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Eufillin - instructions for use, reviews, analogs and forms of release (tablets of 150 mg, injections in ampoules for injections in solution intravenously and intramuscularly) drugs for the treatment of bronchial obstruction in adults, children and in pregnancy

Eufillin - instructions for use, reviews, analogs and forms of release (tablets of 150 mg, injections in ampoules for injections in solution intravenously and intramuscularly) drugs for the treatment of bronchial obstruction in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Eufillin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Euphyllin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Euphyllin in the presence of existing structural analogues. Use for the treatment of asthmatic status and bronchial obstruction in adults, children,as well as during pregnancy and lactation.

 

Eufillin - a bronchodilator, a derivative of xanthine. Inhibits phosphodiesterase, increases accumulation in tissues of cyclic adenosine monophosphate, blocks adenosine (purine) receptors; reduces the flow of calcium ions through the channels of cell membranes, reduces the contractile activity of smooth muscles.

 

Relaxes the muscles of the bronchi, increases mucociliary clearance, stimulates the contraction of the diaphragm, improves the function of the respiratory and intercostal muscles, stimulates the respiratory center, increases its sensitivity to carbon dioxide and improves alveolar ventilation, which ultimately reduces the severity and frequency of episodes of apnea. Normalizing the respiratory function, contributes to the saturation of blood oxygen and reduce the concentration of carbon dioxide.

 

Has a stimulating effect on the activity of the heart, increases the strength and number of heartbeats, increases coronary blood flow and the need for myocardium in oxygen. Reduces the tone of blood vessels (mainly, the vessels of the brain, skin and kidneys).Has peripheral venodilating effect, reduces pulmonary vascular resistance, reduces pressure in the "small" circle of blood circulation. Increases renal blood flow, has a moderate diuretic effect.

 

Expands extrahepatic biliary tract.

 

It inhibits platelet aggregation (suppresses platelet activation factor and PgE2 alpha), increases the resistance of erythrocytes to deformation (improves the rheological properties of blood), reduces thrombus formation and normalizes microcirculation.

 

Has tocolytic effect, increases the acidity of gastric juice.

 

When used in large doses has an enileptogenic effect.

 

Pharmacokinetics

 

In the body, aminophylline (the active ingredient of the drug Euphyllin) is metabolized at physiological pH values ​​with the release of free theophylline. Bronchodilator properties appear at concentrations of theophylline in the blood plasma of 10-20 μg / ml. Concentration above 20 mg / ml is toxic. The excitatory effect on the respiratory center is realized at a lower concentration - 5-10 μg / ml. Penetrates through the placental barrier (concentration in the fetal serum is slightly higher than in the mother's serum). Excreted in breast milk.In unchanged form, adults are 10%. In newborns, a significant proportion is excreted in the form of Caffeine (due to the immaturity of the ways of its further metabolism), in unchanged form - 50%.

 

Indications

  • asthmatic status (additional therapy);
  • apnea of ​​newborns;
  • violation of cerebral circulation by ischemic type (as part of combination therapy);
  • left ventricular failure with bronchospasm and Chain-Stokes breathing disorder;
  • edematous syndrome of renal genesis (as part of complex therapy);
  • acute and chronic heart failure (as part of combination therapy);
  • bronchoobstructive syndrome of various genesis (including bronchial asthma, COPD, including pulmonary emphysema, chronic obstructive bronchitis);
  • hypertension in a small circle of blood circulation;
  • "pulmonary" heart;
  • night apnea.

 

Forms of release

 

Tablets 150 mg.

 

Solution for intravenous administration of 24 mg / ml (injections in ampoules, in droppers).

 

Solution for intramuscular injection 240 mg / ml (injections in ampoules for injection).

 

Instructions for use and dosage

 

Pills

 

Inside, adults should be prescribed 150 mg at the reception 1-3 times a day after meals. Children inside should be prescribed at a rate of 7-10 mg / kg per day in 4 divided doses.The duration of the course of treatment is from several days to several months, depending on the course of the disease and the tolerability of the drug.

