Isoprinosine - instructions for use, reviews, analogs and forms of release (tablets 500 mg) of the drug for the treatment of influenza, herpes, HPV (human papilloma virus) in adults, children and pregnancy

In this article, you can read the instructions for using the drug Isoprinosine. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Isoprinosine in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of isoprinosine in the presence of existing structural analogues. Use to treat influenza, herpes, HPV (human papillomavirus), as well as other colds in adults, children,as well as during pregnancy and lactation.

Isoprinosine - immunostimulating drug with antiviral effect. Isoprinosine is a synthetic complex derivative of purine, which possesses immunostimulating activity and nonspecific antiviral action. It restores the functions of lymphocytes under conditions of immunodepression, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, normalizes the incorporation of thymidine into them. Isoprinosine exerts a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killers, the function of T-suppressors and T-helpers, increases the production of IgG, Interferon gamma, interleukins (IL-1) and IL-2, reduces the formation of pro-inflammatory cytokines-IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against viruses Herpes simplex (herpes simplex virus), cytomegalovirus and measles virus, human T-cell lymphoma virus type 3, polioviruses, influenza A and B, ECHO virus (enterocytopathogenic human virus), encephalomyocarditis and horse encephalitis.The mechanism of the antiviral action of isoprinosine associated with inhibition of viral RNA and digidropteroatsintetazy enzyme involved in the replication of some viruses, virus enhances depressed lymphocyte mRNA synthesis, which is accompanied by inhibition of the biosynthesis of viral RNA and translation of viral proteins, production increases lymphocytes possess antiviral properties of interferon alpha and gamma.

When combined, increases the effect of interferon-alpha, antiviral agents of Acyclovir and zidovudine.

Pharmacokinetics

After oral administration, it is well absorbed from the digestive tract. Inosine is rapidly metabolized by the cycle typical for purine nucleotides, with the formation of uric acid. It is excreted in the urine unchanged and in the form of metabolites for 48 hours. Cumulation is not observed.

Indications

• treatment of influenza and other ARVI;
• infections caused by Herpes simplex virus types 1, 2, 3 and 4: labial and genital herpes, herpetic keratitis;
• shingles, chicken pox;
• infectious mononucleosis caused by the Epstein-Barr virus;
• cytomegalovirus infection;
• measles of heavy current;
• papillomavirus infection: papilloma of the larynx / vocal cords (fibrous type), papillomavirus infection of the genitals in men and women, warts;
• molluscum contagiosum.

Forms of release

Tablets 500 mg.

Instructions for use and dosage

Tablets are taken after meals, washed down with a small amount of water.

The recommended daily intake for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg body weight in 3-4 divided doses, which on average for adults is 6-8 tablets per day, for children - 1/2 tablets per 5 kg of body weight per day.

In severe forms of infectious diseases, the dose can be increased individually up to 100 mg / kg of body weight per day, divided into 4-6 receptions. The maximum daily intake for adults is 3-4 grams per day, for children aged 3 years and older, 50 mg / kg per day

Duration of treatment for acute diseases in adults and children aged 3 years and older is usually from 5 to 14 days. Treatment should continue until the disappearance of clinical symptoms and for another 2 days already in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a doctor.

For chronic relapsing diseases in adults and children aged 3 years and older, treatment should be continued with several courses of 5-10 days with a break in admission in 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

For herpetic infection, adults and children aged 3 years and older receive the drug for 5-10 days before the symptoms disappear, in the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

In case of papillomavirus infection, adults are prescribed 2 tablets 3 per day for adults, and for children 3 years and older 1/2 tablets per 5 kg / body weight per day in 3-4 doses for 14-28 days in the form of monotherapy.

For recurrent genital warts, adults are prescribed 2 tablets 3 per day, children aged 3 years and older - 1/2 tablet per 5 kg / body weight per day in 3-4 divided doses, either as monotherapy or in combination with a surgical treatment for 14-28 days, then with a three-fold repetition of this course at intervals of 1 month.

Side effect

• nausea, vomiting;
• pain in epigastrium;
• itching;
• headache, dizziness, weakness;
• drowsiness, insomnia;
• polyuria;
• joint pain;
• exacerbation of gout.

Contraindications

• urolithiasis disease;
• gout;
• arrhythmias;
• chronic renal failure;
• children under 3 years old (body weight up to 15 kg);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Safety of the use of Isoprinosine during pregnancy and lactation is not established, therefore, the use of the drug is not recommended.

special instructions

After 2 weeks of using Isoprinosine, it is recommended to monitor the content of uric acid in the serum and urine. After 4 weeks of use, it is advisable to monitor liver and kidney function every month (transaminase activity, creatinine, uric acid level).

It is necessary to monitor the level of uric acid in the blood serum when prescribing Isoprinosine in combination with drugs that increase the level of uric acid or drugs that disrupt kidney function.

Impact on the ability to drive vehicles and manage mechanisms

There are no special contra-indications regarding the driving of transport or the management of machines and mechanisms.

Drug Interactions

With simultaneous use of immunosuppressants can reduce the effectiveness of Iprinosin.

Inhibitors of xanthine oxidase and uricosuric agents (including diuretics) may contribute to the risk of increasing the level of uric acid in the serum of patients taking Isoprinosine.

Analogues of the drug Isoprinosine

Structural analogs for the active substance:

• Groprinosin

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