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Aksamon - instructions for use, analogs, reviews and release forms (20 mg tablets) of a drug for the treatment of Alzheimer's disease, paresis and paralysis in adults, children and pregnancy

Aksamon - instructions for use, analogs, reviews and release forms (20 mg tablets) of a drug for the treatment of Alzheimer's disease, paresis and paralysis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Aksamon. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Axamon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aksamon in the presence of existing structural analogues. Use for the treatment of Alzheimer's disease, paresis and paralysis in adults, children, as well as in pregnancy and lactation.

 

Aksamon cholinesterase inhibitor. Stimulates neuromuscular transmission and conduction of excitation along the nerves and cells of smooth muscles due to blockade of the potassium channels of the excitable membrane and inhibition of cholinesterase activity, enhances the effect of acetylcholine, serotonin, histamine, oxytocin on smooth muscle (but does not affect the potassium chloride action).

 

Pharmacokinetics

 

After taking the drug inside, ipidacrin (the active substance of the drug Aksamon) is quickly absorbed from the digestive tract, mainly from the duodenum, to a lesser extent - from the thin and iliac; about 3% of the dose is absorbed from the stomach. Epidacrine rapidly penetrates from the blood into the tissues, so after reaching the equilibrium state, about 2% of the accepted dose of the drug remains in the blood serum. Ipidacrin is biotransformed in the liver and is excreted partially with bile, and mostly by the kidneys, mainly due to tubular secretion, about 1/3 - by glomerular filtration, with only 3.7% of the dose being excreted unchanged.

 

Indications

  • diseases of the peripheral nervous system (neuritis, polyneuritis, polyneuropathy, polyradiculopathy);
  • bulbar paralysis and paresis;
  • recovery period with organic lesions of the CNS, accompanied by motor disorders;
  • myasthenia gravis and myasthenic syndromes;
  • in the complex therapy of demyelinating diseases;
  • Alzheimer's disease and senile dementia of the Alzheimer's type;
  • weakness of labor activity;
  • atony of the intestine.

 

Forms of release

 

Tablets of 20 mg.

 

Instructions for use and dosing regimen

 

The drug is administered to adults.

 

With lesions of the peripheral nervous system, 20 mg 3 times a day are prescribed.

 

With myasthenia gravis, myasthenic syndromes and dimielinizing nervous system lesions, the recommended single dose is 20-40 mg; the frequency of reception is 4-5 times a day. The maximum daily dose is 180-200 mg.

 

For the treatment and prevention of intestinal atony appoint 15-20 mg 2-3 times a day for 1-2 weeks.

 

For the treatment of Alzheimer's disease and mnestic disorders of different genesis, an individual choice of the dosing regimen is required. The average dose is 10-20 mg 2-3 times a day. The duration of therapy is from 1 month to 1 year.

 

To stimulate labor, the drug is prescribed in a dose of 20 mg once.If the effect is insufficient, the preparation is repeated 1-2 times with an interval between doses of 1 hour.

 

Side effect

  • anorexia;
  • hypersalivation;
  • nausea, vomiting;
  • increased peristalsis;
  • diarrhea;
  • dizziness (after repeated administration);
  • ataxia;
  • itching;
  • rash;
  • bronchospasm;
  • bradycardia (manifestation of m-cholinomimetic action).

 

Contraindications

  • epilepsy;
  • extrapyramidal disorders with hyperkinesia;
  • angina pectoris;
  • severe bradycardia;
  • bronchial asthma;
  • propensity to vestibular disorders;
  • pregnancy;
  • lactation period (breastfeeding);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The drug is contraindicated for use in pregnancy and lactation.

 

special instructions

 

With caution appoint with gastric ulcer, thyrotoxicosis, diseases of the cardiovascular system. It is also necessary to take into account the possible increase in the tone of the uterus.

 

The drug is well tolerated, side effects occur rarely (in 6.5% of cases), mildly expressed and, as a rule, do not require drug withdrawal (rapid elimination prevents cumulation and the occurrence of side effects).

