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Heptral - instructions for use, analogs, reviews and release forms (400 mg tablets, injections in ampoules for intravenous and intramuscular injections) of a drug for the treatment of liver diseases in adults, children and in pregnancy

Heptral - instructions for use, analogs, reviews and release forms (400 mg tablets, injections in ampoules for intravenous and intramuscular injections) of a drug for the treatment of liver diseases in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Heptral. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Geptral in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Heptral in the presence of existing structural analogues. Use for the treatment of liver diseases in adults, children, as well as during pregnancy and lactation.

 

Heptral - hepatoprotector, has antidepressant activity. Has choleretic and cholekinetic effect. It has detoxification, regenerating, antioxidant, antifibrozing and neuroprotective properties.

 

Replenishes the deficit of ademetionine (the active substance of the drug Geptral) and stimulates its production in the body, primarily in the liver and brain. Participates in biological reactions of transmethylation (methyl group donor) - the S-adenosyl-L-methionine molecule (ademethionine) donates the methyl group in the reactions of methylation of phospholipids of cell membranes, proteins, hormones, neurotransmitters; transsulfation - the precursor of cysteine, taurine, glutathione (provides redox mechanism of cellular detoxification), coenzyme acetylation. Increases the glutamine content in the liver, cysteine ​​and Taurine in plasma; reduces the content of methionine in the serum, normalizing metabolic reactions in the liver. After decarboxylation it participates in aminopropylation processes as a precursor of polyamines-putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, which are part of the ribosome structure.

 

Has a choleretic effect due to increased mobility and polarization of hepatocyte membranes, due to stimulation of the synthesis of phosphatidylcholine in them. This improves the function of hepatocyte-associated transport systems of bile acids and promotes the passage of bile acids into the biliary system. Effective with intraloble variant of cholestasis (a violation of synthesis and current of bile). It contributes to the detoxification of bile acids, increases the content of conjugated and sulfated bile acids in hepatocytes. Conjugation with taurine increases the solubility of bile acids and their removal from the hepatocyte. The process of sulphation of bile acids contributes to the possibility of their elimination by the kidneys, facilitates the passage through the membrane of the hepatocyte and excretion with bile. In addition, sulfated bile acids protect the liver cells from the toxic effect of non-sulphated bile acids (in high concentrations present in hepatocytes with intrahepatic cholestasis). In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome reduces the severity of skin itching and changes in biochemical parameters, incl.level of direct bilirubin, activity of alkaline phosphatase, aminotransferases.

 

Choleretic and hepatoprotective effects persist up to 3 months after discontinuation of treatment.

 

Efficacy is shown for hepatopathies due to hepatotoxic drugs.

 

The administration of the drug to patients with opioid addiction, accompanied by liver damage, leads to regression of clinical manifestations of abstinence, improvement of the functional state of the liver and the processes of microsomal oxidation.

 

Antidepressant activity manifests itself gradually, beginning with the end of the first week of treatment, and stabilized within 2 weeks of treatment. The drug is effective in recurrent endogenous and neurotic depressions resistant to amitriptyline. Has the ability to interrupt recurrence of depression.

 

The purpose of the drug in osteoarthritis reduces the severity of the pain syndrome, increases the synthesis of proteoglycans and leads to partial regeneration of the cartilaginous tissue.

 

Pharmacokinetics

 

The tablets are covered with a special shell that dissolves only in the intestines, due to this ademetionin is released in the duodenum.Binding to serum proteins is negligible. Penetrates through the blood-brain barrier. Regardless of the route of administration, a significant increase in the concentration of ademetionine in the cerebrospinal fluid is noted. Biotransformatsya in the liver. It is excreted by the kidneys.

 

Indications

  • chronic acalculous cholecystitis;
  • cholangitis;
  • intrahepatic cholestasis;
  • toxic liver damage of various etiologies (including alcohol, viral, drug / antibiotics, antitumor agents, antituberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives);
  • fatty degeneration of the liver;
  • chronic hepatitis;
  • cirrhosis of the liver;
  • encephalopathy, incl. associated with hepatic insufficiency (including alcoholic);
  • depression (including secondary);
  • abstinence syndrome (including alcohol).

 

Forms of release

 

The tablets covered with a cover, soluble in an intestine of 400 mg.

 

Lyophilizate for the preparation of solution for intravenous and intramuscular injection (injections in ampoules for injections).

 

Instructions for use and dosage

 

Pills

 

The drug is prescribed by mouth in a daily dose of 800-1600 mg. The duration of maintenance therapy can be on average 2-4 weeks.

 

Tablets should be swallowed whole, not liquid, preferably taken in the morning, between meals.

 

Ampoules

 

Apply intravenously or intramuscularly.

 

The lyophilizate must be dissolved in a specially applied solvent immediately before administration. The rest of the drug must be disposed of.

 

The drug should not be mixed with alkaline solutions and solutions containing calcium ions.

 

In case the lyophilizate has a color different from almost white to white with a yellowish tinge (due to a crack in the vial or heat exposure), the Heptral drug should not be used.

 

The drug Heptral with intravenous administration is administered very slowly.

 

Initial therapy

 

The recommended dose is 5-12 mg / kg per day in / in or / m.

 

Intrahepatic cholestasis

 

The drug is administered at a dose of 400 mg per day to 800 mg per day (1-2 vials a day) for 2 weeks.

 

Depression

 

The drug is administered at a dose of 400 mg per day to 800 mg per day (1-2 vials a day) for 15-20 days.

 

If necessary, maintenance therapy is recommended to continue taking Heptral in the form of tablets at a dose of 800-1600 mg per day for 2-4 weeks.

 

Side effect

  • gastralgia;
  • dyspepsia;
  • heartburn;
  • allergic reactions.

 

Contraindications

  • 1 and 2 trimester of pregnancy;
  • lactation period (breastfeeding);
  • age to 18 years;
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

It is not recommended to appoint Heptral in the first and second trimesters of pregnancy and lactation (breastfeeding).

 

Use in children

Contraindicated in children and adolescents under the age of 18 years.

 

special instructions

 

Given the tonic effect of Heptral, it is not recommended to apply before bedtime.