 

Higher doses of euphyllin for adults inside: single - 0.5 g, daily - 1.5 g. Higher doses for children inside: single dose - 7 mg / kg, daily - 15 mg / kg.

 

Injection

 

Individual, depending on the indications, age, clinical situation, route and route of administration (intravenously, intramuscularly, via a drip drop), nicotine addiction.

 

Side effect

  • dizziness;
  • headache;
  • insomnia;
  • excitation;
  • anxiety;
  • irritability;
  • tremor;
  • palpitation;
  • tachycardia (including the fetus when taking a pregnant woman in the 3rd trimester);
  • chest pain;
  • lowering blood pressure;
  • abdominal pain;
  • nausea, vomiting;
  • heartburn;
  • exacerbation of peptic ulcer;
  • diarrhea;
  • decreased appetite;
  • skin rash;
  • itching;
  • fever;
  • sensation of tides to the face;
  • hematuria;
  • increased diuresis;
  • increased sweating.

 

Contraindications

  • hypersensitivity (including other xanthine derivatives: caffeine, pentoxifylline, theobromine);
  • epilepsy;
  • peptic ulcer of the stomach and duodenum (in the stage of exacerbation);
  • gastritis with high acidity;
  • arterial hypertension or hypotension of severe course;
  • tachyarrhythmias;
  • hemorrhagic stroke;
  • hemorrhage in the retina of the eye;
  • children's age (up to 3 years).

 

Application in pregnancy and lactation

 

With care, pregnancy, lactation.

 

special instructions

 

Be careful when consuming large quantities of caffeine-containing foods or drinks during the treatment period.

 

Impact on the ability to drive vehicles and manage mechanisms

 

It is necessary to refrain from driving transport and employment by other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

Increases the likelihood of side effects of glucocorticosteroids, mineralocorticosteroids (hypernatremia), funds for general anesthesia (increases the risk of ventricular arrhythmias), xanthines and drugs that excite the central nervous system (increases neurotoxicity), beta-adrenostimulants.

 

Antidiarrhoeal drugs and enterosorbents reduce the absorption of aminophylline.

 

Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives and moracisin, as inducers of microsomal liver enzymes, increase the clearance of aminophylline, which may require an increase in its dose.

 

When combined with antibiotics, the macrolide group, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, small doses of ethanol (alcohol), disulfiram, fluoroquinolones, recombinant interferon-alpha, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, Verapamil and vaccine against influenza The intensity of action of Euphyllin may increase, which may require a reduction in its dose.

 

Strengthens the action of beta-adrenostimulators and diuretics (including by increasing the glomerular filtration), reduces the effectiveness of lithium and beta-blockers. Compatible with antispasmodics, do not use together with other xanthine derivatives.

 

Analogues of the drug Eufillin

 

Structural analogs for the active substance:

  • Aminophylline;
  • Aminophylline-Eskom;
  • Eufillin-Darnitsa;
  • Eufillina injection 2,4%;
  • Euphyllin injection for 24%.