 

During the period of drug use, you should not drink alcohol.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During the period of treatment, patients should avoid driving motor vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

When combined, increases the sedative effect of drugs with a depressing effect on the central nervous system, the effect of other inhibitors of cholinesterase and m-cholinomimetics.

 

Against the background of the use of other cholinergic drugs, the risk of a cholinergic crisis in patients with myasthenia gravis increases.

 

When combined, beta-blockers increase the risk of developing bradycardia.

 

When combined, weakens the effect of local anesthetics, antibiotics, potassium chloride.

 

Atropine and metocinia iodide reduce the severity of side effects of high doses of ipidacrine.

 

Analogues of the drug Aksamon

 

Structural analogs for the active substance:

  • Amiridin 20 mg;
  • Amiridine tablets;
  • Neuromidine.

Similar medicines:

Other medicines:

Reviews (11):
Guests
Peter
We used Aksamon to our grandfather who had Alzheimer's disease. The granddaddy was bad at all, just doctors in the clinic could not immediately determine what he had been sent to all the offices until he got to the hospital. There and already at home he was given Aksamon, although I will not say that the progress was very strong, but at 3 months of treatment he received severe nausea for this drug, so I have no clear opinion about this medicine, since I have to cure him at the full rate failed.
Guests
Faina
There was a squeezing of the ulnar nerve. The doctor appointed an aksamon. Took 2 months. Improvement is real. The motor functions recovered completely.
Guests
Olga
Accepted Aksamon with polyneuropathy of arms and legs for a long time, about half a year with interruptions for other drugs. I can not say that it was Aksamon that helped, most likely everything in the complex, noticed one thing - it became much better to sleep.
Guests
galena
Pain when walking. The axamone was attributed, the leg hurts from the hip to the knee. Is it appropriate to use this drug?
Administrators
admin
galenaThe doctor knows best. With neuropathic pain, the drug Aksamon can be used, and what you have for the diagnosis of a short description of the problem is unclear. With arthrosis, for example, the nature of the pain may be similar, but this medicine is not used.
Visitors
Eltaro
He underwent a course of treatment with this drug in combination with vitamins of group B and nicotinic acid. Diagnosis: Carpal tunnel syndrome (pinching of the median nerve). The mobility of the joint improved. Somewhere after a month of taking drugs, there was a very unpleasant side effect: "pain behind the sternum," a feeling that the squeezes compress the chest. To finish the course of treatment to the end could not. This side effect is described in the instruction as rare and lost after a dose reduction or stopping drug intake for 1-2 days. Lies, or statistics is not collected. Suffered for almost four days, I strongly advise the first appearance of such an effect to immediately throw the drug and consult a doctor. angry The etiology of this pain is not specified either from the cardiovascular system, or from the respiratory system. Anesthetic has no significant effect. Significant reduction in pain was achieved with spasmalgon, camphor and salbutamol (bronchodilator).
Visitors
Rasstriga
After the removal of hernia n4l5, the numbness of the foot was prescribed axamon, trental and movalis. Are these drugs compatible?
Visitors
Rasstriga
From the paresis of the toes after the operation to remove the hernia n4l5, what would you designate?
Administrators
admin
Rasstriga, With the joint use of Trental and Movalis, the potential risk of developing bleeding from the gastrointestinal tract increases. The task of the attending physician is to evaluate the benefit-harm from using this combination and use it if it is shown to a specific patient or to be replaced by another combination of medicines.

The meaning of the appointment of Movalis is incomprehensible to me from the description of your problem. The use of other drugs is adequate.You can still use Glycine, although many experts argue about the potential benefits of using this medication.
Guests
Alla
When you take Axamon, can you take Spazgan from a headache?
Administrators
admin
Alla, Fenpiverinia bromide in the composition of Spazgan possesses anticholinergic action and blocks cholinesterase. Aksamon is also an anticholinesterase agent. I can assume an increase in anticholinergic effects in the joint use of these drugs: dry mouth, decreased sweating, paresis of accommodation, tachycardia, difficulty urinating, but these effects may not happen. I would not use these drugs together to avoid unnecessary complications or took medications for migraine without the components that cause the anticholinesterase effect.

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