 

With the appointment of Heptral, patients with cirrhosis of the liver against a background of hyperaemia require a systematic control of the level of Nitrogen in the blood. During prolonged therapy, it is necessary to determine the content of urea and creatinine in the blood serum.

 

The solution is prepared immediately before use; if the color of the lyophilized powder differs from that of the white powder, it is necessary to refrain from using it.

 

Drug Interactions

 

There was no known drug interaction between Heptral and other drugs.

 

Analogues of the medicinal product Heptral

 

Structural analogs for the active substance:

  • S-adenosyl-L-methionine disulfate p-toluenesulfonate;
  • S-Adenosylmethionine;
  • Ademethionine 1,4-butanedisulfonate;
  • Heptor;
  • Heptor N.

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Reviews (140):
Guests
Alexey
If it were not just a drop deadly price for packing the medicine Geptral (considering that the course of treatment a month the amount is generally impressive, that the tablets that powder for droppers), otherwise the medicine is just wonderful. In the beginning, I was given droppers with this medicine on glucose, then I was prescribed it in tablets. After a month of treatment, the control ultrasound showed no fatty liver hepatosis, although before that doctors shook their heads saying they had big problems with the liver with an unknown result.

Then the truth passed to the cheaper Silimar (all on the advice of a doctor, he would not have dared to appoint such an expensive treatment, and the problem was very serious). In general, a year has passed after the course of treatment with Heptral and Simlimar, as with the liver friend, diet and lack of alcohol and smoking in addition, too, must be observed.
Guests
Svetlana
Oh God! All the side effects that are listed in the annotation of this drug from the nervous system and "others" - it all happened to me !! At first I thought that I fainted, I fail, I return to reality again, then a terrible chill began ... a terrible condition in general, when it freezes and shakes and no strength. Strangely, the first 2 days I suffered normally, apparently as the drug accumulated side-line, I still did not eat anything that day. Well, finally ... swallowed, it was very difficult to swallow food, drank antihistamines. Voobshchem, as that so, have in view of, who was solved on this preparation - be ready to collateral)))
Guests
olga
We took heptral for six weeks, treated the liver after antibiotics, as a result, the analysis is worse than before treatment, which is not the case.
Guests
Elena.
The first review under the nickname Alex, I read on another site. I am convinced that this drug is being promoted by a company that imports it to the territory of Russia. The drug is expensive and it should be bought. It's a lot of money. My doctor always prescribes another medicine. People should be vigilant. Do not give in to false reviews. It's your liver!
Administrators
admin
Elena., I closely follow the reviews, which are posted by visitors in the Directory. If marketers start "hooligan" in advertising their drugs, placing inaccurate information under the guise of reviews, then I send such drugs to the blacklist. In this case, it is more difficult or almost impossible to add the ordered positive feedback because of the strict control of such a remedy on my part. The response of Alexey to the drug Heptral was written once, like on other sites did not find, on order looks like a weak.
Administrators
admin
olga, Variants can be such: or the wrong reason (it at all in a liver is not necessary - here the data of analyzes are necessary,which are rejected from the norm), or the treatment is incorrectly chosen, or the drug in your attitude simply did not work.
Guests
Andrei
I tried a bunch of all hepatoprotectors, but I think this is the best, both in terms of the intensity of the exposure, and the minimal manifestations of side effects. Analyzes after three weeks of use, as in a child. The only thing when I was already taking the pill form, I risked taking it before going to bed, I could not sleep for half a night (well, it's written in the instructions). By the way I compared with the analogue Heptor - the effect of the drug is worse. Everything is fine, except for the high price.
Guests
Kolobok
Applied after the preparation for the competition))) Vprintsipe all ok! Cleared so that the force is gone)))) A month later, I'll pierce)))
Guests
MASTER
"... The administration of the drug to patients with opioid addiction, accompanied by liver damage, leads to regression of clinical manifestations of withdrawal symptoms ...". Can someone tell me on the person who consumes marijuana available to me how can I apply this medication or not?
Administrators
admin
MASTER, To begin with, the line in the manual refers to opioid drugs, and not cannabinoid, to which marijuana refers. And this line means that with the use of the drug Heptral, regression of clinical manifestations of abstinence, that is, a reduction in the symptoms of withdrawal symptoms ("withdrawal"), can occur. And in general, drugs are evil and it is necessary to tie with this business, it all starts with harmless grass, and the outcome is one ...
Guests
Lena
Admin, In general, the regression of clinical manifestations of withdrawal, if translated into a simple language - reducing the symptoms of withdrawal ("breaking"), that is, on the contrary - the craving for drugs decreases, which is logically clear, any "washing and cleansing" of the body contributes to this and does not matter , what a drug this is :-)
Administrators
admin
Lena, Thanks for the amendment and really something I earned and wrote quite the opposite. Has corrected the recommendation. And about the type of drug took verbatim from the instructions, that is, what they could prove, then wrote in the instruction. Thank you again for your help.
Guests
Marina
I go through the treatment with heptral + essential phospholipids 2 times a year, I make 10 systems. (I have chronic hepatitis), it turns out in winter and summer, for 7 years, I did not have any side effects. After treatment, I just fly, ease in the liver and tests are always on control, I'm happy with these drugs.
Guests
Paul
He was treated in the Road Clinic, the doctors there are a professor through one. Assigned heptral, all tests improved at times. The liver is cheerful. Only if he began to heal, then bring the matter to the end, and then the effect will not be, and money to the wind!
Guests
Olga
There was a wild scabies, torn to the ground. Have put in hospital on preservation. It turned out hepatic transaminases were off scale (one of the indicators was more than five hundred was, and the second a little more than seven hundred). We wanted to operate on week 33. Assigned droppers heptral and pills Ursofalk (because of the price was replaced by a slightly cheaper option). Thanks to the heptral, the month was won by my sun, before the operation the lsat was 98, and ltas 124 (with letters I can make mistakes, but the numbers are more important), even above the norm,but nevertheless not five hundred and seven hundred. And I did not have any of the above-mentioned side effects. Now everything is fine.
Guests
Larissa
In the analyzes of AST-171, ALT-293, GGT-137, such a course of treatment was prescribed. 2 droppers neohemodes, 15 injections of heptral for 2 weeks - tablets heptral. It was 8 years ago. There were no side effects. Very satisfied!
Guests
Lee
With indices of ast 900 and alt 700, 7 heptral drops were prescribed, the first 2 droppers passed well, diluted in 200 ml of saline. The third another honey sister did a little faster and got out all the pobochki, smeared on the bed, pounding, nauseous with something terribly sweet, the pressure is still falling by the way! Now we breed on 400 ml fiz r-on and drip very slowly and everything is all right, then we re-take biochemistry. From what is so planted the liver and did not find a reason: tests for viruses are negative, I do not drink and do not smoke did not take. The doctor said that maybe it's paracetamol, which I always knock down the temperature and just drink cold, it's like a poison for the liver in women!
Administrators
admin
LeeParacetamol has a very narrow therapeutic window (there is a high risk of overdose) and it has a hepatotoxic effect in excess of a sufficient dose, perhaps your problems are also due to this. In any case, thanks for the detailed feedback and get well.
Guests
matvey
I drink heptral once a year for two years, the result is still standing. Not worse not better. Although bilirubin was normal.
Guests
Saya
The dear doctor! The doctor appointed me heptral and in / in the form and as a pill, I breastfeed, and it is written about contraindications during lactation (((I want to know your opinion
Administrators
admin
Saya, During breastfeeding, Heptral is used only in cases where the expected benefit of therapy for the mother exceeds the potential risk for the baby. So I would or would not use this medication during breastfeeding, or if it was necessary to use it, I canceled breastfeeding for the duration of treatment.
Visitors
Maksim
Good afternoon! I was prescribed intravenous Heptral, only we do not know how it can be administered and began to be used by mixing it with saline 200 ml., And by injecting it in this way intravenously. Is it correct?
Administrators
admin
Maksim, Yes, you did everything right. First, the drug is diluted with a special solvent, the ampoules of which are applied to the drug, then the resulting solution is diluted with 200 ml of saline to the desired volume and injected intravenously drip slowly in the form of a dropper. Intravenously on a syringe, given the small amount of dilution with this method, it is wise to administer intravenously Heptral.
