Rosex - instructions for use, reviews, analogs and formulations (gel 0.75%, cream or ointment 0.75%) of the drug for the treatment of acne, vaginitis and urethritis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Rosex. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Rosex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Rosex in the presence of existing structural analogs. Use for the treatment of acne, vaginitis and urethritis in adults, children, as well as during pregnancy and lactation.

Rosex antiprotozoal drug.It is believed that the mechanism of action is associated with a violation of the structure of DNA of sensitive microorganisms. It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, as well as obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.).

Metronidazole (the active substance of the drug Rosex) is resistant to aerobic microorganisms.

Pharmacokinetics

Bioavailability is 80%. It is distributed in tissues and body fluids. It penetrates the placental barrier and the BBB. Binding to blood plasma proteins - 20%. Metabolised in the liver by oxidation and binding to glucuronic acid. It is excreted in the urine (60-80%) and feces (6-15%). With topical application, the systemic effect of Rosex is minimal.

Indications

• trichomonas vaginitis and urethritis in women;
• Trichomoniasis urethritis in men;
• giardiasis;
• amoebic dysentery;
• anaerobic infections caused by microorganisms sensitive to metronidazole;
• combined therapy of severe mixed aerobic-anaerobic infections;
• prevention of anaerobic infection in surgical interventions (especially on the organs of the abdominal cavity, urinary tract).

For external and local use:

• treatment of pink and vulgar acne;
• bacterial vaginosis;
• treatment of long-term healing wounds, trophic ulcers.

Forms of release

Gel for external use 0,75%.

Cream for external use 0,75% (sometimes mistakenly say ointment).

Instructions for use and how to use them

Outer and topically apply 2 times a day, the dose is set individually.

Side effect

• nausea, vomiting;
• lack of appetite;
• metallic taste in the mouth;
• headache;
• increased excitability;
• irritability;
• insomnia;
• dizziness;
• confusion of consciousness;
• depression;
• convulsions;
• hallucinations;
• skin rash;
• itching;
• hives;
• leukopenia;
• irritation (with local use).

Contraindications

• organic lesions of the central nervous system
• blood diseases
• liver dysfunction
• 1 trimester of pregnancy
• increased sensitivity to metronidazole.

Application in pregnancy and lactation

Rosex quickly penetrates the placental barrier. In 2 and 3 trimesters of pregnancy, Metronidazole is used only for vital indications.

Rosex is excreted in breast milk. If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

special instructions

Caution is applied to Rosec for liver disease.

In combination with Amoxicillin is not recommended for use in patients younger than 18 years. During the treatment, systematic monitoring of the peripheral blood pattern is necessary.

During treatment of trichomonas vaginitis in women and trichomoniasis in men, it is recommended to abstain from sexual activity; simultaneous treatment of both partners is mandatory.

During the application of metronidazole, a darker color of urine is observed.

During the treatment with metronidazole, alcohol should be avoided because Due to the violation of alcohol oxidation, the accumulation of acetaldehyde may occur. As a result, reactions similar to those characteristic of Disulfiram may occur (spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

Drug Interactions

When used simultaneously with antacids containing aluminum hydroxide, with colestyramin, the absorption of metronidazole from the digestive tract decreases slightly.

With the simultaneous use of metronidazole potentiates the effect of indirect anticoagulants.

With simultaneous use with disulfiram it is possible to develop acute psychosis and impaired consciousness.

It can not be ruled out that the concentration of Carbamazepine in the blood plasma increases and the risk of developing toxic effects increases with simultaneous use with metronidazole.

With simultaneous use with lansoprazole, glossitis, stomatitis and / or the appearance of a dark color of the tongue are possible; with lithium carbonate - it is possible to increase the concentration of lithium in the blood plasma and the development of symptoms of intoxication; with prednisone - increased excretion of metronidazole from the body due to the acceleration of its metabolism in the liver under the influence of prednisone. There may be a decrease in the effectiveness of metronidazole.

With simultaneous use with rifampicin, the clearance of metronidazole increases from the body; with phenytoin - a slight increase in the concentration of phenytoin in the blood plasma is possible, a case of the development of toxic action is described.

With simultaneous use with phenobarbital, the excretion of metronidazole from the body is significantly increased, apparently, due to the acceleration of its metabolism in the liver under the influence of phenobarbital. There may be a decrease in the effectiveness of metronidazole.

With simultaneous use with fluorouracil, toxic action is enhanced, but not the effectiveness of fluorouracil.

A case of development of acute dystonia after taking a single dose of chloroquine in a patient receiving metronidazole is described.

With simultaneous use with cimetidine, it is possible to inhibit metronidazole metabolism in the liver, which can lead to a delay in its excretion and an increase in the concentration in the blood plasma.

With the simultaneous use of ethanol (alcohol) in patients receiving metronidazole, the development of disulfiram-like reactions is possible.

Analogues of the drug Rosex

Structural analogs for the active substance:

• Bacimex;
• Deflamon;
• Clion;
• Metrovagin;
• Metrogil;
• Metroxan;
• Metrolacker;
• Metron;
• Metronidazole;
• Metronidal;
• Metroseptol;
• Orvagil;
• Rosamet;
• Siptrogyl;
• Tricho-PIN;
• Trichobrol;
• Trichopol;
• Trichosept;
• Flagel;
• Efloran.

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