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Reviews (31):
Guests
olga
I better expectorate. Easier to breathe.
Guests
Vlad
A large pillar.
Guests
Valentina
With this tool had to be faced completely by accident. At night she began to choke, she could not take a deep breath. The ambulance doctor gave me an injection and it became so good right away. After that, I constantly have eufillin in tablets. Well help, but I rarely use it, only with attacks - it turned out that it was an allergy to me.
Guests
Rifkat
To me did or made nyxes eufillina many times, somewhere 20 days. Though somehow helped me with terrible pains on the spine.When after the injection of the next fursimide gave a shock: all the pain abruptly ceased all the body from the inside began to tremble and began to die from the foot. The sensitivity of the whole body was gone, the lips bitten up to the blood without pain. When the doctors came running, I almost did not breathe, snoring. Thank you somehow anti-shock drugs pulled out. This was in late August 1999 at the KAMAZ hospital in Nab Chelny.
Administrators
admin
Rifkat, Sometimes it happens. Of course it is interesting that the diagnosis was that the pain in the spine was treated with eufillin (there may be some vascular insufficiency), well, and pathological reactions to combinations of drugs are often found. The main thing to remember about such situations and talk to doctors, and then the combination of euphyllin and diuretic, can occur in the practice of emergency doctors or resuscitators.
Guests
roman
It is possible that with the action of euphyllin, coronary vessels expand to a large extent in response to stimulation of the heart. Euphyllin increases the venous return of blood to the heart, so the cardiac output at the height of the action of euphyllin increases. E.has a stimulating effect on c. n. with., similar to the action of caffeine. Due to stimulation of the centers of vagus nerves in small doses can cause a bradycardia. The diuretic effect is mainly due to the inhibition of reabsorption in the renal tubules.
Administrators
admin
roman, Thank you for additional information on the drug Eufillin. It was interesting to read even to me.
Guests
trufanova nina ivanovna
At me ibs and an obstructive bronchitis, I choke more at night, sometimes even in the afternoon pomnidizolonom the inhaler and an auylline with prednisolone thanks for the information helps or assists. It was interesting to find useful information.
Guests
viktor alekseevich
Several times, the ambulance rescued by intravenous euphillin from attacks = irritation syndrome of the vertebral artery = There were severe dizziness, nausea and vomiting, loss of consciousness for a few seconds. After the introduction, everything was normalized after 1 hour.
Guests
Irina
Yes to me today the doctor the neurologist in a dropper besides other medicines has entered and an euphyllinus. After I got it done, it became much easier for me: a crazy pain in my leg took off, but it was in the compartment with a blockade on the spine. There were no side effects, only improvement. So, if the doctor appoints you to the dropper euphillin, do not be afraid, he really helps, and does not harm.
Guests
Irina
And if the intravenous drug, can it be administered intramuscularly?
Administrators
admin
Irina, I have never asked such a question, but it seems that it is possible, because the composition of the liquid is identical, so the use of intramuscular intravenous form of Eufillin should not be a side effect.
Guests
Slavik
Eufillin can not be administered intramuscularly, only intravenously.
Administrators
admin
SlavikWho told you that. Read carefully the instructions for use. Euphyllin 24% special intramuscular form of the drug.
Guests
Just a sick man.
I'm 62 years old.I have OCBL for 18 years. In the autumn, when there is little rain and a lot of dust on the streets, I have relapses. For a certain period in the bronchi accumulates a lot of mucus, which itself does not depart. Then there is shortness of breath and a shortage of air, even indoors. Begin to swell the face and hands (the brushes are still made red-purple). All this develops very quickly - for 2-3 days. There is a choking and a feeling of inexplicable anxiety. Here I am saved by euphyllin and mineral water. After taking 2-3 days of euphyllin, a purulent plug comes out of the airways and sputum begins to separate. 7-10 days and everything passes. At this time I drink a lot of liquid (mineral water, berry fruit), but in no case milk (it forms a lot of mucus in the body).
On the side effects - so many products are now very harmful, but we eat them all the time. The medicine takes a limited time. The body itself then recover.
I want to add - in the apartment you need to have an air humidifier. These inexpensive wonderful appliances well moisturize the air and in summer in hot weather and in winter in the heating season.
I wish everyone good health. Take care of yourself.
Guests
Lina D.
I have a child of 8 years.I had bronchitis, but my cough was creepy. At the next appointment, the pediatrician prescribed inhalation with euphyllin. So after two inhalations, the cough almost did not become. Earlier about this drug did not hear. Now I will have in my arsenal, as often we suffer from bronchitis.
Guests
Olga