Visitors
Aleksei9157
Hello, how best to apply Heptral intravenously or in muscle with chronic hepatitis?
Administrators
admin
Aleksei9157, I prefer the intravenous route of administration of Heptral, all other things being equal. It is worth noting,that this way of imposing imposes certain obligations on both the patient and the medical staff, because it will not be possible to introduce the drug at home in this way, only in a specially equipped procedural room.
Guests
Bondarenko Oksana
I really like this drug, I tried many things. I have been using this for 5 years. Two courses a year. Expensive, but effective! It suits me, despite my allergy. To that what. I wish everyone good health!
Visitors
oooseverplus
The patient with oncology is assigned heptral intravenously drip with hepamerz solution. The patient received 5 droppers at home, feels well. 2 days break and again continue treatment.
Guests
Oksanchik
I really like Geptral. I pierced it intravenously, only with injections, and not with droppers. Analyzes became normal and there were no side effects.
Guests
lads
I am very upset. Has made 5 injections and 3 weeks of a tablet, and parameters of alt and astas have increased in 4 times.I'm just crying. I have hepatitis c, but the tests were normal. Here after heptral ... And all write helps ...
Visitors
rishat
Began to enter intravenously, reached half, the pressure rose sharply to 170. What was this reaction? And whether it is possible to replace tablets.
Administrators
admin
rishatMore like excitement as a result of injection. Adverse allergic reactions often lead to a drop in blood pressure. So I would try to repeat the dropper. If the situation repeats with the patient's identical psychological state, it is better to switch to a tablet form of the drug or consult a doctor (in any case, it is advisable to consult a doctor who prescribes Heptral), may overdo it with the dose of the drug.
Visitors
Kirill
Good afternoon! Has handed over analyzes ALT-100, AST in norm or rate. Have appointed heptral in tablets with a course of 2 tablets 3 times a day for a month. It seems to me that it exceeds the maximum daily dose of 1600 mg / day in accordance with the instruction or is it allowed to take 2400 mg / day?
Administrators
admin
KirillAnd have you diagnosed any diagnosis? The increase in hepatic enzymes can occur both from hepatitis and from an adverse reaction to other drugs. What is the purpose of the treatment then, if the diagnosis is not known (this follows from the description of the problem and the question). I would start with the pre-examination and after the fact of finding the problem I prescribed treatment. And so Heptral, I prescribe by instructions to 1600 mg per day, but the situations are different and in your case the increased dosage for me is not obvious.
Guests
lads
At me after a chemotherapy fatty hepatosis. I digged through heptral, but no shifts.
Guests
Dionysus
I read a lot of reviews on heptral and I liked everything. Prior to that, I was treated with Essentiale and the effect was not very, and then I decided and bought two packages of heptral and put it myself at home intramuscularly and I will say so, the effect is very good for half a year was enough. Now I'm thinking of repeating the course! Of course, intravenously would be even better intravenously, but I do not want to go to the hospital, I always do my own tests for myself and I myself am treated myself and put the dropper with essential oil, but I do not dare to hesitate for some reason, but it also helps me intramuscularly!
Visitors
Leprikon
Admin, How to take heptral intramuscularly? How to breed? What are the doses?
Administrators
admin
Leprikon, The dosage of the drug for a specific patient is determined by the doctor, and he already proceeds from the diagnosis and severity of the disease. Dilute the preparation for intramuscular injection with the solvent used in the medicine package. When you enter the solution, you do not need to mix it with other solutions (only Heptral should be in the syringe).
Guests
margo
Expensive, but effective for a while, then you need to continue, and so from year to year.
Guests
a guest
Hello, tell me, can Heptral (pills) somehow affect the eyesight? I take a month, I began to notice that I see little at close range. I am 31 years old. Thank you.
Administrators
admin
a guest, Heptral of side effects on vision usually does not give and in the instruction they are not marked. Most likely, the reduction in visual acuity and taking the drug are not related to each other.Address to the oculist.
Guests
a guest
I started to take it. In Kiev, it costs 50 dollars 20 tab, I do not know how it is in Russia. For Kiev, this is expensive. The depression was creepy. Now this is easier. But what I noticed on my own. On the chest sometimes "put a stone slab." And here 20 tabs have already finished, at least 5 more days to drink, "stove" is increasingly worried. A terrible meteorism was in the first place, and neither there nor here, in general, a kapets. I frightened all kinds of parasites with fright, because I could not understand the reason. Perhaps heptral, because I myself am on a fairly tough diet for a month for sure. In addition to depression, it seems like increased efficiency. That is, there is a feeling that it raises the tone. This I really like, if not for this heaviness in the chest (and I also have asthma and I'm very difficult to cope with this, because it crushes, but obviously it's not asthmatic and the inhalers do not remove it), then probably I would have liked it. Price of course kapets what is wrong))
Guests
Vasina Natalya
The doctor appointed intravenously Heptral, one package was punctured - everything was fine.I bought the following and during the introduction of the drug was bad: a severe headache, sparks, a strong heartbeat - instantly, well the doctors immediately helped - brought down the pressure, which was almost 200!
Guests
a guest
Vasina Natalia, I also had the same thing as with you. Heptral was injected intravenously from the syringe. Then he began to drip a dropper on glucose, nausea and heartburn, and unpleasant sensations in the right side. Today I did only the third dropper.
Guests
Misha
Me too, when I / in the introduction is very bad! A strong headache, a strong tide to the head and face, a ripple in my head is unbearable. Even it became terrible. Before reading the comments, I thought that I had a fake, now I do not even know what to think. I stab 2 times a year usually, 3 years, I was all good. What is noteworthy is that the packaging was different, they told the pharmacy not to forge the packaging to change specifically. I do not know...
Administrators
admin
Misha, In fact, you can find out whether a fake or not only by requesting documents for a consignment of drugs in the pharmacy. When there are doubts, I always do so and the pharmacist must provide them.And all the rest of the nonsense and packaging are changing, and we also have enough impure people.
Guests
Curiosity
Hello. Tell me, please, but can I use it for prophylaxis? As well as in what doses - if possible. Prevention - as a lover of fatty, fried, alcohol =)))
Administrators
admin
Curiosity, With the preventive purpose the preparation of Heptral is not used. This medication with its list of indications, which guides the doctor when appointing a particular patient. With a preventive purpose, it is better to use natural natural preparations and supplements, for example, based on seeds and thistle oil, but this is in light cases when there are no obvious problems with the liver.
Guests
Pelargonium
I advise you to first buy 1 package and try it. all people show different side effects. I foolishly bought two packs, swept to 250 fiz. solution and on day 3 the depression increased many times and just like in one of the previous comments "the feeling of a stone slab on the chest."So it is not known what can be expected from heptral :)
Guests
sprat
Concerning the forgery, due to the high cost of the drug in our pharmacy (I live in pgt) are brought only on request and on an advance payment, therefore, it is not possible to claim documents for the party. How to be? In general, I like the drug, I drip a second time.
Administrators
admin
spratIf it is a single delivery, then you can ask for a copy of the original documents for a consignment of medicines, because it is understandable that the originals remain with the main party. All the same, the numbers of the markings on the package and in the documents must match.
Guests
Hermann
He took Heptral for prophylaxis himself, without the advice of a doctor, as he often used alcohol. I took 20 days, after a couple of weeks something like wax came out of me, quite a lot with a very bad smell. I think that the prevention has gone to the benefit.
Visitors
floret
Question to the doctor.To me have appointed or nominated an antibiotic cefixime for liquidation klebsiella (some years can not deduce or remove it or her). And since when taking antibiotics, I get itchy on the mucous, the doctor prescribed Heptral. Will this drug help to remove the itching in the vagina? Can you use something cheaper to relieve itching?
The stomach is removed by oncology. Diffusive changes in the liver, nonspecific. Increase of intrahepatic vascular resistance. LCB, clots of bile, echo suspensions. Increase the volume of the HP. Holedoch.
I received heptral in tablets 2 times a day for 10 days.
Administrators
admin
floret, Itching in the vagina after taking antibiotics is more typical for candidiasis or thrush, so I would prescribe drugs to combat this scourge - clotrimazole, fluconazole and their commercial counterparts.

