

The clearance of GCS rises on the background of drugs of thyroid hormones.

 

Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with the Epstein-Barr virus.

 

Estrogens (including oral estrogen-containing contraceptives) reduce the clearance of GCS, extend T1 / 2 and their therapeutic and toxic effects. The emergence of hirsutism and acne is facilitated by the simultaneous use of other steroid hormones - androgens, estrogens, anabolic, oral contraceptives.

 

Tricyclic antidepressants can increase the severity of depression caused by SCS (not shown for the therapy of these side effects).

 

The risk of developing cataracts increases when used against the background of other SCS, antipsychotics (neuroleptics), carbutamide and azathioprine. Simultaneous administration with m-holinoblokatorami, as well as with funds that have m-holinoblokiruyuschim action (including antihistamines, tricyclic antidepressants), with nitrates contributes to increased intraocular pressure.

 

With the simultaneous use of SCS with live antiviral vaccines and against the background of other types of immunization, the risk of virus activation and the development of infections increases.

 

Analogues of the drug Hydrocortisone

 

Structural analogs for the active substance:

  • Acortin;
  • Hydrocortisone Nycomed;
  • Hydrocortisone Richter;
  • Hydrocortisone-POC;
  • Hydrocortisone acetate;
  • Corteid;
  • Cortef;
  • Latticort;
  • Lokoid Krelo;
  • Lokoid lipocream;
  • Solu-Cortef;
  • Sopolkort N.

Similar medicines:

Other medicines:

Reviews (16):
Guests
nalina
There was an allergy on the inner surface of the thigh: red vesicles, severe itching, so I combed it into the blood (I know that I was stupid, but I could do nothing with this itch). They advised to use hydrocortisone ointment to eliminate allergy vesicles and relieve itching. Just want to say that the medicine lasts for a long time, immediately itching does not remove, but heals. The vesicles on their feet began to dry out about a week after the start of use, then disappeared altogether, there were only white specks, which then were sunburned and passed in the south. Plus from lacks it is necessary to notice that ointment very fat and is badly absorbed, long zhirnit a skin that can be inconvenient because of an arrangement of an eruption on a skin (at me so in general horror, it was necessary to use for hours or two before an exit on street, differently all was in this fat). So hydrocortisone is a good medicine, but with reservations.
Guests
Uh ...
There are no other forms of pills or drops of Hydrocortisone, perhaps these drugs are fakes.

Not true! In Russia, maybe not, but in Europe there are tablets. Repeatedly bought personally.
Administrators
admin
Uh ..., The Directory mentions medicines registered in Russia, so in other countries it is possible to use excellent dosage forms, but here they are not talking about them.
Visitors
Svetlana35
Mom pain in the knee joint while walking, the doctor made an injection in the joint, 2 days later no improvement, how then does it work?
Administrators
admin
Svetlana35, Usually patients respond positively to such strong treatment as intra-articular injection of powerful anti-inflammatory drugs such as hydrocortisone. The pain passes quickly, mobility in the joint is restored. What is the diagnosis of your doctor?
Visitors
Ilya
Tell me, please, is the use of injections of prednisolone in psoriasis justified?
Administrators
admin
Ilya, Yes, such a scheme is practiced. If to you such scheme is registered by the dermatologist accept that as it is prescribed by the doctor.
Guests
Lenok
Hello! I had a severe swelling in my eyes. The hospital prescribed hydrocortisone ointment, and she very well helped, took off a strong swelling and inflammation from the eyes, tk. In the beginning, the eyes were barely opened due to an allergic edema. Everything passed. Thank you!
Guests
jury
I heard that the drug is used for osteochondrosis, who can say something about this?
Administrators
admin
jury, Hydrocortisone, like any other glucocorticosteroids, can be used for osteochondrosis to relieve inflammation, severe pain and relaxation of spasmodic muscles, after which it is possible to continue treatment with other drugs that can enter the spasmodic focus of inflammation. But for a long time the treatment with hormones is osteochondrosis is useless.
Guests
Irina
At the son a neurodermite, than only did not treat, we will try to smear with hydrocortisone. But the question is: can they smear their heads?
Administrators
admin
Irina, Consult a full-time physician with an allergist or dermatologist, because with hormonal preparations in children it is necessary to be cautious and it is unacceptable to independently prescribe and treat the child by them. And so the details in the question (age, previous treatment, symptoms of the disease and the localization of lesions, because it's a big head) and your registration as it should be in the Directory rules, I did not see.
Guests
Olga
In the cold season I suffer from inflammation of the maxillary sinuses. Chronic form over a period of ten years. Green snot and spitting of pustules in the morning simply poison life. During the winter period, several courses of antibiotics, running on washing and repeated punctures. Each year, the same treatment scheme, which proves to be temporary. Three years ago, the ENT-sanatorium doctor where I rested, advised at the time of the beginning of my problem a very simple treatment.Surely everyone has heard about Dolfin powders. This set consists of a measuring bottle with a cap for washing the nose and sachets with a salt mixture to prepare a solution. 240 mg warm water (boiled) there to pour 1 sachet, shake well, so that all the crystals are dissolved and in the ready-made solution add 1 ampoule (5 mg) Dioxydinum and 1 ampoule (2 mg) Hydrocortisone. Shake again and rinse with nose. It turns out about 2 injections in each nostril. Only necessary minutes for 5 before washing to drip a nose with something like Snoop, Rinonorm, Otrivin. Rinse once a day. I'm doing it for the night. Over the winter, 2 courses of 5 days are obtained. The last three years I forgot what the green snot and pain in the frontal part. I absolutely do not claim that this is a 100% tool and whether it can be used by everyone in a row, but it helps me a lot. In any case, consult a doctor - everything is very individual. Health to all!
Guests
Lyudmila
Pain in the knee joint behind, swelling of the knee joint, the neurologist prescribed hydrocortisone for 5 days. Is it harmful?
Administrators
admin
Lyudmila, And what is the diagnosis? Any medicine is poison, the whole question is why, when and in what dosages it is used. In general, clarification is needed on the issue. Register and report the alleged diagnosis of a neurologist, which examinations and tests were prescribed and what was taken before. For primary use of hydrocortisone, without prior anti-inflammatory treatment with non-steroidal anti-inflammatory agents and other weaker drugs, a strong rationale is necessary.
Guests
Larisa Ivanovna
Sometime at an exacerbation of a bronchial asthma to me did or made single injections of hydrocortisone.

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