Aksamon - instructions for use, analogs, reviews and release forms (20 mg tablets) of a drug for the treatment of Alzheimer's disease, paresis and paralysis in adults, children and pregnancy
In this article, you can read the instructions for using the drug Aksamon. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Axamon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aksamon in the presence of existing structural analogues. Use for the treatment of Alzheimer's disease, paresis and paralysis in adults, children, as well as in pregnancy and lactation.
Aksamon cholinesterase inhibitor. Stimulates neuromuscular transmission and conduction of excitation along the nerves and cells of smooth muscles due to blockade of the potassium channels of the excitable membrane and inhibition of cholinesterase activity, enhances the effect of acetylcholine, serotonin, histamine, oxytocin on smooth muscle (but does not affect the potassium chloride action).
Pharmacokinetics
After taking the drug inside, ipidacrin (the active substance of the drug Aksamon) is quickly absorbed from the digestive tract, mainly from the duodenum, to a lesser extent - from the thin and iliac; about 3% of the dose is absorbed from the stomach. Epidacrine rapidly penetrates from the blood into the tissues, so after reaching the equilibrium state, about 2% of the accepted dose of the drug remains in the blood serum. Ipidacrin is biotransformed in the liver and is excreted partially with bile, and mostly by the kidneys, mainly due to tubular secretion, about 1/3 - by glomerular filtration, with only 3.7% of the dose being excreted unchanged.
Indications
- diseases of the peripheral nervous system (neuritis, polyneuritis, polyneuropathy, polyradiculopathy);
- bulbar paralysis and paresis;
- recovery period with organic lesions of the CNS, accompanied by motor disorders;
- myasthenia gravis and myasthenic syndromes;
- in the complex therapy of demyelinating diseases;
- Alzheimer's disease and senile dementia of the Alzheimer's type;
- weakness of labor activity;
- atony of the intestine.
Forms of release
Tablets of 20 mg.
Instructions for use and dosing regimen
The drug is administered to adults.
With lesions of the peripheral nervous system, 20 mg 3 times a day are prescribed.
With myasthenia gravis, myasthenic syndromes and dimielinizing nervous system lesions, the recommended single dose is 20-40 mg; the frequency of reception is 4-5 times a day. The maximum daily dose is 180-200 mg.
For the treatment and prevention of intestinal atony appoint 15-20 mg 2-3 times a day for 1-2 weeks.
For the treatment of Alzheimer's disease and mnestic disorders of different genesis, an individual choice of the dosing regimen is required. The average dose is 10-20 mg 2-3 times a day. The duration of therapy is from 1 month to 1 year.
To stimulate labor, the drug is prescribed in a dose of 20 mg once.If the effect is insufficient, the preparation is repeated 1-2 times with an interval between doses of 1 hour.
Side effect
- anorexia;
- hypersalivation;
- nausea, vomiting;
- increased peristalsis;
- diarrhea;
- dizziness (after repeated administration);
- ataxia;
- itching;
- rash;
- bronchospasm;
- bradycardia (manifestation of m-cholinomimetic action).
Contraindications
- epilepsy;
- extrapyramidal disorders with hyperkinesia;
- angina pectoris;
- severe bradycardia;
- bronchial asthma;
- propensity to vestibular disorders;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy and lactation.
special instructions
With caution appoint with gastric ulcer, thyrotoxicosis, diseases of the cardiovascular system. It is also necessary to take into account the possible increase in the tone of the uterus.
The drug is well tolerated, side effects occur rarely (in 6.5% of cases), mildly expressed and, as a rule, do not require drug withdrawal (rapid elimination prevents cumulation and the occurrence of side effects).
During the period of drug use, you should not drink alcohol.
Impact on the ability to drive vehicles and manage mechanisms
During the period of treatment, patients should avoid driving motor vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions.
Drug Interactions
When combined, increases the sedative effect of drugs with a depressing effect on the central nervous system, the effect of other inhibitors of cholinesterase and m-cholinomimetics.
Against the background of the use of other cholinergic drugs, the risk of a cholinergic crisis in patients with myasthenia gravis increases.
When combined, beta-blockers increase the risk of developing bradycardia.
When combined, weakens the effect of local anesthetics, antibiotics, potassium chloride.
Atropine and metocinia iodide reduce the severity of side effects of high doses of ipidacrine.
Analogues of the drug Aksamon
Structural analogs for the active substance:
- Amiridin 20 mg;
- Amiridine tablets;
- Neuromidine.
Similar medicines:
Other medicines:
- Diprospan - instructions for use, analogs, reviews and release forms (suspension or solution in injection injections in ampoules (including for intra-articular administration)) of the drug for the treatment of inflammation in adults, children and in pregnancy
- Grandaxin - instructions for use, reviews, analogs and formulations (tablets 50 mg) of the drug for the treatment of neuroses, stress and climax in adults, children and pregnancy
- Remens - instructions for use, reviews, analogs and forms of release (drops, tablets) of a homeopathic remedy for the treatment of menopause, menstrual disorders, endometritis and adnexitis in women, including during pregnancy. Composition