Given the problems with the liver, after a course of antibiotic therapy, you can also undergo treatment with the drug Heptral to maintain detoxifying liver function. It will not be worse. The course of treatment for this drug is 2-4 weeks, so that 10 days prescribed by your doctor will be small.
Guests
Lesya
Only today did the 10th injection of Geptral. They did intramuscular to not go to the hospital. As pobochka, strong dizziness. A couple of days just fell, get up afraid. Completed every other day. The liver reacts 20 minutes after the injection with a kind of contented, warm sigh with a smacking.)) I like it very much. Immediately after the introduction, warmth through the veins is felt, hands become hot. Excellent acted as an antidepressant - a good share of pofigizma was added to everything. Adds tone, sleep after it does not work. Today I bought pills, tomorrow I'll start the reception. Then I'll give biochemistry and see what's wrong with the transaminases. But the sensations - the liver really liked it!
Guests
Lyudmila
The doctor prescribed intramuscular injections of heptral for fatty liver hepatosis. Today is the 9th day of treatment, before the tests are taken away, but the mood is fine, the depression is gone, I see no side effects, but I can not fall asleep right away. Then in the tablets take 4 weeks. As a course I will pass, I shall write about results.
Guests
Irina
At my sister a cirrhosis of a liver, two years daily "we sit" on heptral. Expensive, but tried to replace the cheap, immediately deteriorating sharp. I think due to the use of heptral, she still lives. In January of last year, doctors unanimously assured that there were only three months left.
Guests
Andrei
Read the reviews. Many write expensive, and search the Internet for a normal price can not be? I use the analogue from DoctorBest, bought on Ayherbe - 60 capsules of 400 mg of 2300 rubles. In case of occurrence of pobochek it is necessary to realize that cleaning has begun and use of antiallergic and cleansing preparations. Himself used homeopathic drops BodiEnu or drops from the company Hel + wife gave inexpensive, the name is forgotten, for 53 rubles a pill of allergies. Pills-cleaning from the intake of dietary supplements have been several times. In the case of homeopathic drops, relief came in the evening. And when lips and tongue swelled, inexpensive tablets coped completely and finally for three days. For the liver I recommend this formula with the infusion of the saltwort hilly 2 tablespoons per 300 ml of thermos. For bones it is well combined with hondoprotectors, collagen 1-3 gr. and hyaluronic acid.I wish everyone good health, attention and cleansing of ears from noodles, well, who has such a problem of course, because often so-called "official dealers" do not hesitate to make a 300-400% turn, and network companies 500-1000%.
Guests
Former
Before I cured hepatitis (Indian generics sophosbuvira and daklatasvira and ribavirin $ 700 for everything), I did not wait for two years on heptral, but on hepatosan and enterosan from 300 to 400 rubles for a bank of both. It was a tangible aid, he could not undo it. Although it was supposed to be periods to give a rest. At attempt of cancellation in 5 days signs, so ran to a drugstore and took. Yet it is 4.5 times cheaper than heptral and quite effective, judging by my case. In 2013, gep S. Small dizziness and vertigo dv.vsem known. At the end of 2015, the belly went away, fibrosis on elastometry from 1.5 to 2.5. True rigidly followed the diet of 5 salt-free and sugar replaced for honey, jam.
Guests
Baku
I was injected with a syringe intravenously into the hand very, very slowly. I want to pierce again after 2 years. At me a tumor in a liver a hemangioma, a pancreatitis and cholic left.Truth is expensive, but it's necessary.
Visitors
ROA
To the father at mts in a liver have appointed or nominated dlinno. In the appointment in the morning 2 vials / m, in the evening at 20.00 1 bottle. Do not bust in dosage and time injections?
Administrators
admin
ROA, Appointment is some exotic, because I would leave only 2 bottles in the morning, without the evening appointment of Geptral. Although the reason for your father is not trivial, so in severe cases, deviations from the recommended average therapeutic dosages may be observed, and metastases to the liver are just such a difficult situation. If the father is obese, then according to the normative 5-12 mg per 1 kg of the patient's weight, it is possible to fully meet the recommended daily dosage of 1200 mg, for this it is enough to have 100 kg of the body weight of the patient? then the appointment is justified.
Guests
Andrei
Good afternoon. I was prescribed heptral in tablets as a drug in the complex for the treatment of Gilbert's syndrome. Took two days for one tablet in the morning.On the second day after the reception, there was a feeling that my legs and hands were numb, as if the consciousness was losing, accompanied by the weakness of the whole organism.
Visitors
vikulek80
Everyone writes that they first took intravenously, and the doctor assigned me just pills, I have a 2-3 times increase in transaminase in my blood (he said so) and drink these pills. Do I always have to first drip or can I start with pills?
Administrators
admin
vikulek80, Maybe in your medical institution there are no qualified personnel and conditions for setting up intravenous drippers, so the doctor ordered you to take pills. In any case, we will not solve this issue remotely, but if the transaminase excess is several times more logical, it would be more logical to prescribe an injectable injection of Geptral. Can you try the intramuscular injection of this medication, this option is also possible, but it is necessary to coordinate it with the attending physician.
Visitors
vikulek80
vikulek80, The question is transferred to the preparation of Heptor, where it is more appropriate.
admin
Guests
Angry_Pug
Andrew, I also have a zilbera syndrome and the same reaction to taking heptral. Today smeared so much that I thought I would lose consciousness. Here also I think it is necessary to accept further.
Guests
Yuri Vasilievich
I bought Heptral production in Greece - in general, garbage some kind, does not work. Before this packing was another one - used only by Germany, and it managed to buy in Athens pharmacy, Greece, ((((They said that this is the same, but I advise everyone to bypass this Greece because the sensations and the effect of heptral which before these ampoules were absolutely different, more effective.