Have injected intravenously ... To me the neurologist has appointed or nominated in connection with an osteochondrosis if before this terrible maddening pains in a back and a leg did not allow to sit, lay, go ... Now literally an hour from later pains are not present! Put half the dose from 10 ml. While they were injecting nausea, the head was spinning and sitting. A couple of minutes passed, and I was able to go myself without help !!!! :-) a good remedy, though a pimple in the form of excitability a little worries me, but it's better to lie than half-rubbed :-) If you have a doctor appointed colitis! Do not regret, but people over 50 are better with caution!
There is a question now holidays will begin that will be if, a break in a prick of this preparation will be more than 2 days? I was appointed to stab him in a day ...
Administrators
admin
Olga, Nothing will happen.Continue to take prescribed treatment after the holidays. There is still no other way out. Intravenous home at home you will not find enough people to pierce Euphyllin, and that's not necessary.
Guests
Olga
Today, injected intramuscularly eufillin 24. At the injection site, the pain is terrible, just do not convey in words. There is no patience to endure this pain. I do not want to do any more.
Guests
genre
I have asthma. Started in the morning attack of suffocation gradually, on increasing. With my medications, which I use, there was no seizure. I called an ambulance, the doctor made an intravenous injection with euphyllin. For a couple of seconds the choking receded. She began to breathe freely. There were no side effects. Thank you doctor!
Guests
Alice
Tablets were prescribed for euphilin, tk. wheezing does not last more than 2 weeks. After reception after a while the head began to spin and there was a terrible weakness, I thought I would faint, but nothing happened. Now I'm thinking of continuing to drink it, or is it better to wheeze?
Administrators
admin
AliceIt is better to replace Euphyllinum with something else, because bronchial obstruction (what you call wheezing) can be dangerous, including its severe complications. For example, you can use drugs based on Teofillin (Eufilong, Ventax and others). Consult the replacement with your doctor.
Guests
nazir
Hello! A year ago I started a very violent cough and went to the doctor for almost 2 months, the doctor sent me to X-ray. On X-ray revealed as if there is a light rod, sent to the tuberculosis center, there they diagnosed chronic bronchitis. I went through the treatment with stuff that I could. After the treatment, there was nothing a year, now the perspiration began again in his throat, wheezing and coughing, he was advised by euphyllin.
Guests
Barishka
She injected intramuscularly 24%, such pain at the injection site.
Guests
Maksat
I am 52 years old. Diagnosis of chronic bronchitis (chronic obstructive bronchitis, bronchospasm with respiratory failure). After the bath I drank cold water from the refrigerator, and since then I started coughing and my throat ached.Without the appointment of a doctor, he took mucaltin and rinsed his throat with furatsilinom 4-5 a day, sucked anti-inflammatory, antibacterial candy pills for the nasopharynx. The result is zero, there is no improvement, on the contrary I began to cough more and began to suffocate, then I turned to the doctor, she appointed me and now I take intravenous euphyllin with fiz. solution of 0.9% (100 ml) + Metrogil (100 ml) + dexamethasone 0.2 ml. At once it became easier to breathe, I feel I am getting better. Side effects as in the instructions of the drug in the same way there is - dizziness, increased sweating.
Guests
Olga
The first intravenous euphyllin transferred tolerably. On the second injection - loss of consciousness, tachycardia, confused consciousness and speech. I came to myself about 8 hours. All. Never for anything.
Visitors
Ivanchik
The wife was prescribed intravenously, the pregnancy is 36 weeks, the legs swell. Should I give her injections?
Guests
Irina
Bronchitis in lingering form. Assigned 3 droppers solution - saline, dexamethasone, euphyllin.2 droppers passed like nothing, from the 3rd it was so bad, came to the senses with ammonia. True, the sputum began to recede. For me, a heavy drug.
Administrators
admin
IvanchikWhether or not to use the preparation Eufillin for the elimination of edematous syndrome in a pregnant woman, the attending physician decides, but this medicine is used for these purposes.
Guests
Alhaz
I have COPD. At the end of February, in the morning, I began to suffocate. Arriving ambulance doctors introduced euphyllin with prednisolone and it became easier for me. In the afternoon the district doctor came and recommended buying euphyllin in ampoules and prednisolone tablets. 2 tablets for 1 ampoule dissolve and when bouts drip under the tongue 3-4 drops. Today it came in handy - after a small load began to suffocate and had to drip 4 drops under the tongue and after a couple of minutes already released. Today again I will go to see a doctor and ask for hospitalization.
Guests
Pensioner
I take an annual course - 10 droppers (high pressure due to a wrinkled kidney).It helps a lot. From sensations - at introduction gives warmth to a sole of feet, and in an hour after introduction - occurrence of sweat on a neck. It is necessary and can be applied.

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