I take Heptral with a dropper for a long time, and I did not regret money and time, either intravenously or intramuscularly, but believe it there is no effect over the years ... The pains in the liver return all the same, and all this only for a short time and for the sake of self-complacency. I pierced about 20 packs of 400 mg of Ademetionine Heptral and all is useless.
Guests
Edward
Andrei, how was it going?
Visitors
rishat
2 packages were poured. The weakness is incredible, all broken. Worse.Has handed over analyzes, ALT became even above. Conclusion for himself put one, vaunted drugs. Hepatitis c.
Guests
a guest
Good afternoon, I'm already finishing up stabbing the second package of heptral. Sensations from him are incomprehensible, but obvious - it's constantly hot, or cool, or there is a feeling that the pressure has risen, some kind of weakness, although there is no weakness, the feeling in the evenings as if the temperature rose.
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Senya
After receiving heptral, blood sugar sharply increased and "scabies" of the lower third of the limbs began. I immediately canceled and passed. Is there any information on the effect of heptral on diabetes?
Administrators
admin
Senya, Heptral for the exchange of sugars is not affected. Usually, even diabetics take it calmly. I suspect or individual reaction to this medicine of a particular patient, or the problem is in something else.
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Chris
Good afternoon! Can heptral be taken to patients with a distant gallbladder?
Administrators
admin
Chris, Can. Heptral on the bladder does not affect. Only patients with cirrhosis of the liver need periodic monitoring of levels of urea and creatinine in the blood, but this is more the function of the kidneys is additionally involved.
Guests
Irina
To my son 10 years at it or him the US has shown a fatty hepatosis, ALT-91, and AST-47.9. The doctor prescribed heptral in tablets 3 times a day and ursosan 2 capsules at night. I do not understand something, I read the instruction, and there you can not apply it to 18 years. And I'm afraid of side-effects, and he also has autism. He really if something and will disturb, that will not tell. What should I do?
Administrators
admin
Irina, I can assume that it is forbidden to use Heptral in children, because there are not enough clinical studies to use the drug in this age group of patients. In this case, everything is at the discretion of the doctor and parents. If there is nothing to replace a specific medicine, then we appoint it for fear and risk. This does not mean that the drug will give a necessarily negative effect, this is a relative contraindication.Sometimes the truth is that there are abuses on the part of doctors who test drugs on different groups of patients, then they account for this for money to the drug companies, but this is rare.

As for me, judging by the analysis, I would limit myself to Ursosan and a strict diet. It is also necessary to establish the reason why a child suffers from a liver - an infectious disease, hepatitis, a lifestyle. Treatment without eliminating the causes will not do much good.
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indigo
Hello, Doctor! Biochemistry: ALT-96; the norm is up to 41. AST-55; the norm is up to 38. Amylase - 93; the norm is 28-100. Bilirubin total 8; norm 3-17. Glucose is normal. Cholesterol is normal. ЩФ 55; the norm is 40-100. Clinical tests are normal, so is urine. I drink at the moment "Creaton N" and renal collection, all this twice a day. To drink a month. As the urologist still it is registered "Cystonum" but while I drink Kreaton N which the urologist from hospital as has just ordered the doctor. Tell me, please, is it possible to take the heptor as prescribed by the narcologist, or Heptral (as he is praised here on the forum, rather than our Russian analogue "Heptor"), which the therapist prescribed to me, but he also said that you can take as Heptral and as a heptor, prescribed to me by a narcologist, who took me out of alcohol intoxication ...To drink these medicines a month is needed to restore the liver (as far as I know, the liver itself must be restored), and even before I passed these tests, which I quoted above, I drank the antibiotic "Amoxiclav 1000" for a week, which the urologist prescribed (although he told me without an anamnesis , not knowing my sores are chronic and so ... prescribed to drink them as much as 2 weeks). After reading this antibiotic in the instructions, it turned out to be very strong, so another doctor told me that the narcologist said that he had enough for a week to drink it. So the question also arises, can this ALT with AST be increased because of this antibiotic? And yes, on ultrasound I have diffuznizmen.pemen.pechenii and pozhelu.dzhelezy, but they have been before for a long time ... In general, I have a whole bunch of bouquets can say at their 34 years, plus now the kidneys have added, I hope they at least will be cured. Chr.pancreatitis, gastroduodenitis, dyskinesia of the intestines was diagnosed, but it was all the consequences of alcohol, although chronic sores suffice now, now in the hospital the diagnosis was left-sided renal colitis. Although they took with exacerbation hr.pancreatitis. At me a question, whether it is possible to accept preparations Geptor or Geptralum? Now the state of health is sluggish, although it is possible from lying on the couch, plus for the night I still take "Atarax" for sleep.When I sit, there is a loin aches, more precisely a burning sensation that some, can the kidneys, can something with the spine, because they diagnosed osteochondrosis. In the toilet I go to the norms, the urine is light, there is no pain when urinating. I would be very grateful for the answer. Thank you.
Administrators
admin
indigo, So many problems with the gastrointestinal tract, which shows a consultation of the gastroenterologist, with all the analyzes and ultrasound of the abdominal cavity. It is not necessary to look for the causes of a sick liver in antibiotics, this is a one-off reception, but regular consumption or abuse (if you have already met with a narcologist) can easily get liver into alcohol. Of course, the courses of hepatoprotectors Heptral or Heptor are shown not for 1 month, but for months 4-6, provided that the way of life is normalized, the diet is observed and alcohol and smoking are discarded. In the rest, a lot of medicines have been shown, but this will be prescribed by the gastroenterologist, after examination and collection of all diagnoses in a heap, because they are already a lot for a young age.

And yes, I did not hear such a kidney colitis, but there is a kidney colic.
Guests
Asya
On the fifth day of the use of tablets, the pressure increased and the blood ran from the nose with weakened capillaries. Somehow stopped. I'm hypertensive. I thought the pressure after the drug would decrease, but it gets worse. Although the liver stopped "talking", calmed down.
Visitors
indigo
admin, Left-sided renal colic was. This diagnosis was put by the doctor in the record.
In the rest everything is clear, but the therapist did not send me to the gastroenterologist. To see it is necessary to treat the liver first, and only then to the gastroenterologist. Although prescribed Omez, Nosh-na with pain ... trimedate or duspatalin.
In general, thanks for the answer.
Administrators
admin
indigo, The gastroenterologist, including the liver, is engaged, and the pancreas, so to whom, as not to this specialist, solve all your problems with the gastrointestinal tract. Qualification of narrow specialists in their questions is higher than that of ordinary district therapists.
Visitors
I_Katya
Hello! I have such a problem, AST 64, ALT 170, GGTF 79. All other liver and kidney tests are normal, like cholesterol and a general urine test.In the conclusion of ultrasound, the left lobe of the liver is 67 mm, the tail portion is 16 mm, the right lobe is 135 mm. Minor diffuse liver changes! The conclusion of the EGF is normal! The doctor appointed Heptral 10 droppers, berlition 10 drops and ursofalk 1 t - 3 times a day! But! First he put me fatty hepatosis, then he decided that I have acute toxic hepatitis, today, painting the treatment, almost hinted at cirrhosis and liver transplant! Please answer, is the treatment prescribed correctly? And, really, can I have cirrhosis at such rates ?? And then I already exhausted all! Thanks for the answer)
Administrators
admin
I_Katya, According to the ultrasound of the liver, I see hepatitis (and then with a stretch), where the cirrhosis saw a doctor is unclear. There is a category of specialists that motivates patients to be treated with fright. Though medicines as it seems to me it is written out much. I would limit myself to allowing the drippers of Heptral and poprinimal then Ursofalk course 3-4 months and after repeatedly passed the biochemical analysis and repeated ultrasound of the liver. By the way, it would be nice to check sugar in the blood, if this figure was not made, and also observe a strict diet,about which you should have been told by the attending doctor, and also not to drink alcohol and not to smoke, and the liver should come back to normal.
Visitors
Chanterelle
I have a gallbladder removed, can I take Heptral in tablets? High bilirubin, hepatitis suffered as a child. Constant bitterness in the mouth. Thanks for the answer.
Administrators
admin
Chanterelle, With a distant gallbladder, it is better to use drugs based on ursodeoxycholic acid (Urosan, Ursofalk and others) and cholagogue (Allochol, Cholenzym and others). Heptral is a hepatoprotector and, as if worse, you will not do it, but why should it be dispersed. Dosages and dosage regimens will be prescribed by your doctor.
Visitors
5076415
Good afternoon! Have appointed or nominated treatment ursosan and then after a dropper heptral, on 150 ml fizrastvora. Yesterday was the first dropper, after a few hours it was such a feeling that it was very warm in the hands, shoulders and palms. Is this normal? Dripped for 30 minutes, today put the second dropper, 40 minutes, the feeling a little better, but there is a feeling that it's warm.Is this a symptom for lifting a dropper or is it simply necessary to take 200 ml of saline and drip for an hour?
Administrators
admin
5076415, I think all is well with you. Heat can be felt when putting the droppers Heptral and this is not an indication for its cancellation. About Ursosan did not understand, at first this drug was prescribed in capsules, and then droppers Heptral? Ordinarily, on the contrary, they do, and oral administration reinforces the course of drip therapy.
Guests
11 Glory
I was diagnosed with chronic cholecystitis 15 years ago. Six years ago, I turned to my new therapist: "What does he think about the monthly Essential course plus legalon (karsil - if desired), for prevention, cleaning of the gallbladder and removing the heaviness in the side." She advised me to replace it with a course of Geptral (100 days on one tablet in the morning.) I bought five packages in bulk (then it was about 6 thousand), of course, 100 days were stretched for about 4 months.
But the effect was ... Ease in digestion, less belching (and fat and smoked I never gave up), plus went through hemorrhoids.
Now there is regurgitation and heaviness again. I think to pass or take place US, to hand over analyzes and to repeat a course. It is a pity the doctor is different now. Well, I will consult with the new one.
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Svetlana Ivanovna
A year ago he was treated with Heptral (done on Dysoli drip, 10 days) D / z: Chronic hepatitis of unspecified etiology (no antibodies to hepatitis viruses, lambliasis, type 2 diabetes). Complication on the liver, the endocrinologist assumes, gave the drug Metformin. Before normalization of all parameters of blood it was canceled to me. Before the treatment: ALT 294, AST 168, APF 942. After treatment: ALT 50, AST 27, ЩФ 562. After the droppers - Ursosan 1х2р. 10 days. There were no side effects. Heaviness in the right upper quadrant is gone. Treatment with Metformin resumed. And now again liver indicators are disgusting. Has it all happened again? (I confess, I almost do not observe a diet).
Administrators
admin
Svetlana IvanovnaTherefore, it is necessary to cancel Metformin and sit on a rigid diet, so that the parameters of sugars come back to normal without pills, the diet eventually and the liver will help, because fat goes to the circulatory system of this organ directly. Diabetes mellitus type 2 is a disease of a lifestyle.Yes, there is a genetic predisposition, but here the human factor plays a dominant role. You can continue to eat anything horrible, drink Metformin and ruin the liver, and this will result in either hepatitis or cirrhosis. Here, everyone decides what is more important for him-food pleasures or health. You can try to replace Metformin with analogs, but if the cause is in the active substance, then such substitutions will not give much.
Guests
Alla
The first time pricked 5 ampoules, there were no side effects. Immediately a rush of vivacity, like a motor appeared! The effect on the liver is super! At me a dyskinesia of a cholic bubble since the childhood, disturbance of a diet is naturally present, and also I like to drink, that at once is shown in pains of a liver, an eructation, bitterness and yellow teeth. Previously, only essential and painted, well, heptral is quite another matter. A year later I repeated the injections and with the 1 st intravenous immediately it became warm (always cold), terrible hunger, a rush of strength, my legs swelled and it was hard to breathe and panic. Maybe it's like that, as soon as the drug appears it is of good quality, and then do not understand what is being done. The state is eerie, but for the sake of the liver I will endure.
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Irina
Tell me, but the best effect of Heptral injections IV or IV dropper? I the doctor writes out every six months 5 pcs. pricks with chronic hepatitis. Can the effect be better from the droppers?
Administrators
admin
Irina, Injectable Heptral can be administered intramuscularly or intravenously. The latter implies a drip route of administration. Inkjet anybody this preparation does not prick. If you meant the difference between intramuscular and intravenous administration, then it should not be, but I prefer droppers with stereotypic to this medicine.
Visitors
Madina
Hello. The doctor diagnosed: Chronic cholecystitis, pancreatitis, exacerbation. fatty hepatosis. She did an ultrasound. Analyzes ALT-210, AST-51. Assignment of the doctor: Heptral in tablets 500 mg x 2 times a day one month. She refused the injections (because I take other injections for another case). Still pancreatin and omeprazole. I have a question for you. Since it is very expensive, you can replace it with another one.Whether and in general there will be an effect from reception of tablets and as they are deduced from an organism (what way). Just a medicine is expensive so many questions. Your responses and responses were read. But I would like to hear your answer on my behalf. Thank you in advance.
Administrators
admin
MadinaThere are no direct substitutes, only for a group of hepatoprotectors. You can take Karsil, also a hepatoprotector, but cheaper. But given the analysis, I would take Heptral, although it is more expensive. Plus, if you have extra weight - you have to drive a diet. The latter can help even better pills or injections. It is also worthwhile to determine the level of glucose in the blood and make an analysis for hidden sugar, an increase of this parameter can also negatively affect the liver.
Guests
Wise
Has spent on drink week gepral, the pressure has raised or increased.
Visitors
Tatiana 24
Good afternoon! I beg you to help, my mother is 57 years old. There were problems with the liver, alcohol did not drink, but smokes from 30 years. The analysis of a blood AST 103.9 ALT 67.4, a bilirubin the general or common 24.0, a bilirubin a straight line 16.4. Platelets 116. The liver is enlarged by 3 cm. I passed tests for hepatitis B and C.Hepatitis B analysis is negative. result for hepatitis C: Total antibodies to hepatitis C virus-positive CP 10.4 (CORE-positive CP = 14.75, NS-positive CP = 17.01) Other tests for hepatitis C did not pass (PCR quantitative qualitative indicators and genotype) There are stones in the bile bladder, turned to a polyclinic, put cirrhosis of the liver, on the basis of a blood test, wrote out the drug Ursosan and Phosphogliv.Then my mother made a CT scan, cirrhosis was denied, 2 cysts were told in the liver, and then sent to a gastroenterologist, the Gastroenterologist on the basis of available tests and CT scan The diagnosis is as follows: Chronic hepatitis C of moderate activity, unspecified genotype and fibrosis Stage 2: Stage 1: prescribed drugs Ursosan or its analogs alternate with ademetionine (heptral or heptor) 0.4 1 tablets 3 times a day, 2 months twice a year , plus all sorts of herbs and a diet. "Today my mother turned to the gastroenterologist with a question whether it is possible to swallow the drug heptral intravenously?" The doctor replied that it was possible, it would be better and prescribed 2 bottles for 200 ml of saline. Prompt please, whether treatment is correctly appointed or nominated? And why on the basis of only one analysis of antibodies was diagnosed with hepatitis C? In occasion of a preparationHeptral would like to clarify whether the concentration of 2 bottles is strong at 200 ml of saline, maybe better by 400 ml, re-read the entire branch of reviews on your site, and now I'm afraid how the drug behaves in such dosage? Thank you in advance!
I want to add, I published my question some time ago, but did not publish it, because I was not registered, understood and registered.
Prompt, mum koljut drippers with heptralom and plus pentoksifillin, it is not clear what for the second is necessary and it is possible to accept them in pair?
Guests
Irina
Gastroenterologist prescribed Heptral 10 v / m, then 10 days break, then again 10 injections. I cut off the first 10-current, but I do not know why, there were weak, dull, unstable pains in the region. liver and sour taste in the mouth. There may be a coincidence with the treatment of the periodontist, but earlier "such" was not observed. Two days ago there was, quite strong, transverse, pain in the pancreas. I did not notice my mood rising. In general, no positive result yet.
Administrators
admin
Tatiana 24In principle, the description of the problem, treatment is justified, given that it is currently unspecific and is aimed at maintaining the liver. The diagnosis is probably also true, it will be possible to clarify, after having passed the analysis again and then is already preparing for therapy with modern drugs from hepatitis C (Sofosbuvir, Daklatasvir and other protease inhibitors of the virus), this is now the most modern and radical way to get rid of this virus, . Regarding the dilution, two Heptral vials per 200 ml of saline solution is acceptable and this is an adequate dosage, prescribe and more.

About Pentoxifylline for your mother will not say, probably there are problems with microcirculation and tissue ischemia (and at 57 years this is quite acceptable), and therefore added this tool. Worse, it certainly should not do. And yes your mother's main doctor will have an infectious disease specialist who will prescribe specific medicines, and not just supporting the liver.
Guests
Umejon
Question. Tell me, please, the doctor prescribed me Heptral in tablets. I take 3 weeks for 1t 2 times a day. Only today there was bitterness in the throat and in the mouth.Did someone have such symptoms or is it just because of his choleretic effect? Thank you. All of health.
Administrators
admin
UmejonEveryone can have a different choleretic (cholagogic) effect of Heptral. At you for 3 week, at someone at once. This is normal. If tolerable - you can continue the course of treatment, if unbearable treatment is necessary to the doctor who prescribes this medicine for the necessary adjustments.
Guests
Elena
For several years I have been using the drug Heptral 2 times a year, droppers, and between them tablets. I have type 2 diabetes, sugar is high, I have to drink glucose. For the liver, it is harmful. The doctors talked all the time, and it was evident on the uzi that the liver has fatty degeneration and the parenchyma is loose, etc. I recently made an MRI and CT scan and just fell down - everything was fine. Moreover, doctors commented that they rarely see such a healthy liver. Clear borders are dense, nowhere is there any stagnation or anything else bad. The drug is very good, although of course expensive. But what to do...
Visitors
01081980S
I have 2 otr. gr. blood. The baby was born with hemolytic disease 2 months later died. My allo-immune antibodies in the titre after giving birth are 1: 16384. The immunologist advised me to drip Polyoxidonium in combination with Geptral. Can I get rid of the antibodies with this medication? I would very much like to get pregnant in the near future, but there is no point in making such titles.
Administrators
admin
01081980S, I'm sorry for your grief. You can sweat, but until the body itself does not get rid of excess antibodies at the moment nothing will help much (except perhaps exchange of blood transfusions). Any other treatment in your case can be considered as a restorative or placebo.
Guests
Inna
Is there a delay in menstruation after taking the drug?
Administrators
admin
InnaFrom the experience and the instruction of similar side effects for Heptral was not observed. If only consider this as an individual reaction of your body to use this medication.Check can be canceled Heptral and evaluating the regularity of the cycle after that. It is possible that the reason for the delay in another (I would start with the definition of pregnancy, but the age in question is not specified).
Guests
Olgp
Can I use Heptral in cholelithiasis?
Administrators
admin
Olgp, Heptral has, among other things, choleretic effect, therefore, with stones in the bile duct, it is possible only after consulting with the doctor and comparing the possible risk-benefit. I would choose a hepatoprotector without choleretic effect, for example, Essentiale or another remedy based on essential phospholipids.
Guests
galena
For many years he used the drug Heptral, did it intravenously, and was very pleased with it. But in the next course of treatment, injecting the drug sharply increased the pressure of 200, a sharp taste appeared in his mouth, an infernal headache. I gave the drug for analysis, not falsification.
Guests
Tatyana
After the first dropper with heptral there was an ischemic attack in the brain - there were micro strokes earlier. I think that the nurse introduced very quickly and saline was only 100 mg. As a result, I dripped 6 droppers, now I drink tablets - my head and neck are terribly ill. Neuropathologist on vacation - I drink mexidol and for the night grandaxin. That's what I got with heptral.
Guests
Moore
I thought that this was my end, I got scared and was uncomfortable. The same reaction, heat, heartbeat, I thought I'd turn off. We injected it. Previously, this was not. They offered to drip ...

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